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The map label for this gene is ilvA [H]

Identifier: 187934635

GI number: 187934635

Start: 1095082

End: 1096302

Strand: Reverse

Name: ilvA [H]

Synonym: CLL_A1070

Alternate gene names: 187934635

Gene position: 1096302-1095082 (Counterclockwise)

Preceding gene: 187933818

Following gene: 187934145

Centisome position: 28.85

GC content: 30.63

Gene sequence:

>1221_bases
ATGATGACATTAGAGAAATTTCAACAAGCATATGAGACAGTACAAAAAGTAATATTACAAACGAATTTAGTTTATAGTGA
TTATTATTCTGATTGTACCGGAAATAAAATATACTTGAAACCTGAAAATTTACAAAAAACTGGGGCTTATAAAATTAGAG
GTGCTTATTATAAAATTAGTACTCTTACTGATGAAGAAAGAAACAAGGGCTTAATAACAGCATCTGCTGGTAATCATGCT
CAAGGTGTTGCATATGCTGCTCAATTATATAATGTTAATGCTGTAATTGTAATGCCAACTACTACTCCACTTATAAAAGT
AAATCGTACAAAAGCATATGGTGCTGAAGTAATATTATATGGTGATGTTTATGATGAAGCTTGTACTTATGCTTTAGAAC
TTGCAAAACAAAAGGGATATACATTTATTCATCCATTTGATGATTTAGATGTTGCAACAGGGCAAGGTTCTATTGCCATG
GAAATATTAAAAGATTTACCTACCGTTGATATAATTTTAGTTCCAATTGGTGGTGGCGGACTTGCCACTGGTGTTTCTAC
TTTAGCTAAACTTCTTAAGCCTAATATTAAGGTTATAGGCGTTGAACCTTACGGTGCTAATTGTATGGAATCTTCATTAA
AAGCTGGACATGTTGTAACCCTTCAAAAAGTTGATACTATAGCAGATGGTACTGCTGTAAAAACTCCTGGAACTAACATT
TTCCCATATATACAAAAAAATATCGATGAAATTATAACTATTAAAGATCATGAATTAATAGTTGCATTCTTAGATATGTT
AGAAAATCATAAAATGCTTGCAGAAAATTCTGGTTTACTAACAGTTGCCGCACTAAAGCATTTAAATGTAAAAGGTAAAA
ATATTGTATCAATTATAAGCGGTGGAAATATGGATGTAATAACTTTTGCATCTTTAGTACAACATGGCTTAATAGAACGA
GAACGTATCTGTGCATTATCTGTTTTACTTCCTGATAAACCTGGTGAACTAACAAATGTATCTAAAGTAATCGCTGAAGC
TCAAGGAAATATTATAAGACTTGACCATAATCAATTTGTCAGTATAAATAGAAATAGTGCTGTTGAACTTAAGATAACAA
TGGAGACTTTTGGTCCTGAACATAAAAATTCAATAATAAAAGCTTTAAAAGACAATGGATATCATCCTAACGTTTTAAAA
CCTAAAAATATTTATCAATAA

Upstream 100 bases:

>100_bases
CTTTTTTTTCTTACTTGACATTAATTTTTCAAGTGTTATTATAAAAATATCAAATGCCATATTTTATTAAATATACATTA
AAAAGGGGGTTATATAAAAT

Downstream 100 bases:

>100_bases
GTATTTTTTAATCTTTTATTATGTATAGTAAAACTCTAACCAAATTTAATTGGTTAGAGTTTTAATCCATTATATATTCT
TTTTTATATATTCTTTAAGT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MMTLEKFQQAYETVQKVILQTNLVYSDYYSDCTGNKIYLKPENLQKTGAYKIRGAYYKISTLTDEERNKGLITASAGNHA
QGVAYAAQLYNVNAVIVMPTTTPLIKVNRTKAYGAEVILYGDVYDEACTYALELAKQKGYTFIHPFDDLDVATGQGSIAM
EILKDLPTVDIILVPIGGGGLATGVSTLAKLLKPNIKVIGVEPYGANCMESSLKAGHVVTLQKVDTIADGTAVKTPGTNI
FPYIQKNIDEIITIKDHELIVAFLDMLENHKMLAENSGLLTVAALKHLNVKGKNIVSIISGGNMDVITFASLVQHGLIER
ERICALSVLLPDKPGELTNVSKVIAEAQGNIIRLDHNQFVSINRNSAVELKITMETFGPEHKNSIIKALKDNGYHPNVLK
PKNIYQ

Sequences:

>Translated_406_residues
MMTLEKFQQAYETVQKVILQTNLVYSDYYSDCTGNKIYLKPENLQKTGAYKIRGAYYKISTLTDEERNKGLITASAGNHA
QGVAYAAQLYNVNAVIVMPTTTPLIKVNRTKAYGAEVILYGDVYDEACTYALELAKQKGYTFIHPFDDLDVATGQGSIAM
EILKDLPTVDIILVPIGGGGLATGVSTLAKLLKPNIKVIGVEPYGANCMESSLKAGHVVTLQKVDTIADGTAVKTPGTNI
FPYIQKNIDEIITIKDHELIVAFLDMLENHKMLAENSGLLTVAALKHLNVKGKNIVSIISGGNMDVITFASLVQHGLIER
ERICALSVLLPDKPGELTNVSKVIAEAQGNIIRLDHNQFVSINRNSAVELKITMETFGPEHKNSIIKALKDNGYHPNVLK
PKNIYQ
>Mature_406_residues
MMTLEKFQQAYETVQKVILQTNLVYSDYYSDCTGNKIYLKPENLQKTGAYKIRGAYYKISTLTDEERNKGLITASAGNHA
QGVAYAAQLYNVNAVIVMPTTTPLIKVNRTKAYGAEVILYGDVYDEACTYALELAKQKGYTFIHPFDDLDVATGQGSIAM
EILKDLPTVDIILVPIGGGGLATGVSTLAKLLKPNIKVIGVEPYGANCMESSLKAGHVVTLQKVDTIADGTAVKTPGTNI
FPYIQKNIDEIITIKDHELIVAFLDMLENHKMLAENSGLLTVAALKHLNVKGKNIVSIISGGNMDVITFASLVQHGLIER
ERICALSVLLPDKPGELTNVSKVIAEAQGNIIRLDHNQFVSINRNSAVELKITMETFGPEHKNSIIKALKDNGYHPNVLK
PKNIYQ

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=325, Percent_Identity=34.1538461538462, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI19923959, Length=299, Percent_Identity=32.7759197324415, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI33469958, Length=303, Percent_Identity=31.3531353135314, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1790207, Length=388, Percent_Identity=36.0824742268041, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1789505, Length=309, Percent_Identity=36.8932038834951, Blast_Score=198, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71991565, Length=357, Percent_Identity=36.6946778711485, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17537387, Length=399, Percent_Identity=35.0877192982456, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17508781, Length=309, Percent_Identity=29.7734627831715, Blast_Score=134, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6322631, Length=306, Percent_Identity=38.2352941176471, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320930, Length=319, Percent_Identity=37.9310344827586, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6319788, Length=260, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355833, Length=364, Percent_Identity=31.8681318681319, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24645328, Length=296, Percent_Identity=29.0540540540541, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44425; Mature: 44425

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTLEKFQQAYETVQKVILQTNLVYSDYYSDCTGNKIYLKPENLQKTGAYKIRGAYYKIS
CCCHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCCCEEEECCCCCCCCCCEEEEEEEEEEE
TLTDEERNKGLITASAGNHAQGVAYAAQLYNVNAVIVMPTTTPLIKVNRTKAYGAEVILY
ECCCCCCCCEEEEECCCCCCCHHHEEEEEECCEEEEEEECCCCEEEEECCCCCCCEEEEE
GDVYDEACTYALELAKQKGYTFIHPFDDLDVATGQGSIAMEILKDLPTVDIILVPIGGGG
ECCHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCHHHHHHHHHCCCEEEEEEEECCCH
LATGVSTLAKLLKPNIKVIGVEPYGANCMESSLKAGHVVTLQKVDTIADGTAVKTPGTNI
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCEEEEEEHHHHCCCCEEECCCCCC
FPYIQKNIDEIITIKDHELIVAFLDMLENHKMLAENSGLLTVAALKHLNVKGKNIVSIIS
CHHHHCCCCCEEEECCCHHHHHHHHHHHCCCEEECCCCEEEEEEHHHCCCCCCEEEEEEE
GGNMDVITFASLVQHGLIERERICALSVLLPDKPGELTNVSKVIAEAQGNIIRLDHNQFV
CCCCHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCEE
SINRNSAVELKITMETFGPEHKNSIIKALKDNGYHPNVLKPKNIYQ
EECCCCEEEEEEEEHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMTLEKFQQAYETVQKVILQTNLVYSDYYSDCTGNKIYLKPENLQKTGAYKIRGAYYKIS
CCCHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCCCEEEECCCCCCCCCCEEEEEEEEEEE
TLTDEERNKGLITASAGNHAQGVAYAAQLYNVNAVIVMPTTTPLIKVNRTKAYGAEVILY
ECCCCCCCCEEEEECCCCCCCHHHEEEEEECCEEEEEEECCCCEEEEECCCCCCCEEEEE
GDVYDEACTYALELAKQKGYTFIHPFDDLDVATGQGSIAMEILKDLPTVDIILVPIGGGG
ECCHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCHHHHHHHHHCCCEEEEEEEECCCH
LATGVSTLAKLLKPNIKVIGVEPYGANCMESSLKAGHVVTLQKVDTIADGTAVKTPGTNI
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCEEEEEEHHHHCCCCEEECCCCCC
FPYIQKNIDEIITIKDHELIVAFLDMLENHKMLAENSGLLTVAALKHLNVKGKNIVSIIS
CHHHHCCCCCEEEECCCHHHHHHHHHHHCCCEEECCCCEEEEEEHHHCCCCCCEEEEEEE
GGNMDVITFASLVQHGLIERERICALSVLLPDKPGELTNVSKVIAEAQGNIIRLDHNQFV
CCCCHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCEE
SINRNSAVELKITMETFGPEHKNSIIKALKDNGYHPNVLKPKNIYQ
EECCCCEEEEEEEEHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]