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The map label for this gene is dnaA

Identifier: 16272931

GI number: 16272931

Start: 1055909

End: 1057273

Strand: Reverse

Name: dnaA

Synonym: HI0993

Alternate gene names: 16272931

Gene position: 1057273-1055909 (Counterclockwise)

Preceding gene: 16272932

Following gene: 16272930

Centisome position: 57.77

GC content: 39.63

Gene sequence:

>1365_bases
GTGAATCTCTCAAATCTTTGGCAAAGTTGCCTGTTACAACTTCAAGATCAAGTTTCAGCCAGCGATCTTAGCACTTGGCT
TCGTCCTTTACAGGCTGACGTGGTGGCGGATAACCACATTGTTTTATATGCTTCTAATATGTTTGTGAAAGGTTGGGTGG
AAACTCATTATCTCGCACAAATCCAGCAAATTTGTCAAACACTTGCACAAAATCCTGAACTGCGTATTTCTTTAAAAGAA
GGGGTTAAACCTGCACCCAAGATAGTGGAAAGCACACCAAATACATCACTTAGATCAGAAAGTGCGGTAGATTTTCAAGC
TGAATCTAGTGCTTCAGTAAAATTTGAATCTCATCTCAATACTAAACACTTATTTGATAACTTTGTTGAAGGTAAATCGA
ACCAACTCGCACGTGCAGTCGGTCAAAAACTTGCTCAAGCACCAGGCGAACCATCAGCCAATCCTTTCTTTTTATATGGC
GGCACTGGTTTAGGGAAAACTCACTTGTTACACGCCATTGGCAACGGCATTTTAGCCGATAAACCGAATGCACGAGTGCT
TTATATTCACGCAAATAACTTTATGCAACATATGGTAAAAGCAGTGCGTGATAATAAAATGGATCAGTTCAAAAAATTCT
ATCGTTCTCTTGATGCGCTTTTAGTGGATGATATTCAATTTTTCGCTGAAAAAGAAAAAACTCAAGAAGAATTCTTCCAT
ATTTTCAATAGCTTGTTTGAAACAGGTCGCCAGATTATCTTAACTTCGGATCGTTATCCTAAAGAAATTGAAAAAATTGA
AGAACGTTTAAAATCACGTTTTGGCTGGGGCTTAACAACAGCCATTGAACCGCCCGATCTTGAAACCCGTGTAGCGATTT
TATTGAAAAAAGCGGAAGAACATAATATGAACTTGCCAGAAGAAGTCGCTTTCTTCATTGCTCAACGCTTGCGTACCAAC
GTGCGTGAACTTGAGGGTGCATTAAATCGTGTAAAAGCAATGCAAGACTTCAAAGGCGGTGACATTGATATTGATTTCGT
GCGTGATACCTTAAAAGATATTTTGGCTCTGCAAGAACGCTTAGTTACCATTGAAAATATTCAAAAAGTGGTGGCTGAAT
ATTATCGAATTAAGGTTTCAGATTTAAAATCAAAAAGTCGTGCACGTTCAGTGACTCGTCCTCGCCAAATTGCAATGGCG
TTAGCAAAAGAATTAACAAATCGCAGTTTGCCAGAAATCGGTCGTGCCTTTGACCGTGATCACACGACCGTATTAAACGC
TTGCCGAGAAGTACCAAAATTCCGTGAGCAAGACAATAGCATTCAAGAAGATTGGGCGAATTTGATCCGCACTTTGTCCG
CATAA

Upstream 100 bases:

>100_bases
AACTTGGATTTTTTAGAAGATCTTTTCACGCATTTATTGTAAAATCTCCGACAATTTTTACCGCACTTTTCTCTATTACA
AAAACAATAAGGATCCTTTT

Downstream 100 bases:

>100_bases
AAGGAGAACGTAATGCAATTTAGTATTTCAAGAGAAAATTTATTAAAACCGTTGCAACAAGTATGTGGCGTATTGAGTAA
TCGCCCAAATATTCCTGTAT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MNLSNLWQSCLLQLQDQVSASDLSTWLRPLQADVVADNHIVLYASNMFVKGWVETHYLAQIQQICQTLAQNPELRISLKE
GVKPAPKIVESTPNTSLRSESAVDFQAESSASVKFESHLNTKHLFDNFVEGKSNQLARAVGQKLAQAPGEPSANPFFLYG
GTGLGKTHLLHAIGNGILADKPNARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLDALLVDDIQFFAEKEKTQEEFFH
IFNSLFETGRQIILTSDRYPKEIEKIEERLKSRFGWGLTTAIEPPDLETRVAILLKKAEEHNMNLPEEVAFFIAQRLRTN
VRELEGALNRVKAMQDFKGGDIDIDFVRDTLKDILALQERLVTIENIQKVVAEYYRIKVSDLKSKSRARSVTRPRQIAMA
LAKELTNRSLPEIGRAFDRDHTTVLNACREVPKFREQDNSIQEDWANLIRTLSA

Sequences:

>Translated_454_residues
MNLSNLWQSCLLQLQDQVSASDLSTWLRPLQADVVADNHIVLYASNMFVKGWVETHYLAQIQQICQTLAQNPELRISLKE
GVKPAPKIVESTPNTSLRSESAVDFQAESSASVKFESHLNTKHLFDNFVEGKSNQLARAVGQKLAQAPGEPSANPFFLYG
GTGLGKTHLLHAIGNGILADKPNARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLDALLVDDIQFFAEKEKTQEEFFH
IFNSLFETGRQIILTSDRYPKEIEKIEERLKSRFGWGLTTAIEPPDLETRVAILLKKAEEHNMNLPEEVAFFIAQRLRTN
VRELEGALNRVKAMQDFKGGDIDIDFVRDTLKDILALQERLVTIENIQKVVAEYYRIKVSDLKSKSRARSVTRPRQIAMA
LAKELTNRSLPEIGRAFDRDHTTVLNACREVPKFREQDNSIQEDWANLIRTLSA
>Mature_454_residues
MNLSNLWQSCLLQLQDQVSASDLSTWLRPLQADVVADNHIVLYASNMFVKGWVETHYLAQIQQICQTLAQNPELRISLKE
GVKPAPKIVESTPNTSLRSESAVDFQAESSASVKFESHLNTKHLFDNFVEGKSNQLARAVGQKLAQAPGEPSANPFFLYG
GTGLGKTHLLHAIGNGILADKPNARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLDALLVDDIQFFAEKEKTQEEFFH
IFNSLFETGRQIILTSDRYPKEIEKIEERLKSRFGWGLTTAIEPPDLETRVAILLKKAEEHNMNLPEEVAFFIAQRLRTN
VRELEGALNRVKAMQDFKGGDIDIDFVRDTLKDILALQERLVTIENIQKVVAEYYRIKVSDLKSKSRARSVTRPRQIAMA
LAKELTNRSLPEIGRAFDRDHTTVLNACREVPKFREQDNSIQEDWANLIRTLSA

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=476, Percent_Identity=59.453781512605, Blast_Score=561, Evalue=1e-161,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_HAEIN (P43742)

Other databases:

- EMBL:   L42023
- PIR:   B64107
- RefSeq:   NP_439156.1
- ProteinModelPortal:   P43742
- GeneID:   950755
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0993
- NMPDR:   fig|71421.1.peg.960
- TIGR:   HI_0993
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- BioCyc:   HINF71421:HI_0993-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51725; Mature: 51725

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSNLWQSCLLQLQDQVSASDLSTWLRPLQADVVADNHIVLYASNMFVKGWVETHYLAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEECCEEEEHHHHHHHHHH
IQQICQTLAQNPELRISLKEGVKPAPKIVESTPNTSLRSESAVDFQAESSASVKFESHLN
HHHHHHHHHCCCCEEEEHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEHHHCCC
TKHLFDNFVEGKSNQLARAVGQKLAQAPGEPSANPFFLYGGTGLGKTHLLHAIGNGILAD
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCC
KPNARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLDALLVDDIQFFAEKEKTQEEFFH
CCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFNSLFETGRQIILTSDRYPKEIEKIEERLKSRFGWGLTTAIEPPDLETRVAILLKKAEE
HHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
HNMNLPEEVAFFIAQRLRTNVRELEGALNRVKAMQDFKGGDIDIDFVRDTLKDILALQER
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
LVTIENIQKVVAEYYRIKVSDLKSKSRARSVTRPRQIAMALAKELTNRSLPEIGRAFDRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
HTTVLNACREVPKFREQDNSIQEDWANLIRTLSA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLSNLWQSCLLQLQDQVSASDLSTWLRPLQADVVADNHIVLYASNMFVKGWVETHYLAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEECCEEEEHHHHHHHHHH
IQQICQTLAQNPELRISLKEGVKPAPKIVESTPNTSLRSESAVDFQAESSASVKFESHLN
HHHHHHHHHCCCCEEEEHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEHHHCCC
TKHLFDNFVEGKSNQLARAVGQKLAQAPGEPSANPFFLYGGTGLGKTHLLHAIGNGILAD
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCC
KPNARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLDALLVDDIQFFAEKEKTQEEFFH
CCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFNSLFETGRQIILTSDRYPKEIEKIEERLKSRFGWGLTTAIEPPDLETRVAILLKKAEE
HHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
HNMNLPEEVAFFIAQRLRTNVRELEGALNRVKAMQDFKGGDIDIDFVRDTLKDILALQER
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
LVTIENIQKVVAEYYRIKVSDLKSKSRARSVTRPRQIAMALAKELTNRSLPEIGRAFDRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
HTTVLNACREVPKFREQDNSIQEDWANLIRTLSA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800