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The map label for this gene is trpS

Identifier: 16272580

GI number: 16272580

Start: 678551

End: 679555

Strand: Reverse

Name: trpS

Synonym: HI0637

Alternate gene names: 16272580

Gene position: 679555-678551 (Counterclockwise)

Preceding gene: 16272586

Following gene: 16272579

Centisome position: 37.13

GC content: 38.81

Gene sequence:

>1005_bases
ATGGCAAAACCAATTGTTTTTAGTGGCGTGCAGCCTTCTGGTGAATTAACTATCGGAAATTATTTGGGAGCGTTGCGTAA
CTGGGTGAAAATGCAAGAAGATTATGAATGTATTTTTTGCGTAGTTGATTTACATGCGATCACTGTTCGTCAAGATCCTG
TTGCCCTTCGCAAAGCAACCCTTGATGTGCTTGCACTTTATTTAGCGTGCGGAATTGATCCAAATAAAAGTACTATTTTT
GTTCAATCTCACGTTCCAGAACACACGCAATTAAGCTGGGTGTTAAACTGTTACACCTATTTCGGTGAAATGAGCCGAAT
GACGCAATTTAAAGATAAATCAGCGCGTTATGCAGAAAATATTAACGTGGGTTTGTTTGATTACCCTGTGTTAATGGCGG
CGGATATTTTACTTTATCAAGCAAAAAGCGTGCCTGTTGGCGATGACCAAAAACAACACTTAGAAATTACGCGTGATATT
GCAAACCGCTTTAATGCACTTTATGGCAATATTTTCACCATTCCTGAAATTTTCATTGGAAAAGCAGGTGCGCGTATTAT
GTCATTGCAAGATCCTGAAAAGAAAATGTCAAAATCAGATGATAACCGCAACAACGTGGTGACACTTTTAGAAGATCCAA
AATCTGTGGCGAAGAAAATTAAACGTGCCGTAACAGATTCAGATGAGCCGCCTGTTGTTCGTTATGATGTGCAAAATAAA
GCGGGGGTATCTAATCTTTTAGATATTCTTTCTGCGGTTACGGATAAGCCAATTGCTGATCTTGAAAAAGAATTTGAAGG
TAAAATGTACGGACATTTAAAAACTGCAGTAGCGGATGAAGTCTCAACCCTACTTGCTAGTTTACAAGAACGTTTCCATC
AATATCGTAATGATGAAACTTTATTAGATAATATCTTACGACAAGGTGCGGAAAAAGCTCGTGCAAAAGCACAAGAAACC
TTGGCGAAAGTGTATGAAGCAGTGGGTTTTGTCGCTGCAAAATAA

Upstream 100 bases:

>100_bases
AAATATAGCATTTTTAACCTAGCTTTTGAACTCGAACATTAAAAAAGCCTAGAGTTTCTGATATGATGTGTGAACAGTTT
TAAGGTATTAAGGATTGATT

Downstream 100 bases:

>100_bases
TCTGAATAAAAGGATAATATTATGGCAATTCAAACCGAAAAACCGATTGAATGTGTAGGTTGTAATACTTTTGATATGAA
ATCACTTTTCGATAATCGTG

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAKPIVFSGVQPSGELTIGNYLGALRNWVKMQEDYECIFCVVDLHAITVRQDPVALRKATLDVLALYLACGIDPNKSTIF
VQSHVPEHTQLSWVLNCYTYFGEMSRMTQFKDKSARYAENINVGLFDYPVLMAADILLYQAKSVPVGDDQKQHLEITRDI
ANRFNALYGNIFTIPEIFIGKAGARIMSLQDPEKKMSKSDDNRNNVVTLLEDPKSVAKKIKRAVTDSDEPPVVRYDVQNK
AGVSNLLDILSAVTDKPIADLEKEFEGKMYGHLKTAVADEVSTLLASLQERFHQYRNDETLLDNILRQGAEKARAKAQET
LAKVYEAVGFVAAK

Sequences:

>Translated_334_residues
MAKPIVFSGVQPSGELTIGNYLGALRNWVKMQEDYECIFCVVDLHAITVRQDPVALRKATLDVLALYLACGIDPNKSTIF
VQSHVPEHTQLSWVLNCYTYFGEMSRMTQFKDKSARYAENINVGLFDYPVLMAADILLYQAKSVPVGDDQKQHLEITRDI
ANRFNALYGNIFTIPEIFIGKAGARIMSLQDPEKKMSKSDDNRNNVVTLLEDPKSVAKKIKRAVTDSDEPPVVRYDVQNK
AGVSNLLDILSAVTDKPIADLEKEFEGKMYGHLKTAVADEVSTLLASLQERFHQYRNDETLLDNILRQGAEKARAKAQET
LAKVYEAVGFVAAK
>Mature_333_residues
AKPIVFSGVQPSGELTIGNYLGALRNWVKMQEDYECIFCVVDLHAITVRQDPVALRKATLDVLALYLACGIDPNKSTIFV
QSHVPEHTQLSWVLNCYTYFGEMSRMTQFKDKSARYAENINVGLFDYPVLMAADILLYQAKSVPVGDDQKQHLEITRDIA
NRFNALYGNIFTIPEIFIGKAGARIMSLQDPEKKMSKSDDNRNNVVTLLEDPKSVAKKIKRAVTDSDEPPVVRYDVQNKA
GVSNLLDILSAVTDKPIADLEKEFEGKMYGHLKTAVADEVSTLLASLQERFHQYRNDETLLDNILRQGAEKARAKAQETL
AKVYEAVGFVAAK

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=331, Percent_Identity=41.3897280966767, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI41352700, Length=176, Percent_Identity=51.1363636363636, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1789786, Length=332, Percent_Identity=78.6144578313253, Blast_Score=559, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71982800, Length=334, Percent_Identity=36.2275449101796, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71982793, Length=334, Percent_Identity=36.2275449101796, Blast_Score=218, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6320474, Length=345, Percent_Identity=40.8695652173913, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24666151, Length=329, Percent_Identity=41.0334346504559, Blast_Score=254, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_HAEIN (P43835)

Other databases:

- EMBL:   L42023
- PIR:   C64083
- RefSeq:   NP_438797.1
- ProteinModelPortal:   P43835
- SMR:   P43835
- GeneID:   949689
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0637
- NMPDR:   fig|71421.1.peg.607
- TIGR:   HI_0637
- HOGENOM:   HBG293263
- OMA:   NKPGVSN
- ProtClustDB:   PRK00927
- BioCyc:   HINF71421:HI_0637-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 37396; Mature: 37265

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPIVFSGVQPSGELTIGNYLGALRNWVKMQEDYECIFCVVDLHAITVRQDPVALRKAT
CCCCEEEECCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEEEEEHHHEEECCCCHHHHHHH
LDVLALYLACGIDPNKSTIFVQSHVPEHTQLSWVLNCYTYFGEMSRMTQFKDKSARYAEN
HHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INVGLFDYPVLMAADILLYQAKSVPVGDDQKQHLEITRDIANRFNALYGNIFTIPEIFIG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHC
KAGARIMSLQDPEKKMSKSDDNRNNVVTLLEDPKSVAKKIKRAVTDSDEPPVVRYDVQNK
CCCCEEECCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCC
AGVSNLLDILSAVTDKPIADLEKEFEGKMYGHLKTAVADEVSTLLASLQERFHQYRNDET
CCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LLDNILRQGAEKARAKAQETLAKVYEAVGFVAAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKPIVFSGVQPSGELTIGNYLGALRNWVKMQEDYECIFCVVDLHAITVRQDPVALRKAT
CCCEEEECCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEEEEEHHHEEECCCCHHHHHHH
LDVLALYLACGIDPNKSTIFVQSHVPEHTQLSWVLNCYTYFGEMSRMTQFKDKSARYAEN
HHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INVGLFDYPVLMAADILLYQAKSVPVGDDQKQHLEITRDIANRFNALYGNIFTIPEIFIG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHC
KAGARIMSLQDPEKKMSKSDDNRNNVVTLLEDPKSVAKKIKRAVTDSDEPPVVRYDVQNK
CCCCEEECCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCC
AGVSNLLDILSAVTDKPIADLEKEFEGKMYGHLKTAVADEVSTLLASLQERFHQYRNDET
CCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LLDNILRQGAEKARAKAQETLAKVYEAVGFVAAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800