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The map label for this gene is hisB [H]

Identifier: 221632460

GI number: 221632460

Start: 430134

End: 430742

Strand: Reverse

Name: hisB [H]

Synonym: trd_0434

Alternate gene names: 221632460

Gene position: 430742-430134 (Counterclockwise)

Preceding gene: 221632461

Following gene: 221632450

Centisome position: 21.5

GC content: 62.89

Gene sequence:

>609_bases
TTGACAGAAATCCGAAGAGCCTCCATTCGGCGCACGACGACCGAGACCGACGTCAGTGTCGATTTGATCATCGATGGAAC
CGGACGCTCGAGTGTCGCGACCGGGATCGGTGCACTCGACCATTTCTTGACGCTCTTCGCGCGACACGGGCGCTTCGATA
TCGACATCCAGGCGCGCGGTGACCTCCATGTCGATGCGCACCATACGGTGGAGGACGTCGCGCTCTGCCTCGGTCAGGCG
CTCCGACGCGCCCTGGGCGACTGGCGCGGTATTCGTCGTATGGCCGATGCGGCTGTGCCGATGGACGAAGCGCTCGCCCA
GGTAGCCGTCGATCTCAGCGGGCGCGGCTCGTTTCACTACCGTGACCCCTGGCCAGGTGGGGCCGTCGGCCAACTCGAGG
CCGATCTCGTCCGCCACTTTCTGGAGACGCTCGCTCGGGAGGCTCGCATCACGATTCACGTGGTGACACTCTACGGTTCC
AACGTTCACCATCAGATCGAAGCGATTTTCAAAGCACTGGCCCGCGCGCTCGATGCCGCCACCGAACTCGATACCCGCAT
CGCTGGGCAACTGCCCAGTACCAAGGAACACCTGGAAATTCAGGGGTGA

Upstream 100 bases:

>100_bases
GCGACTACTTGCGGATCACCGTCGGGACACCCGAGCAGACCGACCGCATTCTCGCCGCCCTCGACACATTCCGGTGATGG
ACAACGAGAGGAGCACGCCG

Downstream 100 bases:

>100_bases
GCAGCCTCACGACAGACCGAGCGCACGCCTTTGGACGAGCATGAGTTCGCTGATGCCCCGCTCGGCAAGCCGCAACAGCT
GTTCCAGCACCTCGCGTCCG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MTEIRRASIRRTTTETDVSVDLIIDGTGRSSVATGIGALDHFLTLFARHGRFDIDIQARGDLHVDAHHTVEDVALCLGQA
LRRALGDWRGIRRMADAAVPMDEALAQVAVDLSGRGSFHYRDPWPGGAVGQLEADLVRHFLETLAREARITIHVVTLYGS
NVHHQIEAIFKALARALDAATELDTRIAGQLPSTKEHLEIQG

Sequences:

>Translated_202_residues
MTEIRRASIRRTTTETDVSVDLIIDGTGRSSVATGIGALDHFLTLFARHGRFDIDIQARGDLHVDAHHTVEDVALCLGQA
LRRALGDWRGIRRMADAAVPMDEALAQVAVDLSGRGSFHYRDPWPGGAVGQLEADLVRHFLETLAREARITIHVVTLYGS
NVHHQIEAIFKALARALDAATELDTRIAGQLPSTKEHLEIQG
>Mature_201_residues
TEIRRASIRRTTTETDVSVDLIIDGTGRSSVATGIGALDHFLTLFARHGRFDIDIQARGDLHVDAHHTVEDVALCLGQAL
RRALGDWRGIRRMADAAVPMDEALAQVAVDLSGRGSFHYRDPWPGGAVGQLEADLVRHFLETLAREARITIHVVTLYGSN
VHHQIEAIFKALARALDAATELDTRIAGQLPSTKEHLEIQG

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=192, Percent_Identity=42.7083333333333, Blast_Score=151, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324776, Length=219, Percent_Identity=36.5296803652968, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22141; Mature: 22010

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIRRASIRRTTTETDVSVDLIIDGTGRSSVATGIGALDHFLTLFARHGRFDIDIQARG
CCCHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
DLHVDAHHTVEDVALCLGQALRRALGDWRGIRRMADAAVPMDEALAQVAVDLSGRGSFHY
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
RDPWPGGAVGQLEADLVRHFLETLAREARITIHVVTLYGSNVHHQIEAIFKALARALDAA
CCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
TELDTRIAGQLPSTKEHLEIQG
HHHHHHHHCCCCCCHHCEEECC
>Mature Secondary Structure 
TEIRRASIRRTTTETDVSVDLIIDGTGRSSVATGIGALDHFLTLFARHGRFDIDIQARG
CCHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
DLHVDAHHTVEDVALCLGQALRRALGDWRGIRRMADAAVPMDEALAQVAVDLSGRGSFHY
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
RDPWPGGAVGQLEADLVRHFLETLAREARITIHVVTLYGSNVHHQIEAIFKALARALDAA
CCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
TELDTRIAGQLPSTKEHLEIQG
HHHHHHHHCCCCCCHHCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA