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The map label for this gene is thrC

Identifier: 16272061

GI number: 16272061

Start: 92148

End: 93425

Strand: Reverse

Name: thrC

Synonym: HI0087

Alternate gene names: 16272061

Gene position: 93425-92148 (Counterclockwise)

Preceding gene: 16272062

Following gene: 16272060

Centisome position: 5.1

GC content: 39.67

Gene sequence:

>1278_bases
ATGAATTTATACAATATCAAACACCCAGAAGAACAAGTCACTTTTTCTCAGGCTGTTCGTCAAGGTCTTGGGCGGGATCA
AGGTCTATTCTTTCCAGAAGTTATTCCTCAACTTAATAACATTAATGAATTACTTGAATTGCCTCTTGTTGAGCGTAGTC
AAAAAATTCTAGGTGCATTAATTGATGGCGAGTTACCACAAGCAACGTTAGATGCGATGGTGAAAAATGCATTCACTTTT
CCTGCACCGTTAGAAAAAGTGGAAGAAAATATTTATGCACTTGAATTATTTCACGGTCCAACGCTAGCATTTAAAGATTT
TGGTGGGCGTTTTATGGCACAGGCACTTGCTGCGGTACGTGGCGATGGCAAAATTACTATTTTAACGGCTACGTCTGGCG
ATACTGGAGCCGCTGTAGCACATGCGTTTTATGGATTAGAAAATATTAATGTAGTTATCCTTTATCCAAAAGGCAAAATC
AGCCCATTGCAAGAAAAGCTGTTCTGTACTTTAGGTGGGAATATTCGTACTGTTGCGATTAACGCTGATTTCGATGCGTG
TCAGGCTTTGGTTAAGCAAGCCTTTGATGATGTTGAATTGCGCCAAGCTATCGGGCTTAACTCTGCAAATTCTATTAATA
TCAGCCGTTTATTAGCTCAAGTTTGTTATTACTTTGAAGCTGTCGCACAATTGCCAAAAGAAAAACGTGATAATGTCGTG
GTTTCTGTGCCAAGTGGTAATTTTGGTAACTTAACTGCGGGATTAATTGCAAAAACCTTAGGCTTGCCAATAAAACGCTT
TGTCGCCTCAACAAACGCAAATGATACTGTGCCACGTTATTTGAAATCGGGTAATTGGGATCCTAAAACGACAGTTGCAA
CCCTTTCTAATGCAATGGATGTAAGTCGCCCAAATAATTGGCCAAGAGTGGAGGAATTGTTTAAACGAAATGGTTGGGAT
TTAACTGATTTAGGTTCGGGGATGCTAAGTGATAGCGAAACAGAAGATACCTTAAAAGCGATGCAGTCGAAAGGTTATTT
ATGTGAACCTCACGGTGCGATAGCTTATCAGGTGTTGAAAGATCAACTTAAAGCGAGTGAAACAGGAATCTTCCTGTGTA
CGGCGCATCCTGCGAAATTTAAAGAATCCGTAGAACGTATTCTTGGTATTCAGCTTCCATTACCTGAAACACTGGATAAA
CATAATCAGCTACCATTGCTTTCAGATGAAATGGATAATGATTTTGCACAACTACGGGCTTACTTATTGAAGTCATAA

Upstream 100 bases:

>100_bases
TGAAGGTTTTGTGCATGTATGTAAAGTTGATAACGAAGGCACAAGAGAAATTAAATAAGTTAATTTAAATAGATGAAATC
AGATTAAAAACGGATTAAAT

Downstream 100 bases:

>100_bases
AGTGCGGTAAATTTTTATTGTGTTTTGGATAGCATCTGATTTTCAGGTGCTATTTTATTTAGAAAGTATAACGTAGCGAT
AAAATATATTAATTATTTTA

Product: threonine synthase

Products: NA

Alternate protein names: TS

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGALIDGELPQATLDAMVKNAFTF
PAPLEKVEENIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKI
SPLQEKLFCTLGGNIRTVAINADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMDVSRPNNWPRVEELFKRNGWD
LTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLKDQLKASETGIFLCTAHPAKFKESVERILGIQLPLPETLDK
HNQLPLLSDEMDNDFAQLRAYLLKS

Sequences:

>Translated_425_residues
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGALIDGELPQATLDAMVKNAFTF
PAPLEKVEENIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKI
SPLQEKLFCTLGGNIRTVAINADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMDVSRPNNWPRVEELFKRNGWD
LTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLKDQLKASETGIFLCTAHPAKFKESVERILGIQLPLPETLDK
HNQLPLLSDEMDNDFAQLRAYLLKS
>Mature_425_residues
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGALIDGELPQATLDAMVKNAFTF
PAPLEKVEENIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKI
SPLQEKLFCTLGGNIRTVAINADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMDVSRPNNWPRVEELFKRNGWD
LTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLKDQLKASETGIFLCTAHPAKFKESVERILGIQLPLPETLDK
HNQLPLLSDEMDNDFAQLRAYLLKS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family

Homologues:

Organism=Homo sapiens, GI153792148, Length=460, Percent_Identity=30.6521739130435, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI149193323, Length=419, Percent_Identity=30.3102625298329, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1786185, Length=425, Percent_Identity=66.5882352941177, Blast_Score=570, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6319901, Length=447, Percent_Identity=34.8993288590604, Blast_Score=221, Evalue=2e-58,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): THRC_HAEIN (P44503)

Other databases:

- EMBL:   L42023
- PIR:   H64047
- RefSeq:   NP_438260.1
- ProteinModelPortal:   P44503
- SMR:   P44503
- GeneID:   950990
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0087
- NMPDR:   fig|71421.1.peg.86
- TIGR:   HI_0087
- HOGENOM:   HBG521025
- OMA:   NAFTFPA
- ProtClustDB:   PRK09225
- BioCyc:   HINF71421:HI_0087-MONOMER
- BRENDA:   4.2.3.1
- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450
- TIGRFAMs:   TIGR00260

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.3.1

Molecular weight: Translated: 46683; Mature: 46683

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHH
IDGELPQATLDAMVKNAFTFPAPLEKVEENIYALELFHGPTLAFKDFGGRFMAQALAAVR
HCCCCCHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEECCCCEEHHHCCHHHHHHHHHHHC
GDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKISPLQEKLFCTLGGNIRTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHEEEEECCCEEEEEE
NADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCEE
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMD
EECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
VSRPNNWPRVEELFKRNGWDLTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLK
CCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCEECCCCHHHHHHHH
DQLKASETGIFLCTAHPAKFKESVERILGIQLPLPETLDKHNQLPLLSDEMDNDFAQLRA
HHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHH
YLLKS
HHHCC
>Mature Secondary Structure
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHH
IDGELPQATLDAMVKNAFTFPAPLEKVEENIYALELFHGPTLAFKDFGGRFMAQALAAVR
HCCCCCHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEECCCCEEHHHCCHHHHHHHHHHHC
GDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKISPLQEKLFCTLGGNIRTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHEEEEECCCEEEEEE
NADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCEE
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMD
EECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
VSRPNNWPRVEELFKRNGWDLTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLK
CCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCEECCCCHHHHHHHH
DQLKASETGIFLCTAHPAKFKESVERILGIQLPLPETLDKHNQLPLLSDEMDNDFAQLRA
HHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHH
YLLKS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800