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The map label for this gene is icd [H]

Identifier: 197119273

GI number: 197119273

Start: 3345414

End: 3347645

Strand: Reverse

Name: icd [H]

Synonym: Gbem_2901

Alternate gene names: 197119273

Gene position: 3347645-3345414 (Counterclockwise)

Preceding gene: 197119274

Following gene: 197119272

Centisome position: 72.54

GC content: 61.65

Gene sequence:

>2232_bases
ATGACAACAGAAAAAGCAAAGATCGTTTGGACCAAGATCGACGAGGCCCCCGCACTGGCAACCTACTCCCTGCTCCCCAT
CGTCAACGCCTTCACCAAGGCCGCCGGCGTTGTCGTTGAAACCAGGGACATCTCCCTGGCAGGCAGGATCATTGCCAACT
TCCCGGACTACCTGACCGAGAGCCAGAAGATCCCGGACGAGCTGGCGTACCTGGGCGAACTGACCCAGAAGCCGGAAGCG
AACATCATCAAGCTTCCGAACGTCTCCGCCTCGATCCCGCAGCTGAAAGCAGCCATCGCCGAGCTCCAGAGCCAGGGTTA
CAAGCTCCCGGAATACCCGGAAGAGCCGAAGACCGACGAGGAGAAGGCGCTCAACGCACGCTACGCCAAGGTGCTCGGCT
CCGCCGTCAACCCGGTCCTCAGGGAAGGCAACTCCGACCGCCGCGTCGCCAAGGCAGTCAAGGAATACGCCAAGAAGCAC
CCGCACAAGATGGGCGCCTGGTCCTCCGACTCCAAAAGCCACGTCTCCAACATGAGCGCCGGCGACTTCTACCACAGCGA
GAAGTCGGTGACCCTGAAAGACGCCACCGTCGCCCGCATCGAGTTCGTCGACAACTTCGGCAACGTCACCGTGATGAAGG
AAAAGCTCCCGCTGCAGGCAGGCGAGGTGCTGGACGGCTCCTTCATGAACGTGCGCGCCCTGAGGAAGTTCATCCAGGAG
CAGATCGACGACGCTAAAGCCAAGGGCGTGCTCTTCTCCGTGCACCTCAAGGCCACCATGATGAAGATCTCCGACCCGGT
CATCTTCGGCCACTTCGTCTCCGTCTATTTCAAGGACGTCTTCGAGAAGCACGCAGCTACCTTCAAGGAAATCGGCGTCA
ACGCCGACCTGGGCCTTGGCGACCTCTACAAGAAACTCGAGAAGGTTCCGGCAGGGAAGAAGGCCGAGATCGAGGCCGAC
ATCAAGGCCACCTACGCGAAGCAGCCGCCGCTGGCGATGGTCGACTCCGACAAAGGGATCACCAACCTGCACGCGTCCAA
CGACATCATCATCGACGCCTCCATGCCGGTCGTTATCCGCGACTCCGGCAAGATGTGGGCTCCGGACGGCAAACTCGCCG
ACACCAAGTGCGTGATTCCGGATACCTGCTACTCCGAGTGGTACCAGGAGTGCATCCAGTTCTGCAAGGAAAACGGCCAG
TTCGACCCGACCACCATGGGCGCCACCTCCAACGTCGGCCTCATGGCTCAGAAGGCTGAAGAGTACGGCTCACACGACAA
GACCTTCAAGGCTCCGCTGAACGGCACCATGCGCGTAGTCGATGCTTCCGGCGAAGTGCTGATCCAGCACCAGGTCGAAG
AGGGGGACATCTGGCGCGGCTGCCAGGCGAAAGATCTCCCGATCCGCGACTGGGTCAAGCTCGCCGTCAACCGTGCCCGC
GCCACCGGCGCTCCGGCCGTCTTCTGGCTCGACAAGAACAGGGCTCACGACGCCCAGATGATCAAGAAGGTGGAGACCTA
CCTGAAGGACCACGACACCAAAGGGCTCGAGCTGCACATCATGTCCCCGGTCGAGGCGATGAAATTCACCCTCCCCAGGG
CCAAGAAGGGTCTCGACACCATCACCGTGACCGGCAACGCGCTCAGGGATTACCTGACCGACCTGTTCCCGATCCTCGAG
CTCGGCACCTCCGCGAAGATGCTCTCCATCGTTCCGCTTCTTGCGGGCGGCGGCCTCTTCGAAACCGGTGCGGGCGGTTC
TGCTCCGAAGCACGTGCAGCAGTTCCAGCAGGAAGGCTACCTCCGTTGGGACTCCCTGGGCGAGTTCCTGGCCCTGGCAG
TCTCCCTGGAGCACCTGGCAGCAACCTTCAAAAACGAGAAGGCAGCACTCCTCGCCGAGACCCTCGACGCAGCCAACACC
AAGTTCCTGGATCAGAACAAGAACCCGGCGCGTAAGGTAGGCCAGATCGACAACCGCGGCAGCCACTTCTACCTCGCCAT
GTACTGGGCCGAGGCGGTCGCCGCCCAGACCAAGGACGCGGACCTCGCAGCCCGCTTCGCCAAGGTCGCCAAGGAGCTCC
AGGCCAACGAAGAGAAGATCAACGCCGAGCTGATCGGCGCACAGGGCAAGCCGGTCGACATGGGCGGTTACTACCACGCC
GACGATGCCAAGACCGAAGCGGCTATGCGCCCGAGCGCAACGCTGAACGCCATCATCAACTCGATCGTATAA

Upstream 100 bases:

>100_bases
CCCGCAAGCGAATAAAACAGCATATCGGGCACACCGTAGCCGCATAGTTGCCCCTTGAAAACGACTTTAGTGCAATTGGC
ATGAAACCCAAGGAGAGACA

Downstream 100 bases:

>100_bases
AGCTTTCGCTGCACCAGGTAGATAATCTCAATTTAATTACGGAGGAAGAAAAAATGGCACGTAAGAAAATCGCACTTATC
GGTGGTGGACAGATTGGCGG

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MTTEKAKIVWTKIDEAPALATYSLLPIVNAFTKAAGVVVETRDISLAGRIIANFPDYLTESQKIPDELAYLGELTQKPEA
NIIKLPNVSASIPQLKAAIAELQSQGYKLPEYPEEPKTDEEKALNARYAKVLGSAVNPVLREGNSDRRVAKAVKEYAKKH
PHKMGAWSSDSKSHVSNMSAGDFYHSEKSVTLKDATVARIEFVDNFGNVTVMKEKLPLQAGEVLDGSFMNVRALRKFIQE
QIDDAKAKGVLFSVHLKATMMKISDPVIFGHFVSVYFKDVFEKHAATFKEIGVNADLGLGDLYKKLEKVPAGKKAEIEAD
IKATYAKQPPLAMVDSDKGITNLHASNDIIIDASMPVVIRDSGKMWAPDGKLADTKCVIPDTCYSEWYQECIQFCKENGQ
FDPTTMGATSNVGLMAQKAEEYGSHDKTFKAPLNGTMRVVDASGEVLIQHQVEEGDIWRGCQAKDLPIRDWVKLAVNRAR
ATGAPAVFWLDKNRAHDAQMIKKVETYLKDHDTKGLELHIMSPVEAMKFTLPRAKKGLDTITVTGNALRDYLTDLFPILE
LGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFQQEGYLRWDSLGEFLALAVSLEHLAATFKNEKAALLAETLDAANT
KFLDQNKNPARKVGQIDNRGSHFYLAMYWAEAVAAQTKDADLAARFAKVAKELQANEEKINAELIGAQGKPVDMGGYYHA
DDAKTEAAMRPSATLNAIINSIV

Sequences:

>Translated_743_residues
MTTEKAKIVWTKIDEAPALATYSLLPIVNAFTKAAGVVVETRDISLAGRIIANFPDYLTESQKIPDELAYLGELTQKPEA
NIIKLPNVSASIPQLKAAIAELQSQGYKLPEYPEEPKTDEEKALNARYAKVLGSAVNPVLREGNSDRRVAKAVKEYAKKH
PHKMGAWSSDSKSHVSNMSAGDFYHSEKSVTLKDATVARIEFVDNFGNVTVMKEKLPLQAGEVLDGSFMNVRALRKFIQE
QIDDAKAKGVLFSVHLKATMMKISDPVIFGHFVSVYFKDVFEKHAATFKEIGVNADLGLGDLYKKLEKVPAGKKAEIEAD
IKATYAKQPPLAMVDSDKGITNLHASNDIIIDASMPVVIRDSGKMWAPDGKLADTKCVIPDTCYSEWYQECIQFCKENGQ
FDPTTMGATSNVGLMAQKAEEYGSHDKTFKAPLNGTMRVVDASGEVLIQHQVEEGDIWRGCQAKDLPIRDWVKLAVNRAR
ATGAPAVFWLDKNRAHDAQMIKKVETYLKDHDTKGLELHIMSPVEAMKFTLPRAKKGLDTITVTGNALRDYLTDLFPILE
LGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFQQEGYLRWDSLGEFLALAVSLEHLAATFKNEKAALLAETLDAANT
KFLDQNKNPARKVGQIDNRGSHFYLAMYWAEAVAAQTKDADLAARFAKVAKELQANEEKINAELIGAQGKPVDMGGYYHA
DDAKTEAAMRPSATLNAIINSIV
>Mature_742_residues
TTEKAKIVWTKIDEAPALATYSLLPIVNAFTKAAGVVVETRDISLAGRIIANFPDYLTESQKIPDELAYLGELTQKPEAN
IIKLPNVSASIPQLKAAIAELQSQGYKLPEYPEEPKTDEEKALNARYAKVLGSAVNPVLREGNSDRRVAKAVKEYAKKHP
HKMGAWSSDSKSHVSNMSAGDFYHSEKSVTLKDATVARIEFVDNFGNVTVMKEKLPLQAGEVLDGSFMNVRALRKFIQEQ
IDDAKAKGVLFSVHLKATMMKISDPVIFGHFVSVYFKDVFEKHAATFKEIGVNADLGLGDLYKKLEKVPAGKKAEIEADI
KATYAKQPPLAMVDSDKGITNLHASNDIIIDASMPVVIRDSGKMWAPDGKLADTKCVIPDTCYSEWYQECIQFCKENGQF
DPTTMGATSNVGLMAQKAEEYGSHDKTFKAPLNGTMRVVDASGEVLIQHQVEEGDIWRGCQAKDLPIRDWVKLAVNRARA
TGAPAVFWLDKNRAHDAQMIKKVETYLKDHDTKGLELHIMSPVEAMKFTLPRAKKGLDTITVTGNALRDYLTDLFPILEL
GTSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFQQEGYLRWDSLGEFLALAVSLEHLAATFKNEKAALLAETLDAANTK
FLDQNKNPARKVGQIDNRGSHFYLAMYWAEAVAAQTKDADLAARFAKVAKELQANEEKINAELIGAQGKPVDMGGYYHAD
DAKTEAAMRPSATLNAIINSIV

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 81508; Mature: 81377

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEKAKIVWTKIDEAPALATYSLLPIVNAFTKAAGVVVETRDISLAGRIIANFPDYLTE
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCHHHCC
SQKIPDELAYLGELTQKPEANIIKLPNVSASIPQLKAAIAELQSQGYKLPEYPEEPKTDE
CCCCHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKALNARYAKVLGSAVNPVLREGNSDRRVAKAVKEYAKKHPHKMGAWSSDSKSHVSNMSA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCC
GDFYHSEKSVTLKDATVARIEFVDNFGNVTVMKEKLPLQAGEVLDGSFMNVRALRKFIQE
CCCCCCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
QIDDAKAKGVLFSVHLKATMMKISDPVIFGHFVSVYFKDVFEKHAATFKEIGVNADLGLG
HHHHHHHCCEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DLYKKLEKVPAGKKAEIEADIKATYAKQPPLAMVDSDKGITNLHASNDIIIDASMPVVIR
HHHHHHHHCCCCCCCEEEECHHHHCCCCCCCEEEECCCCCEEEECCCCEEEECCCCEEEE
DSGKMWAPDGKLADTKCVIPDTCYSEWYQECIQFCKENGQFDPTTMGATSNVGLMAQKAE
CCCCEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFKAPLNGTMRVVDASGEVLIQHQVEEGDIWRGCQAKDLPIRDWVKLAVNRAR
HHCCCCCEEECCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
ATGAPAVFWLDKNRAHDAQMIKKVETYLKDHDTKGLELHIMSPVEAMKFTLPRAKKGLDT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCHHHCCCCE
ITVTGNALRDYLTDLFPILELGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFQQEGY
EEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCC
LRWDSLGEFLALAVSLEHLAATFKNEKAALLAETLDAANTKFLDQNKNPARKVGQIDNRG
EEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCC
SHFYLAMYWAEAVAAQTKDADLAARFAKVAKELQANEEKINAELIGAQGKPVDMGGYYHA
CEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHCCCEEECCCCCCCCCCCEEEC
DDAKTEAAMRPSATLNAIINSIV
CCCHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TTEKAKIVWTKIDEAPALATYSLLPIVNAFTKAAGVVVETRDISLAGRIIANFPDYLTE
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCHHHCC
SQKIPDELAYLGELTQKPEANIIKLPNVSASIPQLKAAIAELQSQGYKLPEYPEEPKTDE
CCCCHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKALNARYAKVLGSAVNPVLREGNSDRRVAKAVKEYAKKHPHKMGAWSSDSKSHVSNMSA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCC
GDFYHSEKSVTLKDATVARIEFVDNFGNVTVMKEKLPLQAGEVLDGSFMNVRALRKFIQE
CCCCCCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
QIDDAKAKGVLFSVHLKATMMKISDPVIFGHFVSVYFKDVFEKHAATFKEIGVNADLGLG
HHHHHHHCCEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DLYKKLEKVPAGKKAEIEADIKATYAKQPPLAMVDSDKGITNLHASNDIIIDASMPVVIR
HHHHHHHHCCCCCCCEEEECHHHHCCCCCCCEEEECCCCCEEEECCCCEEEECCCCEEEE
DSGKMWAPDGKLADTKCVIPDTCYSEWYQECIQFCKENGQFDPTTMGATSNVGLMAQKAE
CCCCEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFKAPLNGTMRVVDASGEVLIQHQVEEGDIWRGCQAKDLPIRDWVKLAVNRAR
HHCCCCCEEECCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
ATGAPAVFWLDKNRAHDAQMIKKVETYLKDHDTKGLELHIMSPVEAMKFTLPRAKKGLDT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCHHHCCCCE
ITVTGNALRDYLTDLFPILELGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFQQEGY
EEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCC
LRWDSLGEFLALAVSLEHLAATFKNEKAALLAETLDAANTKFLDQNKNPARKVGQIDNRG
EEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCC
SHFYLAMYWAEAVAAQTKDADLAARFAKVAKELQANEEKINAELIGAQGKPVDMGGYYHA
CEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHCCCEEECCCCCCCCCCCEEEC
DDAKTEAAMRPSATLNAIINSIV
CCCHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]