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The map label for this gene is hisB

Identifier: 85059105

GI number: 85059105

Start: 1869213

End: 1870280

Strand: Reverse

Name: hisB

Synonym: SG1127

Alternate gene names: 85059105

Gene position: 1870280-1869213 (Counterclockwise)

Preceding gene: 85059106

Following gene: 85059104

Centisome position: 44.84

GC content: 58.99

Gene sequence:

>1068_bases
GTGAATCAGAAAGTCCTGTTTATCGATCGTGATGGCACGCTCATCAACGAACCCCCCGCGGATTTCCAGGTGGACCGCAT
GGATAAGTTGGCGCTGGAGCCAGGTGTCATCCCCGTGCTGCTGGCGCTGCAAAAAGCCGGCTTCCGACTGGTTATGATTA
CCAACCAGGACGGCCTGGGTACCACCAGTTTTCCCCAGGCGGATTTCGACGGGCCGCATGATCTGATGATGGCCATCTTC
ACCTCCCAGGGCATTGTTTTTGATGAGGTGTTGATTTGCCCGCATTTACCCACCGACGGCTGCGCGTGCCGCAAACCACA
GACGGGGATAGTGACGCCCTGGCTGAAAGAGCACGCGCTAGATAGCGCCCACAGCTATGTCATCGGCGACCGGGAAACCG
ACATGGCGCTCGCGGCCAATATGGGTATCACCGGGCTGAGGTATCAGCGCGCGTCGCTCAATTGGCCGGCGATTGGCGAA
CAGCTGACCCGCAGCGACCGCCACGCACGCGTTAATCGCGTCACGCGGGAAACCGCCATCGATGTGGAAGTCTGGCTCGA
TCGGGAAGGCGACAGCCGAATCAACACCGGCATCGGTTTTTTCGATCACATGCTCGATCAGATTGCCACCCACGGCGGAC
TGCGCATTAATATCGCTGTTAAGGGGGATCTGCATATCGATGATCACCACACGGTGGAAGATACCGCGCTGGCGCTGGGG
GAAGCGCTGAATAAGGCGCTGGGAGACAAACGCGGTATTGGCCGCTTTGGGTTCGTGCTGCCGATGGACGAGTGCCTGGC
GCGCTGCGCGCTGGATATCTCCGGCCGACCGCATCTGGAATACAAAGCCAAGTACAGTTTCCAGCGGGTAGGCGATCTCA
GCACCGAGATGGTAGAGCATTTCTTCCGTTCACTTTCCTATGCCATGGCCTGCACGCTGCATCTGCGCACCAAAGGCAAG
AATGATCATCATCGGGTGGAGAGCCTGTTTAAAGCCTTCGGCCGCACGCTGCGCCAGGCCATCCGCGTGGAGGGCGACAC
GCTGCCCAGCTCAAAAGGAGTGCTGTGA

Upstream 100 bases:

>100_bases
TGGCCGATTGTTTGCGTATTACCATCGGCACTTTGGCGGAGTGCCAGAGCGTGATTGCAGTGTTAAGGGCGTTGAAACCC
TCTTCCAGCAAGGAGTCCCT

Downstream 100 bases:

>100_bases
TGAACGTGGTTGTGCTGGATACCGGCTGCGCCAATCTGTTCTCGGTCACCGCTGCGATACGTCGCCTGGGCTATGAACCG
GTCGTCAGCAGCAACGCCGA

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MNQKVLFIDRDGTLINEPPADFQVDRMDKLALEPGVIPVLLALQKAGFRLVMITNQDGLGTTSFPQADFDGPHDLMMAIF
TSQGIVFDEVLICPHLPTDGCACRKPQTGIVTPWLKEHALDSAHSYVIGDRETDMALAANMGITGLRYQRASLNWPAIGE
QLTRSDRHARVNRVTRETAIDVEVWLDREGDSRINTGIGFFDHMLDQIATHGGLRINIAVKGDLHIDDHHTVEDTALALG
EALNKALGDKRGIGRFGFVLPMDECLARCALDISGRPHLEYKAKYSFQRVGDLSTEMVEHFFRSLSYAMACTLHLRTKGK
NDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL

Sequences:

>Translated_355_residues
MNQKVLFIDRDGTLINEPPADFQVDRMDKLALEPGVIPVLLALQKAGFRLVMITNQDGLGTTSFPQADFDGPHDLMMAIF
TSQGIVFDEVLICPHLPTDGCACRKPQTGIVTPWLKEHALDSAHSYVIGDRETDMALAANMGITGLRYQRASLNWPAIGE
QLTRSDRHARVNRVTRETAIDVEVWLDREGDSRINTGIGFFDHMLDQIATHGGLRINIAVKGDLHIDDHHTVEDTALALG
EALNKALGDKRGIGRFGFVLPMDECLARCALDISGRPHLEYKAKYSFQRVGDLSTEMVEHFFRSLSYAMACTLHLRTKGK
NDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL
>Mature_355_residues
MNQKVLFIDRDGTLINEPPADFQVDRMDKLALEPGVIPVLLALQKAGFRLVMITNQDGLGTTSFPQADFDGPHDLMMAIF
TSQGIVFDEVLICPHLPTDGCACRKPQTGIVTPWLKEHALDSAHSYVIGDRETDMALAANMGITGLRYQRASLNWPAIGE
QLTRSDRHARVNRVTRETAIDVEVWLDREGDSRINTGIGFFDHMLDQIATHGGLRINIAVKGDLHIDDHHTVEDTALALG
EALNKALGDKRGIGRFGFVLPMDECLARCALDISGRPHLEYKAKYSFQRVGDLSTEMVEHFFRSLSYAMACTLHLRTKGK
NDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=81.1267605633803, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1786399, Length=150, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=40.3669724770642, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_SODGM (Q2NTX3)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454807.1
- ProteinModelPortal:   Q2NTX3
- STRING:   Q2NTX3
- GeneID:   3867555
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1127
- NMPDR:   fig|343509.6.peg.2310
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   QDGLGTP
- PhylomeDB:   Q2NTX3
- ProtClustDB:   PRK05446
- BioCyc:   SGLO343509:SG1127-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01022
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01261
- TIGRFAMs:   TIGR01656

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P; SSF54211 Ribosomal_S5_D2-typ_fold; SSF56784 SSF56784

EC number: =3.1.3.15; =4.2.1.19

Molecular weight: Translated: 39470; Mature: 39470

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKVLFIDRDGTLINEPPADFQVDRMDKLALEPGVIPVLLALQKAGFRLVMITNQDGLG
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEECCCCCC
TTSFPQADFDGPHDLMMAIFTSQGIVFDEVLICPHLPTDGCACRKPQTGIVTPWLKEHAL
CCCCCCCCCCCHHHHHHHHHHCCCCEEEHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHH
DSAHSYVIGDRETDMALAANMGITGLRYQRASLNWPAIGEQLTRSDRHARVNRVTRETAI
HCCCCEEECCCCCCCEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEE
DVEVWLDREGDSRINTGIGFFDHMLDQIATHGGLRINIAVKGDLHIDDHHTVEDTALALG
EEEEEEECCCCCCHHCCHHHHHHHHHHHHHCCCEEEEEEEEECEEECCCCCHHHHHHHHH
EALNKALGDKRGIGRFGFVLPMDECLARCALDISGRPHLEYKAKYSFQRVGDLSTEMVEH
HHHHHHHCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCEEEECCCCHHHHCCHHHHHHHH
FFRSLSYAMACTLHLRTKGKNDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL
HHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNQKVLFIDRDGTLINEPPADFQVDRMDKLALEPGVIPVLLALQKAGFRLVMITNQDGLG
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEECCCCCC
TTSFPQADFDGPHDLMMAIFTSQGIVFDEVLICPHLPTDGCACRKPQTGIVTPWLKEHAL
CCCCCCCCCCCHHHHHHHHHHCCCCEEEHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHH
DSAHSYVIGDRETDMALAANMGITGLRYQRASLNWPAIGEQLTRSDRHARVNRVTRETAI
HCCCCEEECCCCCCCEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEE
DVEVWLDREGDSRINTGIGFFDHMLDQIATHGGLRINIAVKGDLHIDDHHTVEDTALALG
EEEEEEECCCCCCHHCCHHHHHHHHHHHHHCCCEEEEEEEEECEEECCCCCHHHHHHHHH
EALNKALGDKRGIGRFGFVLPMDECLARCALDISGRPHLEYKAKYSFQRVGDLSTEMVEH
HHHHHHHCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCEEEECCCCHHHHCCHHHHHHHH
FFRSLSYAMACTLHLRTKGKNDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL
HHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA