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The map label for this gene is hisG

Identifier: 21242572

GI number: 21242572

Start: 2123559

End: 2124473

Strand: Direct

Name: hisG

Synonym: XAC1828

Alternate gene names: 21242572

Gene position: 2123559-2124473 (Clockwise)

Preceding gene: 21242571

Following gene: 21242573

Centisome position: 41.03

GC content: 68.2

Gene sequence:

>915_bases
ATGAGTGCTTCCACGGCAGCGCCGGCACGTGACCGGTTGCGTATCGCCATCCAGAAGAGCGGCCGCCTGGCCGAGCCGGC
GCGCAGCCTGCTGGCCGCCTGCGGGCTGAGCTGGCGGCAGAGCCGCGACAAGCTGTTCTGCTACGGCGAGTCGTTGCCGG
TGGACCTGCTGCTGGTGCGCGACGACGATATCCCCGGCCTGATCGCCGATGGCGTCTGCGACTTGGGCATTGTCGGCCAG
AACGAGCTGGAAGAGCAGGCCGCCGAGCGCCGCCGTCATGGCTTGCCGGCCGCCTATCACGCGGTACGTGGGGTCGGCTT
CGGCCAGTGCCGCCTGATGCTCGCCGTGCCGGAAGAATGGGACTGGCACGGCGTGGCGCAACTGGCGGGCAAGCGTATCG
CCACCAGCTACCCGGCGATCCTGGCCGATTGGCTGGAGCGGCAGGGCATCGAAGCGACGGTGGTGGAGTTGTCCGGTTCG
GTGGAAATCGCGCCGCGCCTGGGCACTGCCGATCTGATCTGCGATCTGGTCTCCAGCGGCGCCACCCTGGCCGCCAACCA
GCTCAAGCCGGTCGAACTGGTGATGGAAAGCGAAGCGGTGCTGGCCGGCGCGGTGCGCGAACCTGCCGATGCGCGTGCCG
GCCTGCTGGCAATGCTGTTGCGGCGCATGGACGGCGTGCTCAAGCTGCGCGACAGCAAGCTGCTGATGTTCCGTGCCGAA
CAGACCAAGGTCGATGCGTTGCGCCGCCTGCTGCCCGATGCTGATCCGCTGGTGCAGTTGCCCGACGATGGCAACGGCGC
GCTGCGCTTGCAGACCATGTGCCACGGCGCGGTGACCTGGCAGCGCCTGGAAGAACTCGAACGCGCAGGTGCGCAAGGCT
TGATGGTGTTGACGGTGGAGCGCTCGCTGGCATGA

Upstream 100 bases:

>100_bases
CGGGCGCGTTGCGCGCACCCTGGACCACGGTGCCGGCGGCTATGCCGCGGCCCTGCGCGAGCAGTCGTCGCGCCCCGACG
ACTCCCACTGAGAGAACAAG

Downstream 100 bases:

>100_bases
AGATTCTCGATTGGTCCCAACTCGACGGTGCCGCACAGACCGACGCATTGACCCGCCCGGTGCAGACCGTGGCCGCACGA
ACGCGCGATGCGGTCGCCGC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSASTAAPARDRLRIAIQKSGRLAEPARSLLAACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIADGVCDLGIVGQ
NELEEQAAERRRHGLPAAYHAVRGVGFGQCRLMLAVPEEWDWHGVAQLAGKRIATSYPAILADWLERQGIEATVVELSGS
VEIAPRLGTADLICDLVSSGATLAANQLKPVELVMESEAVLAGAVREPADARAGLLAMLLRRMDGVLKLRDSKLLMFRAE
QTKVDALRRLLPDADPLVQLPDDGNGALRLQTMCHGAVTWQRLEELERAGAQGLMVLTVERSLA

Sequences:

>Translated_304_residues
MSASTAAPARDRLRIAIQKSGRLAEPARSLLAACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIADGVCDLGIVGQ
NELEEQAAERRRHGLPAAYHAVRGVGFGQCRLMLAVPEEWDWHGVAQLAGKRIATSYPAILADWLERQGIEATVVELSGS
VEIAPRLGTADLICDLVSSGATLAANQLKPVELVMESEAVLAGAVREPADARAGLLAMLLRRMDGVLKLRDSKLLMFRAE
QTKVDALRRLLPDADPLVQLPDDGNGALRLQTMCHGAVTWQRLEELERAGAQGLMVLTVERSLA
>Mature_303_residues
SASTAAPARDRLRIAIQKSGRLAEPARSLLAACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIADGVCDLGIVGQN
ELEEQAAERRRHGLPAAYHAVRGVGFGQCRLMLAVPEEWDWHGVAQLAGKRIATSYPAILADWLERQGIEATVVELSGSV
EIAPRLGTADLICDLVSSGATLAANQLKPVELVMESEAVLAGAVREPADARAGLLAMLLRRMDGVLKLRDSKLLMFRAEQ
TKVDALRRLLPDADPLVQLPDDGNGALRLQTMCHGAVTWQRLEELERAGAQGLMVLTVERSLA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=293, Percent_Identity=44.0273037542662, Blast_Score=237, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6320896, Length=300, Percent_Identity=29.3333333333333, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_XANAC (Q8PLH0)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642154.1
- ProteinModelPortal:   Q8PLH0
- SMR:   Q8PLH0
- GeneID:   1155899
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1828
- NMPDR:   fig|190486.1.peg.1798
- HOGENOM:   HBG391868
- OMA:   LLMFRAE
- ProtClustDB:   PRK00489
- BioCyc:   XAXO190486:XAC1828-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32910; Mature: 32779

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASTAAPARDRLRIAIQKSGRLAEPARSLLAACGLSWRQSRDKLFCYGESLPVDLLLVR
CCCCCCCCCHHHEEEEEECCCCCHHHHHHHHHHHCCHHHCCCCCEEEECCCCCEEEEEEE
DDDIPGLIADGVCDLGIVGQNELEEQAAERRRHGLPAAYHAVRGVGFGQCRLMLAVPEEW
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCC
DWHGVAQLAGKRIATSYPAILADWLERQGIEATVVELSGSVEIAPRLGTADLICDLVSSG
CCHHHHHHHCCHHHHCCHHHHHHHHHHCCCEEEEEEECCCEEEECCCCHHHHHHHHHHCC
ATLAANQLKPVELVMESEAVLAGAVREPADARAGLLAMLLRRMDGVLKLRDSKLLMFRAE
CEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHEEECCCEEEEEECH
QTKVDALRRLLPDADPLVQLPDDGNGALRLQTMCHGAVTWQRLEELERAGAQGLMVLTVE
HHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEC
RSLA
CCCC
>Mature Secondary Structure 
SASTAAPARDRLRIAIQKSGRLAEPARSLLAACGLSWRQSRDKLFCYGESLPVDLLLVR
CCCCCCCCHHHEEEEEECCCCCHHHHHHHHHHHCCHHHCCCCCEEEECCCCCEEEEEEE
DDDIPGLIADGVCDLGIVGQNELEEQAAERRRHGLPAAYHAVRGVGFGQCRLMLAVPEEW
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCC
DWHGVAQLAGKRIATSYPAILADWLERQGIEATVVELSGSVEIAPRLGTADLICDLVSSG
CCHHHHHHHCCHHHHCCHHHHHHHHHHCCCEEEEEEECCCEEEECCCCHHHHHHHHHHCC
ATLAANQLKPVELVMESEAVLAGAVREPADARAGLLAMLLRRMDGVLKLRDSKLLMFRAE
CEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHEEECCCEEEEEECH
QTKVDALRRLLPDADPLVQLPDDGNGALRLQTMCHGAVTWQRLEELERAGAQGLMVLTVE
HHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEC
RSLA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217