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The map label for this gene is maeB [H]

Identifier: 238919162

GI number: 238919162

Start: 1225916

End: 1228195

Strand: Direct

Name: maeB [H]

Synonym: NT01EI_1233

Alternate gene names: 238919162

Gene position: 1225916-1228195 (Clockwise)

Preceding gene: 238919161

Following gene: 238919163

Centisome position: 32.16

GC content: 61.93

Gene sequence:

>2280_bases
ATGGATGAAAAATTAAAACAAAGTGCGCTTGAGTTTCATCAGTATCCCGTTGCGGGGAAAATCCAGGTTGTTCCCACCAA
GCCGCTGGCGACCCAGCGCGATTTGGCGCTGGCCTATTCACCGGGCGTTGCCGCGCCCTGTCTGGAGATCGCTGACGATC
CGTTAGCGGCCTATAAGTATACCGCGCGCGGAAATCTGGTAGGGGTCATCTCTAATGGTACCGCCGTGCTGGGGCTTGGC
AACATCGGTGCCCTGGCAGGGAAGCCGGTGATGGAAGGTAAAGGGGTGTTGTTCAAGAAATTCGCCGGTATCGACGTGTT
TGATATTGAGGTGGATGAGCACGATCCTGACAAGCTGATCGAGGTGATCGCCGCGCTGGAGCCCACCTTTGGCGGCATCA
ACCTTGAAGACATCAAGGCGCCGGAGTGTTTCTATATTGAAAAGAAGCTGCGCGAGCGGATGAAAATCCCGGTGTTCCAC
GACGATCAGCACGGCACGGCGATCATCTGTACCGCCGCCGTACTCAACGGCCTGCGGGTGGTCGACAAACCGATCGATCG
GGTGCGGCTGGTGGTCTCCGGCGCCGGCGCATCGGCGATCGCCTGCCTGAACCTACTGGTGGCGTTGGGGCTGAAGCGTG
AAAATATCACTGCCTGCGACTCCAAGGGGGTGATCTACCGCGGGCGCGACGCGCACCTGGTCGAGAGCAAGGCGGCCTAT
GCCATCGATGACAATGGCTGGCGTACGCTGGCGGATGCGATCCCCGGCGCGGATATTTTCCTGGGCTGCTCCGGCCCCGG
GGTGCTGACGCAGGAGATGGTAAAAACCATGGCGCCGTCACCGCTGATCCTGGCGCTGGCCAACCCGGAGCCGGAGATCC
TGCCGCCGCTGGCCAAGGCGGTTCGCCCCGATGCGATAATCTGTACCGGCCGATCTGACTTCCCCAACCAGGTGAACAAC
GTGCTGTGCTTTCCGTTTATCTTCCGCGGTGCGCTGGACGTCGGGGCGACCACCATCAATGAGGAGATGAAGCTGGCGGC
GGTGCGCGCCATTGCCGATCTGGCGCTGGCGGAGCAGAGTGAGGTGGTCGCCTCTGCCTACGGTGATCAGTCGCTCTCCT
TCGGGCCGGAGTACATTATTCCCAAGCCCTTCGATCCGCGGCTGATCGTGAAAATTGCGCCGGCGGTGGCGCAGGCGGCG
ATGGACTCCGGGGTGGCGACGCGTCCCATCGATGATATGGACGCCTATATCGAGCACCTGACCGAGTTTGTCTACAAGAC
CACCCTGTTTATGAAGCCGGTATTTTCCCAGGCGCGCCAGGATCCCAAGCGGGTCGTGCTGGCGGAGGGGGAGTCGGAGC
GCGTGCTGCACGCCACCCAGGAGCTGGTGACGCTGGGGCTGGCCAAGCCGATCCTGATCGGGCGTCCGCAGGTCATCGCT
CACCGGCTGGAGAAGCTCGGTCTGCACATCGAGATCGGCCGCGATGTCGAGGTGGTCAATAATGAATCCGACCCGCGTTA
TAACGACTATTGGCAAAGCTATTACGGGATCATGAAGCGGCGCGGGATCTCGCAGGCGCAGGCGCGCCGGGCGCTGATTG
CCGATCCGACGGTGATCGCGGCGATCATGGTCAAGCGTGGCGAGGCCGACGCGATGATCTGCGGTACCGAGGGCAACTAC
CAGGATCACTACCGCGTGGTGCGCGAGGTGTTTGGCTACAGTGACGGATGCCATACGGCCGCTGCGATGAATGCCCTGCT
ACTGCCGAGTGGCAACACCTTTATTGCCGATACCTATGTTAACGAGGACCCGAGCGCCGAGCAGCTGGCTGAGATTGTGC
TGATGTCTGCCGACGCGGTGCGTCGCTTCGGTATCGAGCCGAAGGTCGCGCTGCTCTCCCACTCCAACTTTGGCACGGCC
GACTGCCCGTCATCGCGCAAAATGCGCCGGGTACTGGAGCTGGTACAGCAGGCAGCACCGGGGCTGGAGATCGACGGTGA
GATGCACGGTGACGCGGCGCTGGTGGAGAGCACCCGTCTGAGGCAGATGCCGGACAGCCCGCTGAAGGGGGCGGCGAATA
TCCTGATCATGCCCAATATGGAGGCCGCACGCATCAGCTATAACCTGCTGCGGGTCTCCTCCTCGGAGGGGGTTACCGTC
GGGCCGGTGCTGATGGGGATCAGCAAGCCGGTGCATATTCTGACGCCGATCGCCTCCGTGCGCCGTATCGTCAATATGGT
GGCGCTGTCGGTGGTGGAGGCGCAGAGCAGGACGCTGTAG

Upstream 100 bases:

>100_bases
TTTCACAAAACATTTACAGAGTGATAAAGAATCTAGCCCGGCGGCGTCGGGGACGATGGCGGCCGCGGCGCTCGGGGAAT
TAGCAAAAAGGAAACCAACG

Downstream 100 bases:

>100_bases
CCCCGTGATCATGCCGCCTGCGGGCGGCATTTTCGGGTCTCTTGAACCCCCCGGTATGTCGGGGGATATTTATTCTCTGC
GCACCGGTACGACGGTGACG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MDEKLKQSALEFHQYPVAGKIQVVPTKPLATQRDLALAYSPGVAAPCLEIADDPLAAYKYTARGNLVGVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDEHDPDKLIEVIAALEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIICTAAVLNGLRVVDKPIDRVRLVVSGAGASAIACLNLLVALGLKRENITACDSKGVIYRGRDAHLVESKAAY
AIDDNGWRTLADAIPGADIFLGCSGPGVLTQEMVKTMAPSPLILALANPEPEILPPLAKAVRPDAIICTGRSDFPNQVNN
VLCFPFIFRGALDVGATTINEEMKLAAVRAIADLALAEQSEVVASAYGDQSLSFGPEYIIPKPFDPRLIVKIAPAVAQAA
MDSGVATRPIDDMDAYIEHLTEFVYKTTLFMKPVFSQARQDPKRVVLAEGESERVLHATQELVTLGLAKPILIGRPQVIA
HRLEKLGLHIEIGRDVEVVNNESDPRYNDYWQSYYGIMKRRGISQAQARRALIADPTVIAAIMVKRGEADAMICGTEGNY
QDHYRVVREVFGYSDGCHTAAAMNALLLPSGNTFIADTYVNEDPSAEQLAEIVLMSADAVRRFGIEPKVALLSHSNFGTA
DCPSSRKMRRVLELVQQAAPGLEIDGEMHGDAALVESTRLRQMPDSPLKGAANILIMPNMEAARISYNLLRVSSSEGVTV
GPVLMGISKPVHILTPIASVRRIVNMVALSVVEAQSRTL

Sequences:

>Translated_759_residues
MDEKLKQSALEFHQYPVAGKIQVVPTKPLATQRDLALAYSPGVAAPCLEIADDPLAAYKYTARGNLVGVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDEHDPDKLIEVIAALEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIICTAAVLNGLRVVDKPIDRVRLVVSGAGASAIACLNLLVALGLKRENITACDSKGVIYRGRDAHLVESKAAY
AIDDNGWRTLADAIPGADIFLGCSGPGVLTQEMVKTMAPSPLILALANPEPEILPPLAKAVRPDAIICTGRSDFPNQVNN
VLCFPFIFRGALDVGATTINEEMKLAAVRAIADLALAEQSEVVASAYGDQSLSFGPEYIIPKPFDPRLIVKIAPAVAQAA
MDSGVATRPIDDMDAYIEHLTEFVYKTTLFMKPVFSQARQDPKRVVLAEGESERVLHATQELVTLGLAKPILIGRPQVIA
HRLEKLGLHIEIGRDVEVVNNESDPRYNDYWQSYYGIMKRRGISQAQARRALIADPTVIAAIMVKRGEADAMICGTEGNY
QDHYRVVREVFGYSDGCHTAAAMNALLLPSGNTFIADTYVNEDPSAEQLAEIVLMSADAVRRFGIEPKVALLSHSNFGTA
DCPSSRKMRRVLELVQQAAPGLEIDGEMHGDAALVESTRLRQMPDSPLKGAANILIMPNMEAARISYNLLRVSSSEGVTV
GPVLMGISKPVHILTPIASVRRIVNMVALSVVEAQSRTL
>Mature_759_residues
MDEKLKQSALEFHQYPVAGKIQVVPTKPLATQRDLALAYSPGVAAPCLEIADDPLAAYKYTARGNLVGVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDEHDPDKLIEVIAALEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIICTAAVLNGLRVVDKPIDRVRLVVSGAGASAIACLNLLVALGLKRENITACDSKGVIYRGRDAHLVESKAAY
AIDDNGWRTLADAIPGADIFLGCSGPGVLTQEMVKTMAPSPLILALANPEPEILPPLAKAVRPDAIICTGRSDFPNQVNN
VLCFPFIFRGALDVGATTINEEMKLAAVRAIADLALAEQSEVVASAYGDQSLSFGPEYIIPKPFDPRLIVKIAPAVAQAA
MDSGVATRPIDDMDAYIEHLTEFVYKTTLFMKPVFSQARQDPKRVVLAEGESERVLHATQELVTLGLAKPILIGRPQVIA
HRLEKLGLHIEIGRDVEVVNNESDPRYNDYWQSYYGIMKRRGISQAQARRALIADPTVIAAIMVKRGEADAMICGTEGNY
QDHYRVVREVFGYSDGCHTAAAMNALLLPSGNTFIADTYVNEDPSAEQLAEIVLMSADAVRRFGIEPKVALLSHSNFGTA
DCPSSRKMRRVLELVQQAAPGLEIDGEMHGDAALVESTRLRQMPDSPLKGAANILIMPNMEAARISYNLLRVSSSEGVTV
GPVLMGISKPVHILTPIASVRRIVNMVALSVVEAQSRTL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=345, Percent_Identity=26.9565217391304, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI62420880, Length=345, Percent_Identity=26.9565217391304, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI239049447, Length=345, Percent_Identity=26.9565217391304, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI4505143, Length=401, Percent_Identity=26.1845386533666, Blast_Score=80, Evalue=9e-15,
Organism=Homo sapiens, GI4505145, Length=376, Percent_Identity=26.3297872340426, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788806, Length=759, Percent_Identity=81.5546772068511, Blast_Score=1283, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=348, Percent_Identity=30.7471264367816, Blast_Score=157, Evalue=3e-39,
Organism=Escherichia coli, GI1788800, Length=325, Percent_Identity=32.6153846153846, Blast_Score=146, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17537199, Length=417, Percent_Identity=28.0575539568345, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=28.3582089552239, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI78707242, Length=407, Percent_Identity=25.5528255528256, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI78707238, Length=407, Percent_Identity=25.5528255528256, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646388, Length=345, Percent_Identity=28.695652173913, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=28.695652173913, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI78707240, Length=348, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281362674, Length=474, Percent_Identity=25.1054852320675, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21356279, Length=474, Percent_Identity=25.1054852320675, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI281362672, Length=474, Percent_Identity=25.1054852320675, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82004; Mature: 82004

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEKLKQSALEFHQYPVAGKIQVVPTKPLATQRDLALAYSPGVAAPCLEIADDPLAAYKY
CCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHCCCCHHHEEE
TARGNLVGVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDEHDPDKLI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHHH
EVIAALEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTAIICTAAVLNGLRV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHCCHHH
VDKPIDRVRLVVSGAGASAIACLNLLVALGLKRENITACDSKGVIYRGRDAHLVESKAAY
HCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEECCCCCEEECCCCEEECCCCEE
AIDDNGWRTLADAIPGADIFLGCSGPGVLTQEMVKTMAPSPLILALANPEPEILPPLAKA
EECCCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
VRPDAIICTGRSDFPNQVNNVLCFPFIFRGALDVGATTINEEMKLAAVRAIADLALAEQS
CCCCEEEEECCCCCCHHHHCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
EVVASAYGDQSLSFGPEYIIPKPFDPRLIVKIAPAVAQAAMDSGVATRPIDDMDAYIEHL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
TEFVYKTTLFMKPVFSQARQDPKRVVLAEGESERVLHATQELVTLGLAKPILIGRPQVIA
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
HRLEKLGLHIEIGRDVEVVNNESDPRYNDYWQSYYGIMKRRGISQAQARRALIADPTVIA
HHHHHCCEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHH
AIMVKRGEADAMICGTEGNYQDHYRVVREVFGYSDGCHTAAAMNALLLPSGNTFIADTYV
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCEEEEEECC
NEDPSAEQLAEIVLMSADAVRRFGIEPKVALLSHSNFGTADCPSSRKMRRVLELVQQAAP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
GLEIDGEMHGDAALVESTRLRQMPDSPLKGAANILIMPNMEAARISYNLLRVSSSEGVTV
CCEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGISKPVHILTPIASVRRIVNMVALSVVEAQSRTL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDEKLKQSALEFHQYPVAGKIQVVPTKPLATQRDLALAYSPGVAAPCLEIADDPLAAYKY
CCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHCCCCHHHEEE
TARGNLVGVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDEHDPDKLI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHHH
EVIAALEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTAIICTAAVLNGLRV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHCCHHH
VDKPIDRVRLVVSGAGASAIACLNLLVALGLKRENITACDSKGVIYRGRDAHLVESKAAY
HCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEECCCCCEEECCCCEEECCCCEE
AIDDNGWRTLADAIPGADIFLGCSGPGVLTQEMVKTMAPSPLILALANPEPEILPPLAKA
EECCCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
VRPDAIICTGRSDFPNQVNNVLCFPFIFRGALDVGATTINEEMKLAAVRAIADLALAEQS
CCCCEEEEECCCCCCHHHHCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
EVVASAYGDQSLSFGPEYIIPKPFDPRLIVKIAPAVAQAAMDSGVATRPIDDMDAYIEHL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
TEFVYKTTLFMKPVFSQARQDPKRVVLAEGESERVLHATQELVTLGLAKPILIGRPQVIA
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
HRLEKLGLHIEIGRDVEVVNNESDPRYNDYWQSYYGIMKRRGISQAQARRALIADPTVIA
HHHHHCCEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHH
AIMVKRGEADAMICGTEGNYQDHYRVVREVFGYSDGCHTAAAMNALLLPSGNTFIADTYV
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCEEEEEECC
NEDPSAEQLAEIVLMSADAVRRFGIEPKVALLSHSNFGTADCPSSRKMRRVLELVQQAAP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
GLEIDGEMHGDAALVESTRLRQMPDSPLKGAANILIMPNMEAARISYNLLRVSSSEGVTV
CCEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGISKPVHILTPIASVRRIVNMVALSVVEAQSRTL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]