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The map label for this gene is thrB [H]

Identifier: 16272062

GI number: 16272062

Start: 93468

End: 94412

Strand: Reverse

Name: thrB [H]

Synonym: HI0088

Alternate gene names: 16272062

Gene position: 94412-93468 (Counterclockwise)

Preceding gene: 16272063

Following gene: 16272061

Centisome position: 5.16

GC content: 38.62

Gene sequence:

>945_bases
ATGTTAAGAATTTACGCCCCTGCATCTAGCGCGAATATTAGCGTAGGTTTCGATACTTTAGGTGCTGCGATCTCTCCTAT
TGATGGTTCTTTGTTAGGCGATGTGGTTCAAATAGAATCTATTTCAACTGGTTTTGAGTTAGAAAGTGCGGGCTATTTTG
TTCGTAAATTACCGAAAGAACCGCAAAAAAATATTGTTTACCAAGCTTATGTGCTATTTAGCGAGCAATTAAAATTACGC
GGAGCAAATGTTAAACCTTTACGTTTAACGCTCGAAAAAAATATGCCTATTGGCTCTGGTTTAGGCTCTAGTGCTTGTTC
TATTGTTGCTGCATTAGTGGCATTAAATCAGTTTCATAATGAACCTTTTTCGAAAATGGAATTGCTTGAAATGATGGGAG
AATTGGAAGGTCGTATTTCTGGTTCAATCCATTATGATAACGTCGCACCTTGCTATCTTGGCGGTGTGCAATTTATGGTG
CAATCGCTCGGCAATATTTGTCAAAAATTGCCATTTTTTGATAATTGGTATTGGGTGTTAGCCTATCCGGGAATTGAAGT
TTCTACTGCTGAAGCTCGAGCAATTTTACCGAAAAGCTATACTCGACAAAACGTGATTGCCCATGGTCGTCATTTAGGTG
GCTTTGTGCATGCTTGCCATACCCATCAGGAAAATCTTGCCGCGATTATGATGAAAGATGTCATTGCCGAGCCTTATCGT
GAATCTCTGTTACCTAATTTTGCTGAAGTAAAACAAGCTACTCGAGACTTAGGCGCACTTGCCACAGGTATTTCAGGCTC
AGGGCCAACTATTTTCTCTATTGCCCCTGATTTACAAACTGCAATTAAACTTTCAAGTTATTTAGAAAGCCATTATTTAC
AAAATAATGAAGGTTTTGTGCATGTATGTAAAGTTGATAACGAAGGCACAAGAGAAATTAAATAA

Upstream 100 bases:

>100_bases
TCCACTTTTATTACGTGGTTATGGCGCAGGTAATGCAGTTACTGCGGCAGGTATCTTTGCAGATATTTTAAGAACATTAC
AACATTAATAAGGATTCCCA

Downstream 100 bases:

>100_bases
GTTAATTTAAATAGATGAAATCAGATTAAAAACGGATTAAATATGAATTTATACAATATCAAACACCCAGAAGAACAAGT
CACTTTTTCTCAGGCTGTTC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MLRIYAPASSANISVGFDTLGAAISPIDGSLLGDVVQIESISTGFELESAGYFVRKLPKEPQKNIVYQAYVLFSEQLKLR
GANVKPLRLTLEKNMPIGSGLGSSACSIVAALVALNQFHNEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGVQFMV
QSLGNICQKLPFFDNWYWVLAYPGIEVSTAEARAILPKSYTRQNVIAHGRHLGGFVHACHTHQENLAAIMMKDVIAEPYR
ESLLPNFAEVKQATRDLGALATGISGSGPTIFSIAPDLQTAIKLSSYLESHYLQNNEGFVHVCKVDNEGTREIK

Sequences:

>Translated_314_residues
MLRIYAPASSANISVGFDTLGAAISPIDGSLLGDVVQIESISTGFELESAGYFVRKLPKEPQKNIVYQAYVLFSEQLKLR
GANVKPLRLTLEKNMPIGSGLGSSACSIVAALVALNQFHNEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGVQFMV
QSLGNICQKLPFFDNWYWVLAYPGIEVSTAEARAILPKSYTRQNVIAHGRHLGGFVHACHTHQENLAAIMMKDVIAEPYR
ESLLPNFAEVKQATRDLGALATGISGSGPTIFSIAPDLQTAIKLSSYLESHYLQNNEGFVHVCKVDNEGTREIK
>Mature_314_residues
MLRIYAPASSANISVGFDTLGAAISPIDGSLLGDVVQIESISTGFELESAGYFVRKLPKEPQKNIVYQAYVLFSEQLKLR
GANVKPLRLTLEKNMPIGSGLGSSACSIVAALVALNQFHNEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGVQFMV
QSLGNICQKLPFFDNWYWVLAYPGIEVSTAEARAILPKSYTRQNVIAHGRHLGGFVHACHTHQENLAAIMMKDVIAEPYR
ESLLPNFAEVKQATRDLGALATGISGSGPTIFSIAPDLQTAIKLSSYLESHYLQNNEGFVHVCKVDNEGTREIK

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=311, Percent_Identity=60.4501607717042, Blast_Score=404, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34311; Mature: 34311

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIYAPASSANISVGFDTLGAAISPIDGSLLGDVVQIESISTGFELESAGYFVRKLPKE
CEEEEECCCCCEEEECHHHHCCCCCCCCCHHHHHHHEEEECCCCCEECCCCHHHHHCCCC
PQKNIVYQAYVLFSEQLKLRGANVKPLRLTLEKNMPIGSGLGSSACSIVAALVALNQFHN
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHC
EPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGVQFMVQSLGNICQKLPFFDNWYWVL
CCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
AYPGIEVSTAEARAILPKSYTRQNVIAHGRHLGGFVHACHTHQENLAAIMMKDVIAEPYR
EECCCEEECCHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ESLLPNFAEVKQATRDLGALATGISGSGPTIFSIAPDLQTAIKLSSYLESHYLQNNEGFV
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEE
HVCKVDNEGTREIK
EEEEECCCCCCCCC
>Mature Secondary Structure
MLRIYAPASSANISVGFDTLGAAISPIDGSLLGDVVQIESISTGFELESAGYFVRKLPKE
CEEEEECCCCCEEEECHHHHCCCCCCCCCHHHHHHHEEEECCCCCEECCCCHHHHHCCCC
PQKNIVYQAYVLFSEQLKLRGANVKPLRLTLEKNMPIGSGLGSSACSIVAALVALNQFHN
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHC
EPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGVQFMVQSLGNICQKLPFFDNWYWVL
CCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
AYPGIEVSTAEARAILPKSYTRQNVIAHGRHLGGFVHACHTHQENLAAIMMKDVIAEPYR
EECCCEEECCHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ESLLPNFAEVKQATRDLGALATGISGSGPTIFSIAPDLQTAIKLSSYLESHYLQNNEGFV
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEE
HVCKVDNEGTREIK
EEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA