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The map label for this gene is hisB [H]

Identifier: 16272419

GI number: 16272419

Start: 494202

End: 495290

Strand: Direct

Name: hisB [H]

Synonym: HI0471

Alternate gene names: 16272419

Gene position: 494202-495290 (Clockwise)

Preceding gene: 16272418

Following gene: 16272420

Centisome position: 27.0

GC content: 40.77

Gene sequence:

>1089_bases
ATGCAACCTACTCTTTTTATCGACCGAGACGGCACATTAATTGATGAACCAAAAACTGATTTCCAAATTGACAGTTTAGA
GAAACTAAAATTAGAACCGAAAGTGATTCCCGCACTCCTCAGACTGAAAGCGAAATACCGTTTTGTGATAGTTTCTAATC
AAGATGGGCTTGGTACGGATGCTTTTCCGCAAACAGATTTTGATAAGCCCCACAATGTAATGATGGCATTATTTGAATCT
CAGGGCATTACCTTTGATGAAGTACTCATTTGCCCGCATAAGCCCGAAGAAAATTGTCTATGTCGCAAACCAAAAATTAA
GTTGCTTGATCACTATATTCGTAAAAATTTATTCGATATTGACCGCTCTTTTGTCATTGGTGACCGAGAGACCGATGTGC
AATTAGCAGAAAATCTAGGTATTCGAGCTATTCAATACGATCCACAGAAAATGAATTGGGATCTGATTGCAGAAAAATTG
TTGGGGGAAACGGTCACAAACTGTGGCAAACGTCCGCCACGTTTTGCAGAAGTAATTCGTCAAACTAAAGAGACCGATAT
TAAAGTGCAGGTTTGGCTAGATGAAGCTGGTGTAAATGAAATCAAAACCGGCGTTGGTTTTTTTGACCATATGCTCGATC
AAATCGCCACACACGGTGGGTTTAGAATGAACGTGCAGTGTAAAGGCGATTTATGGATTGACGAACATCACACGGTGGAG
GACACCGCTCTCGCCCTTGGACAAGCACTGAAACAAGCCGTTGGTGACAAACGTGGTATTGCCCGTTTCGGCTTTGTGCT
TCCAATGGACGAATGTAAAGCAGAATGTGCTTTAGATTTATCGGGCAGACCTTGGATCAAATTCAATGCCTGCTTTAAAC
GCGATAAAGTGGGCGATTTTAGTACGGAACTCACTGAACATTTCTTTCAATCTTTGGCATTTTCAATGCTTGCCACGCTT
CATTTAAATGTCACAGGTAATAACGATCATCATAAAATAGAGAGCTTATTTAAAGCCTTTGGGAGAACATTAAGACAGGC
GATTCGGATTGAAGGAAATGAAATGCCAAGTTCAAAAGGAGTTTTATAG

Upstream 100 bases:

>100_bases
TTTAAGTCACAGAGCGATTCGAGATTATTTAGTTTTATACTGTTTGTATAAAGCAAATGATAAACCTCATACCATTCATA
TAACATACACGGAGAAAAAT

Downstream 100 bases:

>100_bases
TTGAAAGAGCGGTTAATTTTTGTCGTATTTTTGCAAAATTCGACCGATTGTAAAAGGATAAAAAAATGATAAACATCACG
ATTATAGACACAGGTTGTGC

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTDAFPQTDFDKPHNVMMALFES
QGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDIDRSFVIGDRETDVQLAENLGIRAIQYDPQKMNWDLIAEKL
LGETVTNCGKRPPRFAEVIRQTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
DTALALGQALKQAVGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDFSTELTEHFFQSLAFSMLATL
HLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKGVL

Sequences:

>Translated_362_residues
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTDAFPQTDFDKPHNVMMALFES
QGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDIDRSFVIGDRETDVQLAENLGIRAIQYDPQKMNWDLIAEKL
LGETVTNCGKRPPRFAEVIRQTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
DTALALGQALKQAVGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDFSTELTEHFFQSLAFSMLATL
HLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKGVL
>Mature_362_residues
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTDAFPQTDFDKPHNVMMALFES
QGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDIDRSFVIGDRETDVQLAENLGIRAIQYDPQKMNWDLIAEKL
LGETVTNCGKRPPRFAEVIRQTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
DTALALGQALKQAVGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDFSTELTEHFFQSLAFSMLATL
HLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=362, Percent_Identity=63.5359116022099, Blast_Score=491, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6324776, Length=171, Percent_Identity=45.6140350877193, Blast_Score=156, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 41163; Mature: 41163

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTD
CCCCEEEECCCCEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHCEEEEEEEECCCCCCCC
AFPQTDFDKPHNVMMALFESQGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDI
CCCCCCCCCCHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
DRSFVIGDRETDVQLAENLGIRAIQYDPQKMNWDLIAEKLLGETVTNCGKRPPRFAEVIR
CCCEEECCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCHH
DTALALGQALKQAVGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDF
HHHHHHHHHHHHHHCCCCCHHHHCEEEEHHHHHHHEEEECCCCCCEEEHHHHCCCCCCCH
STELTEHFFQSLAFSMLATLHLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKG
HHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VL
CC
>Mature Secondary Structure
MQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLEPKVIPALLRLKAKYRFVIVSNQDGLGTD
CCCCEEEECCCCEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHCEEEEEEEECCCCCCCC
AFPQTDFDKPHNVMMALFESQGITFDEVLICPHKPEENCLCRKPKIKLLDHYIRKNLFDI
CCCCCCCCCCHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
DRSFVIGDRETDVQLAENLGIRAIQYDPQKMNWDLIAEKLLGETVTNCGKRPPRFAEVIR
CCCEEECCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QTKETDIKVQVWLDEAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVE
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCHH
DTALALGQALKQAVGDKRGIARFGFVLPMDECKAECALDLSGRPWIKFNACFKRDKVGDF
HHHHHHHHHHHHHHCCCCCHHHHCEEEEHHHHHHHEEEECCCCCCEEEHHHHCCCCCCCH
STELTEHFFQSLAFSMLATLHLNVTGNNDHHKIESLFKAFGRTLRQAIRIEGNEMPSSKG
HHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA