Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 160873512

GI number: 160873512

Start: 440040

End: 441263

Strand: Reverse

Name: coaBC [H]

Synonym: Sbal195_0387

Alternate gene names: 160873512

Gene position: 441263-440040 (Counterclockwise)

Preceding gene: 160873518

Following gene: 160873511

Centisome position: 8.25

GC content: 51.47

Gene sequence:

>1224_bases
ATGATGTCTGTGAGTCTGACAAATAAAAACGTCCTGCTGGGCATTGGCGGCGGTATTGCGGCCTATAAAAGTGCTGATTT
AGTCCGTCGCTTAAAAGAGCGTGGCTTTGATGTGCGCGTGGTGATGAGCCAAAGTGCGATGGAATTTATCACGCCTTTGA
CGCTGCAAGCGCTATCTGGACATCCCGTAGCCTCAAGCCTGCTCGATCCAGCGGCAGAAGCAGCCATGGGCCACATAGAA
CTCGCTCGTTGGGCAGATCTCGTCATCATCGCCCCTGCAACCGCAAACCTATTGGCGCGGATTAATGCTGGCATGGCCGA
TGAGCTGATCACCACCACTTGTCTTGCCACAGAGGCGCCTATCGCCCTGTGTCCGGCAATGAATCAGCAGATGTACCGTA
ATCTGGCGACGCAGGCGAATTTAACCAGCCTGGCATCACGTGGCTTTACCCTTTGGGGACCCGCAAGTGGCAGTCAGGCC
TGTGGTGAAGTCGGCCCTGGTCGTATGCTAGAGCCATTAGACATCGCCACACTCGCTACGCAGTTTTTTGCCACTCATGA
CGCAGTTGAACTTAAGCCACTCGCAGGACAGTCAATGCTGATTACCGCAGGGCCAACCCGTGAGGCAATTGATCCCGTCA
GATACATTTCGAATCACAGTTCTGGAAAAATGGGCTTTGCCTTAGCCAAAGCCGCGGCAGATATGGGCGCAACAGTCACC
TTAGTCTCTGGTCCAGTGAATCTAAGCACCCCAGAAGGCGTGACCCGCATTGATGTTGAATCGGCGCAAAATATGCTTGA
CGCTGTGATGGATAACGTTGATAAAAAAGATATTTTTATTGGCTGCGCCGCAGTTGCTGACTATCGCATTAGCGACATCG
CCACCTGTAAGATCAAAAAATCGGCAGAAGAAATGCAACTTGCGCTGGTGAGGAATCCTGATATCTTAGCCACGGTTGCG
AGCTTACCTAACCGTCCTTTTGTGGTGGGATTCGCCGCAGAAACCCATGATGTAGAAGCCTATGCGCGCGATAAACTCAA
ACGTAAAAACTTGAATATGATCGCCGCGAACGACGTTTCCGTTGCTGGTCTAGGCTTTAATGCCGATGCCAATGCCCTGC
GAGTGTTCTGGCCGCACGGCAGTCAAGATTTGCCTGCCACTGACAAACTCACGCTGGCACGGCAATTACTTTCGTTGATA
GTGAAAGAAAAAACAAATACATGA

Upstream 100 bases:

>100_bases
TATTTTCACTTTACTGAGTATGGACGAGATTTTTTGAACTGGGAGAGTCACTAAAATTCACCGCTTTGTGATATTGTTGG
CGGCATTATTTCTATCTCGG

Downstream 100 bases:

>100_bases
AAACACCGATTGAATTAAAAATTCTCGACTCCCGTATCGGCTCAGAATTTCCTTTACCTGCCTACGCTACACCTGGCAGT
GCAGGCATGGATCTTCGCGC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MMSVSLTNKNVLLGIGGGIAAYKSADLVRRLKERGFDVRVVMSQSAMEFITPLTLQALSGHPVASSLLDPAAEAAMGHIE
LARWADLVIIAPATANLLARINAGMADELITTTCLATEAPIALCPAMNQQMYRNLATQANLTSLASRGFTLWGPASGSQA
CGEVGPGRMLEPLDIATLATQFFATHDAVELKPLAGQSMLITAGPTREAIDPVRYISNHSSGKMGFALAKAAADMGATVT
LVSGPVNLSTPEGVTRIDVESAQNMLDAVMDNVDKKDIFIGCAAVADYRISDIATCKIKKSAEEMQLALVRNPDILATVA
SLPNRPFVVGFAAETHDVEAYARDKLKRKNLNMIAANDVSVAGLGFNADANALRVFWPHGSQDLPATDKLTLARQLLSLI
VKEKTNT

Sequences:

>Translated_407_residues
MMSVSLTNKNVLLGIGGGIAAYKSADLVRRLKERGFDVRVVMSQSAMEFITPLTLQALSGHPVASSLLDPAAEAAMGHIE
LARWADLVIIAPATANLLARINAGMADELITTTCLATEAPIALCPAMNQQMYRNLATQANLTSLASRGFTLWGPASGSQA
CGEVGPGRMLEPLDIATLATQFFATHDAVELKPLAGQSMLITAGPTREAIDPVRYISNHSSGKMGFALAKAAADMGATVT
LVSGPVNLSTPEGVTRIDVESAQNMLDAVMDNVDKKDIFIGCAAVADYRISDIATCKIKKSAEEMQLALVRNPDILATVA
SLPNRPFVVGFAAETHDVEAYARDKLKRKNLNMIAANDVSVAGLGFNADANALRVFWPHGSQDLPATDKLTLARQLLSLI
VKEKTNT
>Mature_407_residues
MMSVSLTNKNVLLGIGGGIAAYKSADLVRRLKERGFDVRVVMSQSAMEFITPLTLQALSGHPVASSLLDPAAEAAMGHIE
LARWADLVIIAPATANLLARINAGMADELITTTCLATEAPIALCPAMNQQMYRNLATQANLTSLASRGFTLWGPASGSQA
CGEVGPGRMLEPLDIATLATQFFATHDAVELKPLAGQSMLITAGPTREAIDPVRYISNHSSGKMGFALAKAAADMGATVT
LVSGPVNLSTPEGVTRIDVESAQNMLDAVMDNVDKKDIFIGCAAVADYRISDIATCKIKKSAEEMQLALVRNPDILATVA
SLPNRPFVVGFAAETHDVEAYARDKLKRKNLNMIAANDVSVAGLGFNADANALRVFWPHGSQDLPATDKLTLARQLLSLI
VKEKTNT

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=170, Percent_Identity=32.9411764705882, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI87082301, Length=402, Percent_Identity=61.1940298507463, Blast_Score=468, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17560194, Length=198, Percent_Identity=31.8181818181818, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=105, Percent_Identity=36.1904761904762, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24657262, Length=174, Percent_Identity=29.3103448275862, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43143; Mature: 43143

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSVSLTNKNVLLGIGGGIAAYKSADLVRRLKERGFDVRVVMSQSAMEFITPLTLQALSG
CEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCC
HPVASSLLDPAAEAAMGHIELARWADLVIIAPATANLLARINAGMADELITTTCLATEAP
CCHHHHHHCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCC
IALCPAMNQQMYRNLATQANLTSLASRGFTLWGPASGSQACGEVGPGRMLEPLDIATLAT
EEECCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
QFFATHDAVELKPLAGQSMLITAGPTREAIDPVRYISNHSSGKMGFALAKAAADMGATVT
HHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEE
LVSGPVNLSTPEGVTRIDVESAQNMLDAVMDNVDKKDIFIGCAAVADYRISDIATCKIKK
EEECCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCEEEEEECC
SAEEMQLALVRNPDILATVASLPNRPFVVGFAAETHDVEAYARDKLKRKNLNMIAANDVS
CHHHHEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCE
VAGLGFNADANALRVFWPHGSQDLPATDKLTLARQLLSLIVKEKTNT
EEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMSVSLTNKNVLLGIGGGIAAYKSADLVRRLKERGFDVRVVMSQSAMEFITPLTLQALSG
CEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCC
HPVASSLLDPAAEAAMGHIELARWADLVIIAPATANLLARINAGMADELITTTCLATEAP
CCHHHHHHCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCC
IALCPAMNQQMYRNLATQANLTSLASRGFTLWGPASGSQACGEVGPGRMLEPLDIATLAT
EEECCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
QFFATHDAVELKPLAGQSMLITAGPTREAIDPVRYISNHSSGKMGFALAKAAADMGATVT
HHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEE
LVSGPVNLSTPEGVTRIDVESAQNMLDAVMDNVDKKDIFIGCAAVADYRISDIATCKIKK
EEECCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCEEEEEECC
SAEEMQLALVRNPDILATVASLPNRPFVVGFAAETHDVEAYARDKLKRKNLNMIAANDVS
CHHHHEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCE
VAGLGFNADANALRVFWPHGSQDLPATDKLTLARQLLSLIVKEKTNT
EEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA