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The map label for this gene is hisC [H]

Identifier: 221632461

GI number: 221632461

Start: 430766

End: 431848

Strand: Reverse

Name: hisC [H]

Synonym: trd_0435

Alternate gene names: 221632461

Gene position: 431848-430766 (Counterclockwise)

Preceding gene: 221632466

Following gene: 221632460

Centisome position: 21.56

GC content: 63.16

Gene sequence:

>1083_bases
GTGGCAGCGAGGCGAGCGGTGCGGGCGAGTATCGAGAACGCGGTGGAATATCTTCCTGTCGAGAGCCGCGAAACGATCGC
GGAGCGCCTCGGTGTTCCACCCGAACAGGTGGCCAAGCTCGATGCGAACGAGAACCCGTACGGCCCGCCACCAGCGGTCA
TCGCGGCGCTTGCCTCGCTCCCTGACCTGCATCTCTATCCCGACCCCGACCAACGGCGCGCTCGTGCTGCACTCGCGGAC
TATACCGGCATGCCAGCTGAACGCATTCTTCTGGGTAATGGATCCGATGAACTCATCGATCTGCTCTTGCTCGTGACGAT
CGAGCCTGGCGACGAGGTGGTCGTTCCCGTCCCGAGCTTTGGCGTGTATCTCTCGCGACCACCGCTTTTCGGTGCCCGGG
TCATCACCGTACCACGCCGCGAGGACTTCGACCTCGACCTCGAGACGATCGAAGACGCCATCACTCCCCGCACCAAGCTG
CTCTTCCTCGCCTCACCGAACAACCCGACCGGCAACCTGGTCACTCCACAGCAACTCTCGCGATTACTCCGCACGGGAAT
CCTCGTCGTTCTCGACGAAGCGTACTACGAGTTCGCAGGTCAGACGCTCGCGCCCTTTGCGCGCGAGTTCGAGAATCTCG
TGATCCTCCGGACGTTCAGCAAATGGGCCGGGCTCGCTGGGCTCCGCATCGGTTACGGCATCTTCCCTCCCCATCTCGCG
GCAGCATTGTGGCGTGTCAAGCAGCCGTTCAATGTCAGCACTGCAGCACAAGCGGCGGTCGAGGCTGCGCTGGCTGACCG
CACCTGGCTCATGCAGCGGGTGCTACACGTGCGACTCGAGCGGGGACGTCTCTACCGAGCATTGCGCCGCTACCCCTTCC
TCACCCCATACCCGTCGCACGGAAACTTCATTCTCTGCCGCGTGCATGACGGGAGAGCCCACCAGTTGCACGCCCATCTC
TTGCAGCACGCGATCGTCGTACGACGCTATGATGACGAGTGGCTCCGCGACTACTTGCGGATCACCGTCGGGACACCCGA
GCAGACCGACCGCATTCTCGCCGCCCTCGACACATTCCGGTGA

Upstream 100 bases:

>100_bases
TGAGCACCGAGGCCATGAGCAGGCCTCGCACGCCTTGGCACGCTCGGCCGAACACACGGTACTCTTGCTGCGAGAGTGCA
ACACACGGAGGGAGGGGCGC

Downstream 100 bases:

>100_bases
TGGACAACGAGAGGAGCACGCCGTTGACAGAAATCCGAAGAGCCTCCATTCGGCGCACGACGACCGAGACCGACGTCAGT
GTCGATTTGATCATCGATGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MAARRAVRASIENAVEYLPVESRETIAERLGVPPEQVAKLDANENPYGPPPAVIAALASLPDLHLYPDPDQRRARAALAD
YTGMPAERILLGNGSDELIDLLLLVTIEPGDEVVVPVPSFGVYLSRPPLFGARVITVPRREDFDLDLETIEDAITPRTKL
LFLASPNNPTGNLVTPQQLSRLLRTGILVVLDEAYYEFAGQTLAPFAREFENLVILRTFSKWAGLAGLRIGYGIFPPHLA
AALWRVKQPFNVSTAAQAAVEAALADRTWLMQRVLHVRLERGRLYRALRRYPFLTPYPSHGNFILCRVHDGRAHQLHAHL
LQHAIVVRRYDDEWLRDYLRITVGTPEQTDRILAALDTFR

Sequences:

>Translated_360_residues
MAARRAVRASIENAVEYLPVESRETIAERLGVPPEQVAKLDANENPYGPPPAVIAALASLPDLHLYPDPDQRRARAALAD
YTGMPAERILLGNGSDELIDLLLLVTIEPGDEVVVPVPSFGVYLSRPPLFGARVITVPRREDFDLDLETIEDAITPRTKL
LFLASPNNPTGNLVTPQQLSRLLRTGILVVLDEAYYEFAGQTLAPFAREFENLVILRTFSKWAGLAGLRIGYGIFPPHLA
AALWRVKQPFNVSTAAQAAVEAALADRTWLMQRVLHVRLERGRLYRALRRYPFLTPYPSHGNFILCRVHDGRAHQLHAHL
LQHAIVVRRYDDEWLRDYLRITVGTPEQTDRILAALDTFR
>Mature_359_residues
AARRAVRASIENAVEYLPVESRETIAERLGVPPEQVAKLDANENPYGPPPAVIAALASLPDLHLYPDPDQRRARAALADY
TGMPAERILLGNGSDELIDLLLLVTIEPGDEVVVPVPSFGVYLSRPPLFGARVITVPRREDFDLDLETIEDAITPRTKLL
FLASPNNPTGNLVTPQQLSRLLRTGILVVLDEAYYEFAGQTLAPFAREFENLVILRTFSKWAGLAGLRIGYGIFPPHLAA
ALWRVKQPFNVSTAAQAAVEAALADRTWLMQRVLHVRLERGRLYRALRRYPFLTPYPSHGNFILCRVHDGRAHQLHAHLL
QHAIVVRRYDDEWLRDYLRITVGTPEQTDRILAALDTFR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=234, Percent_Identity=24.3589743589744, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788332, Length=323, Percent_Identity=33.7461300309598, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1788722, Length=292, Percent_Identity=28.0821917808219, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788627, Length=231, Percent_Identity=28.1385281385281, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17567369, Length=252, Percent_Identity=25.3968253968254, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=345, Percent_Identity=31.5942028985507, Blast_Score=146, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322401, Length=230, Percent_Identity=25.6521739130435, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40380; Mature: 40249

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARRAVRASIENAVEYLPVESRETIAERLGVPPEQVAKLDANENPYGPPPAVIAALASL
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHCC
PDLHLYPDPDQRRARAALADYTGMPAERILLGNGSDELIDLLLLVTIEPGDEVVVPVPSF
CCCCCCCCCHHHHHHHHHHHHCCCCHHEEEEECCCHHHEEEEEEEEECCCCCEEEECCCC
GVYLSRPPLFGARVITVPRREDFDLDLETIEDAITPRTKLLFLASPNNPTGNLVTPQQLS
CEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHH
RLLRTGILVVLDEAYYEFAGQTLAPFAREFENLVILRTFSKWAGLAGLRIGYGIFPPHLA
HHHHCCEEEEEHHHHHHHCCCHHHHHHHHHCCEEEEEEHHHHHCCCCHHHCCCCCCHHHH
AALWRVKQPFNVSTAAQAAVEAALADRTWLMQRVLHVRLERGRLYRALRRYPFLTPYPSH
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GNFILCRVHDGRAHQLHAHLLQHAIVVRRYDDEWLRDYLRITVGTPEQTDRILAALDTFR
CCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AARRAVRASIENAVEYLPVESRETIAERLGVPPEQVAKLDANENPYGPPPAVIAALASL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHCC
PDLHLYPDPDQRRARAALADYTGMPAERILLGNGSDELIDLLLLVTIEPGDEVVVPVPSF
CCCCCCCCCHHHHHHHHHHHHCCCCHHEEEEECCCHHHEEEEEEEEECCCCCEEEECCCC
GVYLSRPPLFGARVITVPRREDFDLDLETIEDAITPRTKLLFLASPNNPTGNLVTPQQLS
CEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHH
RLLRTGILVVLDEAYYEFAGQTLAPFAREFENLVILRTFSKWAGLAGLRIGYGIFPPHLA
HHHHCCEEEEEHHHHHHHCCCHHHHHHHHHCCEEEEEEHHHHHCCCCHHHCCCCCCHHHH
AALWRVKQPFNVSTAAQAAVEAALADRTWLMQRVLHVRLERGRLYRALRRYPFLTPYPSH
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GNFILCRVHDGRAHQLHAHLLQHAIVVRRYDDEWLRDYLRITVGTPEQTDRILAALDTFR
CCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA