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The map label for this gene is hisD

Identifier: 21242573

GI number: 21242573

Start: 2124470

End: 2125765

Strand: Direct

Name: hisD

Synonym: XAC1829

Alternate gene names: 21242573

Gene position: 2124470-2125765 (Clockwise)

Preceding gene: 21242572

Following gene: 21242574

Centisome position: 41.05

GC content: 67.36

Gene sequence:

>1296_bases
ATGAAGATTCTCGATTGGTCCCAACTCGACGGTGCCGCACAGACCGACGCATTGACCCGCCCGGTGCAGACCGTGGCCGC
ACGAACGCGCGATGCGGTCGCCGCGTTGATTGCCGACGTACGCACGCGCGGCGATGCCGCATTGCGCGAGATCACCGCGC
ATTTCGATGGCGTGTCGCTGGACAGCTTCGCAGTGAGCGAAGCCGAATTCGCCGCCGCCGAAGCGGCCGTCCCACCGGAG
CTGCGCCAGGCCATGCAGGATGCGGTTGCACGCATCGACACCTTCCACCGCGCCGGTATGAGCGGGGGCTATGCGGTGGA
AACCGCGCCCGGTGTGGTGTGCGAAAAGATCGTGCGTCCGATCGGTCGTGTCGGTTTATACGTGCCGGCCGGCAGCGCGC
CGTTGCCGTCGACGGCATTGATGCTCGGCGTGCCTGCGCGTCTGGCCGGATGCCGCGAGGTGGTGTTGTGCACGCCGCCG
CGCAAGGACGGCAGCGTGGACCCGGCGGTGCTGGTGGCCGCGCGGCTCACCGGCGTGCGCCGCGTGTTCAAGCTCGGCGG
TGCGCAGGCGATCGCGGCGATGGCGTATGGCACCGAATCGCTGCCCAGCTGCGACAAGCTGTTCGGCCCGGGCAACAGCT
ATGTCACCGAAGCCAAGCAGCAGGTGGCCCAGTCCGGTGCGGCGGCGATCGACATGCCGGCCGGCCCCTCGGAAGTCTTG
GTGATCGCCGATGCGGGCGCGCAACCGGCGTTCGTGGCTGCTGACCTATTGTCGCAGGCCGAACACGGGCCCGATTCGCA
GGTGCTGTTGCTCTCCGACAGCGACGCGTTGATCGGTGCGGTGCGAGCGCAGCTGGAAGTTCAGCTGGCGCAACTGTCGC
GTGCCGACATTGCGCGCCAGGCGCTGGCGCAATCGCGGCTGATCAAGGTGCAGACGCTGGATGAGGCGTTTGCGATCAGT
AATCGCTATGCGCCGGAACATCTGATTCTTGCGCTGCGCGAACCGCGCGGATGGTTGGCGCAAGTCGAAGCGGCCGGATC
GGTGTTTCTCGGCGATTACACGCCCGAAGCGCTTGGCGACTACTGCAGCGGCACCAATCATGTATTGCCGACCAGCGGTG
CGGCGCGCGCCTACAGCGGCGTGAGCGTGGCCAGCTTCCAGAACATGGTCAGCGTGCAGGCAGCCAGCAAGGCCGGCATC
GACGGTATCGGCGCATGCGCTTTGGTCCTCGCGCGGGCCGAGGGGCTGGATGCGCATGCCAACGCGGTGGCGCTACGCAT
GGGAGTGGCGGCATGA

Upstream 100 bases:

>100_bases
AGACCATGTGCCACGGCGCGGTGACCTGGCAGCGCCTGGAAGAACTCGAACGCGCAGGTGCGCAAGGCTTGATGGTGTTG
ACGGTGGAGCGCTCGCTGGC

Downstream 100 bases:

>100_bases
GCGCGTCGTCGATTCTGGATCTGGTACGCGAAGACCTGCGTGCATTCGCGGGCTATTCGTCGGCGCGCACCAGCGCGTTG
CAGGGCGATGTGTGGCTCAA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKILDWSQLDGAAQTDALTRPVQTVAARTRDAVAALIADVRTRGDAALREITAHFDGVSLDSFAVSEAEFAAAEAAVPPE
LRQAMQDAVARIDTFHRAGMSGGYAVETAPGVVCEKIVRPIGRVGLYVPAGSAPLPSTALMLGVPARLAGCREVVLCTPP
RKDGSVDPAVLVAARLTGVRRVFKLGGAQAIAAMAYGTESLPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
VIADAGAQPAFVAADLLSQAEHGPDSQVLLLSDSDALIGAVRAQLEVQLAQLSRADIARQALAQSRLIKVQTLDEAFAIS
NRYAPEHLILALREPRGWLAQVEAAGSVFLGDYTPEALGDYCSGTNHVLPTSGAARAYSGVSVASFQNMVSVQAASKAGI
DGIGACALVLARAEGLDAHANAVALRMGVAA

Sequences:

>Translated_431_residues
MKILDWSQLDGAAQTDALTRPVQTVAARTRDAVAALIADVRTRGDAALREITAHFDGVSLDSFAVSEAEFAAAEAAVPPE
LRQAMQDAVARIDTFHRAGMSGGYAVETAPGVVCEKIVRPIGRVGLYVPAGSAPLPSTALMLGVPARLAGCREVVLCTPP
RKDGSVDPAVLVAARLTGVRRVFKLGGAQAIAAMAYGTESLPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
VIADAGAQPAFVAADLLSQAEHGPDSQVLLLSDSDALIGAVRAQLEVQLAQLSRADIARQALAQSRLIKVQTLDEAFAIS
NRYAPEHLILALREPRGWLAQVEAAGSVFLGDYTPEALGDYCSGTNHVLPTSGAARAYSGVSVASFQNMVSVQAASKAGI
DGIGACALVLARAEGLDAHANAVALRMGVAA
>Mature_431_residues
MKILDWSQLDGAAQTDALTRPVQTVAARTRDAVAALIADVRTRGDAALREITAHFDGVSLDSFAVSEAEFAAAEAAVPPE
LRQAMQDAVARIDTFHRAGMSGGYAVETAPGVVCEKIVRPIGRVGLYVPAGSAPLPSTALMLGVPARLAGCREVVLCTPP
RKDGSVDPAVLVAARLTGVRRVFKLGGAQAIAAMAYGTESLPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
VIADAGAQPAFVAADLLSQAEHGPDSQVLLLSDSDALIGAVRAQLEVQLAQLSRADIARQALAQSRLIKVQTLDEAFAIS
NRYAPEHLILALREPRGWLAQVEAAGSVFLGDYTPEALGDYCSGTNHVLPTSGAARAYSGVSVASFQNMVSVQAASKAGI
DGIGACALVLARAEGLDAHANAVALRMGVAA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=427, Percent_Identity=51.7564402810305, Blast_Score=421, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319819, Length=425, Percent_Identity=47.2941176470588, Blast_Score=378, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_XANAC (Q8PLG9)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642155.1
- ProteinModelPortal:   Q8PLG9
- SMR:   Q8PLG9
- GeneID:   1155900
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1829
- NMPDR:   fig|190486.1.peg.1799
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   XAXO190486:XAC1829-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 44439; Mature: 44439

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 326-326 ACT_SITE 327-327 BINDING 127-127 BINDING 189-189 BINDING 212-212 BINDING 237-237 BINDING 259-259 BINDING 262-262 BINDING 327-327 BINDING 360-360 BINDING 414-414 BINDING 419-419

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILDWSQLDGAAQTDALTRPVQTVAARTRDAVAALIADVRTRGDAALREITAHFDGVSL
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
DSFAVSEAEFAAAEAAVPPELRQAMQDAVARIDTFHRAGMSGGYAVETAPGVVCEKIVRP
CHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
IGRVGLYVPAGSAPLPSTALMLGVPARLAGCREVVLCTPPRKDGSVDPAVLVAARLTGVR
HHHCEEEECCCCCCCCCHHHEECCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
RVFKLGGAQAIAAMAYGTESLPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
HHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEE
VIADAGAQPAFVAADLLSQAEHGPDSQVLLLSDSDALIGAVRAQLEVQLAQLSRADIARQ
EEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQSRLIKVQTLDEAFAISNRYAPEHLILALREPRGWLAQVEAAGSVFLGDYTPEALGD
HHHHHHEEEEEEHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHCCCCEEECCCCHHHHHH
YCSGTNHVLPTSGAARAYSGVSVASFQNMVSVQAASKAGIDGIGACALVLARAEGLDAHA
HHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
NAVALRMGVAA
CCEEEECCCCC
>Mature Secondary Structure
MKILDWSQLDGAAQTDALTRPVQTVAARTRDAVAALIADVRTRGDAALREITAHFDGVSL
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
DSFAVSEAEFAAAEAAVPPELRQAMQDAVARIDTFHRAGMSGGYAVETAPGVVCEKIVRP
CHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
IGRVGLYVPAGSAPLPSTALMLGVPARLAGCREVVLCTPPRKDGSVDPAVLVAARLTGVR
HHHCEEEECCCCCCCCCHHHEECCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
RVFKLGGAQAIAAMAYGTESLPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
HHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEE
VIADAGAQPAFVAADLLSQAEHGPDSQVLLLSDSDALIGAVRAQLEVQLAQLSRADIARQ
EEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQSRLIKVQTLDEAFAISNRYAPEHLILALREPRGWLAQVEAAGSVFLGDYTPEALGD
HHHHHHEEEEEEHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHCCCCEEECCCCHHHHHH
YCSGTNHVLPTSGAARAYSGVSVASFQNMVSVQAASKAGIDGIGACALVLARAEGLDAHA
HHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
NAVALRMGVAA
CCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217