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The map label for this gene is hemH

Identifier: 186477251

GI number: 186477251

Start: 2812729

End: 2813799

Strand: Reverse

Name: hemH

Synonym: Bphy_2502

Alternate gene names: 186477251

Gene position: 2813799-2812729 (Counterclockwise)

Preceding gene: 186477252

Following gene: 186477250

Centisome position: 80.88

GC content: 64.52

Gene sequence:

>1071_bases
ATGCGCTTCGACCTCGAGCGGCCCTTGCAGTCTGCTGCGGCACATCGCGTCGCCGTGTTGCTGATCAATCTCGGCACGCC
CGATGCGCCGACGCCCCGTGCCGTGCGGCGCTACCTCGCGCAGTTTCTGTCCGATCCGCGTGTGGTCGAGATCCCGTCGC
TGGTGTGGCAAATCATCTTGCGCCTTTTCATTCTGCCGTTTCGCGGCGTGGCCTCGGCGAAGAAATACGCGTCGGTGTGG
ATGCCCGAAGGCTCGCCGTTGCGGGTGCACACGCAAAAGCAGGTCGAAGGGCTGCGGCATCTGCTGCATCTGAACGACTA
CACGGTGATCGTGGAGTACGCGATGCGCTACGGCACGCCCGACATTCCCGCCATGCTCAACCAGTTGAAGCTGGCGGGCG
CCGAGCGCATCCTGCTGATGCCGATGTACCCGCAGTATTCGGCGTCCACGACGGCCACTGCGTTCGACGCAGCATTTGTG
GCGCTCAGGCGGATGCGCAATCAGCCCGAAATCCGCACCGTGCGCCAGTACGCGGATCACCCCGCATACATCGCGGCGCT
CGCGGCGCAGGTCAATCACTACTGGCATGCACACGGCCGTCCCGACTTCGCGGCGGGCGACAAGCTGGTGTTGAGTTTTC
ACGGCGTGCCCAAGCGCACGCTGGACCTGGGCGATCCATATCACGATCAATGTCAACAAACTGCGACGCTGCTGATGCAT
GCGCTCGGGCTGACGTCCGTCGAATGCCGCGTGACGTTTCAGTCGCGCTTCGGCAAGGCCGAGTGGCTTCAGCCTTACAC
GGCGCCCACGCTCAAGGAACTGGGTGCGGCGGGGGTGCATCGCGCGGACGTGTTCTGCCCGGGCTTCACGGCGGACTGTC
TGGAGACGATCGAGGAAATCGGCATGGAAGTGCGCGACGAGTTCCTGCACGCAGGCGGGAAAGTTTTTCACGCCATTCCC
TGCCTGAACGCGGCGCCGGCGTGGATCGCGGCGCTCGGCGAAATCGTCGCGCAGCATCTGCAGGGCTGGCCGGTTCAGGC
AGCGACCCCGCAAAGCGCGTCTGTGGCTTGA

Upstream 100 bases:

>100_bases
CAATTGGCCGAACGGCCAGGTATCGCCGGCAGACCGCGCCGCTATAATGGGCTTCCCGTCCATTACGTGTCGCGCCTGTG
CGCGGCTCTTGTCTTTGCCT

Downstream 100 bases:

>100_bases
ATTTGCGCATCCGGCACACAACCTGCATCCGTACAACGGCGCATGGCATCCCTTAGGCGTGTGCAGACACCTGAAGAAGG
ACTGATGAACTACAGGATTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MRFDLERPLQSAAAHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPSLVWQIILRLFILPFRGVASAKKYASVW
MPEGSPLRVHTQKQVEGLRHLLHLNDYTVIVEYAMRYGTPDIPAMLNQLKLAGAERILLMPMYPQYSASTTATAFDAAFV
ALRRMRNQPEIRTVRQYADHPAYIAALAAQVNHYWHAHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTATLLMH
ALGLTSVECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVHRADVFCPGFTADCLETIEEIGMEVRDEFLHAGGKVFHAIP
CLNAAPAWIAALGEIVAQHLQGWPVQAATPQSASVA

Sequences:

>Translated_356_residues
MRFDLERPLQSAAAHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPSLVWQIILRLFILPFRGVASAKKYASVW
MPEGSPLRVHTQKQVEGLRHLLHLNDYTVIVEYAMRYGTPDIPAMLNQLKLAGAERILLMPMYPQYSASTTATAFDAAFV
ALRRMRNQPEIRTVRQYADHPAYIAALAAQVNHYWHAHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTATLLMH
ALGLTSVECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVHRADVFCPGFTADCLETIEEIGMEVRDEFLHAGGKVFHAIP
CLNAAPAWIAALGEIVAQHLQGWPVQAATPQSASVA
>Mature_356_residues
MRFDLERPLQSAAAHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPSLVWQIILRLFILPFRGVASAKKYASVW
MPEGSPLRVHTQKQVEGLRHLLHLNDYTVIVEYAMRYGTPDIPAMLNQLKLAGAERILLMPMYPQYSASTTATAFDAAFV
ALRRMRNQPEIRTVRQYADHPAYIAALAAQVNHYWHAHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTATLLMH
ALGLTSVECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVHRADVFCPGFTADCLETIEEIGMEVRDEFLHAGGKVFHAIP
CLNAAPAWIAALGEIVAQHLQGWPVQAATPQSASVA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=270, Percent_Identity=27.037037037037, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=27.1375464684015, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1786681, Length=324, Percent_Identity=45.9876543209877, Blast_Score=271, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6324750, Length=354, Percent_Identity=24.0112994350282, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17864156, Length=350, Percent_Identity=24.5714285714286, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651774, Length=270, Percent_Identity=24.0740740740741, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_BURP8 (B2JGE7)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858721.1
- GeneID:   6243986
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2502
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 39514; Mature: 39514

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLERPLQSAAAHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPSLVWQIIL
CCCCHHHHHHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RLFILPFRGVASAKKYASVWMPEGSPLRVHTQKQVEGLRHLLHLNDYTVIVEYAMRYGTP
HHHHHCCCCHHHHHHHHHEECCCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DIPAMLNQLKLAGAERILLMPMYPQYSASTTATAFDAAFVALRRMRNQPEIRTVRQYADH
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIAALAAQVNHYWHAHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTATLLMH
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLTSVECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVHRADVFCPGFTADCLETIEEI
HHCCCCEEEEEEEHHHCCCHHHCCCCCCHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFLHAGGKVFHAIPCLNAAPAWIAALGEIVAQHLQGWPVQAATPQSASVA
HHHHHHHHHHCCCHHEEHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFDLERPLQSAAAHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPSLVWQIIL
CCCCHHHHHHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RLFILPFRGVASAKKYASVWMPEGSPLRVHTQKQVEGLRHLLHLNDYTVIVEYAMRYGTP
HHHHHCCCCHHHHHHHHHEECCCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DIPAMLNQLKLAGAERILLMPMYPQYSASTTATAFDAAFVALRRMRNQPEIRTVRQYADH
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIAALAAQVNHYWHAHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTATLLMH
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLTSVECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVHRADVFCPGFTADCLETIEEI
HHCCCCEEEEEEEHHHCCCHHHCCCCCCHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFLHAGGKVFHAIPCLNAAPAWIAALGEIVAQHLQGWPVQAATPQSASVA
HHHHHHHHHHCCCHHEEHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA