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The map label for this gene is atoB

Identifier: 16272712

GI number: 16272712

Start: 833490

End: 834671

Strand: Reverse

Name: atoB

Synonym: HI0771

Alternate gene names: 16272712

Gene position: 834671-833490 (Counterclockwise)

Preceding gene: 16272713

Following gene: 16272708

Centisome position: 45.61

GC content: 40.44

Gene sequence:

>1182_bases
ATGGAAAATGTTGTTATTGTTAGTGCAGTTAGAACACCGATCGGCAGCTTTAATGGTGCATTATCTTCCGTAAGTGCGGT
TGATTTAGGTGCAATTGTGATACAAGAAGCCATCAAACGTGCCAACATTGAAAGTGCATTAGTTAATGAAGTCATCATGG
GGAACGTATTACAAGCAGGACTAGGGCAAAATCCAGCCCGTCAAGCAGCATTAAAAGCAGGAATAGAGAAAGAAATCCCT
TCTTTAACAATCAATAAAGTATGTGGATCTGGTCTAAAAAGTGTCGCATTAGGTGCACAGTCTATTATCAGTGGTGATGC
TGATATTGTTGTTGTGGGTGGCATGGAAAATATGAGCCAAGCACCTTATCTTTTAGATAGCAAAGTACGACAAGGCGTCA
AAATGGGTAATCTCACATTAAGGGACACAATGATTGAAGACGGACTAACTTGCGCTAGCAATCACTATCATATGGGGATT
ACTGCCGAAAATATTGCAGAACAATATGGTATTAGCCGCCAAGCACAAGATGAACTCGCATTACGTTCACAAACCTTAGC
ATCTCAAGCCGTGCAATTAGGTGTATTTGATAAGGAAATTGTCCCTGTTATGGTAAAAACTCGCAAAGGTGACATTATTG
TTTCACGAGACGAGTATCCTAAAGCAGATACTACAGCTGAAGGTTTAGCTAAATTAAAACCTGCTTTCAAAAAAGAGGGT
ACTGTCACCGCAGGTAACGCTTCTGGCATTAATGATGGTGCTGCAGCACTTATTTTAGTTAGCGAAAGCAAAGCTCATGC
ACTTGGATTAAAAGCCATTGCAAAAATTAGAAGCTATGCCAGCGGTGGGGTAGATCCATCTGTTATGGGATTAGGTCCAG
TTCCAGCAACGCAAAAAGCATTGAAAAAAGCAGGAATAAATCTTGATGATATCGATCTGATAGAAGCAAATGAAGCCTTT
GCCTCACAGTTCTTAGGTGTTGGCAAAGATCTCAATTTGGATATGAATAAAACCAATATTCATGGTGGAGCGATCGCACT
TGGGCATCCAATCGGCGCGAGTGGTGCAAGGATTTTAGTAACGTTATTGCACAATCTTATCGAAAAAGATAAAAAACTTG
GACTTGCTACACTTTGTATTGGCGGTGGTCAAGGGATTTCTATGATTGTAGAACGCTTATAA

Upstream 100 bases:

>100_bases
TTGGCGTGAGAGATATTATGGGCTTCTGTATGACCGCACTTATCTTCACCGCACCAATTTTTATTATTGGTTTATATTTC
TTATAGAAAAGGAGTTAAAA

Downstream 100 bases:

>100_bases
CTATTTACTTCCTAAACTACAACAGCGAAATATTTCACTTCTAACTAAAAAAGCGAATTTCTTTTAAGAAATTCGCTTTT
CTTTTGATATCCAATTATTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAGLGQNPARQAALKAGIEKEIP
SLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQAPYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGI
TAENIAEQYGISRQAQDELALRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
TVTAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKALKKAGINLDDIDLIEANEAF
ASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILVTLLHNLIEKDKKLGLATLCIGGGQGISMIVERL

Sequences:

>Translated_393_residues
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAGLGQNPARQAALKAGIEKEIP
SLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQAPYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGI
TAENIAEQYGISRQAQDELALRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
TVTAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKALKKAGINLDDIDLIEANEAF
ASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILVTLLHNLIEKDKKLGLATLCIGGGQGISMIVERL
>Mature_393_residues
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAGLGQNPARQAALKAGIEKEIP
SLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQAPYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGI
TAENIAEQYGISRQAQDELALRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
TVTAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKALKKAGINLDDIDLIEANEAF
ASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILVTLLHNLIEKDKKLGLATLCIGGGQGISMIVERL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=54.1984732824427, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=45.959595959596, Blast_Score=347, Evalue=8e-96,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=45.2020202020202, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=42.4242424242424, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=33.8823529411765, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI194353979, Length=397, Percent_Identity=29.7229219143577, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=66.9211195928753, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=54.8469387755102, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=44.3890274314214, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=44.3890274314214, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=34.1981132075472, Blast_Score=210, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=45.7800511508951, Blast_Score=346, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=40.4580152671756, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=38.0710659898477, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=32.4705882352941, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=32.48730964467, Blast_Score=193, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=45.9798994974874, Blast_Score=314, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=38.2278481012658, Blast_Score=229, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=58.0152671755725, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=45.6632653061224, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=44.2455242966752, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=34.8235294117647, Blast_Score=222, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATOB_HAEIN (P44873)

Other databases:

- EMBL:   L42023
- RefSeq:   NP_438930.1
- ProteinModelPortal:   P44873
- SMR:   P44873
- GeneID:   950638
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0771
- TIGR:   HI_0771
- HOGENOM:   HBG370930
- OMA:   CAFNEYH
- ProtClustDB:   CLSK891768
- BioCyc:   HINF71421:HI_0771-MONOMER
- BRENDA:   2.3.1.9
- GO:   GO:0005737
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR18919
- PIRSF:   PIRSF000429
- TIGRFAMs:   TIGR01930

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N; SSF53901 Thiolase-like

EC number: =2.3.1.9

Molecular weight: Translated: 40802; Mature: 40802

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00098 THIOLASE_1; PS00737 THIOLASE_2; PS00099 THIOLASE_3

Important sites: ACT_SITE 88-88 ACT_SITE 349-349 ACT_SITE 379-379

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAG
CCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
LGQNPARQAALKAGIEKEIPSLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQ
CCCCHHHHHHHHHCHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGITAENIAEQYGISRQAQDELA
CCHHHHHHHHCCCHHCCEEEHHHHHHCCCEECCCCEEECCCHHHHHHHHCCCHHHHHHHH
LRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHCHHHHCCC
TVTAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKA
CEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHH
LKKAGINLDDIDLIEANEAFASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILV
HHHCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHH
TLLHNLIEKDKKLGLATLCIGGGQGISMIVERL
HHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCC
>Mature Secondary Structure
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAG
CCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
LGQNPARQAALKAGIEKEIPSLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQ
CCCCHHHHHHHHHCHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGITAENIAEQYGISRQAQDELA
CCHHHHHHHHCCCHHCCEEEHHHHHHCCCEECCCCEEECCCHHHHHHHHCCCHHHHHHHH
LRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHCHHHHCCC
TVTAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKA
CEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHH
LKKAGINLDDIDLIEANEAFASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILV
HHHCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHH
TLLHNLIEKDKKLGLATLCIGGGQGISMIVERL
HHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800