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The map label for this gene is hisC

Identifier: 16272418

GI number: 16272418

Start: 492987

End: 494090

Strand: Direct

Name: hisC

Synonym: HI0470

Alternate gene names: 16272418

Gene position: 492987-494090 (Clockwise)

Preceding gene: 16272417

Following gene: 16272419

Centisome position: 26.94

GC content: 40.58

Gene sequence:

>1104_bases
ATGAATGATTACAATTCGCACATTTTACAATGGAAGAAAACAATAATGACAATCACAACTTTATCCCGACAAAATATACA
AGCCTTAACGCCATATCAATCCGCTCGAAAACTCGGCGGCAATGGTACGATTTGGCTGAATGCAAATGAATATCCAACTT
CGCCTGAATTTCAGCTTTCGGGTAAGGATTTAAACCGCTACCCCGAACCTCAGCCTCAAAGAGTGGTACAGGCTTATGCG
AATTATGCGGGCGTTTCAACTGAAAATGTACTCGTTACTCGTGGCGGTGATGAAGGCATTGAATTGATAATCCACACTTT
TTGCGAACCCAAACAAGATGCCATTTTATTCTGTCCTCCGACTTACGGAATGTATGCAGTGAGTGCTGAAACGGCAGGTG
TGCTAAGTAAGACCGTGCCTTTAACTGACGATTTTCAGCTTAATTTGCCAGAAATCAAAAATCATCTTAATGATGTAAAA
GTAGTCTTTGTATGCAGCCCAAATAATCCGACAGGTAATTTGCTCAAGCAATCAGATATACTCGATCTTTTGCAAATCAC
GGCAGGCAAAGCGATTGTGGTGGTGGACGAAGCCTATATTGAGTTCTGTCCTGAAGCAAGCGTTATTAATTTGCTTAAAA
ATTATCCGCACTTAGCAATTATCCGCACGCTCTCTAAAGCCTTTGCTTTAGCTGGATTGCGTTGTGGTTTTGTGTTAGCA
AACCCTGAGCTAATTGACATCTTAAGTAAGGTAATCGCTCCATATCCTATCCCTGTGCCGAGTGCTGATCTTGCGGAACA
AGCGTTAAGACCTTCGAACATCGCCACTGTTCAAGCTCTCACACAAGAACTTCTTTCCAATCGTCAATGGCTTGCTAAAG
CTCTTTTAGTTTTACATCAAGTGGAAAAAGTGTATGAAAGTGAAGCTAATTATCTGTTGATCAAATGTCAAAACGGGCAA
GCTGTGTTTAAGGCATTGTGGGAACAAGGAATTATTTTAAGAGACCAGAATAAGACATTGCATTTACAAAATTGTATTCG
CATTACTGTGGGAACAAGGAATGAGTGTGAGAAAGTTGTTGAAGCAATTAAGGAGGTAAAATGA

Upstream 100 bases:

>100_bases
TAAGTGTAAGATTGGCGAAACTCAATATCTAAGATATTAATTATAGATCTAAGCACGACACGTAAGCAGTCAAATTTTCA
TACAACAATACGAAATATGT

Downstream 100 bases:

>100_bases
ACCACCTCCTATTTAAGTCACAGAGCGATTCGAGATTATTTAGTTTTATACTGTTTGTATAAAGCAAATGATAAACCTCA
TACCATTCATATAACATACA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MNDYNSHILQWKKTIMTITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLSGKDLNRYPEPQPQRVVQAYA
NYAGVSTENVLVTRGGDEGIELIIHTFCEPKQDAILFCPPTYGMYAVSAETAGVLSKTVPLTDDFQLNLPEIKNHLNDVK
VVFVCSPNNPTGNLLKQSDILDLLQITAGKAIVVVDEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLA
NPELIDILSKVIAPYPIPVPSADLAEQALRPSNIATVQALTQELLSNRQWLAKALLVLHQVEKVYESEANYLLIKCQNGQ
AVFKALWEQGIILRDQNKTLHLQNCIRITVGTRNECEKVVEAIKEVK

Sequences:

>Translated_367_residues
MNDYNSHILQWKKTIMTITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLSGKDLNRYPEPQPQRVVQAYA
NYAGVSTENVLVTRGGDEGIELIIHTFCEPKQDAILFCPPTYGMYAVSAETAGVLSKTVPLTDDFQLNLPEIKNHLNDVK
VVFVCSPNNPTGNLLKQSDILDLLQITAGKAIVVVDEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLA
NPELIDILSKVIAPYPIPVPSADLAEQALRPSNIATVQALTQELLSNRQWLAKALLVLHQVEKVYESEANYLLIKCQNGQ
AVFKALWEQGIILRDQNKTLHLQNCIRITVGTRNECEKVVEAIKEVK
>Mature_367_residues
MNDYNSHILQWKKTIMTITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLSGKDLNRYPEPQPQRVVQAYA
NYAGVSTENVLVTRGGDEGIELIIHTFCEPKQDAILFCPPTYGMYAVSAETAGVLSKTVPLTDDFQLNLPEIKNHLNDVK
VVFVCSPNNPTGNLLKQSDILDLLQITAGKAIVVVDEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLA
NPELIDILSKVIAPYPIPVPSADLAEQALRPSNIATVQALTQELLSNRQWLAKALLVLHQVEKVYESEANYLLIKCQNGQ
AVFKALWEQGIILRDQNKTLHLQNCIRITVGTRNECEKVVEAIKEVK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=351, Percent_Identity=60.3988603988604, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=35.0923482849604, Blast_Score=185, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_HAEIN (P44423)

Other databases:

- EMBL:   L42023
- PIR:   E64070
- RefSeq:   NP_438631.1
- ProteinModelPortal:   P44423
- SMR:   P44423
- GeneID:   949558
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0470
- NMPDR:   fig|71421.1.peg.444
- TIGR:   HI_0470
- HOGENOM:   HBG646350
- OMA:   FKTLWDQ
- ProtClustDB:   PRK01688
- BioCyc:   HINF71421:HI_0470-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40795; Mature: 40795

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDYNSHILQWKKTIMTITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLS
CCCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHCCCCEEEEEECCCCCCCCCEEEC
GKDLNRYPEPQPQRVVQAYANYAGVSTENVLVTRGGDEGIELIIHTFCEPKQDAILFCPP
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEECC
TYGMYAVSAETAGVLSKTVPLTDDFQLNLPEIKNHLNDVKVVFVCSPNNPTGNLLKQSDI
CCCEEEEECHHHHHHHCCCCCCCCCEECCHHHHCCCCCEEEEEEECCCCCCCCHHHHHHH
LDLLQITAGKAIVVVDEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLA
HHHHHHCCCCEEEEEEHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEC
NPELIDILSKVIAPYPIPVPSADLAEQALRPSNIATVQALTQELLSNRQWLAKALLVLHQ
CCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
VEKVYESEANYLLIKCQNGQAVFKALWEQGIILRDQNKTLHLQNCIRITVGTRNECEKVV
HHHHHHCCCCEEEEEECCCHHHHHHHHHCCCEEECCCCEEEECCEEEEEECCHHHHHHHH
EAIKEVK
HHHHHCC
>Mature Secondary Structure
MNDYNSHILQWKKTIMTITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLS
CCCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHCCCCEEEEEECCCCCCCCCEEEC
GKDLNRYPEPQPQRVVQAYANYAGVSTENVLVTRGGDEGIELIIHTFCEPKQDAILFCPP
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEECC
TYGMYAVSAETAGVLSKTVPLTDDFQLNLPEIKNHLNDVKVVFVCSPNNPTGNLLKQSDI
CCCEEEEECHHHHHHHCCCCCCCCCEECCHHHHCCCCCEEEEEEECCCCCCCCHHHHHHH
LDLLQITAGKAIVVVDEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLA
HHHHHHCCCCEEEEEEHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEC
NPELIDILSKVIAPYPIPVPSADLAEQALRPSNIATVQALTQELLSNRQWLAKALLVLHQ
CCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
VEKVYESEANYLLIKCQNGQAVFKALWEQGIILRDQNKTLHLQNCIRITVGTRNECEKVV
HHHHHHCCCCEEEEEECCCHHHHHHHHHCCCEEECCCCEEEECCEEEEEECCHHHHHHHH
EAIKEVK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800