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The map label for this gene is hisC

Identifier: 21242574

GI number: 21242574

Start: 2125762

End: 2126853

Strand: Direct

Name: hisC

Synonym: XAC1830

Alternate gene names: 21242574

Gene position: 2125762-2126853 (Clockwise)

Preceding gene: 21242573

Following gene: 21242575

Centisome position: 41.07

GC content: 66.3

Gene sequence:

>1092_bases
ATGAGCGCGTCGTCGATTCTGGATCTGGTACGCGAAGACCTGCGTGCATTCGCGGGCTATTCGTCGGCGCGCACCAGCGC
GTTGCAGGGCGATGTGTGGCTCAACGCCAACGAGTCTGCCTGGGCCAATCCCGCCGATCCCGACGCCAGCACACGGCGCT
ATCCCGACCCGCAACCCAAGGGCCTGCGCAGCGCGCTTGCGGCGCTGTACGGTTGCGCACCGGAGCAGCTGTTGATCGGC
CGCGGCAGCGACGAGGCGATCGATCTGCTGGTACGTGGCCTGTGCGTGCCAGAGCGCGATGCGGTGCTGGTCACGCCGCC
GGTGTTCGGCATGTACGCCGTGTGCGCACGGCTGCAGAACGCGCCGCTGGTGGACGTGCCGCTGGTCGACGGGCCCGACG
GTTTCCATGCGGATATCCCGGCGATCGTGGCAATGGCATTGTCTTCGAACGCGAAGTTGGTGTTCCTGTGTTCGCCGTCC
AATCCTGCTGGTTCGGCCATCGCGCTGGACCAGATCGAACAAGCGCTGCAGGCCTTGCAAGGCAAGGCGCTGGTGGTGGT
GGACGAGGCCTACGGCGAATTTTCCGATGTGCCTTCGGCGGTCGGCCTGCTCGGGCGTTACGACAATCTCGCCGTGTTGC
GCACGCTTTCCAAAGCGCATGCATTGGCGGCGGCACGTATCGGCACGCTGATCGCCAATGCCGAGTTGATCGCCTTGCTG
CGCCGCTGCCAGGCGCCGTACCCGGTGCCCACACCATGTGCAGCCATGGCCGAGCAGGCTTTGTCTGCGCCAGCGCTGGA
GGTTACCCGCCGCCGCATCGCCGAGGTGCGTAGCGAACGCGAACGTATGCACAAGGCGTTGGTGCAGCTGCCTGGCGTAC
GTCAGGTCTATCCCTCGCAAGGCAACTTCCTGCTGGTGCGTTTCGACGATGCCGAAGGCGCATTCCAGGCGCTCCTGGAG
GCCGGGGTGGTGGTGCGCGATCAACGCGCAGTGCCGCGCCTGGCCGACGCGTTGCGGATCACGCTGGGCACGAACGAACA
GAACCAGCGCGTGCTGAGCGCGCTGCAACGCACGCAGGAGGCCGCCGCATGA

Upstream 100 bases:

>100_bases
CCGGCATCGACGGTATCGGCGCATGCGCTTTGGTCCTCGCGCGGGCCGAGGGGCTGGATGCGCATGCCAACGCGGTGGCG
CTACGCATGGGAGTGGCGGC

Downstream 100 bases:

>100_bases
CCCCGATTCTTTTTGTCGACCGCGACGGCACGCTGATCGTCGAGCCGGCCGATTACCAGATCGACGCCTACGAAAAATTG
CGCTTGGTCGATCACGTGAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSASSILDLVREDLRAFAGYSSARTSALQGDVWLNANESAWANPADPDASTRRYPDPQPKGLRSALAALYGCAPEQLLIG
RGSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQNAPLVDVPLVDGPDGFHADIPAIVAMALSSNAKLVFLCSPS
NPAGSAIALDQIEQALQALQGKALVVVDEAYGEFSDVPSAVGLLGRYDNLAVLRTLSKAHALAAARIGTLIANAELIALL
RRCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERERMHKALVQLPGVRQVYPSQGNFLLVRFDDAEGAFQALLE
AGVVVRDQRAVPRLADALRITLGTNEQNQRVLSALQRTQEAAA

Sequences:

>Translated_363_residues
MSASSILDLVREDLRAFAGYSSARTSALQGDVWLNANESAWANPADPDASTRRYPDPQPKGLRSALAALYGCAPEQLLIG
RGSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQNAPLVDVPLVDGPDGFHADIPAIVAMALSSNAKLVFLCSPS
NPAGSAIALDQIEQALQALQGKALVVVDEAYGEFSDVPSAVGLLGRYDNLAVLRTLSKAHALAAARIGTLIANAELIALL
RRCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERERMHKALVQLPGVRQVYPSQGNFLLVRFDDAEGAFQALLE
AGVVVRDQRAVPRLADALRITLGTNEQNQRVLSALQRTQEAAA
>Mature_362_residues
SASSILDLVREDLRAFAGYSSARTSALQGDVWLNANESAWANPADPDASTRRYPDPQPKGLRSALAALYGCAPEQLLIGR
GSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQNAPLVDVPLVDGPDGFHADIPAIVAMALSSNAKLVFLCSPSN
PAGSAIALDQIEQALQALQGKALVVVDEAYGEFSDVPSAVGLLGRYDNLAVLRTLSKAHALAAARIGTLIANAELIALLR
RCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERERMHKALVQLPGVRQVYPSQGNFLLVRFDDAEGAFQALLEA
GVVVRDQRAVPRLADALRITLGTNEQNQRVLSALQRTQEAAA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=360, Percent_Identity=43.0555555555556, Blast_Score=281, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6322075, Length=374, Percent_Identity=32.8877005347594, Blast_Score=181, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_XANAC (P58891)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642156.1
- ProteinModelPortal:   P58891
- SMR:   P58891
- GeneID:   1155901
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1830
- NMPDR:   fig|190486.1.peg.1800
- HOGENOM:   HBG646350
- OMA:   IMRVIAP
- ProtClustDB:   PRK04781
- BioCyc:   XAXO190486:XAC1830-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38702; Mature: 38571

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASSILDLVREDLRAFAGYSSARTSALQGDVWLNANESAWANPADPDASTRRYPDPQPK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCH
GLRSALAALYGCAPEQLLIGRGSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQN
HHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHCC
APLVDVPLVDGPDGFHADIPAIVAMALSSNAKLVFLCSPSNPAGSAIALDQIEQALQALQ
CCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHC
GKALVVVDEAYGEFSDVPSAVGLLGRYDNLAVLRTLSKAHALAAARIGTLIANAELIALL
CCEEEEEECCCCCHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERERMHKALVQLPGVRQVYPSQ
HHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GNFLLVRFDDAEGAFQALLEAGVVVRDQRAVPRLADALRITLGTNEQNQRVLSALQRTQE
CCEEEEEECCCCHHHHHHHHCCCEEECCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHH
AAA
HCC
>Mature Secondary Structure 
SASSILDLVREDLRAFAGYSSARTSALQGDVWLNANESAWANPADPDASTRRYPDPQPK
CHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCH
GLRSALAALYGCAPEQLLIGRGSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQN
HHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHCC
APLVDVPLVDGPDGFHADIPAIVAMALSSNAKLVFLCSPSNPAGSAIALDQIEQALQALQ
CCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHC
GKALVVVDEAYGEFSDVPSAVGLLGRYDNLAVLRTLSKAHALAAARIGTLIANAELIALL
CCEEEEEECCCCCHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERERMHKALVQLPGVRQVYPSQ
HHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GNFLLVRFDDAEGAFQALLEAGVVVRDQRAVPRLADALRITLGTNEQNQRVLSALQRTQE
CCEEEEEECCCCHHHHHHHHCCCEEECCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHH
AAA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217