Click here to switch to the map view.

The map label for this gene is map-1 [C]

Identifier: 86609596

GI number: 86609596

Start: 2249862

End: 2250650

Strand: Direct

Name: map-1 [C]

Synonym: CYB_2149

Alternate gene names: 86609596

Gene position: 2249862-2250650 (Clockwise)

Preceding gene: 86609595

Following gene: 86609597

Centisome position: 73.85

GC content: 60.33

Gene sequence:

>789_bases
ATGAACCAGCTCACGCAAGCCCCTCAGCCCATTGTGTTGCTCTCTTCGCGGGAACTGGAGAAAATGCGGCGGGCTTGTCG
CCTGGCGGCAGATCTGCTCAAGCACTTGGAGCCGATGGTGCGACCAGGGGTCACCACCCAAGAGCTCAACGACGAGGCCG
AGCGATGGACGCGGGCGCATGGGGCCAGAAGCGCCCCTTTGGGCTACCATGGCTTTCCCAAGTCCATCTGCACCAGCGTC
AACCACGTGGTTTGCCACGGCATTCCCAGCCCCAAGCAGATCCTGCGAGAAGGCGACATCATCAACATCGATGTCACCCC
GGTTTTGGATGGCTACCATGGCGATACCTCCAAAACCTTCTTTGTCGGACAGCCTTCTGAGCGGGCGCGGCGCCTGGTGG
AGGTGACCGAAGAATGTCTGCGGCGGGGCATTGCTGCTGTAAAGCCGGGGGGGAGAGTCGGCGACATTGGCGCTGCCATC
CAAGAATATGCCGAGGCCCAGGGCTACAGCGTGGTGCGCGATTTTGTCGGGCATGGGGTGGGACGGCAATTCCACACTGC
TCCCCAGATCCCCCACTACGGCGAGCGAGGAAAAGGGGAGAAACTCCGCCCCGGCATGGTGTTCACCATCGAGCCGATGA
TCAACGAGGGCACCTGGGAGGTGAAGGTGCTCTCCGACGGGTGGACGGCGGTAACTTTAGATGGCAAGCTCTCGGCGCAA
TTTGAACATACAGTCGCCGTTACCGAAACCGGTGTAGAAATTTTAACCCTGCCTTCCCAAAGCCCTTGA

Upstream 100 bases:

>100_bases
ATAAGGTCTCATGATGGAAGACATGCGAGCGTTGTTGACAGACCTCAGCCGTCGCTCCCAGCGATGGGGGGAGCAGTTGG
GATCCGCTTTGCAGACGGGT

Downstream 100 bases:

>100_bases
GCCATCATGAACAGCGCCCCCGCTCTCCGCCTGCGCCTCTCCTCCGAGAACCTGCTGCTGCTGCTGGCGGCGGCAGTGGG
GTTGGCCACGGGGCTGTTGG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNQLTQAPQPIVLLSSRELEKMRRACRLAADLLKHLEPMVRPGVTTQELNDEAERWTRAHGARSAPLGYHGFPKSICTSV
NHVVCHGIPSPKQILREGDIINIDVTPVLDGYHGDTSKTFFVGQPSERARRLVEVTEECLRRGIAAVKPGGRVGDIGAAI
QEYAEAQGYSVVRDFVGHGVGRQFHTAPQIPHYGERGKGEKLRPGMVFTIEPMINEGTWEVKVLSDGWTAVTLDGKLSAQ
FEHTVAVTETGVEILTLPSQSP

Sequences:

>Translated_262_residues
MNQLTQAPQPIVLLSSRELEKMRRACRLAADLLKHLEPMVRPGVTTQELNDEAERWTRAHGARSAPLGYHGFPKSICTSV
NHVVCHGIPSPKQILREGDIINIDVTPVLDGYHGDTSKTFFVGQPSERARRLVEVTEECLRRGIAAVKPGGRVGDIGAAI
QEYAEAQGYSVVRDFVGHGVGRQFHTAPQIPHYGERGKGEKLRPGMVFTIEPMINEGTWEVKVLSDGWTAVTLDGKLSAQ
FEHTVAVTETGVEILTLPSQSP
>Mature_262_residues
MNQLTQAPQPIVLLSSRELEKMRRACRLAADLLKHLEPMVRPGVTTQELNDEAERWTRAHGARSAPLGYHGFPKSICTSV
NHVVCHGIPSPKQILREGDIINIDVTPVLDGYHGDTSKTFFVGQPSERARRLVEVTEECLRRGIAAVKPGGRVGDIGAAI
QEYAEAQGYSVVRDFVGHGVGRQFHTAPQIPHYGERGKGEKLRPGMVFTIEPMINEGTWEVKVLSDGWTAVTLDGKLSAQ
FEHTVAVTETGVEILTLPSQSP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=254, Percent_Identity=51.5748031496063, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI40385867, Length=245, Percent_Identity=46.1224489795918, Blast_Score=217, Evalue=7e-57,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=52.4193548387097, Blast_Score=276, Evalue=7e-76,
Organism=Escherichia coli, GI1788728, Length=244, Percent_Identity=25.8196721311475, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=253, Percent_Identity=46.6403162055336, Blast_Score=235, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6323273, Length=247, Percent_Identity=48.582995951417, Blast_Score=249, Evalue=3e-67,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=47.9674796747967, Blast_Score=230, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24583427, Length=242, Percent_Identity=47.9338842975207, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI19920384, Length=229, Percent_Identity=27.5109170305677, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28746; Mature: 28746

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLTQAPQPIVLLSSRELEKMRRACRLAADLLKHLEPMVRPGVTTQELNDEAERWTRAH
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GARSAPLGYHGFPKSICTSVNHVVCHGIPSPKQILREGDIINIDVTPVLDGYHGDTSKTF
CCCCCCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHCCCEEEEEECEEECCCCCCCCCEE
FVGQPSERARRLVEVTEECLRRGIAAVKPGGRVGDIGAAIQEYAEAQGYSVVRDFVGHGV
EEECCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCC
GRQFHTAPQIPHYGERGKGEKLRPGMVFTIEPMINEGTWEVKVLSDGWTAVTLDGKLSAQ
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCEEEEECCCCCCC
FEHTVAVTETGVEILTLPSQSP
CCEEEEEEECCEEEEECCCCCC
>Mature Secondary Structure
MNQLTQAPQPIVLLSSRELEKMRRACRLAADLLKHLEPMVRPGVTTQELNDEAERWTRAH
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GARSAPLGYHGFPKSICTSVNHVVCHGIPSPKQILREGDIINIDVTPVLDGYHGDTSKTF
CCCCCCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHCCCEEEEEECEEECCCCCCCCCEE
FVGQPSERARRLVEVTEECLRRGIAAVKPGGRVGDIGAAIQEYAEAQGYSVVRDFVGHGV
EEECCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCC
GRQFHTAPQIPHYGERGKGEKLRPGMVFTIEPMINEGTWEVKVLSDGWTAVTLDGKLSAQ
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCEEEEECCCCCCC
FEHTVAVTETGVEILTLPSQSP
CCEEEEEEECCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]