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The map label for this gene is exuT [H]

Identifier: 197105915

GI number: 197105915

Start: 2806068

End: 2807354

Strand: Direct

Name: exuT [H]

Synonym: PHZ_c2454

Alternate gene names: 197105915

Gene position: 2806068-2807354 (Clockwise)

Preceding gene: 197105914

Following gene: 197105916

Centisome position: 70.22

GC content: 69.62

Gene sequence:

>1287_bases
ATGGCCACAGCCGCCGAACGGACTGACGCCGCAGCCCCGCCCGCCGTCGTGGGCCGCTACCGCTGGGTGGTGGTGGGGCT
CCTCTTTGCGGCGATGGTGATCAACTACGTCGATCGCCAGACCATCGGGCTGCTGAAGGCCGACCTCACCGCCGAGTTCG
GCTGGAGCGAGACGGACTACGCCGACCTCGTCTTCTGGTTCCAGGCCGCCTACGCCATCGCCTACCTGGCCTGGGGCCGG
GTCATCGACCGGATCGGCGCCCGCTGGGGCTTCGGCCTCGCCTTCCTGCTCTGGCACGTCGGCCACATCGCCACGGCCGG
CGCCCGCTCGCTGAGCGGCTTCATCTTCGCCCGCGTCGTCCTGGGCCTGGGCGAAGGCGGCGCGTTCCCGGCCGGCATCA
AGTCGGTGGCCGAGTGGTTCCCCAAGAAGGAGCGCGCGCTCGCCACCGGCATCTTCAACGCCGGCACCAACATCGGCGCC
ATCGTCACGCCCCTGGTGATCCCGGCGATCACCCTGGCCTGGGGCTGGCAGGCGGCGTTCATCGTCACCGGCGTGGCGGG
CCTCGTGTGGCTGCCCATCTGGCTGCTGGTCTACCGCCGGCCGCGCGAGCATCCGAAGGTCACCGCCGCCGAGCTGGCGC
ACATCGAGCAGGATCCGCCGGACACGGTGGAGAAGGTCGCCTGGACCAAGCTGCTGCGCTACCGCGAGACCTGGGCCTAC
GCGATCGGCAAGTTCCTGATCGACCCCGTCTGGTGGATGTTCCTGTTCTGGCTGCCGGACTTCCTCGGCAAGCGCCACGG
CCTCGATCTGATGAGCTTCGGCCCGCCCCTGGTGGCCATCTACCTGCTCTCGGACGTCGGCAGCGTGGCCGGCGGCTGGA
TGTCCTCGCGCTTCATGCACCTGGGCTGGTCGGTGAACCGCGCGCGCAAGATGACCATGCTGATCTGCGCCCTGCTGGCC
CTGCCGGTGGCTTTCGCCGCCTTCGCCTCGAACCTGTGGGTCGCCGTGCTGATCATCGGCGTGGCCACCGCCGCCCACCA
GGGCTTCTCGGCCAACCTCTACACCCTGCCCGGCGACGTCTTCCCGCGGGCGGCGGTGGGCTCGGTCGTCGGCATCGGCG
GCATGCTGGGCGCCATCGGCGGCATGGTGATGTCGAAGTACGCCGGCTACGTGCTGGAGCAGATCGGCACCTACACCCCG
ATCTTCGTGGTGGCCGCATCGGCCTACCTGCTGGCCCTGCTGGTCGTGCACATCCTCACGCCGAAGATGGAGCCGGTGAA
GCTGTGA

Upstream 100 bases:

>100_bases
ATCGAGGCCGGCCAATCGGCCCGAATCGTCTTCGGCGACCTGCAGGAGATCCGCTGCCAGGCGGTCACCGCGGCGCCGGA
GGACCAGGGAGGAAACAACG

Downstream 100 bases:

>100_bases
GGGCCGCCCCCGCGCTCCTGGGGGTCCTCGCACTCGGCGGGGCGGCGGGACTGGCGCTCGCCGCCCCGCCCGCCGTGTTC
GTGAACGAGGCTGACGTCGT

Product: major facilitator family transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MATAAERTDAAAPPAVVGRYRWVVVGLLFAAMVINYVDRQTIGLLKADLTAEFGWSETDYADLVFWFQAAYAIAYLAWGR
VIDRIGARWGFGLAFLLWHVGHIATAGARSLSGFIFARVVLGLGEGGAFPAGIKSVAEWFPKKERALATGIFNAGTNIGA
IVTPLVIPAITLAWGWQAAFIVTGVAGLVWLPIWLLVYRRPREHPKVTAAELAHIEQDPPDTVEKVAWTKLLRYRETWAY
AIGKFLIDPVWWMFLFWLPDFLGKRHGLDLMSFGPPLVAIYLLSDVGSVAGGWMSSRFMHLGWSVNRARKMTMLICALLA
LPVAFAAFASNLWVAVLIIGVATAAHQGFSANLYTLPGDVFPRAAVGSVVGIGGMLGAIGGMVMSKYAGYVLEQIGTYTP
IFVVAASAYLLALLVVHILTPKMEPVKL

Sequences:

>Translated_428_residues
MATAAERTDAAAPPAVVGRYRWVVVGLLFAAMVINYVDRQTIGLLKADLTAEFGWSETDYADLVFWFQAAYAIAYLAWGR
VIDRIGARWGFGLAFLLWHVGHIATAGARSLSGFIFARVVLGLGEGGAFPAGIKSVAEWFPKKERALATGIFNAGTNIGA
IVTPLVIPAITLAWGWQAAFIVTGVAGLVWLPIWLLVYRRPREHPKVTAAELAHIEQDPPDTVEKVAWTKLLRYRETWAY
AIGKFLIDPVWWMFLFWLPDFLGKRHGLDLMSFGPPLVAIYLLSDVGSVAGGWMSSRFMHLGWSVNRARKMTMLICALLA
LPVAFAAFASNLWVAVLIIGVATAAHQGFSANLYTLPGDVFPRAAVGSVVGIGGMLGAIGGMVMSKYAGYVLEQIGTYTP
IFVVAASAYLLALLVVHILTPKMEPVKL
>Mature_427_residues
ATAAERTDAAAPPAVVGRYRWVVVGLLFAAMVINYVDRQTIGLLKADLTAEFGWSETDYADLVFWFQAAYAIAYLAWGRV
IDRIGARWGFGLAFLLWHVGHIATAGARSLSGFIFARVVLGLGEGGAFPAGIKSVAEWFPKKERALATGIFNAGTNIGAI
VTPLVIPAITLAWGWQAAFIVTGVAGLVWLPIWLLVYRRPREHPKVTAAELAHIEQDPPDTVEKVAWTKLLRYRETWAYA
IGKFLIDPVWWMFLFWLPDFLGKRHGLDLMSFGPPLVAIYLLSDVGSVAGGWMSSRFMHLGWSVNRARKMTMLICALLAL
PVAFAAFASNLWVAVLIIGVATAAHQGFSANLYTLPGDVFPRAAVGSVVGIGGMLGAIGGMVMSKYAGYVLEQIGTYTPI
FVVAASAYLLALLVVHILTPKMEPVKL

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=387, Percent_Identity=25.0645994832041, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI9966811, Length=377, Percent_Identity=25.9946949602122, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI9945322, Length=355, Percent_Identity=25.9154929577465, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI21322234, Length=351, Percent_Identity=24.5014245014245, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI6912666, Length=356, Percent_Identity=24.1573033707865, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367193, Length=403, Percent_Identity=32.5062034739454, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI2367379, Length=357, Percent_Identity=31.3725490196078, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082320, Length=432, Percent_Identity=28.7037037037037, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789515, Length=436, Percent_Identity=25.2293577981651, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789152, Length=449, Percent_Identity=26.2806236080178, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI87082071, Length=381, Percent_Identity=23.0971128608924, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17535049, Length=422, Percent_Identity=25.3554502369668, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17552542, Length=372, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI86561091, Length=204, Percent_Identity=30.3921568627451, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25141316, Length=204, Percent_Identity=30.3921568627451, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533554, Length=313, Percent_Identity=27.1565495207668, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533556, Length=313, Percent_Identity=27.1565495207668, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25141318, Length=186, Percent_Identity=30.1075268817204, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17566884, Length=273, Percent_Identity=27.4725274725275, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25141341, Length=149, Percent_Identity=31.5436241610738, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560030, Length=221, Percent_Identity=23.9819004524887, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24580790, Length=381, Percent_Identity=23.8845144356955, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24584153, Length=350, Percent_Identity=25.1428571428571, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641682, Length=389, Percent_Identity=24.1645244215938, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583789, Length=378, Percent_Identity=23.8095238095238, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19920686, Length=408, Percent_Identity=23.2843137254902, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648416, Length=384, Percent_Identity=24.21875, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356189, Length=384, Percent_Identity=24.21875, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24654215, Length=391, Percent_Identity=24.5524296675192, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922400, Length=391, Percent_Identity=24.5524296675192, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130167, Length=387, Percent_Identity=25.3229974160207, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639764, Length=447, Percent_Identity=21.0290827740492, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62484226, Length=381, Percent_Identity=23.0971128608924, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129235, Length=401, Percent_Identity=25.6857855361596, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45550460, Length=255, Percent_Identity=24.7058823529412, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24655255, Length=255, Percent_Identity=24.7058823529412, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221474708, Length=181, Percent_Identity=24.8618784530387, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46525; Mature: 46394

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCC
>Mature Secondary Structure 
ATAAERTDAAAPPAVVGRYRWVVVGLLFAAMVINYVDRQTIGLLKADLTAEFGWSETDY
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ADLVFWFQAAYAIAYLAWGRVIDRIGARWGFGLAFLLWHVGHIATAGARSLSGFIFARVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLGEGGAFPAGIKSVAEWFPKKERALATGIFNAGTNIGAIVTPLVIPAITLAWGWQAAF
HHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHH
IVTGVAGLVWLPIWLLVYRRPREHPKVTAAELAHIEQDPPDTVEKVAWTKLLRYRETWAY
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AIGKFLIDPVWWMFLFWLPDFLGKRHGLDLMSFGPPLVAIYLLSDVGSVAGGWMSSRFMH
HHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGWSVNRARKMTMLICALLALPVAFAAFASNLWVAVLIIGVATAAHQGFSANLYTLPGDV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCC
FPRAAVGSVVGIGGMLGAIGGMVMSKYAGYVLEQIGTYTPIFVVAASAYLLALLVVHILT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PKMEPVKL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]