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The map label for this gene is eriC [C]

Identifier: 86609597

GI number: 86609597

Start: 2250657

End: 2252528

Strand: Direct

Name: eriC [C]

Synonym: CYB_2150

Alternate gene names: 86609597

Gene position: 2250657-2252528 (Clockwise)

Preceding gene: 86609596

Following gene: 86609602

Centisome position: 73.87

GC content: 62.77

Gene sequence:

>1872_bases
ATGAACAGCGCCCCCGCTCTCCGCCTGCGCCTCTCCTCCGAGAACCTGCTGCTGCTGCTGGCGGCGGCAGTGGGGTTGGC
CACGGGGCTGTTGGTGGTTGGATTTCGCTACTTGATTGGCTGGTGGCGCTATCTGCTGCAGGACACCCTCGTGGATGGCA
TCGGCAGGGCTGCAGAACACTATGGCCTGTGGCTGCTGGGATCCTGGACACTGGCTCTGGCGCCGGTGCTGGGGGGCCTG
CTGATCGGCGCTTTGGGGGCAGTTGTGCCCTTTCCCAACTTGAGCCTCTCCAGCTTGGTGAGTCCTGCTCGTCCTTTGGC
ACTTCAGCCCTGGTGGATCCCGCTCAAGCTCTTGGCGGCTGCCATCTCGTTGGGCGCGGGAGCTTCCCTTGGCCCTGAGG
CCCCCAGTGTGGAAAGTGGCGCTTTGCTGGGATCCCTGCTGGGGCAAAACCTACGCCTCTCGCGGGAGCGGGTGCAACTG
TTGATGGCTGCCGGAGCAGCGGCTGGCCTGGCGGCAGGGTTTAACGCGCCCATTGCCGGGGTGTTTTTGGCGCTGGAGCT
GGCTTTGGCCCGCACCTTCACCACTTCTGCTGTCAGTGTGGTGGTGTTGGCGGCGGTGGTCTCCGCCTTGATCGCCCAGG
TGGGGTTGGGGGCACAACCCGCTTTTCTTTTGCCCACCATCACCCAGCCGGCTTTTGTCTTGCCGGACTACGAGATCCAC
AGCTTGCTGGAGGTACCTCTGTATCTCGGCTTGGGCTTTTTGGCCAGCCTGGTTTCTATGGCCTTCAGCTACACCCTGGA
GTGGGGCAAGCACCTGTTCAACAGTGGCCCCCTGGCGGCCTGGCCAGCTTGGAGCAAGCCCATTTTGGGGGGCGGGATCC
TGGGCTGCGCGGGCTTGGGGATCCCATTGGCGTTGGGGGTGGGCTATGAAACCATTGAGTCGATTCTGCAGGCCGTTCCC
TTTTCTCTTGGCCATCTGGGCCTGCTCCTATTGGGCAAGCTGTTGCTGAGCGCTTTGAGCCTGGGCAGCGGCTTTGTGGG
GGGAACCTTTGCCCCGGCTTTGTTCATGGGGGCAGTGCTGGGGGCAGGCTACGGTCAGGTGCTATCCCAAGCTTTGCCCC
TGATTGCCTTGTCTCCCCCCGCTGCCTACGCCATGGTGGGCATGGCGGCTGTGTTGGCGGCCAGTGTGCGGGCTCCGCTA
ACGGCCATCTTGCTGCTGTTTGAGATGACGCGGGACTATCACATTGCGCTGCCGGTGATGGCGGCAGTGGGTTTGAGCAT
CTGGCTGACGGAGCAGTTGCATTCGCCGGCCATCTACCCTTCCGCCCGTCGCTATCGCCACGCAACGCTTGACGGAGTCC
TTGGGCAGGAGCCTAGAGAGCTGACGGTGCAAGAGGTGATGGTGCCCCCATCTCTTTTGCTTCGGCAAGACACACCGCTG
CGAGAAGCTCTGGAGAGTTTGCTGCAGCAAAAGTGCCATAGCGCGTTGGTGGTGGACGGACAGGAGCGGCTGCGGGGCAT
TCTCACCCTGGAAGACCTGGAGCGGGCCTTGGCCCACAAGGAGGCGGCGGAGTTGGCGGAGCTAACCGTACAGGAGGTCA
GCCAATCCCCAGTTCTCACCACCTTCCCCGATGAGGCGGTGGCAGTGGCAGCCGAGCCGATGTACGAATACGATTTGCGC
CAATTGCCGGTGGTTTCTCGGGAAGACCCAGAGCAGATCGTCGGCCTGTTGGATCGAGAGCGGGTGCTGCTCTCCCAAGA
GATTCAATCGGTGCGGCAAGCCCTGGAGTTGGAAGTTCCCCCAGCAGAGAGAGACGCCGGCAGGAACGGACAAGAGGGGA
TCCCCGATGCTTCTACTGCGCCCGCAGAATAG

Upstream 100 bases:

>100_bases
TTTAGATGGCAAGCTCTCGGCGCAATTTGAACATACAGTCGCCGTTACCGAAACCGGTGTAGAAATTTTAACCCTGCCTT
CCCAAAGCCCTTGAGCCATC

Downstream 100 bases:

>100_bases
AGCCCTGCTGTCGGGATCAGCGCTGCCGCCCAGAAGGGCAGGTGGGACGCAGCGGGCAGCGGCCACATTCGGGCATACGG
GCCTTGCAGATGCGCTTGCC

Product: chloride channel (ClC) family protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MNSAPALRLRLSSENLLLLLAAAVGLATGLLVVGFRYLIGWWRYLLQDTLVDGIGRAAEHYGLWLLGSWTLALAPVLGGL
LIGALGAVVPFPNLSLSSLVSPARPLALQPWWIPLKLLAAAISLGAGASLGPEAPSVESGALLGSLLGQNLRLSRERVQL
LMAAGAAAGLAAGFNAPIAGVFLALELALARTFTTSAVSVVVLAAVVSALIAQVGLGAQPAFLLPTITQPAFVLPDYEIH
SLLEVPLYLGLGFLASLVSMAFSYTLEWGKHLFNSGPLAAWPAWSKPILGGGILGCAGLGIPLALGVGYETIESILQAVP
FSLGHLGLLLLGKLLLSALSLGSGFVGGTFAPALFMGAVLGAGYGQVLSQALPLIALSPPAAYAMVGMAAVLAASVRAPL
TAILLLFEMTRDYHIALPVMAAVGLSIWLTEQLHSPAIYPSARRYRHATLDGVLGQEPRELTVQEVMVPPSLLLRQDTPL
REALESLLQQKCHSALVVDGQERLRGILTLEDLERALAHKEAAELAELTVQEVSQSPVLTTFPDEAVAVAAEPMYEYDLR
QLPVVSREDPEQIVGLLDRERVLLSQEIQSVRQALELEVPPAERDAGRNGQEGIPDASTAPAE

Sequences:

>Translated_623_residues
MNSAPALRLRLSSENLLLLLAAAVGLATGLLVVGFRYLIGWWRYLLQDTLVDGIGRAAEHYGLWLLGSWTLALAPVLGGL
LIGALGAVVPFPNLSLSSLVSPARPLALQPWWIPLKLLAAAISLGAGASLGPEAPSVESGALLGSLLGQNLRLSRERVQL
LMAAGAAAGLAAGFNAPIAGVFLALELALARTFTTSAVSVVVLAAVVSALIAQVGLGAQPAFLLPTITQPAFVLPDYEIH
SLLEVPLYLGLGFLASLVSMAFSYTLEWGKHLFNSGPLAAWPAWSKPILGGGILGCAGLGIPLALGVGYETIESILQAVP
FSLGHLGLLLLGKLLLSALSLGSGFVGGTFAPALFMGAVLGAGYGQVLSQALPLIALSPPAAYAMVGMAAVLAASVRAPL
TAILLLFEMTRDYHIALPVMAAVGLSIWLTEQLHSPAIYPSARRYRHATLDGVLGQEPRELTVQEVMVPPSLLLRQDTPL
REALESLLQQKCHSALVVDGQERLRGILTLEDLERALAHKEAAELAELTVQEVSQSPVLTTFPDEAVAVAAEPMYEYDLR
QLPVVSREDPEQIVGLLDRERVLLSQEIQSVRQALELEVPPAERDAGRNGQEGIPDASTAPAE
>Mature_623_residues
MNSAPALRLRLSSENLLLLLAAAVGLATGLLVVGFRYLIGWWRYLLQDTLVDGIGRAAEHYGLWLLGSWTLALAPVLGGL
LIGALGAVVPFPNLSLSSLVSPARPLALQPWWIPLKLLAAAISLGAGASLGPEAPSVESGALLGSLLGQNLRLSRERVQL
LMAAGAAAGLAAGFNAPIAGVFLALELALARTFTTSAVSVVVLAAVVSALIAQVGLGAQPAFLLPTITQPAFVLPDYEIH
SLLEVPLYLGLGFLASLVSMAFSYTLEWGKHLFNSGPLAAWPAWSKPILGGGILGCAGLGIPLALGVGYETIESILQAVP
FSLGHLGLLLLGKLLLSALSLGSGFVGGTFAPALFMGAVLGAGYGQVLSQALPLIALSPPAAYAMVGMAAVLAASVRAPL
TAILLLFEMTRDYHIALPVMAAVGLSIWLTEQLHSPAIYPSARRYRHATLDGVLGQEPRELTVQEVMVPPSLLLRQDTPL
REALESLLQQKCHSALVVDGQERLRGILTLEDLERALAHKEAAELAELTVQEVSQSPVLTTFPDEAVAVAAEPMYEYDLR
QLPVVSREDPEQIVGLLDRERVLLSQEIQSVRQALELEVPPAERDAGRNGQEGIPDASTAPAE

Specific function: Selective chloride channel [C]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=430, Percent_Identity=30.9302325581395, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081943, Length=325, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 65527; Mature: 65527

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAPALRLRLSSENLLLLLAAAVGLATGLLVVGFRYLIGWWRYLLQDTLVDGIGRAAEH
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGLWLLGSWTLALAPVLGGLLIGALGAVVPFPNLSLSSLVSPARPLALQPWWIPLKLLAA
CCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHH
AISLGAGASLGPEAPSVESGALLGSLLGQNLRLSRERVQLLMAAGAAAGLAAGFNAPIAG
HHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VFLALELALARTFTTSAVSVVVLAAVVSALIAQVGLGAQPAFLLPTITQPAFVLPDYEIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCEECCCHHHH
SLLEVPLYLGLGFLASLVSMAFSYTLEWGKHLFNSGPLAAWPAWSKPILGGGILGCAGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCC
IPLALGVGYETIESILQAVPFSLGHLGLLLLGKLLLSALSLGSGFVGGTFAPALFMGAVL
HHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
GAGYGQVLSQALPLIALSPPAAYAMVGMAAVLAASVRAPLTAILLLFEMTRDYHIALPVM
HCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AAVGLSIWLTEQLHSPAIYPSARRYRHATLDGVLGQEPRELTVQEVMVPPSLLLRQDTPL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCH
REALESLLQQKCHSALVVDGQERLRGILTLEDLERALAHKEAAELAELTVQEVSQSPVLT
HHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
TFPDEAVAVAAEPMYEYDLRQLPVVSREDPEQIVGLLDRERVLLSQEIQSVRQALELEVP
ECCCCHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAERDAGRNGQEGIPDASTAPAE
CCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSAPALRLRLSSENLLLLLAAAVGLATGLLVVGFRYLIGWWRYLLQDTLVDGIGRAAEH
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGLWLLGSWTLALAPVLGGLLIGALGAVVPFPNLSLSSLVSPARPLALQPWWIPLKLLAA
CCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHH
AISLGAGASLGPEAPSVESGALLGSLLGQNLRLSRERVQLLMAAGAAAGLAAGFNAPIAG
HHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VFLALELALARTFTTSAVSVVVLAAVVSALIAQVGLGAQPAFLLPTITQPAFVLPDYEIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCEECCCHHHH
SLLEVPLYLGLGFLASLVSMAFSYTLEWGKHLFNSGPLAAWPAWSKPILGGGILGCAGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCC
IPLALGVGYETIESILQAVPFSLGHLGLLLLGKLLLSALSLGSGFVGGTFAPALFMGAVL
HHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
GAGYGQVLSQALPLIALSPPAAYAMVGMAAVLAASVRAPLTAILLLFEMTRDYHIALPVM
HCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AAVGLSIWLTEQLHSPAIYPSARRYRHATLDGVLGQEPRELTVQEVMVPPSLLLRQDTPL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCH
REALESLLQQKCHSALVVDGQERLRGILTLEDLERALAHKEAAELAELTVQEVSQSPVLT
HHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
TFPDEAVAVAAEPMYEYDLRQLPVVSREDPEQIVGLLDRERVLLSQEIQSVRQALELEVP
ECCCCHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAERDAGRNGQEGIPDASTAPAE
CCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]