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The map label for this gene is lpxA [H]

Identifier: 220932591

GI number: 220932591

Start: 1876528

End: 1877337

Strand: Reverse

Name: lpxA [H]

Synonym: Hore_17550

Alternate gene names: 220932591

Gene position: 1877337-1876528 (Counterclockwise)

Preceding gene: 220932592

Following gene: 220932590

Centisome position: 72.82

GC content: 43.7

Gene sequence:

>810_bases
GTGAAACCTAAGCATGAAGGAAAACTTCTTCATATGGCCAAGATTCATGAGACTGCCATTGTGCATCCCGGTGCCAAAAT
CGGCAAAAATGTTGAGATCGGGCCATATTCTATAATTGGAGAAAATGTTGAAATCGGTGAGGGGACCAAAATAGGCCCCC
ATGTTGTCGTTGAAGGCTGGACAACCATTGGCAAGAATAATCAAATCTTCCACGGGGCTTCTATTGGTCTAGAACCCCAG
GATATGAAATTTAAAGGAGAAAAAAGCTATCTATTTATTGGAGATAACAATATAATCAGGGAAAATGTAACCATTCACCG
GGGTACCGAAGAGGGGGGCGGCGAGACCAGGATTGGTAATAATAACCTGATAATGGCTTATTGCCATGTAGCCCATGACT
GTCAACTCGGAAACCATATAATTATGTCCAATGCTACCAATCTGGCCGGGCATGTTATTATAGAGGACTATGTTGTTATG
TCTGGTTTGACCGGGGTTCATCAGTTTGTAAGAGTCGGAAAAATGGCCATGGTCGGGGCCCATTCCAAGGTTGTTAAAGA
TGTGCCTCCATATATTCTTGTTGATGGACATCCGGCCCGGGTTAATGGTATCAATGTAGTTGGCCTGCGGAGAAATGGGG
TTGACCCTGATTTGAGACAGGAAATTAAAAGGGCCTATAAAATTCTCTACCGTTCCAATCTCAATACTTCCCAGGCCATT
GAAAAGATGGATCAGGAACTGGATGCCAGTGAAGAAATTGAACACTTTTTAAGGTTTTTACGTAATGCCCAGCGCGGGAT
TTGCCGTTAG

Upstream 100 bases:

>100_bases
TCGGCAAGATTGCAGCTAAAGGTTTTGTTGAGGATGAATTAGCAGCTGAGGCTGAATTAATGTTTGCTATAAATGATAAG
TAGAAAGGGGCTTGGTAGGT

Downstream 100 bases:

>100_bases
GTGGGTGGTCAAAGATGTCAAAAATAGGTTTAATTGCCGGCAGGGGTAAATTGCCTGCCATCTGGGCTGCAAGTGCGCGG
GACCGGGGACATGATGTTTA

Product: acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKPKHEGKLLHMAKIHETAIVHPGAKIGKNVEIGPYSIIGENVEIGEGTKIGPHVVVEGWTTIGKNNQIFHGASIGLEPQ
DMKFKGEKSYLFIGDNNIIRENVTIHRGTEEGGGETRIGNNNLIMAYCHVAHDCQLGNHIIMSNATNLAGHVIIEDYVVM
SGLTGVHQFVRVGKMAMVGAHSKVVKDVPPYILVDGHPARVNGINVVGLRRNGVDPDLRQEIKRAYKILYRSNLNTSQAI
EKMDQELDASEEIEHFLRFLRNAQRGICR

Sequences:

>Translated_269_residues
MKPKHEGKLLHMAKIHETAIVHPGAKIGKNVEIGPYSIIGENVEIGEGTKIGPHVVVEGWTTIGKNNQIFHGASIGLEPQ
DMKFKGEKSYLFIGDNNIIRENVTIHRGTEEGGGETRIGNNNLIMAYCHVAHDCQLGNHIIMSNATNLAGHVIIEDYVVM
SGLTGVHQFVRVGKMAMVGAHSKVVKDVPPYILVDGHPARVNGINVVGLRRNGVDPDLRQEIKRAYKILYRSNLNTSQAI
EKMDQELDASEEIEHFLRFLRNAQRGICR
>Mature_269_residues
MKPKHEGKLLHMAKIHETAIVHPGAKIGKNVEIGPYSIIGENVEIGEGTKIGPHVVVEGWTTIGKNNQIFHGASIGLEPQ
DMKFKGEKSYLFIGDNNIIRENVTIHRGTEEGGGETRIGNNNLIMAYCHVAHDCQLGNHIIMSNATNLAGHVIIEDYVVM
SGLTGVHQFVRVGKMAMVGAHSKVVKDVPPYILVDGHPARVNGINVVGLRRNGVDPDLRQEIKRAYKILYRSNLNTSQAI
EKMDQELDASEEIEHFLRFLRNAQRGICR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=257, Percent_Identity=45.5252918287938, Blast_Score=238, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 29775; Mature: 29775

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPKHEGKLLHMAKIHETAIVHPGAKIGKNVEIGPYSIIGENVEIGEGTKIGPHVVVEGW
CCCCCCCCEEEEEEHHHHEEECCCHHHCCCCCCCCEEEECCCEEECCCCCCCCEEEEECE
TTIGKNNQIFHGASIGLEPQDMKFKGEKSYLFIGDNNIIRENVTIHRGTEEGGGETRIGN
EEECCCCEEEECCCCCCCCCCCEECCCCCEEEECCCCEEECCEEEEECCCCCCCCEEECC
NNLIMAYCHVAHDCQLGNHIIMSNATNLAGHVIIEDYVVMSGLTGVHQFVRVGKMAMVGA
CCEEEEEEEECCCCCCCCEEEEECCCCCCEEEEEHHHHHHHCCHHHHHHHHHHHHHEECC
HSKVVKDVPPYILVDGHPARVNGINVVGLRRNGVDPDLRQEIKRAYKILYRSNLNTSQAI
CHHHHHCCCCEEEECCCCCEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
EKMDQELDASEEIEHFLRFLRNAQRGICR
HHHHHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKPKHEGKLLHMAKIHETAIVHPGAKIGKNVEIGPYSIIGENVEIGEGTKIGPHVVVEGW
CCCCCCCCEEEEEEHHHHEEECCCHHHCCCCCCCCEEEECCCEEECCCCCCCCEEEEECE
TTIGKNNQIFHGASIGLEPQDMKFKGEKSYLFIGDNNIIRENVTIHRGTEEGGGETRIGN
EEECCCCEEEECCCCCCCCCCCEECCCCCEEEECCCCEEECCEEEEECCCCCCCCEEECC
NNLIMAYCHVAHDCQLGNHIIMSNATNLAGHVIIEDYVVMSGLTGVHQFVRVGKMAMVGA
CCEEEEEEEECCCCCCCCEEEEECCCCCCEEEEEHHHHHHHCCHHHHHHHHHHHHHEECC
HSKVVKDVPPYILVDGHPARVNGINVVGLRRNGVDPDLRQEIKRAYKILYRSNLNTSQAI
CHHHHHCCCCEEEECCCCCEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
EKMDQELDASEEIEHFLRFLRNAQRGICR
HHHHHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA