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The map label for this gene is purE

Identifier: 170757832

GI number: 170757832

Start: 3116339

End: 3116818

Strand: Reverse

Name: purE

Synonym: CLD_1662

Alternate gene names: 170757832

Gene position: 3116818-3116339 (Counterclockwise)

Preceding gene: 170755102

Following gene: 170756658

Centisome position: 78.74

GC content: 33.12

Gene sequence:

>480_bases
ATGAAAGTAGCTATTATTTTTGGAAGTAAATCTGATACTGATAAAATGAAGGGAGCGGCTAAAGCTTTAAAAGAGTTTAG
TATAGAATATAAAGCTTACATACTTTCAGCACACAGAGTACCAGAAAAGTTGATGGAAACAATTGAAGATTTAGAAAAGG
AAGGTTATGAATGTATAATTGCTGGGGCAGGTCTTGCAGCACATTTACCTGGGGTTATAGCTTCTCATACGATTCTTCCG
GTTATAGGAGTGCCTATAGAAGCCGCAGTTGGAGGAATGGATTCACTTTTATCTATGGTTCAAATGCCTAAATCTATACC
TGTAGCTACAGTGGGTATAAATAATAGTTATAATGCAGGAATGCTTGCGGTACAAATATTATCTTTAAAGTATGATGAAT
TAGAAGAAAAACTTATAGAATATAGAAAAGATATGAAAGAAAAATTTATAAATGATAACAAAGAGGGAGTGGAGTTATAA

Upstream 100 bases:

>100_bases
TTAGCTATGCTTTTGCAGTGCGCTTAAGTTCCGCTTTAGGATTCTCCATAGAAATCTTAGCGGAATTTTTTATATATTTA
AATATAAGGAGGTCTAGTAC

Downstream 100 bases:

>100_bases
TGGAAAAGAAGGATATGTTATATGAAGGAAAGGCTAAAAAAATATTTGGAACGGATGATAAGGATACAGTTGTTGTGTAT
TATAAAGATGATGCCACAGC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MKVAIIFGSKSDTDKMKGAAKALKEFSIEYKAYILSAHRVPEKLMETIEDLEKEGYECIIAGAGLAAHLPGVIASHTILP
VIGVPIEAAVGGMDSLLSMVQMPKSIPVATVGINNSYNAGMLAVQILSLKYDELEEKLIEYRKDMKEKFINDNKEGVEL

Sequences:

>Translated_159_residues
MKVAIIFGSKSDTDKMKGAAKALKEFSIEYKAYILSAHRVPEKLMETIEDLEKEGYECIIAGAGLAAHLPGVIASHTILP
VIGVPIEAAVGGMDSLLSMVQMPKSIPVATVGINNSYNAGMLAVQILSLKYDELEEKLIEYRKDMKEKFINDNKEGVEL
>Mature_159_residues
MKVAIIFGSKSDTDKMKGAAKALKEFSIEYKAYILSAHRVPEKLMETIEDLEKEGYECIIAGAGLAAHLPGVIASHTILP
VIGVPIEAAVGGMDSLLSMVQMPKSIPVATVGINNSYNAGMLAVQILSLKYDELEEKLIEYRKDMKEKFINDNKEGVEL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=41.5584415584416, Blast_Score=119, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324702, Length=131, Percent_Identity=51.1450381679389, Blast_Score=128, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17343; Mature: 17343

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAIIFGSKSDTDKMKGAAKALKEFSIEYKAYILSAHRVPEKLMETIEDLEKEGYECII
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEE
AGAGLAAHLPGVIASHTILPVIGVPIEAAVGGMDSLLSMVQMPKSIPVATVGINNSYNAG
ECCCHHHHCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCH
MLAVQILSLKYDELEEKLIEYRKDMKEKFINDNKEGVEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKVAIIFGSKSDTDKMKGAAKALKEFSIEYKAYILSAHRVPEKLMETIEDLEKEGYECII
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEE
AGAGLAAHLPGVIASHTILPVIGVPIEAAVGGMDSLLSMVQMPKSIPVATVGINNSYNAG
ECCCHHHHCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCH
MLAVQILSLKYDELEEKLIEYRKDMKEKFINDNKEGVEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]