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The map label for this gene is GdhA [H]

Identifier: 20807660

GI number: 20807660

Start: 1204764

End: 1206005

Strand: Direct

Name: GdhA [H]

Synonym: TTE1205

Alternate gene names: 20807660

Gene position: 1204764-1206005 (Clockwise)

Preceding gene: 20807659

Following gene: 20807661

Centisome position: 44.8

GC content: 40.34

Gene sequence:

>1242_bases
ATGGCAGTTAATCCTTTAAAGGCTGTTCAAGAACAGATAAAAAATGCTTGTGAACTTCTCAATTTAGAAGAATCAGTCTA
TGAGATATTAAAAGAGCCTCTCAGAGTAATGGAAGTTTCCATTCCCGTACAGATGGACGATGGAACAGTGAAGGTATTTA
AAGGTTACAGGTCACAGCACAACGATGCCCTTGGACCTGCAAAAGGGGGAATAAGATTTCATCCGGACGTTACACTTGAT
GAAGTAAAAGCTCTTTCTATGTGGATGACCTTTAAATGCGGTGTAGTTGGGCTTCCATACGGCGGAGGAAAAGGAGGAGT
AGCAGTTAATCCTCAAGAACTTTCACCAACAGAACTAGAAAGATTGAGTAGAGGTTATATTCGGGCAATTTCCAGTATAA
TAGGGCCTGAAAAGGATATACCAGCACCTGACGTAGGTACAAATGCTCAAGTGATGGCATGGATGGTAGATGAGTATAAC
AAAATAGTCGGTTATAATAGTCCGGCAGTTATAACAGGAAAACCTTTGATATACGGGGGTTCAAAAGGTAGGGTTGATGC
TACAGGATATGGAGTAGCGCTAATCGCGCGCGAAGCTGCGAAAAAGTTAGAAATGGATATAAAGAACTGTACTGTAGCCA
TACAGGGTTACGGAAATGTAGGAAGTTACACGGGAATTCACCTGCAGAGACTGGGTGCAAAGATCGTAGGGGTAGTAGAT
ATATATGGAGGGGTATATAACGAAAGGGGAATTGACGCAGAGAAGTTAGCAGAACATGTGAGAAAGACAGGGAGTGTCAA
AGACTTTGAGGGCACTACTTCTTTAACAAATGAGGAACTATTTGCATTGGACGTAGATGTACTAATTCCCGCAGCTCTTG
AGAATCAAATTACGGAAGAAAATGCTCCGAATGTGAAAGCGAGGATGGTATGTGAAGCGGCAAATGGTCCTACAACACCT
GAGGCAGACAGGATACTGAGAGAAAAAGGAATTTTTGTAGTACCGGATATACTTGCTAATTCTGGTGGGGTGATTGTTTC
TTACTTCGAGTGGGTGCAGAATTTGATGAATTATTATTGGACTGAAGAAGAAATAAAAGAAAGGCAAGAGATTGTGATGA
TAAATGCATTTAATAATATATACCAATTGGCTCAAGAATATAAGGTTGATATGAGAACAGCTGCTTATATGATTGCTATA
AAGAGAATATATGAAGCGATGAAAGTAAGAGGATGGATATAG

Upstream 100 bases:

>100_bases
ATGGCTTCCCTGACGATTAAATTTTTATAGGGGTAAGGGGAAGAAATGTAACATTTTCCCTTACCCCGAAAAATAAAAAA
TTATGAGGAGGAATGTAAGA

Downstream 100 bases:

>100_bases
AGGAGGTAGAAAAATGAATCTCTCGCAGAATGCTCTTCAAATAACCCCTTCTATGACTTTAGAAATAACGGCAAAGGCGA
GACAGTTAAAGGCAGAGGGA

Product: glutamate dehydrogenase/leucine dehydrogenase

Products: NA

Alternate protein names: NAD-GDH [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MAVNPLKAVQEQIKNACELLNLEESVYEILKEPLRVMEVSIPVQMDDGTVKVFKGYRSQHNDALGPAKGGIRFHPDVTLD
EVKALSMWMTFKCGVVGLPYGGGKGGVAVNPQELSPTELERLSRGYIRAISSIIGPEKDIPAPDVGTNAQVMAWMVDEYN
KIVGYNSPAVITGKPLIYGGSKGRVDATGYGVALIAREAAKKLEMDIKNCTVAIQGYGNVGSYTGIHLQRLGAKIVGVVD
IYGGVYNERGIDAEKLAEHVRKTGSVKDFEGTTSLTNEELFALDVDVLIPAALENQITEENAPNVKARMVCEAANGPTTP
EADRILREKGIFVVPDILANSGGVIVSYFEWVQNLMNYYWTEEEIKERQEIVMINAFNNIYQLAQEYKVDMRTAAYMIAI
KRIYEAMKVRGWI

Sequences:

>Translated_413_residues
MAVNPLKAVQEQIKNACELLNLEESVYEILKEPLRVMEVSIPVQMDDGTVKVFKGYRSQHNDALGPAKGGIRFHPDVTLD
EVKALSMWMTFKCGVVGLPYGGGKGGVAVNPQELSPTELERLSRGYIRAISSIIGPEKDIPAPDVGTNAQVMAWMVDEYN
KIVGYNSPAVITGKPLIYGGSKGRVDATGYGVALIAREAAKKLEMDIKNCTVAIQGYGNVGSYTGIHLQRLGAKIVGVVD
IYGGVYNERGIDAEKLAEHVRKTGSVKDFEGTTSLTNEELFALDVDVLIPAALENQITEENAPNVKARMVCEAANGPTTP
EADRILREKGIFVVPDILANSGGVIVSYFEWVQNLMNYYWTEEEIKERQEIVMINAFNNIYQLAQEYKVDMRTAAYMIAI
KRIYEAMKVRGWI
>Mature_412_residues
AVNPLKAVQEQIKNACELLNLEESVYEILKEPLRVMEVSIPVQMDDGTVKVFKGYRSQHNDALGPAKGGIRFHPDVTLDE
VKALSMWMTFKCGVVGLPYGGGKGGVAVNPQELSPTELERLSRGYIRAISSIIGPEKDIPAPDVGTNAQVMAWMVDEYNK
IVGYNSPAVITGKPLIYGGSKGRVDATGYGVALIAREAAKKLEMDIKNCTVAIQGYGNVGSYTGIHLQRLGAKIVGVVDI
YGGVYNERGIDAEKLAEHVRKTGSVKDFEGTTSLTNEELFALDVDVLIPAALENQITEENAPNVKARMVCEAANGPTTPE
ADRILREKGIFVVPDILANSGGVIVSYFEWVQNLMNYYWTEEEIKERQEIVMINAFNNIYQLAQEYKVDMRTAAYMIAIK
RIYEAMKVRGWI

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=354, Percent_Identity=41.2429378531073, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI4885281, Length=348, Percent_Identity=41.9540229885057, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1788059, Length=400, Percent_Identity=31.25, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17544676, Length=456, Percent_Identity=34.6491228070175, Blast_Score=271, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6319256, Length=398, Percent_Identity=31.9095477386935, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6324951, Length=414, Percent_Identity=30.9178743961353, Blast_Score=169, Evalue=6e-43,
Organism=Drosophila melanogaster, GI45549226, Length=356, Percent_Identity=40.7303370786517, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI45553475, Length=356, Percent_Identity=40.7303370786517, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24649283, Length=357, Percent_Identity=39.4957983193277, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24649460, Length=295, Percent_Identity=40, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.2 [H]

Molecular weight: Translated: 45504; Mature: 45373

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNPLKAVQEQIKNACELLNLEESVYEILKEPLRVMEVSIPVQMDDGTVKVFKGYRSQH
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEEEECCCEEEEHHHHHHCC
NDALGPAKGGIRFHPDVTLDEVKALSMWMTFKCGVVGLPYGGGKGGVAVNPQELSPTELE
CCCCCCCCCCEEECCCCCHHHHHHHHHHHEEECCEEECCCCCCCCCEEECCCCCCHHHHH
RLSRGYIRAISSIIGPEKDIPAPDVGTNAQVMAWMVDEYNKIVGYNSPAVITGKPLIYGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCEEEECCEEEECC
SKGRVDATGYGVALIAREAAKKLEMDIKNCTVAIQGYGNVGSYTGIHLQRLGAKIVGVVD
CCCCEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCHHHEEHHH
IYGGVYNERGIDAEKLAEHVRKTGSVKDFEGTTSLTNEELFALDVDVLIPAALENQITEE
HHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCC
NAPNVKARMVCEAANGPTTPEADRILREKGIFVVPDILANSGGVIVSYFEWVQNLMNYYW
CCCCCEEEEEEECCCCCCCCHHHHHHHHCCCEEECHHHCCCCCEEEHHHHHHHHHHHHCC
TEEEIKERQEIVMINAFNNIYQLAQEYKVDMRTAAYMIAIKRIYEAMKVRGWI
CHHHHHCHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVNPLKAVQEQIKNACELLNLEESVYEILKEPLRVMEVSIPVQMDDGTVKVFKGYRSQH
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEEEECCCEEEEHHHHHHCC
NDALGPAKGGIRFHPDVTLDEVKALSMWMTFKCGVVGLPYGGGKGGVAVNPQELSPTELE
CCCCCCCCCCEEECCCCCHHHHHHHHHHHEEECCEEECCCCCCCCCEEECCCCCCHHHHH
RLSRGYIRAISSIIGPEKDIPAPDVGTNAQVMAWMVDEYNKIVGYNSPAVITGKPLIYGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCEEEECCEEEECC
SKGRVDATGYGVALIAREAAKKLEMDIKNCTVAIQGYGNVGSYTGIHLQRLGAKIVGVVD
CCCCEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCHHHEEHHH
IYGGVYNERGIDAEKLAEHVRKTGSVKDFEGTTSLTNEELFALDVDVLIPAALENQITEE
HHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCC
NAPNVKARMVCEAANGPTTPEADRILREKGIFVVPDILANSGGVIVSYFEWVQNLMNYYW
CCCCCEEEEEEECCCCCCCCHHHHHHHHCCCEEECHHHCCCCCEEEHHHHHHHHHHHHCC
TEEEIKERQEIVMINAFNNIYQLAQEYKVDMRTAAYMIAIKRIYEAMKVRGWI
CHHHHHCHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA