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The map label for this gene is fadI [H]

Identifier: 77456884

GI number: 77456884

Start: 768993

End: 770270

Strand: Direct

Name: fadI [H]

Synonym: Pfl01_0656

Alternate gene names: 77456884

Gene position: 768993-770270 (Clockwise)

Preceding gene: 77456879

Following gene: 77456886

Centisome position: 11.94

GC content: 64.16

Gene sequence:

>1278_bases
ATGAGTCAGCTGCGCCGCGTCGCGATCATTGGTGGCAACCGTATTCCGTTCGCCCGCTCCAACGGGCCGTATGCCACCGC
GAGCAATCAGGTGATGCTCACCGCCGCCCTCGAAGGCCTGATCGAACGCTACAACCTGCACGGCCAGCGCATCGGCGAAG
TGGTCGCAGGGGCGGTGCTGAAATTGTCACGGGATATGAACCTGACCCGCGAGTGCGTGCTTGGCTCACGCCTGTCACCG
GCCACCCCGGCCTACGACATTCAGCAGGCCTGCGGAACCGGCCTGGAAGCGGCGTTGCTGGTGGCGAACAAGATTGCCCT
CGGCCAGATTGATTGCGGTATTGCCGGCGGCGTCGACACCACGTCGGACGCGCCGATCAGCGTCAGCGAAGGCCTGCGCA
AGATCCTGCTGCAAGCCAACCGCGCCAAGACCACCGGCGACAAGCTCAAGACCTTTCTGCAATTGCGCCCGAAACACCTG
ATCCCCGAATTCCCGCGCAACGGCGAACCGCGCACCGGCCTGTCGATGGGCGAGCACTGCGAGTCGATGGCGCAGACCTG
GAACATTCCCCGCGAAGAACAGGATCAACTGGCCTTCGAAAGCCACCACAAACTGGCGGCGTCCTACAGCGAAGGCTGGC
ACAACGACCTGATGACCCCGTTCCTCGGCCTGACCCGCGACAACAACCTGCGCCCGGACCTGACCCTGGAAAAACTCGCG
ACCCTGAAGCCGGCCTTCGAGAAAAGCGCCAAGGGCACGCTGACCGCCGGCAACTCCACGCCGCTGACCGATGGCGCCTC
GGTGGTGTTGCTGGGTAGTGAAGAGTGGGCGAAGGAGCGTGGTCTGCCAATCCTTGCGTATCTGCGCGACGGCGAAGCAG
CGGCGGTGGATTTCGTCAACGGCGCCGAAGGGCTGCTGATGGCTCCGGTCTATGCGGTGCCACGCTTGCTGGCCCGCAAT
GGAATGACCTTGCAGGACTTCGACTACTACGAAATCCACGAGGCCTTTGCTGCGCAGGTGTTGTGCACGTTGAAGGCCTG
GGAAGATCCGGAATACTGCAAGACCCGGCTCGGGCTGGACGCGCCGTTGGGGGGGATTGATCGTAGCCGCTTGAACGTCA
AGGGCAGCTCACTGGCGGCGGGGCATCCGTTTGCCGCGACGGGCGGGCGGATCGTGGCGAACCTGGCGAAGTTGCTGGAT
GCGGCGGGGCAGGGGCGGGGGTTGATTTCGATTTGTGCGGCTGGCGGACAGGGTGTGACGGCGATCATCGAGCGCTAG

Upstream 100 bases:

>100_bases
TACGCTAGAACAGCAGAGTAGTTTGCCCTCGGCGCTTTTGTGGCCCGACCGGGTTTTCAGCGCTCGATTTTCAGACCGGA
TATTTCACAAGGAGCATTTC

Downstream 100 bases:

>100_bases
AAGAGCAAAAGCTTGCCCTCACCCTAACCCTCTCCCGGAGGGAGAGGGGACTGATTGGGGGATATTGGAGAGGTTCACCG
ACGTGAGAGATTGGTTATGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSQLRRVAIIGGNRIPFARSNGPYATASNQVMLTAALEGLIERYNLHGQRIGEVVAGAVLKLSRDMNLTRECVLGSRLSP
ATPAYDIQQACGTGLEAALLVANKIALGQIDCGIAGGVDTTSDAPISVSEGLRKILLQANRAKTTGDKLKTFLQLRPKHL
IPEFPRNGEPRTGLSMGEHCESMAQTWNIPREEQDQLAFESHHKLAASYSEGWHNDLMTPFLGLTRDNNLRPDLTLEKLA
TLKPAFEKSAKGTLTAGNSTPLTDGASVVLLGSEEWAKERGLPILAYLRDGEAAAVDFVNGAEGLLMAPVYAVPRLLARN
GMTLQDFDYYEIHEAFAAQVLCTLKAWEDPEYCKTRLGLDAPLGGIDRSRLNVKGSSLAAGHPFAATGGRIVANLAKLLD
AAGQGRGLISICAAGGQGVTAIIER

Sequences:

>Translated_425_residues
MSQLRRVAIIGGNRIPFARSNGPYATASNQVMLTAALEGLIERYNLHGQRIGEVVAGAVLKLSRDMNLTRECVLGSRLSP
ATPAYDIQQACGTGLEAALLVANKIALGQIDCGIAGGVDTTSDAPISVSEGLRKILLQANRAKTTGDKLKTFLQLRPKHL
IPEFPRNGEPRTGLSMGEHCESMAQTWNIPREEQDQLAFESHHKLAASYSEGWHNDLMTPFLGLTRDNNLRPDLTLEKLA
TLKPAFEKSAKGTLTAGNSTPLTDGASVVLLGSEEWAKERGLPILAYLRDGEAAAVDFVNGAEGLLMAPVYAVPRLLARN
GMTLQDFDYYEIHEAFAAQVLCTLKAWEDPEYCKTRLGLDAPLGGIDRSRLNVKGSSLAAGHPFAATGGRIVANLAKLLD
AAGQGRGLISICAAGGQGVTAIIER
>Mature_424_residues
SQLRRVAIIGGNRIPFARSNGPYATASNQVMLTAALEGLIERYNLHGQRIGEVVAGAVLKLSRDMNLTRECVLGSRLSPA
TPAYDIQQACGTGLEAALLVANKIALGQIDCGIAGGVDTTSDAPISVSEGLRKILLQANRAKTTGDKLKTFLQLRPKHLI
PEFPRNGEPRTGLSMGEHCESMAQTWNIPREEQDQLAFESHHKLAASYSEGWHNDLMTPFLGLTRDNNLRPDLTLEKLAT
LKPAFEKSAKGTLTAGNSTPLTDGASVVLLGSEEWAKERGLPILAYLRDGEAAAVDFVNGAEGLLMAPVYAVPRLLARNG
MTLQDFDYYEIHEAFAAQVLCTLKAWEDPEYCKTRLGLDAPLGGIDRSRLNVKGSSLAAGHPFAATGGRIVANLAKLLDA
AGQGRGLISICAAGGQGVTAIIER

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=37.0023419203747, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI4501853, Length=433, Percent_Identity=29.0993071593533, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI167614485, Length=435, Percent_Identity=28.9655172413793, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI148539872, Length=429, Percent_Identity=25.8741258741259, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI4557237, Length=438, Percent_Identity=27.1689497716895, Blast_Score=146, Evalue=4e-35,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=38.6861313868613, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87082165, Length=433, Percent_Identity=30.715935334873, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1788554, Length=433, Percent_Identity=30.0230946882217, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1787663, Length=436, Percent_Identity=29.8165137614679, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI48994986, Length=435, Percent_Identity=28.0459770114943, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=35.6132075471698, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17535921, Length=434, Percent_Identity=28.110599078341, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=427, Percent_Identity=26.9320843091335, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25147385, Length=433, Percent_Identity=24.2494226327945, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322031, Length=434, Percent_Identity=29.9539170506912, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=443, Percent_Identity=30.0225733634311, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=38.6416861826698, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24655093, Length=432, Percent_Identity=26.1574074074074, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24640423, Length=437, Percent_Identity=25.1716247139588, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI17648125, Length=431, Percent_Identity=27.6102088167053, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 45464; Mature: 45332

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLRRVAIIGGNRIPFARSNGPYATASNQVMLTAALEGLIERYNLHGQRIGEVVAGAVL
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KLSRDMNLTRECVLGSRLSPATPAYDIQQACGTGLEAALLVANKIALGQIDCGIAGGVDT
HHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCC
TSDAPISVSEGLRKILLQANRAKTTGDKLKTFLQLRPKHLIPEFPRNGEPRTGLSMGEHC
CCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHH
ESMAQTWNIPREEQDQLAFESHHKLAASYSEGWHNDLMTPFLGLTRDNNLRPDLTLEKLA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TLKPAFEKSAKGTLTAGNSTPLTDGASVVLLGSEEWAKERGLPILAYLRDGEAAAVDFVN
HHCHHHHHCCCCEEECCCCCCCCCCCEEEEECCHHHHHHCCCEEEEEEECCCEEEEEECC
GAEGLLMAPVYAVPRLLARNGMTLQDFDYYEIHEAFAAQVLCTLKAWEDPEYCKTRLGLD
CCCCCEECHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
APLGGIDRSRLNVKGSSLAAGHPFAATGGRIVANLAKLLDAAGQGRGLISICAAGGQGVT
CCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCE
AIIER
EEECC
>Mature Secondary Structure 
SQLRRVAIIGGNRIPFARSNGPYATASNQVMLTAALEGLIERYNLHGQRIGEVVAGAVL
CCCCEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KLSRDMNLTRECVLGSRLSPATPAYDIQQACGTGLEAALLVANKIALGQIDCGIAGGVDT
HHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCC
TSDAPISVSEGLRKILLQANRAKTTGDKLKTFLQLRPKHLIPEFPRNGEPRTGLSMGEHC
CCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHH
ESMAQTWNIPREEQDQLAFESHHKLAASYSEGWHNDLMTPFLGLTRDNNLRPDLTLEKLA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TLKPAFEKSAKGTLTAGNSTPLTDGASVVLLGSEEWAKERGLPILAYLRDGEAAAVDFVN
HHCHHHHHCCCCEEECCCCCCCCCCCEEEEECCHHHHHHCCCEEEEEEECCCEEEEEECC
GAEGLLMAPVYAVPRLLARNGMTLQDFDYYEIHEAFAAQVLCTLKAWEDPEYCKTRLGLD
CCCCCEECHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
APLGGIDRSRLNVKGSSLAAGHPFAATGGRIVANLAKLLDAAGQGRGLISICAAGGQGVT
CCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCE
AIIER
EEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA