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The map label for this gene is selB

Identifier: 15668672

GI number: 15668672

Start: 436910

End: 438319

Strand: Direct

Name: selB

Synonym: MJ0495

Alternate gene names: 15668672

Gene position: 436910-438319 (Clockwise)

Preceding gene: 15668671

Following gene: 15668673

Centisome position: 26.24

GC content: 33.83

Gene sequence:

>1410_bases
TTGGTGATTTCTATGGAAATGAAAAATGTAAATGTTGGTTTGTTTGGGCATATTGACCATGGAAAAACACAACTGGCAAA
GCAACTGACTGAAATAGCTTCAACCTCTGCCTTAGATAAACCAAAAGAATCCCAAAAGAGAGGAATAACCATTGATTTGG
GATTCTCTTCCTTCACATTGGATAGATATAGGATTACCTTAGTCGATGCCCCTGGACATTCTGAGTTGATAAGAACAGCT
ATTGGGGCAGGAAATATAATTGATGCCGCTTTATTAGTTGTAGATGCCAAAGAAGGGCCAAAGACACAAACAGGAGAGCA
TCTGTTAGTTTTAGATTTATTAAACATCCCTACGATTGTTGTTATAAATAAGATAGACATTGCAAATGATGAAGAGATTA
AAAGAACTGAAATGTTTATGAAACAAATACTAAACTCAACAATAAATTTAAAAAACTCTAAGATTATTAAAATCTCAGCA
AAAACTGGAGAGGGAATAGGGGAATTAAAAAAAGAGCTTAAAAATCTGTTAGACAGCTTAGATATTAAGAGAGATATAAA
TAGCTATCTAAAAATGCCTATTGACCATGCATTTAAAATAAAAGGGGTTGGAACAGTTGTAACAGGAACGATTCATAAGG
GAAAGGTGGAGGTTGGAGATAATCTTAGGATTTTACCAATAAATCATGAAGTTAAGGTTAAAAGCATACAGTGCTTTAAA
CAGGATGTCTCTATAGCTTATGCAGGAGATAGGGTTGGAATGGCGTTAATGGGTGTAGAACCAGAGAGTTTATTTAGAGG
TTGCATATTAACTTCAGAGGATACAAAATTAAAGGTAGTAGATAAGTTTATAGCAAAAGTAAAGATTCTTGAGTTGTTTA
AATATAACTTAGCTCCAAAGATGAAGGTTCATATAAACATTGGGCTTTTAACAGTCCCAGCCACAATAATTCCATATAAA
ATAGAGAAGATTAATGACAAAGAGGAACCAATAATACTGGAAGAAATTAAAGGGGGAGATTCTTGCTACTGTATCTTTAA
GTTAGAGGAAAGAGTTGTTGTTGATGAAGGAGATAAGATTTTAATAATGAGGTTGGATTTGCCGCCAACAACTTTAAGGA
TTTGTGGATTTGGGGAGGTTATTGATTTTGGAGAAGTAGAGGTTAAAAAGATTGTTGTAAAAGAGGGAAAGGTTGTTAAA
AAGAAAGATAAAATCTATATTGAGGGATTAGCATCTTCTAAAACAGCTGGAGAAAAACTTATTGGGGGGAAAGTTTATAT
CCCTGATAAGAATATATGGGGAGTTATTAAGGGGACGTTTGGAACTAAAGGGGCTTTAATTGCTGAGTTTGATGAGGAAG
TTAATGGAGGAGAAAAAGTTGTATTAAAAAGAGTAAGAAAATGGGGATAA

Upstream 100 bases:

>100_bases
AAAATAAAATTTTTAGGAATAAAAAAACCAAAGAGATGGTTTGTAATTAGAAGAGAAAGGTTGAAAGCTAAAAAACAAAA
ATAAATAATTAATAAATAAT

Downstream 100 bases:

>100_bases
ATTCATAGGTATTAAAACCGCATCTTTTATATACTCAACACAACAAAAATAAATTTTACCGATAAATTATTTTAGCTGTC
TTGGTGAGAGTTGTGTATGT

Product: EF-1 alpha family translation factor

Products: GDP; phosphate

Alternate protein names: SelB translation factor

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MVISMEMKNVNVGLFGHIDHGKTQLAKQLTEIASTSALDKPKESQKRGITIDLGFSSFTLDRYRITLVDAPGHSELIRTA
IGAGNIIDAALLVVDAKEGPKTQTGEHLLVLDLLNIPTIVVINKIDIANDEEIKRTEMFMKQILNSTINLKNSKIIKISA
KTGEGIGELKKELKNLLDSLDIKRDINSYLKMPIDHAFKIKGVGTVVTGTIHKGKVEVGDNLRILPINHEVKVKSIQCFK
QDVSIAYAGDRVGMALMGVEPESLFRGCILTSEDTKLKVVDKFIAKVKILELFKYNLAPKMKVHINIGLLTVPATIIPYK
IEKINDKEEPIILEEIKGGDSCYCIFKLEERVVVDEGDKILIMRLDLPPTTLRICGFGEVIDFGEVEVKKIVVKEGKVVK
KKDKIYIEGLASSKTAGEKLIGGKVYIPDKNIWGVIKGTFGTKGALIAEFDEEVNGGEKVVLKRVRKWG

Sequences:

>Translated_469_residues
MVISMEMKNVNVGLFGHIDHGKTQLAKQLTEIASTSALDKPKESQKRGITIDLGFSSFTLDRYRITLVDAPGHSELIRTA
IGAGNIIDAALLVVDAKEGPKTQTGEHLLVLDLLNIPTIVVINKIDIANDEEIKRTEMFMKQILNSTINLKNSKIIKISA
KTGEGIGELKKELKNLLDSLDIKRDINSYLKMPIDHAFKIKGVGTVVTGTIHKGKVEVGDNLRILPINHEVKVKSIQCFK
QDVSIAYAGDRVGMALMGVEPESLFRGCILTSEDTKLKVVDKFIAKVKILELFKYNLAPKMKVHINIGLLTVPATIIPYK
IEKINDKEEPIILEEIKGGDSCYCIFKLEERVVVDEGDKILIMRLDLPPTTLRICGFGEVIDFGEVEVKKIVVKEGKVVK
KKDKIYIEGLASSKTAGEKLIGGKVYIPDKNIWGVIKGTFGTKGALIAEFDEEVNGGEKVVLKRVRKWG
>Mature_469_residues
MVISMEMKNVNVGLFGHIDHGKTQLAKQLTEIASTSALDKPKESQKRGITIDLGFSSFTLDRYRITLVDAPGHSELIRTA
IGAGNIIDAALLVVDAKEGPKTQTGEHLLVLDLLNIPTIVVINKIDIANDEEIKRTEMFMKQILNSTINLKNSKIIKISA
KTGEGIGELKKELKNLLDSLDIKRDINSYLKMPIDHAFKIKGVGTVVTGTIHKGKVEVGDNLRILPINHEVKVKSIQCFK
QDVSIAYAGDRVGMALMGVEPESLFRGCILTSEDTKLKVVDKFIAKVKILELFKYNLAPKMKVHINIGLLTVPATIIPYK
IEKINDKEEPIILEEIKGGDSCYCIFKLEERVVVDEGDKILIMRLDLPPTTLRICGFGEVIDFGEVEVKKIVVKEGKVVK
KKDKIYIEGLASSKTAGEKLIGGKVYIPDKNIWGVIKGTFGTKGALIAEFDEEVNGGEKVVLKRVRKWG

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily

Homologues:

Organism=Homo sapiens, GI54607086, Length=364, Percent_Identity=35.989010989011, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI34147630, Length=308, Percent_Identity=29.5454545454545, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI223555963, Length=335, Percent_Identity=28.6567164179104, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI5729864, Length=335, Percent_Identity=28.6567164179104, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI4503475, Length=350, Percent_Identity=26.8571428571429, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4503471, Length=368, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI46094014, Length=333, Percent_Identity=26.4264264264264, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194018522, Length=334, Percent_Identity=25.748502994012, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI194097354, Length=334, Percent_Identity=25.748502994012, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI194018520, Length=334, Percent_Identity=25.748502994012, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI82546879, Length=281, Percent_Identity=25.6227758007117, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI157426893, Length=168, Percent_Identity=30.952380952381, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4503507, Length=277, Percent_Identity=24.9097472924188, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI53729339, Length=215, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI53729337, Length=215, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI94966754, Length=130, Percent_Identity=37.6923076923077, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI2367247, Length=261, Percent_Identity=32.183908045977, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789737, Length=302, Percent_Identity=32.7814569536424, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1790412, Length=302, Percent_Identity=32.7814569536424, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789108, Length=286, Percent_Identity=24.1258741258741, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI48994988, Length=284, Percent_Identity=26.7605633802817, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788922, Length=184, Percent_Identity=29.3478260869565, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17506081, Length=477, Percent_Identity=29.769392033543, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17556456, Length=319, Percent_Identity=31.974921630094, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17506079, Length=475, Percent_Identity=26.7368421052632, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI25141371, Length=276, Percent_Identity=32.2463768115942, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17552884, Length=347, Percent_Identity=27.6657060518732, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17569207, Length=347, Percent_Identity=27.6657060518732, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI115532067, Length=307, Percent_Identity=28.3387622149837, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115532065, Length=307, Percent_Identity=28.3387622149837, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32566303, Length=331, Percent_Identity=25.6797583081571, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32566629, Length=337, Percent_Identity=24.9258160237389, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17509919, Length=290, Percent_Identity=25.5172413793103, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17557151, Length=221, Percent_Identity=28.0542986425339, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565438, Length=282, Percent_Identity=24.468085106383, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71994658, Length=222, Percent_Identity=25.6756756756757, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=326, Percent_Identity=33.7423312883436, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6325337, Length=324, Percent_Identity=26.5432098765432, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319594, Length=324, Percent_Identity=26.5432098765432, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320377, Length=287, Percent_Identity=28.2229965156794, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322937, Length=369, Percent_Identity=24.390243902439, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323320, Length=177, Percent_Identity=34.4632768361582, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320863, Length=264, Percent_Identity=23.1060606060606, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19922690, Length=397, Percent_Identity=34.7607052896725, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI19921738, Length=293, Percent_Identity=34.1296928327645, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI281363316, Length=306, Percent_Identity=31.3725490196078, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17864358, Length=306, Percent_Identity=31.3725490196078, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45553807, Length=344, Percent_Identity=27.6162790697674, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI45553816, Length=344, Percent_Identity=27.6162790697674, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24651721, Length=344, Percent_Identity=27.6162790697674, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17864154, Length=344, Percent_Identity=27.6162790697674, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24652838, Length=347, Percent_Identity=27.6657060518732, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17137572, Length=347, Percent_Identity=27.6657060518732, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45550900, Length=300, Percent_Identity=28, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24647048, Length=273, Percent_Identity=24.5421245421245, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24647046, Length=273, Percent_Identity=24.5421245421245, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI78706572, Length=260, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19922512, Length=281, Percent_Identity=23.8434163701068, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24654852, Length=281, Percent_Identity=23.8434163701068, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELB_METJA (Q57918)

Other databases:

- EMBL:   L77117
- PIR:   G64361
- RefSeq:   NP_247471.1
- ProteinModelPortal:   Q57918
- SMR:   Q57918
- GeneID:   1451357
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0495
- NMPDR:   fig|243232.1.peg.508
- TIGR:   MJ0495
- HOGENOM:   HBG539066
- OMA:   FGHIDHG
- ProtClustDB:   CLSK876208
- BioCyc:   MJAN243232:MJ_0495-MONOMER
- GO:   GO:0005737
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- PRINTS:   PR00315
- TIGRFAMs:   TIGR00475
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; SSF50465 Elong_init_C; SSF50447 Translat_factor

EC number: 3.6.5.3

Molecular weight: Translated: 51850; Mature: 51850

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVISMEMKNVNVGLFGHIDHGKTQLAKQLTEIASTSALDKPKESQKRGITIDLGFSSFTL
CEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCEEEE
DRYRITLVDAPGHSELIRTAIGAGNIIDAALLVVDAKEGPKTQTGEHLLVLDLLNIPTIV
EEEEEEEEECCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEEECCCCEEE
VINKIDIANDEEIKRTEMFMKQILNSTINLKNSKIIKISAKTGEGIGELKKELKNLLDSL
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
DIKRDINSYLKMPIDHAFKIKGVGTVVTGTIHKGKVEVGDNLRILPINHEVKVKSIQCFK
HHHHHHHHHHCCCCCCEEEEECCCEEEEEEEECCEEEECCCEEEEECCCCEEEHHHHHHH
QDVSIAYAGDRVGMALMGVEPESLFRGCILTSEDTKLKVVDKFIAKVKILELFKYNLAPK
HCCEEEEECCCCCEEEECCCHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC
MKVHINIGLLTVPATIIPYKIEKINDKEEPIILEEIKGGDSCYCIFKLEERVVVDEGDKI
EEEEEEEEEEEECCEEEEEEEEECCCCCCCEEEEECCCCCCEEEEEEEEEEEEEECCCEE
LIMRLDLPPTTLRICGFGEVIDFGEVEVKKIVVKEGKVVKKKDKIYIEGLASSKTAGEKL
EEEEECCCCCEEEEECCCCCCCCCCEEEEEEEECCCCEEEECCEEEEEEECCCCCCCCCE
IGGKVYIPDKNIWGVIKGTFGTKGALIAEFDEEVNGGEKVVLKRVRKWG
ECCEEEECCCCEEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVISMEMKNVNVGLFGHIDHGKTQLAKQLTEIASTSALDKPKESQKRGITIDLGFSSFTL
CEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCEEEE
DRYRITLVDAPGHSELIRTAIGAGNIIDAALLVVDAKEGPKTQTGEHLLVLDLLNIPTIV
EEEEEEEEECCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEEECCCCEEE
VINKIDIANDEEIKRTEMFMKQILNSTINLKNSKIIKISAKTGEGIGELKKELKNLLDSL
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
DIKRDINSYLKMPIDHAFKIKGVGTVVTGTIHKGKVEVGDNLRILPINHEVKVKSIQCFK
HHHHHHHHHHCCCCCCEEEEECCCEEEEEEEECCEEEECCCEEEEECCCCEEEHHHHHHH
QDVSIAYAGDRVGMALMGVEPESLFRGCILTSEDTKLKVVDKFIAKVKILELFKYNLAPK
HCCEEEEECCCCCEEEECCCHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC
MKVHINIGLLTVPATIIPYKIEKINDKEEPIILEEIKGGDSCYCIFKLEERVVVDEGDKI
EEEEEEEEEEEECCEEEEEEEEECCCCCCCEEEEECCCCCCEEEEEEEEEEEEEECCCEE
LIMRLDLPPTTLRICGFGEVIDFGEVEVKKIVVKEGKVVKKKDKIYIEGLASSKTAGEKL
EEEEECCCCCEEEEECCCCCCCCCCEEEEEEEECCCCEEEECCEEEEEEECCCCCCCCCE
IGGKVYIPDKNIWGVIKGTFGTKGALIAEFDEEVNGGEKVVLKRVRKWG
ECCEEEECCCCEEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087; 10860743