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The map label for this gene is trxC [H]

Identifier: 74316241

GI number: 74316241

Start: 246134

End: 246511

Strand: Reverse

Name: trxC [H]

Synonym: Tbd_0223

Alternate gene names: 74316241

Gene position: 246511-246134 (Counterclockwise)

Preceding gene: 74316242

Following gene: 74316239

Centisome position: 8.47

GC content: 60.58

Gene sequence:

>378_bases
ATGGCTGTCATCGAACTCACCAAGGACAACTTCGAAACCACGATCAACGGCAACGACGTCGTGATCGTCGACTTCTGGGC
GCCGTGGTGCGGCCCGTGTCGCGGCTTTGCGCCGATTTTCGAAGCAGCGTCGGAAAAGCACCCCAACATCGTCTTCGCCA
AGGTCAACACCGAGGTCGAGCAGGATCTCGCCGGGTACTTCCAGATCCGCTCGATCCCCACGCTGATGGTGTTTCGCGAG
CAGGTCATCCTCTACTCTGAAGCCGGATCGCTGCCGGCGAACGCGCTCGATTCCCTGATCGAACAGGTGATGGGGCTGGA
CATGGCACAGGTCCACAAGGACATCGCCGACCAGCAGTCCCAGCAGGGCGAAGCCTGA

Upstream 100 bases:

>100_bases
GAGGCCCGCCATCCGTGATAGGGTGGCACTCGGCGCGAGGTTTCGTCCTCGCGCTTTTTATTTGCCGTCCCGGCATCGTC
AAAATTCTGCAGGAATCCCC

Downstream 100 bases:

>100_bases
TCAGGACCGCGGGACTGCGGCAAGCAGTTGCCGCAGCAGCGGCAGCGTGATCGCTCGACGCGTTTCGAGGCTGAGGCGAT
CCAGCGCCTCGAGGACGCGT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 125; Mature: 124

Protein sequence:

>125_residues
MAVIELTKDNFETTINGNDVVIVDFWAPWCGPCRGFAPIFEAASEKHPNIVFAKVNTEVEQDLAGYFQIRSIPTLMVFRE
QVILYSEAGSLPANALDSLIEQVMGLDMAQVHKDIADQQSQQGEA

Sequences:

>Translated_125_residues
MAVIELTKDNFETTINGNDVVIVDFWAPWCGPCRGFAPIFEAASEKHPNIVFAKVNTEVEQDLAGYFQIRSIPTLMVFRE
QVILYSEAGSLPANALDSLIEQVMGLDMAQVHKDIADQQSQQGEA
>Mature_124_residues
AVIELTKDNFETTINGNDVVIVDFWAPWCGPCRGFAPIFEAASEKHPNIVFAKVNTEVEQDLAGYFQIRSIPTLMVFREQ
VILYSEAGSLPANALDSLIEQVMGLDMAQVHKDIADQQSQQGEA

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758304, Length=79, Percent_Identity=44.3037974683544, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI50592994, Length=64, Percent_Identity=39.0625, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI21361657, Length=82, Percent_Identity=39.0243902439024, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788936, Length=103, Percent_Identity=42.7184466019417, Blast_Score=97, Evalue=4e-22,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=35.6435643564356, Blast_Score=76, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17569137, Length=81, Percent_Identity=41.9753086419753, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI32566189, Length=81, Percent_Identity=41.9753086419753, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI193209454, Length=81, Percent_Identity=41.9753086419753, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554386, Length=81, Percent_Identity=43.2098765432099, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17507915, Length=85, Percent_Identity=37.6470588235294, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=81, Percent_Identity=35.8024691358025, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=91, Percent_Identity=37.3626373626374, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=76, Percent_Identity=39.4736842105263, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=69, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=75, Percent_Identity=30.6666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532254, Length=82, Percent_Identity=39.0243902439024, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115532252, Length=82, Percent_Identity=39.0243902439024, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=87, Percent_Identity=34.4827586206897, Blast_Score=68, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319806, Length=80, Percent_Identity=36.25, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=64, Percent_Identity=35.9375, Blast_Score=62, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647799, Length=82, Percent_Identity=42.6829268292683, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24658597, Length=86, Percent_Identity=36.046511627907, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639068, Length=99, Percent_Identity=31.3131313131313, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 13845; Mature: 13714

Theoretical pI: Translated: 4.04; Mature: 4.04

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIELTKDNFETTINGNDVVIVDFWAPWCGPCRGFAPIFEAASEKHPNIVFAKVNTEVE
CEEEEEECCCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHH
QDLAGYFQIRSIPTLMVFREQVILYSEAGSLPANALDSLIEQVMGLDMAQVHKDIADQQS
HHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QQGEA
CCCCC
>Mature Secondary Structure 
AVIELTKDNFETTINGNDVVIVDFWAPWCGPCRGFAPIFEAASEKHPNIVFAKVNTEVE
EEEEEECCCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHH
QDLAGYFQIRSIPTLMVFREQVILYSEAGSLPANALDSLIEQVMGLDMAQVHKDIADQQS
HHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QQGEA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]