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The map label for this gene is map [H]

Identifier: 221632957

GI number: 221632957

Start: 933912

End: 934661

Strand: Reverse

Name: map [H]

Synonym: trd_0963

Alternate gene names: 221632957

Gene position: 934661-933912 (Counterclockwise)

Preceding gene: 221632958

Following gene: 221632956

Centisome position: 46.66

GC content: 63.73

Gene sequence:

>750_bases
ATGCCGATCGTCCTGAAGTCGCTGCGCGAAATCGACGCTATGCGACGTGCTGGGCAAATCGTCGCCCTTGTTCTCGAGGA
ACTGCGGGAGAACGTGCGACCGGGGGTGACGACGGGTGACCTCGATCGCTTGGCAGCGGCAGTGATGGCTCGGGAAGGTG
GACGCTCCGCGTTTCTCGGTTACCGCGGTTTTCCGGCGCATATCTGCACGTCAGTCAACGAGCAGGTTTTACATGGGATC
CCGGGGCGACGAGTTCTCCGCGATGGGGATCTCCTGAAGCTCGACGTGGGCATCGAGTGGCATGGGTTGTGCGCTGATGC
AGCGATCAGCGTGGTCGTGGGACGGGGAAATCGCGTAGCTGAACAACTCGTTGCGGTTGCCGAAGAGGCTTTCTGGGCCG
GATTCGCGCAGGCACGGCCGGGTAAGCATGTCGGTGACATCGGTGCAGCGATCGCCGCTGTGATCCGGCGCGCGGGATTC
GCTGTGATCGAAGGCTATGCGGGGCACGGGGTAGGGCGGGCGCTCCATGAAGAGCCGTCCGTACCGAACGACGGCCAGCC
AGGCGAGGGTGTGCTCCTCCGGTCAGGCATGACGCTGGCGATCGAGCCGATGCTCGCTGCCGGGGGCGGCAAGACGCGCG
TCTTACGGGACGGTTGGACGGTCGTGACGTTGGATGGTCGTCTGGCAGCGCATTTCGAGCATACGGTCTGGGTGCGTGAT
GATGGACCGATGGTGCTCACCCAGCCTTAA

Upstream 100 bases:

>100_bases
GTGCTCGGGATTTGGTCATCGACATCGACGGGAATCGGCCGATCGATGTGGTGACGCGCGATCTCCTCGTTGCGCTGGAA
TCACGACTCGCGCACAACCC

Downstream 100 bases:

>100_bases
TCGACTGTGGTATATTTCGTGTTTGTGATGCGTGCGAGCGATCGCGCGTGAGTGGGGTGTCTTGTGCCGAAGAAGGACGT
CATCGAAGTCGAAGGGACGG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MPIVLKSLREIDAMRRAGQIVALVLEELRENVRPGVTTGDLDRLAAAVMAREGGRSAFLGYRGFPAHICTSVNEQVLHGI
PGRRVLRDGDLLKLDVGIEWHGLCADAAISVVVGRGNRVAEQLVAVAEEAFWAGFAQARPGKHVGDIGAAIAAVIRRAGF
AVIEGYAGHGVGRALHEEPSVPNDGQPGEGVLLRSGMTLAIEPMLAAGGGKTRVLRDGWTVVTLDGRLAAHFEHTVWVRD
DGPMVLTQP

Sequences:

>Translated_249_residues
MPIVLKSLREIDAMRRAGQIVALVLEELRENVRPGVTTGDLDRLAAAVMAREGGRSAFLGYRGFPAHICTSVNEQVLHGI
PGRRVLRDGDLLKLDVGIEWHGLCADAAISVVVGRGNRVAEQLVAVAEEAFWAGFAQARPGKHVGDIGAAIAAVIRRAGF
AVIEGYAGHGVGRALHEEPSVPNDGQPGEGVLLRSGMTLAIEPMLAAGGGKTRVLRDGWTVVTLDGRLAAHFEHTVWVRD
DGPMVLTQP
>Mature_248_residues
PIVLKSLREIDAMRRAGQIVALVLEELRENVRPGVTTGDLDRLAAAVMAREGGRSAFLGYRGFPAHICTSVNEQVLHGIP
GRRVLRDGDLLKLDVGIEWHGLCADAAISVVVGRGNRVAEQLVAVAEEAFWAGFAQARPGKHVGDIGAAIAAVIRRAGFA
VIEGYAGHGVGRALHEEPSVPNDGQPGEGVLLRSGMTLAIEPMLAAGGGKTRVLRDGWTVVTLDGRLAAHFEHTVWVRDD
GPMVLTQP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=35.2226720647773, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=32.520325203252, Blast_Score=151, Evalue=5e-37,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=40.5622489959839, Blast_Score=205, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71996291, Length=240, Percent_Identity=35, Blast_Score=151, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=33.0645161290323, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21355531, Length=240, Percent_Identity=38.3333333333333, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=34.1463414634146, Blast_Score=147, Evalue=6e-36,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 26463; Mature: 26332

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVLKSLREIDAMRRAGQIVALVLEELRENVRPGVTTGDLDRLAAAVMAREGGRSAFLG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
YRGFPAHICTSVNEQVLHGIPGRRVLRDGDLLKLDVGIEWHGLCADAAISVVVGRGNRVA
CCCCHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCEEECCHHHHEEEEEECCCHHHH
EQLVAVAEEAFWAGFAQARPGKHVGDIGAAIAAVIRRAGFAVIEGYAGHGVGRALHEEPS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHCCCC
VPNDGQPGEGVLLRSGMTLAIEPMLAAGGGKTRVLRDGWTVVTLDGRLAAHFEHTVWVRD
CCCCCCCCCCEEEECCCEEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEEEEEEEEEC
DGPMVLTQP
CCCEEEECC
>Mature Secondary Structure 
PIVLKSLREIDAMRRAGQIVALVLEELRENVRPGVTTGDLDRLAAAVMAREGGRSAFLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
YRGFPAHICTSVNEQVLHGIPGRRVLRDGDLLKLDVGIEWHGLCADAAISVVVGRGNRVA
CCCCHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCEEECCHHHHEEEEEECCCHHHH
EQLVAVAEEAFWAGFAQARPGKHVGDIGAAIAAVIRRAGFAVIEGYAGHGVGRALHEEPS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHCCCC
VPNDGQPGEGVLLRSGMTLAIEPMLAAGGGKTRVLRDGWTVVTLDGRLAAHFEHTVWVRD
CCCCCCCCCCEEEECCCEEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEEEEEEEEEC
DGPMVLTQP
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842; 7559358 [H]