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The map label for this gene is nadA [H]

Identifier: 74316239

GI number: 74316239

Start: 244278

End: 245309

Strand: Reverse

Name: nadA [H]

Synonym: Tbd_0221

Alternate gene names: 74316239

Gene position: 245309-244278 (Counterclockwise)

Preceding gene: 74316241

Following gene: 74316238

Centisome position: 8.43

GC content: 66.47

Gene sequence:

>1032_bases
ATGGTGGAGGAAGTGCTAGACGCCGAAGAGCGCGCCTCGCTCAAGACCCGCATCAAGACGCTGATGAAGGAGCAGGATGC
GGTGCTCGTCGCCCACTACTACACCTCGGCCGACCTCCAGGATCTGGCCGAGGAAACCGGCGGCTGCGTCTCCGATTCGC
TCGAGATGGCGCGCTTCGGCCACGCCCACCCGGCGCGCACGCTGACCGTCGCGGGCGTGAAATTCATGGGCGAGACGGCG
AAGATCCTCAACCCCGAGAAGCGCGTCCTGATGCCCGATCTCGGCGCCGAATGCTCGCTCGACCTCGCCTGTCCGGCCGA
CGAATTCACGGCCTTCTGCGACGCCCACCCCGATCGTCTCTCGGTCGTCTACGCCAACACCAGCGCCGAAGTCAAAGCGC
GTGCCGACTGGGTCGTGACCTCTGGTATCGCGGTCAAGATCGTGAAATACCTGCACCAGCAGGGCCACAAACTCTTGTGG
GCGCCCGACCGCCACCTCGGCGAATACGTGCGTCGCGTCAGCGGCGCGGACATGATCCTGTGGCAGGGCTCATGCGTCGT
GCACGAGGCCTTCAAAGCCGAGGCCCTCAAATCGCTGCACGCGGCGCACCCGGCGGCCGCGGTACTCGTGCATCCGGAGT
CGCCCGAGTCGGTGATCGCGCTGGCCGACATCGTCGGCTCGACCACGCAGTTGATCGAAGCGGTGCGCACGCTACCCAAC
CCCGAATTCATCGTCGCGACCGACAACGGCATCTTTCACAAGATGCACGCGGCCGCGCCCGGAAAGACGCTGATCGAGGC
GCCCACGGCCGGCGAAGGCGCGACCTGCGTCTCGTGCGCGCACTGCCCGTGGATGGCGATGAACGGCCTGCGAAAACTCG
CCGCCGTGCTCGAATCCGCGGCAGTCGGCAAGCGCAGCGCCAACGAGATCCACGTCGAAGAATCGGTCGGCCAGCGCGCG
CGGCGCTCGATCCAGAAAATGCTGGACTTCGCCGCGGCCGAAAAAGCCGGCCGCATCCAGCTCGGCGACTGA

Upstream 100 bases:

>100_bases
GCAAGGCTATACTTGCGATTCTTCGTTTGTCGAACGCCAGGCCGTGCCCGTGACTCCCGCCTTTCCTGTTCCGGTGAAAC
CCGTCATTCAAGCCCCGCCC

Downstream 100 bases:

>100_bases
GCATAGACAGCGTATGGCCGGAACCAGCCTTCTCGCCCTGCTCGACGACATCACCACCGTCCTCGACGACGTGTCGGTAC
TGACCAAGGTCGCCGCCAAG

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MVEEVLDAEERASLKTRIKTLMKEQDAVLVAHYYTSADLQDLAEETGGCVSDSLEMARFGHAHPARTLTVAGVKFMGETA
KILNPEKRVLMPDLGAECSLDLACPADEFTAFCDAHPDRLSVVYANTSAEVKARADWVVTSGIAVKIVKYLHQQGHKLLW
APDRHLGEYVRRVSGADMILWQGSCVVHEAFKAEALKSLHAAHPAAAVLVHPESPESVIALADIVGSTTQLIEAVRTLPN
PEFIVATDNGIFHKMHAAAPGKTLIEAPTAGEGATCVSCAHCPWMAMNGLRKLAAVLESAAVGKRSANEIHVEESVGQRA
RRSIQKMLDFAAAEKAGRIQLGD

Sequences:

>Translated_343_residues
MVEEVLDAEERASLKTRIKTLMKEQDAVLVAHYYTSADLQDLAEETGGCVSDSLEMARFGHAHPARTLTVAGVKFMGETA
KILNPEKRVLMPDLGAECSLDLACPADEFTAFCDAHPDRLSVVYANTSAEVKARADWVVTSGIAVKIVKYLHQQGHKLLW
APDRHLGEYVRRVSGADMILWQGSCVVHEAFKAEALKSLHAAHPAAAVLVHPESPESVIALADIVGSTTQLIEAVRTLPN
PEFIVATDNGIFHKMHAAAPGKTLIEAPTAGEGATCVSCAHCPWMAMNGLRKLAAVLESAAVGKRSANEIHVEESVGQRA
RRSIQKMLDFAAAEKAGRIQLGD
>Mature_343_residues
MVEEVLDAEERASLKTRIKTLMKEQDAVLVAHYYTSADLQDLAEETGGCVSDSLEMARFGHAHPARTLTVAGVKFMGETA
KILNPEKRVLMPDLGAECSLDLACPADEFTAFCDAHPDRLSVVYANTSAEVKARADWVVTSGIAVKIVKYLHQQGHKLLW
APDRHLGEYVRRVSGADMILWQGSCVVHEAFKAEALKSLHAAHPAAAVLVHPESPESVIALADIVGSTTQLIEAVRTLPN
PEFIVATDNGIFHKMHAAAPGKTLIEAPTAGEGATCVSCAHCPWMAMNGLRKLAAVLESAAVGKRSANEIHVEESVGQRA
RRSIQKMLDFAAAEKAGRIQLGD

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=327, Percent_Identity=62.3853211009174, Blast_Score=439, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 36958; Mature: 36958

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEEVLDAEERASLKTRIKTLMKEQDAVLVAHYYTSADLQDLAEETGGCVSDSLEMARFG
CCHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHCC
HAHPARTLTVAGVKFMGETAKILNPEKRVLMPDLGAECSLDLACPADEFTAFCDAHPDRL
CCCCCCEEEEHHHHHHCCHHHHCCCCHHEECCCCCCCCCEEECCCHHHHHHHHCCCCCEE
SVVYANTSAEVKARADWVVTSGIAVKIVKYLHQQGHKLLWAPDRHLGEYVRRVSGADMIL
EEEEECCCCCEEECCCEEEECCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCEEE
WQGSCVVHEAFKAEALKSLHAAHPAAAVLVHPESPESVIALADIVGSTTQLIEAVRTLPN
ECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCC
PEFIVATDNGIFHKMHAAAPGKTLIEAPTAGEGATCVSCAHCPWMAMNGLRKLAAVLESA
CCEEEEECCCCEEEHHCCCCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHH
AVGKRSANEIHVEESVGQRARRSIQKMLDFAAAEKAGRIQLGD
HCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MVEEVLDAEERASLKTRIKTLMKEQDAVLVAHYYTSADLQDLAEETGGCVSDSLEMARFG
CCHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHCC
HAHPARTLTVAGVKFMGETAKILNPEKRVLMPDLGAECSLDLACPADEFTAFCDAHPDRL
CCCCCCEEEEHHHHHHCCHHHHCCCCHHEECCCCCCCCCEEECCCHHHHHHHHCCCCCEE
SVVYANTSAEVKARADWVVTSGIAVKIVKYLHQQGHKLLWAPDRHLGEYVRRVSGADMIL
EEEEECCCCCEEECCCEEEECCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCEEE
WQGSCVVHEAFKAEALKSLHAAHPAAAVLVHPESPESVIALADIVGSTTQLIEAVRTLPN
ECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCC
PEFIVATDNGIFHKMHAAAPGKTLIEAPTAGEGATCVSCAHCPWMAMNGLRKLAAVLESA
CCEEEEECCCCEEEHHCCCCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHH
AVGKRSANEIHVEESVGQRARRSIQKMLDFAAAEKAGRIQLGD
HCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA