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The map label for this gene is prlC

Identifier: 30995361

GI number: 30995361

Start: 229603

End: 231642

Strand: Direct

Name: prlC

Synonym: HI0214

Alternate gene names: 30995361

Gene position: 229603-231642 (Clockwise)

Preceding gene: 30995360

Following gene: 16272178

Centisome position: 12.55

GC content: 40.78

Gene sequence:

>2040_bases
ATGTCAAATCCATTACTTAACATTCAAGGCCTACCGCCATTTTCACAAATCAAGCCAGAACACATTCGACCAGCTGTTGA
AAAATTAATTCAAGATTGTCGCAATACGATAGAACAAGTGTTAAAACAACCGCACTTTACTTGGGAAAATTTCATTTTGC
CTTTAACGGAAACTAATGATCGCTTAAATCGTGCTTGGTCGCCCGTTTCTCATCTCAATTCAGTAAAAAATAGCACTGAA
TTACGTGAAGCCTATCAAACGTGCTTGCCGTTACTTTCTGAATACAGCACTTGGGTTGGTCAGCATAAGGGGCTTTATAA
TGCCTATTTAGCGTTAAAAAATAGTGCTGAATTTGCCGATTATTCGATTGCACAAAAGAAAGCCATTGAAAATTCACTGC
GTGATTTTGAACTTTCAGGCATTGGGCTTTCCGAAGAGAAACAACAACGTTATGGCGAAATTGTGGCACGCTTATCGGAA
TTAAATTCACAATTTAGCAATAACGTATTAGATGCCACCATGGGTTGGGAAAAACTCATTGAAAACGAAGCAGAACTTGC
TGGTTTACCTGAATCCGCACTACAAGCTGCACAACAATCTGCCGAAAGTAAAGGATTAAAGGGCTATCGTTTTACGTTAG
AAATCCCAAGTTATTTGCCTGTGATGACTTACTGCGAAAATCGTGCATTGCGTGAAGAAATGTACCGTGCTTATGCAACA
CGTGCCTCTGAACAAGGCCCTAACGCTGGCAAATGGGACAACAGTAAAGTTATGGAAGAAATTCTGACGTTACGCGTTGA
ACTGGCAAAATTACTCGGTTTTAATACTTATACCGAACTTTCACTTGCCACAAAAATGGCAGAAAACCCACAACAAGTGC
TTGATTTCTTAGATCATCTTGCCGAACGTGCCAAACCACAAGGCGAAAAAGAACTGCAAGAATTGAAAGGTTACTGCGAA
AAAGAATTTGGTGTCACTGAACTTGCACCTTGGGATATTGGTTTTTACAGCGAAAAACAAAAACAACATTTATACGCCAT
TAATGATGAAGAACTTCGCCCATATTTTCCAGAAAATCGCGTGATTTCAGGATTGTTTGAATTAATTAAACGCATTTTTA
ATATTCGTGCAGTGGAACGCAAAGGTGTGGATACTTGGCATAAAGATGTACGTTTCTTTGATTTAATCGATGAAAATGAT
CAACTCCGTGGCAGTTTCTATCTTGATTTATATGCACGCGAACACAAACGTGGTGGTGCGTGGATGGATGACTGTATCGG
ACGTAAGCGTAAACTGGATGGCAGCATTGAAACGCCTGTGGCTTATTTAACCTGTAACTTCAACGCACCGATAGGGAATA
AACCAGCGTTATTTACTCACAATGAAGTCACCACGCTATTCCACGAATTTGGGCACGGAATCCATCATATGCTCACGCAA
ATTGATGTATCCGATGTGGCGGGAATAAATGGCGTGCCTTGGGATGCTGTGGAATTACCAAGTCAATTTATGGAAAACTG
GTGCTGGGAAGAAGAGGCTTTGGCGTTTATTTCAGGACATTACGAAACAGGCGAGCCGTTGCCAAAAGAAAAACTCACGC
AATTGTTAAAAGCGAAAAATTTCCAAGCTGCGATGTTTATCTTACGTCAGCTTGAATTTGGTATTTTTGATTTCCGTTTA
CATCACACCTTTGATGCGGAAAAAACCAATCAAATTTTGGATACACTTAAATCAGTGAAATCACAAGTTGCCGTCATAAA
AGGCGTAGATTGGGCAAGAGCGCCACACAGCTTCAGCCATATTTTTGCAGGGGGCTACGCCGCAGGTTATTACAGCTATT
TATGGGCTGAAGTATTATCGGCTGATGCTTATTCACGCTTTGAAGAAGAAGGTATTTTCAACCCAATCACCGGCAAATCA
TTCTTAGATGAAATTCTCACCCGTGGCGGCTCAGAAGAACCAATGGAACTCTTCAAACGCTTCCGTGGCCGTGAACCGCA
ATTAGATGCGTTGTTAAGACATAAAGGAATTATGAACTAA

Upstream 100 bases:

>100_bases
GCAAACTATTATTACTGATTTTTTAGATTTTTCAACCTTGATATTATAGAATTTGCCGTCACATAAAAAAACAGTTTTCA
AAAAAGGAACATTTATGTCT

Downstream 100 bases:

>100_bases
TACGTCAAACTATAGGGCATGCACAACATGCCCTTTCTCAAATATTTTCCTCGACATAAAAACATAGTAAATTTTAACCG
CACTTTATCTAGACAAAACC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MSNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETNDRLNRAWSPVSHLNSVKNSTE
LREAYQTCLPLLSEYSTWVGQHKGLYNAYLALKNSAEFADYSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSE
LNSQFSNNVLDATMGWEKLIENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYAT
RASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHLAERAKPQGEKELQELKGYCE
KEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENRVISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDEND
QLRGSFYLDLYAREHKRGGAWMDDCIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQ
IDVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKNFQAAMFILRQLEFGIFDFRL
HHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKS
FLDEILTRGGSEEPMELFKRFRGREPQLDALLRHKGIMN

Sequences:

>Translated_679_residues
MSNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETNDRLNRAWSPVSHLNSVKNSTE
LREAYQTCLPLLSEYSTWVGQHKGLYNAYLALKNSAEFADYSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSE
LNSQFSNNVLDATMGWEKLIENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYAT
RASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHLAERAKPQGEKELQELKGYCE
KEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENRVISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDEND
QLRGSFYLDLYAREHKRGGAWMDDCIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQ
IDVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKNFQAAMFILRQLEFGIFDFRL
HHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKS
FLDEILTRGGSEEPMELFKRFRGREPQLDALLRHKGIMN
>Mature_678_residues
SNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETNDRLNRAWSPVSHLNSVKNSTEL
REAYQTCLPLLSEYSTWVGQHKGLYNAYLALKNSAEFADYSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSEL
NSQFSNNVLDATMGWEKLIENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYATR
ASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHLAERAKPQGEKELQELKGYCEK
EFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENRVISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDENDQ
LRGSFYLDLYAREHKRGGAWMDDCIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQI
DVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKNFQAAMFILRQLEFGIFDFRLH
HTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKSF
LDEILTRGGSEEPMELFKRFRGREPQLDALLRHKGIMN

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4)

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family

Homologues:

Organism=Homo sapiens, GI4507491, Length=675, Percent_Identity=29.7777777777778, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI14149738, Length=678, Percent_Identity=30.5309734513274, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI156105687, Length=664, Percent_Identity=26.2048192771084, Blast_Score=198, Evalue=2e-50,
Organism=Escherichia coli, GI1789913, Length=678, Percent_Identity=71.976401179941, Blast_Score=1025, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=683, Percent_Identity=29.1361639824305, Blast_Score=291, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71999758, Length=567, Percent_Identity=27.1604938271605, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32565901, Length=582, Percent_Identity=22.1649484536082, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319793, Length=688, Percent_Identity=29.9418604651163, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6322715, Length=704, Percent_Identity=25.2840909090909, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21356111, Length=701, Percent_Identity=27.8174037089872, Blast_Score=256, Evalue=5e-68,
Organism=Drosophila melanogaster, GI20129717, Length=586, Percent_Identity=26.6211604095563, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OPDA_HAEIN (P44573)

Other databases:

- EMBL:   L42023
- PIR:   C64055
- RefSeq:   NP_438383.2
- ProteinModelPortal:   P44573
- SMR:   P44573
- MEROPS:   M03.004
- GeneID:   951121
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0214
- NMPDR:   fig|71421.1.peg.203
- TIGR:   HI_0214
- HOGENOM:   HBG678447
- OMA:   WSPVSHL
- ProtClustDB:   CLSK870199
- BioCyc:   HINF71421:HI_0214-MONOMER
- BRENDA:   3.4.24.70
- GO:   GO:0006508
- InterPro:   IPR001567

Pfam domain/function: PF01432 Peptidase_M3

EC number: =3.4.24.70

Molecular weight: Translated: 77800; Mature: 77669

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 471-471

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETND
CCCCCEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCH
RLNRAWSPVSHLNSVKNSTELREAYQTCLPLLSEYSTWVGQHKGLYNAYLALKNSAEFAD
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHH
YSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSELNSQFSNNVLDATMGWEKLI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYAT
CCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
RASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHL
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHH
AERAKPQGEKELQELKGYCEKEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENR
HHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCHH
VISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDENDQLRGSFYLDLYAREHKRGGA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHEEEECCCCCCCCEEEEEEEHHHHCCCCC
WMDDCIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQ
CHHHHHCHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHH
IDVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKN
CCHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
FQAAMFILRQLEFGIFDFRLHHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSH
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHH
IFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKSFLDEILTRGGSEEPMELFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHH
FRGREPQLDALLRHKGIMN
HCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETND
CCCCEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCH
RLNRAWSPVSHLNSVKNSTELREAYQTCLPLLSEYSTWVGQHKGLYNAYLALKNSAEFAD
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHH
YSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSELNSQFSNNVLDATMGWEKLI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYAT
CCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
RASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHL
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHH
AERAKPQGEKELQELKGYCEKEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENR
HHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCHH
VISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDENDQLRGSFYLDLYAREHKRGGA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHEEEECCCCCCCCEEEEEEEHHHHCCCCC
WMDDCIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQ
CHHHHHCHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHH
IDVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKN
CCHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
FQAAMFILRQLEFGIFDFRLHHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSH
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHH
IFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKSFLDEILTRGGSEEPMELFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHH
FRGREPQLDALLRHKGIMN
HCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800