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The map label for this gene is tktA [H]

Identifier: 220903758

GI number: 220903758

Start: 588921

End: 590924

Strand: Reverse

Name: tktA [H]

Synonym: Ddes_0480

Alternate gene names: 220903758

Gene position: 590924-588921 (Counterclockwise)

Preceding gene: 220903759

Following gene: 220903757

Centisome position: 20.57

GC content: 62.52

Gene sequence:

>2004_bases
ATGCCCACCCGCAGACAGTGCGCCAACGCCATCCGCGCCCTTGCCATGGACGCTATTGAGAAAGCCCGCTCCGGCCACCC
CGGTGCGCCCCTCGGCATGGCCGATATGGCCGAAGCCCTCTGGCGGCACGGTTTCAGGCATAATCCTGCCAATCCCCTGT
GGTTCAACCGCGACCGCTTTGTACTCTCCAACGGGCATGCGTCCATGCTGCTCTACGCCCTGCTGCACCTCACGGGCTAC
GACATCCCCATGGAAGAAATACGCAATTTCCGCCAGTGGGGAGCAAAAACCGCCGGGCATCCCGAATACGAGCCGCATCT
GGGTATTGAAATGACCACCGGCCCTCTGGGGCAGGGCATTGCCTCCGCCGTGGGCATGGCCCTGGCCGAGAGCATGCTGG
CCGCGCAGTTCAACACTCCCGAGTACAAGGTTGTGGACCACCACACCTACGTTTTTGTGGGCGACGGCTGCCTGATGGAA
GGCGTTTCGCATGAGGCCTGTTCCCTTGCGGGAACCTGGGGCCTCGGCAAGCTCATCGCCATGTATGACTCCAACGGTAT
TTCCATTGACGGCAAGATCGACGGCTGGTTCAACGAAGACGTGGCCGCCCGCTACCGCGCCTACAACTGGCAGGTCATCG
GCCCTGTTGACGGGCATGACGCCGCCGCTCTGGACAAAGCCCTGGCCGAAGCAAAGGCCGATACGGACCGCCCGAGCCTC
ATCATCTGCCGCACCCACATCGGCTTCGCCTCTCCCAAGGCCGATTCGGCCTCCAGCCACGGCTCCCCCCTGGGCGAAGA
CGGCGTAGCCGCCACGCGTGATGCCCTTGGCTGGCACGAACCGCCCTTTACCATTCCGCAGGACATCTACAGCGCCTGGA
ACGCACGTGTGGCCGGAAAATCTCTGGAAGCGGCATGGGACAATCTTTTTGCCGCCTATGCCGAAGCCCATCCTGAAAAG
GCCGCCGAACTGACCCGGCGCATGCGCGGCGAACTGCCCGCAGACTGGGCTGAAATTGCCCGCAACGCCGTTACCGAGGC
CGTCAGCCAGGGGGCCGATACGGCTACCCGTGTGGCCTCCAAAACAACCCTGGAATATCTTGTGCCGCGCCTGCCCGAAC
TGGCGGGCGGCTCTGCCGACCTCACAGGCTCTGTTGGTACGCTCACAAGCTCGTCGATACATATGGATGTAAAGAATCAC
ACCGGCAACTACATTTCCTACGGTGTGCGCGAATTCGGCATGAGTGCCATCATGAACGGCCTGGCCCTGCACGGCGGCTT
TATTCCCTATGCAGGAACGTTCCTTGCGTTTGCCGATCAAGCCAAAAACGCCCTGCGTCTGGCTGCCATTATGGGCATCC
GCGTCATATGGGTGCTGACGCACGACTCCATCGGCGTGGGTGAAGACGGTCCCACCCACCAGCCTGTGGAACAGCTGGGG
ATGCTGCGCCTCATGCCGGGCTTCAACCTCTGGCGCCCCTGCGACACAGTGGAAACCGCCGTGGCCTGGACTTGCGCCCT
GGAAGCCGGGCATACGCCTTCGGGCCTCTCCCTTTCGCGCCAGACCCTGCCCTTCTGCCCGCGCAGCGAGGAACAGGTGG
CGGCTATTGCCCGTGGCGGCTATGTGCTGCGCGACTGCGAAGGAACCCCCGAGATCATCATCATGGCTACCGGTTCCGAA
GTTGCCCTGGCGCTTGGCGCTGCCGAACAGCTTGCCGCTGACGGCCGCAAGGCGCGTGTCGTCTCCATGCCCTGCGCCGA
GTTATTTGACGCCCAGAGCGATGAATACAAAGAAAGCGTGCTGCCTTCCGCTGTCCGTGCGCGGCTGGCGATTGAAGCCT
CTGCGTCTGACTGGTGGCTCAAGTATGTAGGCCTTGACGGAGCGGTTATCGGCATGGAAGGCTTTGGGGCTTCGGCTCCG
GGCAAGGTGGTTTTTGAACGTCTTGGCTTTACCGTAGCCAACACGCTGGAAAAAGCCCGCGCCCTCATGGCCGGAAAACG
CTGA

Upstream 100 bases:

>100_bases
AAATCTCTGGACGGCCGCGAGCAGCGCCCCGCGCTGCAAAAGGCCGCCCGGCGTCAGACCTTTGCCCTTACTCATCCCAA
GCAAAAATAGAGGAATGATC

Downstream 100 bases:

>100_bases
CAACACTTCCGCGCGGGCGCTTCTTCAGACGCGCCCGCGCGTATAAAAACATATTGCCTGACATGCCGGCGGCAGGCAGG
ATCAGCCTGACTGTTGCGCG

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MPTRRQCANAIRALAMDAIEKARSGHPGAPLGMADMAEALWRHGFRHNPANPLWFNRDRFVLSNGHASMLLYALLHLTGY
DIPMEEIRNFRQWGAKTAGHPEYEPHLGIEMTTGPLGQGIASAVGMALAESMLAAQFNTPEYKVVDHHTYVFVGDGCLME
GVSHEACSLAGTWGLGKLIAMYDSNGISIDGKIDGWFNEDVAARYRAYNWQVIGPVDGHDAAALDKALAEAKADTDRPSL
IICRTHIGFASPKADSASSHGSPLGEDGVAATRDALGWHEPPFTIPQDIYSAWNARVAGKSLEAAWDNLFAAYAEAHPEK
AAELTRRMRGELPADWAEIARNAVTEAVSQGADTATRVASKTTLEYLVPRLPELAGGSADLTGSVGTLTSSSIHMDVKNH
TGNYISYGVREFGMSAIMNGLALHGGFIPYAGTFLAFADQAKNALRLAAIMGIRVIWVLTHDSIGVGEDGPTHQPVEQLG
MLRLMPGFNLWRPCDTVETAVAWTCALEAGHTPSGLSLSRQTLPFCPRSEEQVAAIARGGYVLRDCEGTPEIIIMATGSE
VALALGAAEQLAADGRKARVVSMPCAELFDAQSDEYKESVLPSAVRARLAIEASASDWWLKYVGLDGAVIGMEGFGASAP
GKVVFERLGFTVANTLEKARALMAGKR

Sequences:

>Translated_667_residues
MPTRRQCANAIRALAMDAIEKARSGHPGAPLGMADMAEALWRHGFRHNPANPLWFNRDRFVLSNGHASMLLYALLHLTGY
DIPMEEIRNFRQWGAKTAGHPEYEPHLGIEMTTGPLGQGIASAVGMALAESMLAAQFNTPEYKVVDHHTYVFVGDGCLME
GVSHEACSLAGTWGLGKLIAMYDSNGISIDGKIDGWFNEDVAARYRAYNWQVIGPVDGHDAAALDKALAEAKADTDRPSL
IICRTHIGFASPKADSASSHGSPLGEDGVAATRDALGWHEPPFTIPQDIYSAWNARVAGKSLEAAWDNLFAAYAEAHPEK
AAELTRRMRGELPADWAEIARNAVTEAVSQGADTATRVASKTTLEYLVPRLPELAGGSADLTGSVGTLTSSSIHMDVKNH
TGNYISYGVREFGMSAIMNGLALHGGFIPYAGTFLAFADQAKNALRLAAIMGIRVIWVLTHDSIGVGEDGPTHQPVEQLG
MLRLMPGFNLWRPCDTVETAVAWTCALEAGHTPSGLSLSRQTLPFCPRSEEQVAAIARGGYVLRDCEGTPEIIIMATGSE
VALALGAAEQLAADGRKARVVSMPCAELFDAQSDEYKESVLPSAVRARLAIEASASDWWLKYVGLDGAVIGMEGFGASAP
GKVVFERLGFTVANTLEKARALMAGKR
>Mature_666_residues
PTRRQCANAIRALAMDAIEKARSGHPGAPLGMADMAEALWRHGFRHNPANPLWFNRDRFVLSNGHASMLLYALLHLTGYD
IPMEEIRNFRQWGAKTAGHPEYEPHLGIEMTTGPLGQGIASAVGMALAESMLAAQFNTPEYKVVDHHTYVFVGDGCLMEG
VSHEACSLAGTWGLGKLIAMYDSNGISIDGKIDGWFNEDVAARYRAYNWQVIGPVDGHDAAALDKALAEAKADTDRPSLI
ICRTHIGFASPKADSASSHGSPLGEDGVAATRDALGWHEPPFTIPQDIYSAWNARVAGKSLEAAWDNLFAAYAEAHPEKA
AELTRRMRGELPADWAEIARNAVTEAVSQGADTATRVASKTTLEYLVPRLPELAGGSADLTGSVGTLTSSSIHMDVKNHT
GNYISYGVREFGMSAIMNGLALHGGFIPYAGTFLAFADQAKNALRLAAIMGIRVIWVLTHDSIGVGEDGPTHQPVEQLGM
LRLMPGFNLWRPCDTVETAVAWTCALEAGHTPSGLSLSRQTLPFCPRSEEQVAAIARGGYVLRDCEGTPEIIIMATGSEV
ALALGAAEQLAADGRKARVVSMPCAELFDAQSDEYKESVLPSAVRARLAIEASASDWWLKYVGLDGAVIGMEGFGASAPG
KVVFERLGFTVANTLEKARALMAGKR

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=582, Percent_Identity=26.4604810996564, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI4507521, Length=582, Percent_Identity=26.4604810996564, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI133778974, Length=586, Percent_Identity=25.0853242320819, Blast_Score=131, Evalue=3e-30,
Organism=Escherichia coli, GI48994911, Length=664, Percent_Identity=59.1867469879518, Blast_Score=833, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=665, Percent_Identity=58.4962406015038, Blast_Score=820, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=581, Percent_Identity=25.9896729776248, Blast_Score=158, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=673, Percent_Identity=47.8454680534918, Blast_Score=592, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319593, Length=677, Percent_Identity=44.7562776957164, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=599, Percent_Identity=25.8764607679466, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45550715, Length=599, Percent_Identity=25.8764607679466, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24666278, Length=586, Percent_Identity=25.938566552901, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24645119, Length=565, Percent_Identity=26.0176991150442, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71528; Mature: 71397

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2 ; PS01346 CLAUDIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTRRQCANAIRALAMDAIEKARSGHPGAPLGMADMAEALWRHGFRHNPANPLWFNRDRF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCEE
VLSNGHASMLLYALLHLTGYDIPMEEIRNFRQWGAKTAGHPEYEPHLGIEMTTGPLGQGI
EEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCHHHH
ASAVGMALAESMLAAQFNTPEYKVVDHHTYVFVGDGCLMEGVSHEACSLAGTWGLGKLIA
HHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHCCCCCHHHHHCCCCCHHHEEE
MYDSNGISIDGKIDGWFNEDVAARYRAYNWQVIGPVDGHDAAALDKALAEAKADTDRPSL
EECCCCEEECCEECCCCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCE
IICRTHIGFASPKADSASSHGSPLGEDGVAATRDALGWHEPPFTIPQDIYSAWNARVAGK
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCHHCCC
SLEAAWDNLFAAYAEAHPEKAAELTRRMRGELPADWAEIARNAVTEAVSQGADTATRVAS
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
KTTLEYLVPRLPELAGGSADLTGSVGTLTSSSIHMDVKNHTGNYISYGVREFGMSAIMNG
HHHHHHHHHCCHHHCCCCCCCCCCCCCEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LALHGGFIPYAGTFLAFADQAKNALRLAAIMGIRVIWVLTHDSIGVGEDGPTHQPVEQLG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCHHHHC
MLRLMPGFNLWRPCDTVETAVAWTCALEAGHTPSGLSLSRQTLPFCPRSEEQVAAIARGG
CEEECCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
YVLRDCEGTPEIIIMATGSEVALALGAAEQLAADGRKARVVSMPCAELFDAQSDEYKESV
EEEEECCCCCCEEEEECCCCEEEECCCHHHHHCCCCCEEEEECCHHHHHCCCCHHHHHHH
LPSAVRARLAIEASASDWWLKYVGLDGAVIGMEGFGASAPGKVVFERLGFTVANTLEKAR
CCHHHHHEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHCHHHHHHHHHHH
ALMAGKR
HHHCCCC
>Mature Secondary Structure 
PTRRQCANAIRALAMDAIEKARSGHPGAPLGMADMAEALWRHGFRHNPANPLWFNRDRF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCEE
VLSNGHASMLLYALLHLTGYDIPMEEIRNFRQWGAKTAGHPEYEPHLGIEMTTGPLGQGI
EEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCHHHH
ASAVGMALAESMLAAQFNTPEYKVVDHHTYVFVGDGCLMEGVSHEACSLAGTWGLGKLIA
HHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHCCCCCHHHHHCCCCCHHHEEE
MYDSNGISIDGKIDGWFNEDVAARYRAYNWQVIGPVDGHDAAALDKALAEAKADTDRPSL
EECCCCEEECCEECCCCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCE
IICRTHIGFASPKADSASSHGSPLGEDGVAATRDALGWHEPPFTIPQDIYSAWNARVAGK
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCHHCCC
SLEAAWDNLFAAYAEAHPEKAAELTRRMRGELPADWAEIARNAVTEAVSQGADTATRVAS
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
KTTLEYLVPRLPELAGGSADLTGSVGTLTSSSIHMDVKNHTGNYISYGVREFGMSAIMNG
HHHHHHHHHCCHHHCCCCCCCCCCCCCEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LALHGGFIPYAGTFLAFADQAKNALRLAAIMGIRVIWVLTHDSIGVGEDGPTHQPVEQLG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCHHHHC
MLRLMPGFNLWRPCDTVETAVAWTCALEAGHTPSGLSLSRQTLPFCPRSEEQVAAIARGG
CEEECCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
YVLRDCEGTPEIIIMATGSEVALALGAAEQLAADGRKARVVSMPCAELFDAQSDEYKESV
EEEEECCCCCCEEEEECCCCEEEECCCHHHHHCCCCCEEEEECCHHHHHCCCCHHHHHHH
LPSAVRARLAIEASASDWWLKYVGLDGAVIGMEGFGASAPGKVVFERLGFTVANTLEKAR
CCHHHHHEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHCHHHHHHHHHHH
ALMAGKR
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]