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The map label for this gene is pcn

Identifier: 15668422

GI number: 15668422

Start: 234296

End: 235039

Strand: Direct

Name: pcn

Synonym: MJ0247

Alternate gene names: 15668422

Gene position: 234296-235039 (Clockwise)

Preceding gene: 15668414

Following gene: 15668423

Centisome position: 14.07

GC content: 32.39

Gene sequence:

>744_bases
ATGTTCAGAGGAGTTATGGAGAGTGCAAAAGAGTTTAAAAAAGTTGTTGATACAATCTCAACACTTTTAGATGAGATATG
TTTTGAAGTTGATGAGGAAGGGATAAAAGCGAGTGCAATGGACCCAAGCCATGTTGCTTTAGTTAGTTTGGAAATCCCAA
GATTGGCTTTTGAAGAATATGAAGCAGATTCTCATGATATTGGTATAGATTTAGAGGCATTTAAAAAAGTAATGAATAGA
GCTAAAGCTAAAGATAGGCTAATTTTAGAGTTAGACGAAGAAAAGAATAAATTAAATGTTATATTTGAAAACACTGGAAA
GAGAAAGTTCAGCTTAGCTTTGTTAGATATATCTGCCTCATCAGTTAAAGTTCCTGAAATAGAATATCCAAACGTAATCA
TGATTAAAGGAGATGCGTTTAAAGAGGCTTTAAAGGATGCTGATTTATTCAGTGATTATGTAATTTTAAAAGCTGATGAG
GATAAGTTTGTTATTCATGCTAAGGGAGATTTAAACGAGAATGAAGCAATATTTGAAAAGGATAGCTCAGCTATAATTAG
CTTAGAGGTTAAAGAAGAGGCAAAAAGTGCTTTCAATTTAGATTATTTAATGGACATGGTTAAGGGTGTTAGCTCAGGAG
ACATTATTAAGATTTACTTAGGTAATGACATGCCTCTAAAATTAGAATATTCAATTGCAGGGGTAAATTTAACCTTCCTA
TTGGCTCCAAGAATTGAAGGATAA

Upstream 100 bases:

>100_bases
ACATAAAAAGGTATTTATAAAACCTCAAATAGGTTTTATATTTATTCCCTCAGAAAAGTATATTTATTTTGGCAACTACC
TAAAATATTGGTGATATATT

Downstream 100 bases:

>100_bases
AAACCATTCTGCAGCATTTACTATATTTTGAGGGTTTTCATAATTATTATTTATTTCAGATGTTTTTCAAAAGACCACAA
ACCATATTTTGTGATAACCA

Product: proliferating-cell nuclear antigen Pol30

Products: NA

Alternate protein names: Proliferating cell nuclear antigen homolog; PCNA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MFRGVMESAKEFKKVVDTISTLLDEICFEVDEEGIKASAMDPSHVALVSLEIPRLAFEEYEADSHDIGIDLEAFKKVMNR
AKAKDRLILELDEEKNKLNVIFENTGKRKFSLALLDISASSVKVPEIEYPNVIMIKGDAFKEALKDADLFSDYVILKADE
DKFVIHAKGDLNENEAIFEKDSSAIISLEVKEEAKSAFNLDYLMDMVKGVSSGDIIKIYLGNDMPLKLEYSIAGVNLTFL
LAPRIEG

Sequences:

>Translated_247_residues
MFRGVMESAKEFKKVVDTISTLLDEICFEVDEEGIKASAMDPSHVALVSLEIPRLAFEEYEADSHDIGIDLEAFKKVMNR
AKAKDRLILELDEEKNKLNVIFENTGKRKFSLALLDISASSVKVPEIEYPNVIMIKGDAFKEALKDADLFSDYVILKADE
DKFVIHAKGDLNENEAIFEKDSSAIISLEVKEEAKSAFNLDYLMDMVKGVSSGDIIKIYLGNDMPLKLEYSIAGVNLTFL
LAPRIEG
>Mature_247_residues
MFRGVMESAKEFKKVVDTISTLLDEICFEVDEEGIKASAMDPSHVALVSLEIPRLAFEEYEADSHDIGIDLEAFKKVMNR
AKAKDRLILELDEEKNKLNVIFENTGKRKFSLALLDISASSVKVPEIEYPNVIMIKGDAFKEALKDADLFSDYVILKADE
DKFVIHAKGDLNENEAIFEKDSSAIISLEVKEEAKSAFNLDYLMDMVKGVSSGDIIKIYLGNDMPLKLEYSIAGVNLTFL
LAPRIEG

Specific function: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication

COG id: COG0592

COG function: function code L; DNA polymerase sliding clamp subunit (PCNA homolog)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PCNA family

Homologues:

Organism=Homo sapiens, GI33239451, Length=256, Percent_Identity=26.171875, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI4505641, Length=256, Percent_Identity=26.171875, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71995072, Length=219, Percent_Identity=28.310502283105, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319564, Length=253, Percent_Identity=29.2490118577075, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24585303, Length=239, Percent_Identity=26.3598326359833, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136790, Length=257, Percent_Identity=25.6809338521401, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45552759, Length=257, Percent_Identity=25.6809338521401, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCNA_METJA (Q57697)

Other databases:

- EMBL:   L77117
- PIR:   H64330
- RefSeq:   NP_247218.1
- ProteinModelPortal:   Q57697
- SMR:   Q57697
- GeneID:   1451101
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0247
- NMPDR:   fig|243232.1.peg.255
- TIGR:   MJ0247
- HOGENOM:   HBG553564
- OMA:   ICRDLSQ
- ProtClustDB:   PRK01115
- BioCyc:   MJAN243232:MJ_0247-MONOMER
- HAMAP:   MF_00317
- InterPro:   IPR000730
- InterPro:   IPR022649
- InterPro:   IPR022659
- InterPro:   IPR022648
- PANTHER:   PTHR11352
- PRINTS:   PR00339
- TIGRFAMs:   TIGR00590

Pfam domain/function: PF02747 PCNA_C; PF00705 PCNA_N

EC number: NA

Molecular weight: Translated: 27638; Mature: 27638

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS01251 PCNA_1; PS00293 PCNA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRGVMESAKEFKKVVDTISTLLDEICFEVDEEGIKASAMDPSHVALVSLEIPRLAFEEY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEEECCHHHHHHC
EADSHDIGIDLEAFKKVMNRAKAKDRLILELDEEKNKLNVIFENTGKRKFSLALLDISAS
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEEEEECCC
SVKVPEIEYPNVIMIKGDAFKEALKDADLFSDYVILKADEDKFVIHAKGDLNENEAIFEK
CEECCCCCCCCEEEEECHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCEEEEC
DSSAIISLEVKEEAKSAFNLDYLMDMVKGVSSGDIIKIYLGNDMPLKLEYSIAGVNLTFL
CCCEEEEEEEHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEEECEEEEEE
LAPRIEG
EECCCCC
>Mature Secondary Structure
MFRGVMESAKEFKKVVDTISTLLDEICFEVDEEGIKASAMDPSHVALVSLEIPRLAFEEY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEEECCHHHHHHC
EADSHDIGIDLEAFKKVMNRAKAKDRLILELDEEKNKLNVIFENTGKRKFSLALLDISAS
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEEEEECCC
SVKVPEIEYPNVIMIKGDAFKEALKDADLFSDYVILKADEDKFVIHAKGDLNENEAIFEK
CEECCCCCCCCEEEEECHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCEEEEC
DSSAIISLEVKEEAKSAFNLDYLMDMVKGVSSGDIIKIYLGNDMPLKLEYSIAGVNLTFL
CCCEEEEEEEHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEEECEEEEEE
LAPRIEG
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087