Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 87199910

GI number: 87199910

Start: 2005196

End: 2006644

Strand: Direct

Name: zwf [H]

Synonym: Saro_1893

Alternate gene names: 87199910

Gene position: 2005196-2006644 (Clockwise)

Preceding gene: 87199909

Following gene: 87199911

Centisome position: 56.3

GC content: 64.39

Gene sequence:

>1449_bases
ATGATCGAGTCCAGCTGTTCCGCACTGCTGCTGTTCGGCGCGACCGGCGACCTTTCCCGCCGGATGCTTCTGCCTTCGCT
CTACGCCCTTCACGAAGACGGCCTGATCCGGCCGGACCTGCGCATCGTGGGCACGGCCCGGTCCGAGCATGACGACGCCG
AGTTCCGCGAATTCGCCCGCGAGGCGCTTGCCGAATTCCTGCCCGAGGACCGGCGGGACGAGGAAAAGCTCGCGAGTTTC
CTCGAACGGCTCGAATACCAGACCCTCGATGCCTCGAATGTCGATGGCTTCGGCGAACTGGCCCGCAAGCTGGGCGACAC
CTCGTGCGGCCTCTCGATTTTCCTGTCCACCGCGCCGTTCCTGTTCGAACCGACGATCGAAGGCCTGCGCCGGGCGGGCT
TGGCCCATGAGAACGTGCGGATCGGCCTTGAAAAGCCGCTCGGGAACGACCTTGCATCGTCCACCCGTATCAACGATGCG
GTTGCCGCCGCCTTTGCCGAGGAACAGATCTTCCGGATCGACCATTACCTTGGCAAGGAAACGGTCCAGAACCTCATGGC
ACTGCGCTTTGCCAACATGATGTTCGAGCCGTTGTGGAACGCAGGCGGTATCGACCATGTGCAGATCACGGTTAGCGAGA
CGGTCGGCCTCGAAGGGCGCAAGGGCTTCTACGACGACACCGGCGCACTGCGCGACATGGTGCAGAACCACATGCTCCAG
TTGCTCGCCCTGACCGCAATGGAGCCGCCGGCAAGCCTCGACGCCACGTCGATCCGCGACGAAAAGGTCAAGGTCCTGCG
CGCGCTTCGCCCGGTCAAGGCGGAGGAAATGGTGCGGGGCCAGTACCGCGCCGGGGCGGTGAAGGGCACGTCGGTCACCG
GATACCAGGAAGACCTTGGCGAAGTGTCCGACACGGAGACCTTCGTGGCGATCAAGGCCCATGTCGACAACTGGCGTTGG
ACCGGCGTGCCGTTCTACCTGCGCACCGGCAAGCGACTTGGCGAGCGGCGCAGCGAGATCGTGGTCGAGTTCAAGCCTGT
TCCGCACAACCTCTTTGCCGAGCGCGGGGGAAGGCTTCGCCCCAACCGCCTCGTCATCCGCCTCCAGCCCGAGGAATATG
TGCGGCTGCAGGTGATGGCGAAGGAGCCGGGGCTCGACCGTGGCGGTATTGTGCTGCGCGACGTCAATCTCGACCTTTCG
TTGACCGCAGCCTTCGCCAAGGCGCGCCGCCGCATTGCCTACGAACGCCTGCTGCTCGACCTGATCGAGGGCGAACAGAC
CTTGTTCGTCCGGCGAGACGAAGTGGAAGCGCAGTGGAAGTGGGTCGACGCCATCCGCAAGGTCTGGGCCGACACCGACA
TGGAAGCCAAGCCCTATGCCGCAGGAAGCTGGGGGCCGAACGCAGGCATCGCCCTTACCGAGCGGGACGGGAGAAGCTGG
AATGACTGA

Upstream 100 bases:

>100_bases
CTGCATACATATGCGTGCTGAATCGCAGCGCCTTAGGGTCTAGGGCCTTCGTGCGAGGCACGGTTGCCGAGACCGCAACG
CCAAGGGGAGATATGCGTCG

Downstream 100 bases:

>100_bases
GCCGCAACCGGCGACAGTCTCGTGGGCCCAGCCAGGCAATGCGACTGCGGTTGCCGATCATATCGCGCGGGTCGTGAATG
CACCGGGGCGGAAGAGGATC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MIESSCSALLLFGATGDLSRRMLLPSLYALHEDGLIRPDLRIVGTARSEHDDAEFREFAREALAEFLPEDRRDEEKLASF
LERLEYQTLDASNVDGFGELARKLGDTSCGLSIFLSTAPFLFEPTIEGLRRAGLAHENVRIGLEKPLGNDLASSTRINDA
VAAAFAEEQIFRIDHYLGKETVQNLMALRFANMMFEPLWNAGGIDHVQITVSETVGLEGRKGFYDDTGALRDMVQNHMLQ
LLALTAMEPPASLDATSIRDEKVKVLRALRPVKAEEMVRGQYRAGAVKGTSVTGYQEDLGEVSDTETFVAIKAHVDNWRW
TGVPFYLRTGKRLGERRSEIVVEFKPVPHNLFAERGGRLRPNRLVIRLQPEEYVRLQVMAKEPGLDRGGIVLRDVNLDLS
LTAAFAKARRRIAYERLLLDLIEGEQTLFVRRDEVEAQWKWVDAIRKVWADTDMEAKPYAAGSWGPNAGIALTERDGRSW
ND

Sequences:

>Translated_482_residues
MIESSCSALLLFGATGDLSRRMLLPSLYALHEDGLIRPDLRIVGTARSEHDDAEFREFAREALAEFLPEDRRDEEKLASF
LERLEYQTLDASNVDGFGELARKLGDTSCGLSIFLSTAPFLFEPTIEGLRRAGLAHENVRIGLEKPLGNDLASSTRINDA
VAAAFAEEQIFRIDHYLGKETVQNLMALRFANMMFEPLWNAGGIDHVQITVSETVGLEGRKGFYDDTGALRDMVQNHMLQ
LLALTAMEPPASLDATSIRDEKVKVLRALRPVKAEEMVRGQYRAGAVKGTSVTGYQEDLGEVSDTETFVAIKAHVDNWRW
TGVPFYLRTGKRLGERRSEIVVEFKPVPHNLFAERGGRLRPNRLVIRLQPEEYVRLQVMAKEPGLDRGGIVLRDVNLDLS
LTAAFAKARRRIAYERLLLDLIEGEQTLFVRRDEVEAQWKWVDAIRKVWADTDMEAKPYAAGSWGPNAGIALTERDGRSW
ND
>Mature_482_residues
MIESSCSALLLFGATGDLSRRMLLPSLYALHEDGLIRPDLRIVGTARSEHDDAEFREFAREALAEFLPEDRRDEEKLASF
LERLEYQTLDASNVDGFGELARKLGDTSCGLSIFLSTAPFLFEPTIEGLRRAGLAHENVRIGLEKPLGNDLASSTRINDA
VAAAFAEEQIFRIDHYLGKETVQNLMALRFANMMFEPLWNAGGIDHVQITVSETVGLEGRKGFYDDTGALRDMVQNHMLQ
LLALTAMEPPASLDATSIRDEKVKVLRALRPVKAEEMVRGQYRAGAVKGTSVTGYQEDLGEVSDTETFVAIKAHVDNWRW
TGVPFYLRTGKRLGERRSEIVVEFKPVPHNLFAERGGRLRPNRLVIRLQPEEYVRLQVMAKEPGLDRGGIVLRDVNLDLS
LTAAFAKARRRIAYERLLLDLIEGEQTLFVRRDEVEAQWKWVDAIRKVWADTDMEAKPYAAGSWGPNAGIALTERDGRSW
ND

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=486, Percent_Identity=36.8312757201646, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI109389365, Length=486, Percent_Identity=36.8312757201646, Blast_Score=305, Evalue=8e-83,
Organism=Homo sapiens, GI52145310, Length=475, Percent_Identity=28.4210526315789, Blast_Score=166, Evalue=6e-41,
Organism=Escherichia coli, GI1788158, Length=480, Percent_Identity=50.2083333333333, Blast_Score=456, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17538218, Length=486, Percent_Identity=36.0082304526749, Blast_Score=308, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6324088, Length=474, Percent_Identity=34.5991561181435, Blast_Score=265, Evalue=9e-72,
Organism=Drosophila melanogaster, GI24643350, Length=469, Percent_Identity=35.3944562899787, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24643352, Length=469, Percent_Identity=35.3944562899787, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=28.2786885245902, Blast_Score=182, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54175; Mature: 54175

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIESSCSALLLFGATGDLSRRMLLPSLYALHEDGLIRPDLRIVGTARSEHDDAEFREFAR
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
EALAEFLPEDRRDEEKLASFLERLEYQTLDASNVDGFGELARKLGDTSCGLSIFLSTAPF
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCC
LFEPTIEGLRRAGLAHENVRIGLEKPLGNDLASSTRINDAVAAAFAEEQIFRIDHYLGKE
EECHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCHH
TVQNLMALRFANMMFEPLWNAGGIDHVQITVSETVGLEGRKGFYDDTGALRDMVQNHMLQ
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHH
LLALTAMEPPASLDATSIRDEKVKVLRALRPVKAEEMVRGQYRAGAVKGTSVTGYQEDLG
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCHHHCCCCCCCCCCCCHHHHC
EVSDTETFVAIKAHVDNWRWTGVPFYLRTGKRLGERRSEIVVEFKPVPHNLFAERGGRLR
CCCCCCEEEEEEEECCCEEECCCCCEECCCHHHHCCCCCEEEEEECCCHHHHHHCCCCCC
PNRLVIRLQPEEYVRLQVMAKEPGLDRGGIVLRDVNLDLSLTAAFAKARRRIAYERLLLD
CCEEEEEECCCCEEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LIEGEQTLFVRRDEVEAQWKWVDAIRKVWADTDMEAKPYAAGSWGPNAGIALTERDGRSW
HHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCC
ND
CC
>Mature Secondary Structure
MIESSCSALLLFGATGDLSRRMLLPSLYALHEDGLIRPDLRIVGTARSEHDDAEFREFAR
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
EALAEFLPEDRRDEEKLASFLERLEYQTLDASNVDGFGELARKLGDTSCGLSIFLSTAPF
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCC
LFEPTIEGLRRAGLAHENVRIGLEKPLGNDLASSTRINDAVAAAFAEEQIFRIDHYLGKE
EECHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCHH
TVQNLMALRFANMMFEPLWNAGGIDHVQITVSETVGLEGRKGFYDDTGALRDMVQNHMLQ
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHH
LLALTAMEPPASLDATSIRDEKVKVLRALRPVKAEEMVRGQYRAGAVKGTSVTGYQEDLG
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCHHHCCCCCCCCCCCCHHHHC
EVSDTETFVAIKAHVDNWRWTGVPFYLRTGKRLGERRSEIVVEFKPVPHNLFAERGGRLR
CCCCCCEEEEEEEECCCEEECCCCCEECCCHHHHCCCCCEEEEEECCCHHHHHHCCCCCC
PNRLVIRLQPEEYVRLQVMAKEPGLDRGGIVLRDVNLDLSLTAAFAKARRRIAYERLLLD
CCEEEEEECCCCEEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LIEGEQTLFVRRDEVEAQWKWVDAIRKVWADTDMEAKPYAAGSWGPNAGIALTERDGRSW
HHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCC
ND
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]