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The map label for this gene is yeaE [H]

Identifier: 91789894

GI number: 91789894

Start: 4260754

End: 4261596

Strand: Reverse

Name: yeaE [H]

Synonym: Bpro_4055

Alternate gene names: 91789894

Gene position: 4261596-4260754 (Counterclockwise)

Preceding gene: 91789896

Following gene: 91789888

Centisome position: 81.95

GC content: 65.36

Gene sequence:

>843_bases
ATGGCTGTCATGAAAAGCGTATTGCTGCCTTGTGGCGAAGCCGTGCCGGCATTGGGAATGGGTACCTGGTGCATGGGGGA
GACACTTGGGCGGCGAGCCCAGGAGCTCGCCACGCTCAGGCGGGGCCTTGATTTGGGCTGCACGCTCGTCGATACCGCCG
AAATGTATGGCGAAGGCCTGGCGGAAGCGCTGGTGGGCGAGGCGATCCAGGGGCGTCGCGACGAGGCCTTTCTGGTCACC
AAGGTCTATCCGCACAATGCCTCGTTTGCTGGCGCGCAGGCGGCTTGCGAGCGCAGTCTGCGCCGCCTGAAAACCGACCG
CATCGATCTGTACCTGCTGCATTGGCGCGGCAATGTTCCGCTGGCCGAAACCCTGCGCGCTTTTCAGGCCCTGCAGCAAG
CCGGCAAGATTCGCCACTATGGTGTCAGCAACCTGGATATCTCCGACATGGAGGAGTTGTGGTCCTTGCCCGGCGGCCAC
GGCGTGCAGACCAACCAGCTGCTCTACAACCTGACGCGCCGCGGCATTGAATGGGATTTGCTGCCCTGGCTGCACGAACG
CCACATCCCGGTGATGGCCTACTCACCCATCGAGCAGTCCCGGCTGCTGCGCCAGCCCGGACTGACCGGCTTCGCGCAGC
GCCACGGCATGCGGCCCGCGCAGGCTGCGCTGGCCTGGCTGCTGGCCCGGGACGGCGTCATGGCCATCCCCAAGACCAGC
CACCCGGACCGGCTGACGGAAAACATCGCCGCGGCAGACATGGCGCTGAGTGGCGAGCAGCTCGCGGAACTTGACGCGCT
TTTCCGTCCGCCGTCCGGCCCCATCGCGCTTGAAATGATCTAG

Upstream 100 bases:

>100_bases
CTTCGGGCGGGATTGATTCCGCCAACGCATTAATCAGTTCGGCGCGCGCAGGCCGGATATTTCTTGTCCCGGAGCCGGTA
CGGCGCGATGCGGCGCTACC

Downstream 100 bases:

>100_bases
TGTGGTGTTGCATGCTTGACGGCACCCATAAAACCGATGAATTTTTGGTCAGGGCAAGGCGCAAACCACAGCAATAGCCC
CGCTATTGCGCGGATTTGCA

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MAVMKSVLLPCGEAVPALGMGTWCMGETLGRRAQELATLRRGLDLGCTLVDTAEMYGEGLAEALVGEAIQGRRDEAFLVT
KVYPHNASFAGAQAACERSLRRLKTDRIDLYLLHWRGNVPLAETLRAFQALQQAGKIRHYGVSNLDISDMEELWSLPGGH
GVQTNQLLYNLTRRGIEWDLLPWLHERHIPVMAYSPIEQSRLLRQPGLTGFAQRHGMRPAQAALAWLLARDGVMAIPKTS
HPDRLTENIAAADMALSGEQLAELDALFRPPSGPIALEMI

Sequences:

>Translated_280_residues
MAVMKSVLLPCGEAVPALGMGTWCMGETLGRRAQELATLRRGLDLGCTLVDTAEMYGEGLAEALVGEAIQGRRDEAFLVT
KVYPHNASFAGAQAACERSLRRLKTDRIDLYLLHWRGNVPLAETLRAFQALQQAGKIRHYGVSNLDISDMEELWSLPGGH
GVQTNQLLYNLTRRGIEWDLLPWLHERHIPVMAYSPIEQSRLLRQPGLTGFAQRHGMRPAQAALAWLLARDGVMAIPKTS
HPDRLTENIAAADMALSGEQLAELDALFRPPSGPIALEMI
>Mature_279_residues
AVMKSVLLPCGEAVPALGMGTWCMGETLGRRAQELATLRRGLDLGCTLVDTAEMYGEGLAEALVGEAIQGRRDEAFLVTK
VYPHNASFAGAQAACERSLRRLKTDRIDLYLLHWRGNVPLAETLRAFQALQQAGKIRHYGVSNLDISDMEELWSLPGGHG
VQTNQLLYNLTRRGIEWDLLPWLHERHIPVMAYSPIEQSRLLRQPGLTGFAQRHGMRPAQAALAWLLARDGVMAIPKTSH
PDRLTENIAAADMALSGEQLAELDALFRPPSGPIALEMI

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24497577, Length=308, Percent_Identity=27.2727272727273, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI5174391, Length=308, Percent_Identity=27.2727272727273, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI223468663, Length=303, Percent_Identity=29.042904290429, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI310109922, Length=309, Percent_Identity=26.8608414239482, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI5174695, Length=297, Percent_Identity=26.5993265993266, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI5453543, Length=329, Percent_Identity=25.8358662613982, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI310109920, Length=329, Percent_Identity=25.8358662613982, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI45446745, Length=329, Percent_Identity=25.8358662613982, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4503285, Length=329, Percent_Identity=25.8358662613982, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI24497585, Length=303, Percent_Identity=27.0627062706271, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI291291012, Length=271, Percent_Identity=28.4132841328413, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4502049, Length=298, Percent_Identity=27.5167785234899, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI223718702, Length=194, Percent_Identity=30.4123711340206, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI41152114, Length=216, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI41327764, Length=165, Percent_Identity=31.5151515151515, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788081, Length=272, Percent_Identity=50.3676470588235, Blast_Score=275, Evalue=2e-75,
Organism=Escherichia coli, GI87081735, Length=297, Percent_Identity=31.3131313131313, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1786400, Length=262, Percent_Identity=28.2442748091603, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082198, Length=275, Percent_Identity=29.0909090909091, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1787674, Length=255, Percent_Identity=28.6274509803922, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788070, Length=299, Percent_Identity=28.0936454849498, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789199, Length=333, Percent_Identity=28.2282282282282, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789375, Length=316, Percent_Identity=27.5316455696203, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17537077, Length=300, Percent_Identity=29, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17537075, Length=300, Percent_Identity=29.6666666666667, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17561298, Length=286, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17552492, Length=282, Percent_Identity=25.886524822695, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71998625, Length=271, Percent_Identity=28.4132841328413, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17561300, Length=269, Percent_Identity=28.2527881040892, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17566692, Length=298, Percent_Identity=26.8456375838926, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17564128, Length=312, Percent_Identity=25.9615384615385, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17550248, Length=296, Percent_Identity=24.6621621621622, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320576, Length=276, Percent_Identity=29.7101449275362, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322556, Length=273, Percent_Identity=27.1062271062271, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45553081, Length=299, Percent_Identity=24.4147157190635, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24657054, Length=302, Percent_Identity=25.4966887417219, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI20129731, Length=301, Percent_Identity=26.578073089701, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24662789, Length=306, Percent_Identity=25.1633986928105, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281366140, Length=255, Percent_Identity=24.3137254901961, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30867; Mature: 30736

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVMKSVLLPCGEAVPALGMGTWCMGETLGRRAQELATLRRGLDLGCTLVDTAEMYGEGL
CHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHH
AEALVGEAIQGRRDEAFLVTKVYPHNASFAGAQAACERSLRRLKTDRIDLYLLHWRGNVP
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
LAETLRAFQALQQAGKIRHYGVSNLDISDMEELWSLPGGHGVQTNQLLYNLTRRGIEWDL
HHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCH
LPWLHERHIPVMAYSPIEQSRLLRQPGLTGFAQRHGMRPAQAALAWLLARDGVMAIPKTS
HHHHHHCCCCEEEECCCHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCEEECCCCC
HPDRLTENIAAADMALSGEQLAELDALFRPPSGPIALEMI
CCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
AVMKSVLLPCGEAVPALGMGTWCMGETLGRRAQELATLRRGLDLGCTLVDTAEMYGEGL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHH
AEALVGEAIQGRRDEAFLVTKVYPHNASFAGAQAACERSLRRLKTDRIDLYLLHWRGNVP
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
LAETLRAFQALQQAGKIRHYGVSNLDISDMEELWSLPGGHGVQTNQLLYNLTRRGIEWDL
HHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCH
LPWLHERHIPVMAYSPIEQSRLLRQPGLTGFAQRHGMRPAQAALAWLLARDGVMAIPKTS
HHHHHHCCCCEEEECCCHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCEEECCCCC
HPDRLTENIAAADMALSGEQLAELDALFRPPSGPIALEMI
CCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]