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The map label for this gene is dut [H]

Identifier: 160873511

GI number: 160873511

Start: 439585

End: 440043

Strand: Reverse

Name: dut [H]

Synonym: Sbal195_0386

Alternate gene names: 160873511

Gene position: 440043-439585 (Counterclockwise)

Preceding gene: 160873512

Following gene: 160873510

Centisome position: 8.23

GC content: 48.8

Gene sequence:

>459_bases
ATGAAAACACCGATTGAATTAAAAATTCTCGACTCCCGTATCGGCTCAGAATTTCCTTTACCTGCCTACGCTACACCTGG
CAGTGCAGGCATGGATCTTCGCGCCATGATCGACACGACTTTGACTATAGCACCGGGTGAAACCGTGCTTATTCCAACGG
GGATTGCCATTCATGTTGCCGATCCAGGACTGGCTGCAGTGATTTTGCCGCGCTCAGGTCTTGGCCATAAACACGGTATC
GTACTGGGGAATCTGGTCGGACTCATAGATTCAGATTACCAAGGACCCTTAATGGTGTCTTGCTGGAATCGTAGCGACAG
TCCTTTTGCCTTAGAAATTGGCGATCGTCTCGCACAACTGGTGTTTGTTCCTGTAGTACAAGCACAATTCAAACTCGTTG
ATGAGTTCGACAGCTCAGATCGTGGCGAAGGCGGATTTGGCCATTCAGGCACTAAATAA

Upstream 100 bases:

>100_bases
GAGTGTTCTGGCCGCACGGCAGTCAAGATTTGCCTGCCACTGACAAACTCACGCTGGCACGGCAATTACTTTCGTTGATA
GTGAAAGAAAAAACAAATAC

Downstream 100 bases:

>100_bases
TCCCCTAAGTCGTTATTGAGCCAAGGATACTGCAATGGCTGTAAGCCCAAAAATTAATCGTCGTGAACATATTTTGCAAT
GTCTAGCACAGATGCTAGAA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MKTPIELKILDSRIGSEFPLPAYATPGSAGMDLRAMIDTTLTIAPGETVLIPTGIAIHVADPGLAAVILPRSGLGHKHGI
VLGNLVGLIDSDYQGPLMVSCWNRSDSPFALEIGDRLAQLVFVPVVQAQFKLVDEFDSSDRGEGGFGHSGTK

Sequences:

>Translated_152_residues
MKTPIELKILDSRIGSEFPLPAYATPGSAGMDLRAMIDTTLTIAPGETVLIPTGIAIHVADPGLAAVILPRSGLGHKHGI
VLGNLVGLIDSDYQGPLMVSCWNRSDSPFALEIGDRLAQLVFVPVVQAQFKLVDEFDSSDRGEGGFGHSGTK
>Mature_152_residues
MKTPIELKILDSRIGSEFPLPAYATPGSAGMDLRAMIDTTLTIAPGETVLIPTGIAIHVADPGLAAVILPRSGLGHKHGI
VLGNLVGLIDSDYQGPLMVSCWNRSDSPFALEIGDRLAQLVFVPVVQAQFKLVDEFDSSDRGEGGFGHSGTK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=144, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI4503423, Length=144, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI70906441, Length=146, Percent_Identity=32.8767123287671, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1790071, Length=148, Percent_Identity=68.2432432432432, Blast_Score=224, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71988561, Length=130, Percent_Identity=36.1538461538462, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319729, Length=133, Percent_Identity=39.0977443609023, Blast_Score=77, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24583610, Length=132, Percent_Identity=35.6060606060606, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI19921126, Length=132, Percent_Identity=35.6060606060606, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16037; Mature: 16037

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPIELKILDSRIGSEFPLPAYATPGSAGMDLRAMIDTTLTIAPGETVLIPTGIAIHVA
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECEEEEECCCCEEEEECCEEEEEE
DPGLAAVILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRSDSPFALEIGDRLAQL
CCCEEEEEEECCCCCCCCCEEEEHEEEECCCCCCCCEEEEEECCCCCCEEEEHHHHHHHH
VFVPVVQAQFKLVDEFDSSDRGEGGFGHSGTK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTPIELKILDSRIGSEFPLPAYATPGSAGMDLRAMIDTTLTIAPGETVLIPTGIAIHVA
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECEEEEECCCCEEEEECCEEEEEE
DPGLAAVILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRSDSPFALEIGDRLAQL
CCCEEEEEEECCCCCCCCCEEEEHEEEECCCCCCCCEEEEEECCCCCCEEEEHHHHHHHH
VFVPVVQAQFKLVDEFDSSDRGEGGFGHSGTK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA