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The map label for this gene is envZ [H]

Identifier: 99081320

GI number: 99081320

Start: 1579845

End: 1581173

Strand: Reverse

Name: envZ [H]

Synonym: TM1040_1479

Alternate gene names: 99081320

Gene position: 1581173-1579845 (Counterclockwise)

Preceding gene: 99081322

Following gene: 99081318

Centisome position: 49.4

GC content: 60.8

Gene sequence:

>1329_bases
ATGAAACTCTCTGATCTCAAACACTATGTACCGCGCCTTCCCAGCGGGATCTACGGCCGGGCGGCGCTTATTCTGTTGAT
GCCGGTGGTGGCTTTACAACTGGTGGTGGCCTTTGTGTTCATTCGCCGAGACCTTGAGGACATCACGCAGCAAATGGCCT
ACACTGTTGCGCGCGAGCTCAATGTCATCAGCGATCAGATCGCCACCGCAGAAAGTCCCGAAGCGGCCCTGAGTGACCTT
CAGCCGATGTTGCAGCGGCTCAATTTTCAGATGCGTTTTATCTCTGCCGAGGAGCCCACGCCGCAGAACTCCATTCCGTT
TGAGGATCTGTCTGGCCGTTTTGTGCGCGACTCCATGGTGGGATACCTGCCGCAGTTCCAGTCCATCCGGTTCACGCGCT
CCCACGCCAGCTATATCATGATCGATACAAAATTTGGTCTCGCGGAGGTGAAGTTCAGCCGCCGTCGCGTGACCGTCGCC
GCACCACACCAGTTGATCGTGATCACGGTGCTGTTTGGCTTTATGCTTGTGGTGATCGCCATGGCCTATATGCGCAACCA
ACTGCGCCCCATCAAACGGCTCGCGGATGCGGCCGAGGCCTTTGGGCGCGGGCGGGTGATCCCCTATCACCCGCGTGGGG
CAACCGAGGTACGCGCGGCGGGGGCGGCTTTCAATGACATGCGCGCGCGCATTGATCGGCAGATCGAACAGCGCACCTTG
ATGTTGTCAGGGGTCAGCCACGACCTGCGCACGCCTTTGACGCGCTTGAAACTGAGCCTCTCGATGCTGGACGACGAGGA
GGCCGAGCCGATGTTGCAGGACGTGAAGGAGATGGAAGCTATGGTCGATGCCTTTCTCGACTTCTCGCGCGGTGTGACTA
CAAGCGCGATGGAGGAAACCGACCCCTGCAAGCTCGTGGAGGAAGCGGTCGAGAACTGGACCCGACAGGGCAAGACCGTG
CATCTGGTAGAGACGGTCGGCAATCGCCGGGTGCCGCTGCGGGCCGCTGCGGTGCGTCGTGCCCTTGACAATCTGATTTC
AAACGCGGTGCGCTATGGCACGCGCGCCCGAGTGTCGGTTGCAGTGATGCAGAAATCGCTGCGCATTCGGGTGGAGGATG
ACGGCCCTGGTATCCCCGAAGCATTGCGCGGGGATGCGATGCGCCCCTTCACGCGGCTTGATCCGGCGCGGAATCAGGAT
CTGGGCACCGGTGTCGGGCTGGGGTTGGCCATTGTGGCTGATATTGCCCGCGCCCATGGTGGAACACTGCGCCTTGGCAC
CAGCGAAGAGCTGGGCGGGCTTCAGGCCGATATTGTGATCGCGCTCTGA

Upstream 100 bases:

>100_bases
GCGAAGCCGGGTTTGGGGTTGAACCCATCGGTGGGTTGCGATCTGCTCATGATGTGCCTCATCCTTGGGGACGCAGAATT
GTCCCGCTCTAGGCTTAGTC

Downstream 100 bases:

>100_bases
GCGGCCTCAACCGGCGCTGTGACAAGATTTTTGGTACACTCAAGCAAGTGCGATACGGGCGACAGAGCAGCTGCGATCGG
GGCAATTGCGTCCTGGATGG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKLSDLKHYVPRLPSGIYGRAALILLMPVVALQLVVAFVFIRRDLEDITQQMAYTVARELNVISDQIATAESPEAALSDL
QPMLQRLNFQMRFISAEEPTPQNSIPFEDLSGRFVRDSMVGYLPQFQSIRFTRSHASYIMIDTKFGLAEVKFSRRRVTVA
APHQLIVITVLFGFMLVVIAMAYMRNQLRPIKRLADAAEAFGRGRVIPYHPRGATEVRAAGAAFNDMRARIDRQIEQRTL
MLSGVSHDLRTPLTRLKLSLSMLDDEEAEPMLQDVKEMEAMVDAFLDFSRGVTTSAMEETDPCKLVEEAVENWTRQGKTV
HLVETVGNRRVPLRAAAVRRALDNLISNAVRYGTRARVSVAVMQKSLRIRVEDDGPGIPEALRGDAMRPFTRLDPARNQD
LGTGVGLGLAIVADIARAHGGTLRLGTSEELGGLQADIVIAL

Sequences:

>Translated_442_residues
MKLSDLKHYVPRLPSGIYGRAALILLMPVVALQLVVAFVFIRRDLEDITQQMAYTVARELNVISDQIATAESPEAALSDL
QPMLQRLNFQMRFISAEEPTPQNSIPFEDLSGRFVRDSMVGYLPQFQSIRFTRSHASYIMIDTKFGLAEVKFSRRRVTVA
APHQLIVITVLFGFMLVVIAMAYMRNQLRPIKRLADAAEAFGRGRVIPYHPRGATEVRAAGAAFNDMRARIDRQIEQRTL
MLSGVSHDLRTPLTRLKLSLSMLDDEEAEPMLQDVKEMEAMVDAFLDFSRGVTTSAMEETDPCKLVEEAVENWTRQGKTV
HLVETVGNRRVPLRAAAVRRALDNLISNAVRYGTRARVSVAVMQKSLRIRVEDDGPGIPEALRGDAMRPFTRLDPARNQD
LGTGVGLGLAIVADIARAHGGTLRLGTSEELGGLQADIVIAL
>Mature_442_residues
MKLSDLKHYVPRLPSGIYGRAALILLMPVVALQLVVAFVFIRRDLEDITQQMAYTVARELNVISDQIATAESPEAALSDL
QPMLQRLNFQMRFISAEEPTPQNSIPFEDLSGRFVRDSMVGYLPQFQSIRFTRSHASYIMIDTKFGLAEVKFSRRRVTVA
APHQLIVITVLFGFMLVVIAMAYMRNQLRPIKRLADAAEAFGRGRVIPYHPRGATEVRAAGAAFNDMRARIDRQIEQRTL
MLSGVSHDLRTPLTRLKLSLSMLDDEEAEPMLQDVKEMEAMVDAFLDFSRGVTTSAMEETDPCKLVEEAVENWTRQGKTV
HLVETVGNRRVPLRAAAVRRALDNLISNAVRYGTRARVSVAVMQKSLRIRVEDDGPGIPEALRGDAMRPFTRLDPARNQD
LGTGVGLGLAIVADIARAHGGTLRLGTSEELGGLQADIVIAL

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=275, Percent_Identity=36.3636363636364, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1787894, Length=285, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=33.457249070632, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=27.6223776223776, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082128, Length=285, Percent_Identity=27.719298245614, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790861, Length=311, Percent_Identity=27.6527331189711, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786783, Length=226, Percent_Identity=30.9734513274336, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=30.8035714285714, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789403, Length=352, Percent_Identity=25.8522727272727, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=24.1992882562278, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=283, Percent_Identity=24.7349823321555, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=29.0178571428571, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=25.3164556962025, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49151; Mature: 49151

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSDLKHYVPRLPSGIYGRAALILLMPVVALQLVVAFVFIRRDLEDITQQMAYTVAREL
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVISDQIATAESPEAALSDLQPMLQRLNFQMRFISAEEPTPQNSIPFEDLSGRFVRDSMV
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCCHHHHHHH
GYLPQFQSIRFTRSHASYIMIDTKFGLAEVKFSRRRVTVAAPHQLIVITVLFGFMLVVIA
HHCCCHHHEEEEECCCCEEEEECCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
MAYMRNQLRPIKRLADAAEAFGRGRVIPYHPRGATEVRAAGAAFNDMRARIDRQIEQRTL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MLSGVSHDLRTPLTRLKLSLSMLDDEEAEPMLQDVKEMEAMVDAFLDFSRGVTTSAMEET
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
DPCKLVEEAVENWTRQGKTVHLVETVGNRRVPLRAAAVRRALDNLISNAVRYGTRARVSV
CHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AVMQKSLRIRVEDDGPGIPEALRGDAMRPFTRLDPARNQDLGTGVGLGLAIVADIARAHG
HHHHHHHEEEECCCCCCCCHHHCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GTLRLGTSEELGGLQADIVIAL
CEEEECCCHHHCCCEEEEEEEC
>Mature Secondary Structure
MKLSDLKHYVPRLPSGIYGRAALILLMPVVALQLVVAFVFIRRDLEDITQQMAYTVAREL
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVISDQIATAESPEAALSDLQPMLQRLNFQMRFISAEEPTPQNSIPFEDLSGRFVRDSMV
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCCHHHHHHH
GYLPQFQSIRFTRSHASYIMIDTKFGLAEVKFSRRRVTVAAPHQLIVITVLFGFMLVVIA
HHCCCHHHEEEEECCCCEEEEECCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
MAYMRNQLRPIKRLADAAEAFGRGRVIPYHPRGATEVRAAGAAFNDMRARIDRQIEQRTL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MLSGVSHDLRTPLTRLKLSLSMLDDEEAEPMLQDVKEMEAMVDAFLDFSRGVTTSAMEET
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
DPCKLVEEAVENWTRQGKTVHLVETVGNRRVPLRAAAVRRALDNLISNAVRYGTRARVSV
CHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AVMQKSLRIRVEDDGPGIPEALRGDAMRPFTRLDPARNQDLGTGVGLGLAIVADIARAHG
HHHHHHHEEEECCCCCCCCHHHCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GTLRLGTSEELGGLQADIVIAL
CEEEECCCHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]