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The map label for this gene is adk [H]

Identifier: 221632958

GI number: 221632958

Start: 934646

End: 935347

Strand: Reverse

Name: adk [H]

Synonym: trd_0964

Alternate gene names: 221632958

Gene position: 935347-934646 (Counterclockwise)

Preceding gene: 221632959

Following gene: 221632957

Centisome position: 46.7

GC content: 60.54

Gene sequence:

>702_bases
GTGGCTGGACGCTGTCACGTCATCGTGATCGGTCCCCAGGGGTCAGGGAAGGGCACGCAGGCAGCGCGTGTCGCTCCGCT
TTTGCGATTGGTGCATGTTGCAACTGGTGACCTCTTCCGGCAGTTGATGACGCGTGACGACGAACTGGCACGCGAGGTTC
GCAGCTATTATGATCGTGGCGCGCTGGTTCCGGATGAATTGACGTTGCGCGTGTTGTTGGCTCGGCTCGATGAACTCGAA
CGGGAGCAGGGCGATCAGTATCGCGGTGCGCTCCTCGATGGTTATCCACGGAATCTCGCACAGGCGGAAGCACTTGATCG
CGTTCTGACGGAGCGAGGTGACGTCATCGCTGCGGTGGTGCACTTGGTGGTACCGCGCGAGGTGCTTATCGAGCGGCTGA
GTGGTCGTCTGATCTGTCCAACGTGTGGAGCAACCTATCACGTGCGCTTCTCGCCACCACGAGTCGCCGGCATTTGCGAT
CACTGTGGTGGAGCGCTCATGCAACGCAGCGACGATACGCCGGAAGCCATCGCGCGACGTCTCGAAACGTACGAGCAACA
GACAGCACCGCTGCTGGACTATTACCGTGCTCGGGATTTGGTCATCGACATCGACGGGAATCGGCCGATCGATGTGGTGA
CGCGCGATCTCCTCGTTGCGCTGGAATCACGACTCGCGCACAACCCATGCCGATCGTCCTGA

Upstream 100 bases:

>100_bases
GCTCCTGATCGTCGTTGGTGTGGCGATCGATACGATGCGACAGTTGGAAGCGCAGCTCCTCATGCGCAATTACGAAGGGT
TCATCCGGTAGGGGGAACGG

Downstream 100 bases:

>100_bases
AGTCGCTGCGCGAAATCGACGCTATGCGACGTGCTGGGCAAATCGTCGCCCTTGTTCTCGAGGAACTGCGGGAGAACGTG
CGACCGGGGGTGACGACGGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MAGRCHVIVIGPQGSGKGTQAARVAPLLRLVHVATGDLFRQLMTRDDELAREVRSYYDRGALVPDELTLRVLLARLDELE
REQGDQYRGALLDGYPRNLAQAEALDRVLTERGDVIAAVVHLVVPREVLIERLSGRLICPTCGATYHVRFSPPRVAGICD
HCGGALMQRSDDTPEAIARRLETYEQQTAPLLDYYRARDLVIDIDGNRPIDVVTRDLLVALESRLAHNPCRSS

Sequences:

>Translated_233_residues
MAGRCHVIVIGPQGSGKGTQAARVAPLLRLVHVATGDLFRQLMTRDDELAREVRSYYDRGALVPDELTLRVLLARLDELE
REQGDQYRGALLDGYPRNLAQAEALDRVLTERGDVIAAVVHLVVPREVLIERLSGRLICPTCGATYHVRFSPPRVAGICD
HCGGALMQRSDDTPEAIARRLETYEQQTAPLLDYYRARDLVIDIDGNRPIDVVTRDLLVALESRLAHNPCRSS
>Mature_232_residues
AGRCHVIVIGPQGSGKGTQAARVAPLLRLVHVATGDLFRQLMTRDDELAREVRSYYDRGALVPDELTLRVLLARLDELER
EQGDQYRGALLDGYPRNLAQAEALDRVLTERGDVIAAVVHLVVPREVLIERLSGRLICPTCGATYHVRFSPPRVAGICDH
CGGALMQRSDDTPEAIARRLETYEQQTAPLLDYYRARDLVIDIDGNRPIDVVTRDLLVALESRLAHNPCRSS

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=40.5, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=38.3177570093458, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=38.3177570093458, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=37.1859296482412, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=37.1859296482412, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=37.1859296482412, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=37.1859296482412, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI22749187, Length=189, Percent_Identity=32.2751322751323, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI7706497, Length=208, Percent_Identity=27.8846153846154, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28144897, Length=227, Percent_Identity=29.9559471365639, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI28144899, Length=227, Percent_Identity=29.9559471365639, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=35.1851851851852, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17552384, Length=203, Percent_Identity=37.9310344827586, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17537943, Length=223, Percent_Identity=33.6322869955157, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=212, Percent_Identity=29.7169811320755, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17567503, Length=211, Percent_Identity=28.436018957346, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=37.2093023255814, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321018, Length=207, Percent_Identity=35.7487922705314, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=220, Percent_Identity=24.0909090909091, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI22026816, Length=203, Percent_Identity=38.423645320197, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17737899, Length=205, Percent_Identity=37.0731707317073, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645822, Length=205, Percent_Identity=37.0731707317073, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 25901; Mature: 25770

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRCHVIVIGPQGSGKGTQAARVAPLLRLVHVATGDLFRQLMTRDDELAREVRSYYDRG
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ALVPDELTLRVLLARLDELEREQGDQYRGALLDGYPRNLAQAEALDRVLTERGDVIAAVV
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHH
HLVVPREVLIERLSGRLICPTCGATYHVRFSPPRVAGICDHCGGALMQRSDDTPEAIARR
HHHCCHHHHHHHHCCCEEECCCCCEEEEEECCCHHHHHHHHHCHHHHHCCCCCHHHHHHH
LETYEQQTAPLLDYYRARDLVIDIDGNRPIDVVTRDLLVALESRLAHNPCRSS
HHHHHHHCCHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AGRCHVIVIGPQGSGKGTQAARVAPLLRLVHVATGDLFRQLMTRDDELAREVRSYYDRG
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ALVPDELTLRVLLARLDELEREQGDQYRGALLDGYPRNLAQAEALDRVLTERGDVIAAVV
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHH
HLVVPREVLIERLSGRLICPTCGATYHVRFSPPRVAGICDHCGGALMQRSDDTPEAIARR
HHHCCHHHHHHHHCCCEEECCCCCEEEEEECCCHHHHHHHHHCHHHHHCCCCCHHHHHHH
LETYEQQTAPLLDYYRARDLVIDIDGNRPIDVVTRDLLVALESRLAHNPCRSS
HHHHHHHCCHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]