Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 222524636

GI number: 222524636

Start: 1738784

End: 1741252

Strand: Reverse

Name: gyrA [H]

Synonym: Chy400_1360

Alternate gene names: 222524636

Gene position: 1741252-1738784 (Counterclockwise)

Preceding gene: 222524640

Following gene: 222524627

Centisome position: 33.05

GC content: 58.16

Gene sequence:

>2469_bases
ATGGAAATCGGTATCGTCCGGCCCGTCAACATCACCAATGAGATGCGGACGGCCTATCTCAGCTACGCGATGAGCGTCAT
CGTCTCGCGTGCGCTCCCTGATGCACGTGATGGCTTGAAGCCGGTGCAGCGCCGTATTCTCTACGGCATGTGGGACATGG
GCTTTCGCAGTAATCAGCCATACAAAAAGAGTGCCCGTATCGTGGGCGATGTGCTCGGTAAAATGCACCCCCACGGTGAC
AGTGCCGTCTACGATGCGCTGGCCCGCATGGCTCAGCCCTGGAGTATGCGGTATCCCCTGATCGATGGCCAGGGTAACTT
CGGTTCCATCGATGGCGATCCGCCCGCAGCGATGCGCTACACCGAAGCGCGCCTGGCGCCAATTGCCGAAGAGTTGCTCA
GTGAGATTGAGAAAGATACCGTCGATTTTCGTGATAACTTCGATGGCAGCTACCGCGAGCCGGTCGTGCTCCCGGCCATT
CTGCCCAATCTGCTGCTCAACGGTGCTTCCGGGATTGCGGTTGGTATGGCAACCAACATTCCACCGCACAACCTCGGCGA
ACTCTGCGATGCGATCAGCTATCTAATCGAACACCCGGAGGCCACGGTTGAGGAGCTGATGAAGATCATCCCCGGCCCTG
ACTTTCCAACTGCCGGGCTGATTCTGGGCACCGAGGGGATTTTAGCCGCGTACAGCACCGGGCGTGGGCAGATTACGCTG
CGCGCCAAGACACATATCGAAGAGGCCGGGCGCGGTGCCTTTATGATCGTCGTCACCGAATTGCCGTATCAGGTCAACAA
GGCTCGTCTGCAAGAGCGAATTGCCGAGCTGGTCAAAGATCGCAAGATCGAGGGTATTCGCGATGTGCGAGATGAGAGCG
ACCGCACCGGCATGCGGTTGGTGATCCTTTTGAAACAAGATGCCCAACCCAAGAAGGTGCTCAATGCGCTCTACAAGCAC
ACCCAAATGCAGACTACCTTCGGGATCAATATGCTGGCACTGGTCGAGCACGGTCGTCAGCCGCGCGTCTTGACCCTCAA
ACGCCTCTTGCAAGAGTACATCACCCACCGGCAAGAGGTTATTCGACGCCGAACCGAGTTCGATCTGGCCCGTGCTCGGG
AACGTGCCCACATTCTGGAGGGCTTGAAGATTGCGCTCGATAACCTGGACGCTGTCATTCAGACCATCCGCGACTCGCGA
ACTGCTGAGAGCGCCCGCAATAACCTGATGAGTAATTTTTCGCTTACCGAGCGGCAGGCGCAGGCTATCCTCGATCTTCA
GTTACGCCGTCTGGCTGCGCTCGAACGCAAGAAGATCGAAGATGAATACCGTGAGGTGATCAAGCTGATCGCCGAACTGG
AAGATATTCTGGCCAATCCGCGCAAGGTGTTGCACCTGATCCAGCAAGACCTGACTCGCCTGAAAGAGAAGTATGGCGAT
CCGCGGCGCACCCGCATTATTCCTGATGTCACCGGTGAAGTGAGCGACGAAGACCTGATCCCCGATGTGCGGGTGATGAT
TACCTTGACCGACCGTGGCTATATCAAGCGTCAGTTACCTGATGCCTACCGCACCCAGCGCCGTGGTGGTCGAGGCATCA
AGGGTATGCTGACCAGAGAACAGGATATTGTGCGCCACCTGTTGACGTGCAATTCGCTCGACAACCTGCTCTTCTTCACC
GACCGCGGCAAGGTCTATCAACTGAAGGCGCACGAAGTACCCGACAGCTCCCGAACGGCGAAGGGTTTGCCACTGGTAAA
CCTGATTTCGCTCGAACCGGGTGAACAGGTGACGTCAATGCTGGCCGTGCGCGAGTTTGATGCCGAGTATCTGGTGATGG
CGACGGTGCGCGGGAAGATCAAGCGCACGCAATTGCGTGAGTACAGTCAGGTGCGCTCGAACGGCCTAATCGCGATTGGC
CTGGAAGAGGGTGATGTGCTGGGTTGGGTGCGGGTCAGCCACGGCCACGAAGACATCTTGCTGACGACGGCTCGCGGTCA
GACGCTGCGTTTCGAGCAGAGCGAAGTGCGACCAATGGGTCGTCCGGCCACCGGCGTGATCGGGATCAACCTGGCAGACG
GTGATCGCGTTGTCAGTATGGATCTGGCTGAAGAGGGGGCCGATCTGCTGGTTGTGACTGCGCGAGGGATAGGCAAGCGA
ACAGCACTCTCTGAATATCCGGTCAAAGGCCGGGCTACCGGTGGCGTCATTACCATCAAACTGCGCAACGATCTTGACGA
AGTTGCTGCTGCGGCGGTTGTCCGTGAGCATTCTCTGCTCACCTTTATCACCACCGGTGGGATGGTATTGCGCACCAGCG
CCAGCGAGATCTCACGCCTGGGCCGGGCCACGCAGGGGGTGACCATCGTCAATGTGGCGACCGGTGATCGGGTGGCTGCG
CTATCGGTGGAAGACCCGGAAGAGAACGGTAACGGCTCCACGCCGACATTAATCGATCCGTTGTCGTAG

Upstream 100 bases:

>100_bases
TATGTTTCATTTTATTCGACAGAAACGCCTGGATCGGGTATAATGTGAGATGGCAAACATCGCATAATAATGCGCTAAAA
CCGACGTAACGGAGTAACAA

Downstream 100 bases:

>100_bases
GGGGCAGGGGACAAAATACTGGAATCAAATCTGGTGTCATCGTGGTCGTAGCGGATTATCCACCGATCACGCCGACACCG
CTCCTGGGCGCGGCGGCGCA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 822; Mature: 822

Protein sequence:

>822_residues
MEIGIVRPVNITNEMRTAYLSYAMSVIVSRALPDARDGLKPVQRRILYGMWDMGFRSNQPYKKSARIVGDVLGKMHPHGD
SAVYDALARMAQPWSMRYPLIDGQGNFGSIDGDPPAAMRYTEARLAPIAEELLSEIEKDTVDFRDNFDGSYREPVVLPAI
LPNLLLNGASGIAVGMATNIPPHNLGELCDAISYLIEHPEATVEELMKIIPGPDFPTAGLILGTEGILAAYSTGRGQITL
RAKTHIEEAGRGAFMIVVTELPYQVNKARLQERIAELVKDRKIEGIRDVRDESDRTGMRLVILLKQDAQPKKVLNALYKH
TQMQTTFGINMLALVEHGRQPRVLTLKRLLQEYITHRQEVIRRRTEFDLARARERAHILEGLKIALDNLDAVIQTIRDSR
TAESARNNLMSNFSLTERQAQAILDLQLRRLAALERKKIEDEYREVIKLIAELEDILANPRKVLHLIQQDLTRLKEKYGD
PRRTRIIPDVTGEVSDEDLIPDVRVMITLTDRGYIKRQLPDAYRTQRRGGRGIKGMLTREQDIVRHLLTCNSLDNLLFFT
DRGKVYQLKAHEVPDSSRTAKGLPLVNLISLEPGEQVTSMLAVREFDAEYLVMATVRGKIKRTQLREYSQVRSNGLIAIG
LEEGDVLGWVRVSHGHEDILLTTARGQTLRFEQSEVRPMGRPATGVIGINLADGDRVVSMDLAEEGADLLVVTARGIGKR
TALSEYPVKGRATGGVITIKLRNDLDEVAAAAVVREHSLLTFITTGGMVLRTSASEISRLGRATQGVTIVNVATGDRVAA
LSVEDPEENGNGSTPTLIDPLS

Sequences:

>Translated_822_residues
MEIGIVRPVNITNEMRTAYLSYAMSVIVSRALPDARDGLKPVQRRILYGMWDMGFRSNQPYKKSARIVGDVLGKMHPHGD
SAVYDALARMAQPWSMRYPLIDGQGNFGSIDGDPPAAMRYTEARLAPIAEELLSEIEKDTVDFRDNFDGSYREPVVLPAI
LPNLLLNGASGIAVGMATNIPPHNLGELCDAISYLIEHPEATVEELMKIIPGPDFPTAGLILGTEGILAAYSTGRGQITL
RAKTHIEEAGRGAFMIVVTELPYQVNKARLQERIAELVKDRKIEGIRDVRDESDRTGMRLVILLKQDAQPKKVLNALYKH
TQMQTTFGINMLALVEHGRQPRVLTLKRLLQEYITHRQEVIRRRTEFDLARARERAHILEGLKIALDNLDAVIQTIRDSR
TAESARNNLMSNFSLTERQAQAILDLQLRRLAALERKKIEDEYREVIKLIAELEDILANPRKVLHLIQQDLTRLKEKYGD
PRRTRIIPDVTGEVSDEDLIPDVRVMITLTDRGYIKRQLPDAYRTQRRGGRGIKGMLTREQDIVRHLLTCNSLDNLLFFT
DRGKVYQLKAHEVPDSSRTAKGLPLVNLISLEPGEQVTSMLAVREFDAEYLVMATVRGKIKRTQLREYSQVRSNGLIAIG
LEEGDVLGWVRVSHGHEDILLTTARGQTLRFEQSEVRPMGRPATGVIGINLADGDRVVSMDLAEEGADLLVVTARGIGKR
TALSEYPVKGRATGGVITIKLRNDLDEVAAAAVVREHSLLTFITTGGMVLRTSASEISRLGRATQGVTIVNVATGDRVAA
LSVEDPEENGNGSTPTLIDPLS
>Mature_822_residues
MEIGIVRPVNITNEMRTAYLSYAMSVIVSRALPDARDGLKPVQRRILYGMWDMGFRSNQPYKKSARIVGDVLGKMHPHGD
SAVYDALARMAQPWSMRYPLIDGQGNFGSIDGDPPAAMRYTEARLAPIAEELLSEIEKDTVDFRDNFDGSYREPVVLPAI
LPNLLLNGASGIAVGMATNIPPHNLGELCDAISYLIEHPEATVEELMKIIPGPDFPTAGLILGTEGILAAYSTGRGQITL
RAKTHIEEAGRGAFMIVVTELPYQVNKARLQERIAELVKDRKIEGIRDVRDESDRTGMRLVILLKQDAQPKKVLNALYKH
TQMQTTFGINMLALVEHGRQPRVLTLKRLLQEYITHRQEVIRRRTEFDLARARERAHILEGLKIALDNLDAVIQTIRDSR
TAESARNNLMSNFSLTERQAQAILDLQLRRLAALERKKIEDEYREVIKLIAELEDILANPRKVLHLIQQDLTRLKEKYGD
PRRTRIIPDVTGEVSDEDLIPDVRVMITLTDRGYIKRQLPDAYRTQRRGGRGIKGMLTREQDIVRHLLTCNSLDNLLFFT
DRGKVYQLKAHEVPDSSRTAKGLPLVNLISLEPGEQVTSMLAVREFDAEYLVMATVRGKIKRTQLREYSQVRSNGLIAIG
LEEGDVLGWVRVSHGHEDILLTTARGQTLRFEQSEVRPMGRPATGVIGINLADGDRVVSMDLAEEGADLLVVTARGIGKR
TALSEYPVKGRATGGVITIKLRNDLDEVAAAAVVREHSLLTFITTGGMVLRTSASEISRLGRATQGVTIVNVATGDRVAA
LSVEDPEENGNGSTPTLIDPLS

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=349, Percent_Identity=23.7822349570201, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI19913406, Length=377, Percent_Identity=24.4031830238727, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1788562, Length=834, Percent_Identity=48.4412470023981, Blast_Score=775, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=695, Percent_Identity=38.5611510791367, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI212645845, Length=362, Percent_Identity=22.6519337016575, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17535065, Length=355, Percent_Identity=25.3521126760563, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=354, Percent_Identity=25.1412429378531, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=344, Percent_Identity=25, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17136538, Length=354, Percent_Identity=24.8587570621469, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91494; Mature: 91494

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIGIVRPVNITNEMRTAYLSYAMSVIVSRALPDARDGLKPVQRRILYGMWDMGFRSNQP
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCCCCCC
YKKSARIVGDVLGKMHPHGDSAVYDALARMAQPWSMRYPLIDGQGNFGSIDGDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCHHHHH
TEARLAPIAEELLSEIEKDTVDFRDNFDGSYREPVVLPAILPNLLLNGASGIAVGMATNI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEECCC
PPHNLGELCDAISYLIEHPEATVEELMKIIPGPDFPTAGLILGTEGILAAYSTGRGQITL
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCEEEE
RAKTHIEEAGRGAFMIVVTELPYQVNKARLQERIAELVKDRKIEGIRDVRDESDRTGMRL
EEHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCEE
VILLKQDAQPKKVLNALYKHTQMQTTFGINMLALVEHGRQPRVLTLKRLLQEYITHRQEV
EEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IRRRTEFDLARARERAHILEGLKIALDNLDAVIQTIRDSRTAESARNNLMSNFSLTERQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QAILDLQLRRLAALERKKIEDEYREVIKLIAELEDILANPRKVLHLIQQDLTRLKEKYGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCC
PRRTRIIPDVTGEVSDEDLIPDVRVMITLTDRGYIKRQLPDAYRTQRRGGRGIKGMLTRE
CHHEEECCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHCCHHHHHHHCCCCCCCHHHCCH
QDIVRHLLTCNSLDNLLFFTDRGKVYQLKAHEVPDSSRTAKGLPLVNLISLEPGEQVTSM
HHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHH
LAVREFDAEYLVMATVRGKIKRTQLREYSQVRSNGLIAIGLEEGDVLGWVRVSHGHEDIL
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCCEE
LTTARGQTLRFEQSEVRPMGRPATGVIGINLADGDRVVSMDLAEEGADLLVVTARGIGKR
EEECCCCEEEECHHHCCCCCCCCCEEEEEEECCCCEEEEEEHHHCCCCEEEEEECCCCCC
TALSEYPVKGRATGGVITIKLRNDLDEVAAAAVVREHSLLTFITTGGMVLRTSASEISRL
CCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCEEEEECHHHHHHH
GRATQGVTIVNVATGDRVAALSVEDPEENGNGSTPTLIDPLS
CCHHCCEEEEEEECCCEEEEEEECCCCCCCCCCCCCEECCCC
>Mature Secondary Structure
MEIGIVRPVNITNEMRTAYLSYAMSVIVSRALPDARDGLKPVQRRILYGMWDMGFRSNQP
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCCCCCC
YKKSARIVGDVLGKMHPHGDSAVYDALARMAQPWSMRYPLIDGQGNFGSIDGDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCHHHHH
TEARLAPIAEELLSEIEKDTVDFRDNFDGSYREPVVLPAILPNLLLNGASGIAVGMATNI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEECCC
PPHNLGELCDAISYLIEHPEATVEELMKIIPGPDFPTAGLILGTEGILAAYSTGRGQITL
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCEEEE
RAKTHIEEAGRGAFMIVVTELPYQVNKARLQERIAELVKDRKIEGIRDVRDESDRTGMRL
EEHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCEE
VILLKQDAQPKKVLNALYKHTQMQTTFGINMLALVEHGRQPRVLTLKRLLQEYITHRQEV
EEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IRRRTEFDLARARERAHILEGLKIALDNLDAVIQTIRDSRTAESARNNLMSNFSLTERQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QAILDLQLRRLAALERKKIEDEYREVIKLIAELEDILANPRKVLHLIQQDLTRLKEKYGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCC
PRRTRIIPDVTGEVSDEDLIPDVRVMITLTDRGYIKRQLPDAYRTQRRGGRGIKGMLTRE
CHHEEECCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHCCHHHHHHHCCCCCCCHHHCCH
QDIVRHLLTCNSLDNLLFFTDRGKVYQLKAHEVPDSSRTAKGLPLVNLISLEPGEQVTSM
HHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHH
LAVREFDAEYLVMATVRGKIKRTQLREYSQVRSNGLIAIGLEEGDVLGWVRVSHGHEDIL
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCCEE
LTTARGQTLRFEQSEVRPMGRPATGVIGINLADGDRVVSMDLAEEGADLLVVTARGIGKR
EEECCCCEEEECHHHCCCCCCCCCEEEEEEECCCCEEEEEEHHHCCCCEEEEEECCCCCC
TALSEYPVKGRATGGVITIKLRNDLDEVAAAAVVREHSLLTFITTGGMVLRTSASEISRL
CCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCEEEEECHHHHHHH
GRATQGVTIVNVATGDRVAALSVEDPEENGNGSTPTLIDPLS
CCHHCCEEEEEEECCCEEEEEEECCCCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]