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The map label for this gene is ribA

Identifier: 30995360

GI number: 30995360

Start: 226608

End: 227258

Strand: Direct

Name: ribA

Synonym: HI0212

Alternate gene names: 30995360

Gene position: 226608-227258 (Clockwise)

Preceding gene: 16272172

Following gene: 30995361

Centisome position: 12.38

GC content: 38.56

Gene sequence:

>651_bases
ATGGCAAAAATTCAGCTAGTTGCGCAAGCCAATTTACCCACTGAATACGGTATTTTCAAAATGGTGGGATTTGAATTCCC
AGATACAAAAAAAGAACATGTAGCCTTAGTGATGGGCGATATTTCTAATGCTGATGAACCTGTATTAGCACGTATCCATT
CTGAATGTTTAACTGGCGATGCGCTTCACAGCTTAAAATGCGATTGTGGGTTCCAACTGGCGACAGCATTAAAACAAATT
CAAGAAGAAGGTCGCGGAGTCTTAATTTATCATCGTGAAGAAGGTCGCGGAATTGGTTTGATTAATAAAATCCGTGCTTA
TTCTTTACAAGATAAAGGAATGGATACCATTGAAGCTAATCTTGCTTTAGGTTTCAAAGCGGATGAACGCAACTTTGAAG
TCTGTGCCGATATGTTTGAGCTACTTGGTGTAAAAAAAGTTCGCTTAATGACCAACAACCCAGAAAAAGTAGAAACCATG
AAAAAAGCAGGTATCAACGTGGTTGAACGAGTACCGCTTAATGTAGGCGAAAACCGCTACAACACAAAATATCTTGATAC
AAAAGCGAAAAAAATGGGGCATTACATTGTGCATAACAATGACGAACAACATTTAATGACCTGTCCACATTGCCAGGAAG
AGATTATTTAA

Upstream 100 bases:

>100_bases
AATAACGTATATAATGACAGCCTTTTGAACATGCTCGCCCCTTGATAACAAAAATAACGCGCGCATTCTAACAGAAATGA
CTACGAATAAGGATCACTTT

Downstream 100 bases:

>100_bases
CAAATAAGATATGTTTAAAAAGCCATACTGTTATATTGAACAGTATGGCTTTTTTATTTAAACTTTATGTTATGGAATAA
TCAAAAGATTTTTTAGCATA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MAKIQLVAQANLPTEYGIFKMVGFEFPDTKKEHVALVMGDISNADEPVLARIHSECLTGDALHSLKCDCGFQLATALKQI
QEEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLALGFKADERNFEVCADMFELLGVKKVRLMTNNPEKVETM
KKAGINVVERVPLNVGENRYNTKYLDTKAKKMGHYIVHNNDEQHLMTCPHCQEEII

Sequences:

>Translated_216_residues
MAKIQLVAQANLPTEYGIFKMVGFEFPDTKKEHVALVMGDISNADEPVLARIHSECLTGDALHSLKCDCGFQLATALKQI
QEEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLALGFKADERNFEVCADMFELLGVKKVRLMTNNPEKVETM
KKAGINVVERVPLNVGENRYNTKYLDTKAKKMGHYIVHNNDEQHLMTCPHCQEEII
>Mature_215_residues
AKIQLVAQANLPTEYGIFKMVGFEFPDTKKEHVALVMGDISNADEPVLARIHSECLTGDALHSLKCDCGFQLATALKQIQ
EEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLALGFKADERNFEVCADMFELLGVKKVRLMTNNPEKVETMK
KAGINVVERVPLNVGENRYNTKYLDTKAKKMGHYIVHNNDEQHLMTCPHCQEEII

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=68.0412371134021, Blast_Score=273, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6319438, Length=197, Percent_Identity=39.0862944162437, Blast_Score=122, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_HAEI8 (Q4QNX8)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_247929.1
- ProteinModelPortal:   Q4QNX8
- SMR:   Q4QNX8
- STRING:   Q4QNX8
- GeneID:   3429637
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0309
- eggNOG:   COG0807
- HOGENOM:   HBG735778
- PhylomeDB:   Q4QNX8
- ProtClustDB:   PRK00393
- BioCyc:   HINF281310:NTHI0309-MONOMER
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 24320; Mature: 24189

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 128-128 ACT_SITE 130-130 BINDING 72-72 BINDING 116-116 BINDING 151-151 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIQLVAQANLPTEYGIFKMVGFEFPDTKKEHVALVMGDISNADEPVLARIHSECLTGD
CCEEEEEEECCCCCCCCHHEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCH
ALHSLKCDCGFQLATALKQIQEEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEAN
HHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEE
LALGFKADERNFEVCADMFELLGVKKVRLMTNNPEKVETMKKAGINVVERVPLNVGENRY
EEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCEEEECCCCCCCCCC
NTKYLDTKAKKMGHYIVHNNDEQHLMTCPHCQEEII
CCCHHHHHHHHHCEEEEECCCCCEEEECCCHHHHCC
>Mature Secondary Structure 
AKIQLVAQANLPTEYGIFKMVGFEFPDTKKEHVALVMGDISNADEPVLARIHSECLTGD
CEEEEEEECCCCCCCCHHEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCH
ALHSLKCDCGFQLATALKQIQEEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEAN
HHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEE
LALGFKADERNFEVCADMFELLGVKKVRLMTNNPEKVETMKKAGINVVERVPLNVGENRY
EEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCEEEECCCCCCCCCC
NTKYLDTKAKKMGHYIVHNNDEQHLMTCPHCQEEII
CCCHHHHHHHHHCEEEEECCCCCEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA