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The map label for this gene is icd [H]

Identifier: 99080318

GI number: 99080318

Start: 497149

End: 499365

Strand: Reverse

Name: icd [H]

Synonym: TM1040_0477

Alternate gene names: 99080318

Gene position: 499365-497149 (Counterclockwise)

Preceding gene: 99080320

Following gene: 99080317

Centisome position: 15.6

GC content: 61.61

Gene sequence:

>2217_bases
ATGGCAGAAAATTCAACGCCGGACATTTTGTATACCATTGTAGACGAAGCGCCCGAGCTGGCCTCGGCATCTTTCCTGCC
GATCATCCGCAAATTTGCGGATGCTGCCGGTGTCAGCGTTGGCACAAAGGACATTTCGCTGGCCGCACGCATTATCGCGA
CCTTCCCGGAGAACCTCACCGAAGAGCAGCGCCAAAGCGATGACCTCGCCGCGCTGGGCGAGCTGGTGAAGACCCCCGAC
GCAAATGTCATCAAACTGCCCAACATCTCTGCATCCGTGCCCCAGCTGGTGGCCGCGATCGAGGAACTGCAGGCGCAGGG
GTACAAGCTGCCCGACTACCCCTACGAGCCCGCAACCGACGCGGAAAAGGAAATCCGCGCCCGCTACGACACCATCAAGG
GCTCCGCGGTGAACCCAGTCCTGCGCGAAGGCAACTCGGACCGTCGTTCGGCCAAAGCCGTGAAGAACTACGCTCAGAAC
AACCCGCATTCGATGGGCGCATGGTCTGGCGACAGCAAGACCAAAGTCTCGTCGATGCCCGGCAACGACTTTTATGCCAA
CGAGAAATCCGCCACCATTTCCGCCGAGCAGGCCGGTGACGCGAAGATCGAATTTGTCGCAAAAGACGGGTCCGTCACCG
TTCTGAAAGACGGCTGGCCGCTGGCAGAAGGCACGGTTGCCGATGCGACCTTCATGTCCGCCAAAGCGCTCGCCGCGTTC
CTGTCTGGCGCGATCGAGGATACCAAGGCGGACGGCACCATGTTCTCGCTGCACATGAAGGCCACCATGATGAAGGTCTC
CGACCCGATCATCTTTGGCCACGCGGTCAAAGCCTGGCTCGGCCCTGTGTGGGATAAACACGGCGCCGCAATTGCTGCCG
CAGGTGGGTCGCCGAACTCCGGTCTGGGTGCGGTTCTGGCCGCCATCGACAGCCTGCCCAACGCAGATGAGATCAAATCC
GAGATCGCCGCGCTCGAACGCCCCTCCATGTATATGGTGGACAGCGACAAGGGTATCACCAACCTGCATGTGCCCTCCGA
CGTGATCATCGATGCCTCCATGCCGGCCGTGATCCGTGCTGGCGGTAAGGGCTGGGACGAGACCGGCGCCAAGGGCGACA
CCAACTGCGTGATCCCCGACCGCTGCTACTCCACCGTCTATGACGAGACCATCAACTTCTTCAAAGCCAATGGCGCGCTC
GACGTGACCACTGCCGGTTCGGTCGCAAACGTCGGCTTGATGGCGCAAAAGGCGGAAGAGTATGGCTCGCACCCGACGAC
CTTCGAAGCCCCGGCAGACGGCGAGATCCGCGTTATTCTGGCCAATGGCGAGACCCTGCACAGCCACGAAGTCGAGGCCG
GCGACATCTGGCGCGCCTGCACCGTGAAAAAGGCTCCAATCGAGAACTGGATTCAACTGGCTTTGGACCGTCAGCGCCTG
ACCGGGTCCGAGGCGATCTTCTGGCTGGACGCAAACCGCGCCCATGACGCAGAGCTGATCAAATACGTCAAACCCGCGCT
TGATGCGGCTGGCGTCGCCGACAAGTTCCTGATCATGGCGCCGCGCGAAGCCACCCGTCAGAGCCTCGAGACCATCACTG
CGGGCAAGGACAGCATCGCCATCACCGGCAACGTGCTGCGCGACTACCTGACCGACCTGTTCCCGATCCTCGAGCTTGGC
ACCTCGGCCAAGATGCTGTCGATTGTGAAGCTGATGAACGGCGGCGGCTTGTTTGAGACCGGCGCAGGCGGTTCCGCGCC
CAAACACGTGCAGCAACTGGTTGAGGAAAACCACCTGCGTTGGGACTCCATGGGTGAGTTCTGCGCTCTGGGCGAAAGCC
TGAAGTTCCTCGCCGATGTCAAAGGCAACGAGAAGGCAGGCGTGCTTGGCGCAGCTGCCGAGGTTGCGACCCAAGGCATC
CTCGACAACAACAAATCGCCCGAGCGCAAAGTCGGCCAGCCCGACAACCGCGACAGCCACTACTGGTTTGCCCGCTACTG
GGCAGAAGCCCTCGCGGCACAGGGTGATGACGCGGAGCTGGCCGCGCATTTCAAACCGATTGCCGAGGCTCTTGCCTCCA
ACGAAGCGGCGATTCTGTCTGAACTCGCCGCCGCTCAGGGAGGCGCAGCCGACATCGGTGGCTATTACCACCCCTCCGTT
GAAAAGAAGGCCGCCGTCATGCGCCCCTCTGCAACCCTCAACGGCATCATCGGCTGA

Upstream 100 bases:

>100_bases
GCCCCGCGCCCCCTGCCGGACAAGTATCAAGTGACGCGGCACACGCGCACCGAATTGACGACGAACAACAGCTTCCGAAT
TCGCAGAAAGGTTGTGGAAC

Downstream 100 bases:

>100_bases
GCCTGACCTCAGGATCAAAGTCCAAAAATCACAAGGCGCCCGGCACAGTCCGGGCGCTTTTTGCATGGTCAGAGGGGAAA
CCCGCCTCTGTTCCACAGGT

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 738; Mature: 737

Protein sequence:

>738_residues
MAENSTPDILYTIVDEAPELASASFLPIIRKFADAAGVSVGTKDISLAARIIATFPENLTEEQRQSDDLAALGELVKTPD
ANVIKLPNISASVPQLVAAIEELQAQGYKLPDYPYEPATDAEKEIRARYDTIKGSAVNPVLREGNSDRRSAKAVKNYAQN
NPHSMGAWSGDSKTKVSSMPGNDFYANEKSATISAEQAGDAKIEFVAKDGSVTVLKDGWPLAEGTVADATFMSAKALAAF
LSGAIEDTKADGTMFSLHMKATMMKVSDPIIFGHAVKAWLGPVWDKHGAAIAAAGGSPNSGLGAVLAAIDSLPNADEIKS
EIAALERPSMYMVDSDKGITNLHVPSDVIIDASMPAVIRAGGKGWDETGAKGDTNCVIPDRCYSTVYDETINFFKANGAL
DVTTAGSVANVGLMAQKAEEYGSHPTTFEAPADGEIRVILANGETLHSHEVEAGDIWRACTVKKAPIENWIQLALDRQRL
TGSEAIFWLDANRAHDAELIKYVKPALDAAGVADKFLIMAPREATRQSLETITAGKDSIAITGNVLRDYLTDLFPILELG
TSAKMLSIVKLMNGGGLFETGAGGSAPKHVQQLVEENHLRWDSMGEFCALGESLKFLADVKGNEKAGVLGAAAEVATQGI
LDNNKSPERKVGQPDNRDSHYWFARYWAEALAAQGDDAELAAHFKPIAEALASNEAAILSELAAAQGGAADIGGYYHPSV
EKKAAVMRPSATLNGIIG

Sequences:

>Translated_738_residues
MAENSTPDILYTIVDEAPELASASFLPIIRKFADAAGVSVGTKDISLAARIIATFPENLTEEQRQSDDLAALGELVKTPD
ANVIKLPNISASVPQLVAAIEELQAQGYKLPDYPYEPATDAEKEIRARYDTIKGSAVNPVLREGNSDRRSAKAVKNYAQN
NPHSMGAWSGDSKTKVSSMPGNDFYANEKSATISAEQAGDAKIEFVAKDGSVTVLKDGWPLAEGTVADATFMSAKALAAF
LSGAIEDTKADGTMFSLHMKATMMKVSDPIIFGHAVKAWLGPVWDKHGAAIAAAGGSPNSGLGAVLAAIDSLPNADEIKS
EIAALERPSMYMVDSDKGITNLHVPSDVIIDASMPAVIRAGGKGWDETGAKGDTNCVIPDRCYSTVYDETINFFKANGAL
DVTTAGSVANVGLMAQKAEEYGSHPTTFEAPADGEIRVILANGETLHSHEVEAGDIWRACTVKKAPIENWIQLALDRQRL
TGSEAIFWLDANRAHDAELIKYVKPALDAAGVADKFLIMAPREATRQSLETITAGKDSIAITGNVLRDYLTDLFPILELG
TSAKMLSIVKLMNGGGLFETGAGGSAPKHVQQLVEENHLRWDSMGEFCALGESLKFLADVKGNEKAGVLGAAAEVATQGI
LDNNKSPERKVGQPDNRDSHYWFARYWAEALAAQGDDAELAAHFKPIAEALASNEAAILSELAAAQGGAADIGGYYHPSV
EKKAAVMRPSATLNGIIG
>Mature_737_residues
AENSTPDILYTIVDEAPELASASFLPIIRKFADAAGVSVGTKDISLAARIIATFPENLTEEQRQSDDLAALGELVKTPDA
NVIKLPNISASVPQLVAAIEELQAQGYKLPDYPYEPATDAEKEIRARYDTIKGSAVNPVLREGNSDRRSAKAVKNYAQNN
PHSMGAWSGDSKTKVSSMPGNDFYANEKSATISAEQAGDAKIEFVAKDGSVTVLKDGWPLAEGTVADATFMSAKALAAFL
SGAIEDTKADGTMFSLHMKATMMKVSDPIIFGHAVKAWLGPVWDKHGAAIAAAGGSPNSGLGAVLAAIDSLPNADEIKSE
IAALERPSMYMVDSDKGITNLHVPSDVIIDASMPAVIRAGGKGWDETGAKGDTNCVIPDRCYSTVYDETINFFKANGALD
VTTAGSVANVGLMAQKAEEYGSHPTTFEAPADGEIRVILANGETLHSHEVEAGDIWRACTVKKAPIENWIQLALDRQRLT
GSEAIFWLDANRAHDAELIKYVKPALDAAGVADKFLIMAPREATRQSLETITAGKDSIAITGNVLRDYLTDLFPILELGT
SAKMLSIVKLMNGGGLFETGAGGSAPKHVQQLVEENHLRWDSMGEFCALGESLKFLADVKGNEKAGVLGAAAEVATQGIL
DNNKSPERKVGQPDNRDSHYWFARYWAEALAAQGDDAELAAHFKPIAEALASNEAAILSELAAAQGGAADIGGYYHPSVE
KKAAVMRPSATLNGIIG

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 78301; Mature: 78170

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENSTPDILYTIVDEAPELASASFLPIIRKFADAAGVSVGTKDISLAARIIATFPENLT
CCCCCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHH
EEQRQSDDLAALGELVKTPDANVIKLPNISASVPQLVAAIEELQAQGYKLPDYPYEPATD
HHHHCCCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AEKEIRARYDTIKGSAVNPVLREGNSDRRSAKAVKNYAQNNPHSMGAWSGDSKTKVSSMP
HHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCC
GNDFYANEKSATISAEQAGDAKIEFVAKDGSVTVLKDGWPLAEGTVADATFMSAKALAAF
CCCCCCCCCCCEEECCCCCCCEEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
LSGAIEDTKADGTMFSLHMKATMMKVSDPIIFGHAVKAWLGPVWDKHGAAIAAAGGSPNS
HHHHHHCCCCCCCEEEEEHHHHHHHHCCCEEEHHHHHHHHCHHHCCCCCEEEECCCCCCC
GLGAVLAAIDSLPNADEIKSEIAALERPSMYMVDSDKGITNLHVPSDVIIDASMPAVIRA
CHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCCCHHEEC
GGKGWDETGAKGDTNCVIPDRCYSTVYDETINFFKANGALDVTTAGSVANVGLMAQKAEE
CCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHHHHH
YGSHPTTFEAPADGEIRVILANGETLHSHEVEAGDIWRACTVKKAPIENWIQLALDRQRL
HCCCCCEECCCCCCCEEEEEECCCEECCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHC
TGSEAIFWLDANRAHDAELIKYVKPALDAAGVADKFLIMAPREATRQSLETITAGKDSIA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEE
ITGNVLRDYLTDLFPILELGTSAKMLSIVKLMNGGGLFETGAGGSAPKHVQQLVEENHLR
EEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCC
WDSMGEFCALGESLKFLADVKGNEKAGVLGAAAEVATQGILDNNKSPERKVGQPDNRDSH
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
YWFARYWAEALAAQGDDAELAAHFKPIAEALASNEAAILSELAAAQGGAADIGGYYHPSV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCC
EKKAAVMRPSATLNGIIG
HHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AENSTPDILYTIVDEAPELASASFLPIIRKFADAAGVSVGTKDISLAARIIATFPENLT
CCCCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHH
EEQRQSDDLAALGELVKTPDANVIKLPNISASVPQLVAAIEELQAQGYKLPDYPYEPATD
HHHHCCCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AEKEIRARYDTIKGSAVNPVLREGNSDRRSAKAVKNYAQNNPHSMGAWSGDSKTKVSSMP
HHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCC
GNDFYANEKSATISAEQAGDAKIEFVAKDGSVTVLKDGWPLAEGTVADATFMSAKALAAF
CCCCCCCCCCCEEECCCCCCCEEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
LSGAIEDTKADGTMFSLHMKATMMKVSDPIIFGHAVKAWLGPVWDKHGAAIAAAGGSPNS
HHHHHHCCCCCCCEEEEEHHHHHHHHCCCEEEHHHHHHHHCHHHCCCCCEEEECCCCCCC
GLGAVLAAIDSLPNADEIKSEIAALERPSMYMVDSDKGITNLHVPSDVIIDASMPAVIRA
CHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCCCHHEEC
GGKGWDETGAKGDTNCVIPDRCYSTVYDETINFFKANGALDVTTAGSVANVGLMAQKAEE
CCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHHHHH
YGSHPTTFEAPADGEIRVILANGETLHSHEVEAGDIWRACTVKKAPIENWIQLALDRQRL
HCCCCCEECCCCCCCEEEEEECCCEECCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHC
TGSEAIFWLDANRAHDAELIKYVKPALDAAGVADKFLIMAPREATRQSLETITAGKDSIA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEE
ITGNVLRDYLTDLFPILELGTSAKMLSIVKLMNGGGLFETGAGGSAPKHVQQLVEENHLR
EEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCC
WDSMGEFCALGESLKFLADVKGNEKAGVLGAAAEVATQGILDNNKSPERKVGQPDNRDSH
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
YWFARYWAEALAAQGDDAELAAHFKPIAEALASNEAAILSELAAAQGGAADIGGYYHPSV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCC
EKKAAVMRPSATLNGIIG
HHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]