Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 154248290

GI number: 154248290

Start: 4845171

End: 4847444

Strand: Direct

Name: comEC [H]

Synonym: Xaut_4370

Alternate gene names: 154248290

Gene position: 4845171-4847444 (Clockwise)

Preceding gene: 154248287

Following gene: 154248300

Centisome position: 91.26

GC content: 72.52

Gene sequence:

>2274_bases
ATGACGCAGCAGGACCAGCGTCCGGCGCGGACCAGCGGACGGGCCGCCGTTCTCGGCGGCGCGCGCACCGCCGCGCGCCG
GGCGATGCCCCCCGGCCTCGCCCGCGTGCTGGATGCCCTGCGCGCCCGCCTCGCCGCGGATCTTGCCGCCGAGGCCGCCT
CCGGCCGGTTGATCCTCTGGCTTCCGGCGGCATTCACCCTTGGCATCCTCATCTACTTCGGGGCGGCGCAGGAGCCGTCC
CTTGCCGTCGCCGGGGTGCTTTTGGCCGCTCTTTGCGGGGGCGCGGTGCTGCTGCGGGCGCGACCGGTGGCGTTCGGCGC
GATGGTGGCCCTTGCCGCCGTAACAGCGGGCTTCACCACCGCGAGCGTGCGCACCGCGCTGGTGGCGCACGAGATCGCCA
CGCCCGGCAAGGGGCCGGTGCGGCTGTCGGGCTTCGTGGAGCGGGTGGAGCATCGCCCAAAGGGGGATCGCATCCTGCTG
CGTCTCGACGCCGGGCCGGTGAAGGGACTGGACAAGGTTCCGCGCCTCGTCCGCCTCACCCTGCGCAAGGGCTGGGCGCC
GCCGGTGGGCACCCATGTCACCCAGCTCGCCCAGTTGCTGCCGCCGCTCGGGCCGGCCATGCCCGGTGCCCATGATTTCG
GCCGGAACCCCTGGTTCGCCGGCATCGGCGGCGTGGGCTACGGCCTGGGGCGGCCCAAGCTCGCGGAGCCGGCGGAACCA
CCCTTGTCGGTACGCCTCGCCATGGCGGTGGAGGCCGTGCGCGACAGCCTATCCCGCCGCATCCGGGCCTCGCTGTCCGG
CACGCCGGCGGAAATCGCCGTCGCGCTGGTAGCAGGCGACCGTTCCGCGATCGCGCCGGAGGTGGAAGAGAGCATGCGCG
TGTCCGGGCTCACGCACATCCTGTCCATCTCTGGCCTGCACATGGCGCTGGTCGCGGGCACGCTGTTCGCGTTCATGCGC
GGCGGCCTCGCTCTGGTGCCGGCGCTGGCGCTGGGCTTCCCCATCAAGTCGCTGGCGGCCGTCGCCGCCCTCACCGGCAG
CGCCGCCTATCTGGTGCTGTCCGGCAATGACGTTCCGGCGCAGCGCTCGTTCGTGATGACAGCGCTGGTATTGAGCGGCG
TGCTGGTGGGCCGGCCGGCGCTGACCCTGCGCACCGTGGGCGTGGCCGGGGTCTGCGTGCTCGCCTTCACCCCCGAGGCG
GCGCTCGATCCCGGCACGCAAATGTCGTTCGCCGCCACCCTCGCCCTCGTTGCCGCCTATGAGCGCCTGCGGCCCATGCG
CGCCCTGCCGCGACCCGACGGATGGGTCGGGCAGGCCGCCATCTGGCTCGCGGTTTTGGTGGGCGGGACGGCGCTCACCT
CCCTGGTGGCGGGGCTGGCGACGGCGCCCTACGGCATCTTCCACTTCCAGCGCGTGGCGCCCTATGGCCTGCTCGCCAAT
CTCGCCGCCATGCCGGCAGTGTCGTTCATGGTGATGCCCTTCGGCCTGCTGGGCGTGCTGCTGATGCCGTTCGGATTCGA
TCATCTGGCCTGGCCGGTGATGGGCAAAGGCATCGAGATCATGGTGGCGGTCTCGGACGCCATCGCGGTGCTGCCAGGGG
CCGACGGCAGGGTCGATCCGGTCGGCGCGCCGACGCTCGCCCTGTTCAGCCTGGGCCTGACGGCGCTTTGCCTGCTGCGC
GGATGGCTCACGGCGGTCGCGATCGTGCCGTTCGCCCTCGCCCTGCTCATGTCCGGCGCGCCGCCGCGGCCGGACATTCT
CATCGCACCCGATGCCCAGACGGTCGCCGTGCGCGGGCCCGACGGGCGGCTCTCGGTGCTCGGCGCGCGCAGCCAGCGGC
TGGTGGTGGAGCAGTGGATGACGCGGGAGGGTGACATGCGAAAGGCGGGTGCCGAAGGGCTTGCCGCGCTGTTCACCTGC
GATCCCCTCGGCTGCACCGCTCCCTTGCCGGGCGGCGGCACCATCGCCGTATCGCGGCGGGCGGAAAGCCTGGAGGCAGA
CTGCCTGGAATCGCGCATTGTCGTCACACGGGATGTGCCGCCCCGGCGCTGTCCGGCCCAGGTGGTGACGCCTGAAACGC
TGCAGCGCACCGGCACATTGGCCTATCACTTCCGTAAGGGAATGAGCAGCGAGGGGGCAAGCGGCGGCGACTGGCAGATT
GAGCCAACCCGCAAGCCCAACGTCCAGCGCCCCTGGATGCCGCCCCTGCCACCTGAGCCCGCCCCGCAGCGCCCGGCGAC
GGACGATCCGGAAGCCGACGCCGCATCGGAGTGA

Upstream 100 bases:

>100_bases
CATAGGCGCCGGGCACAAGGAATACGGCCGCCTTGTCCGGCGGGCCGGGCGCCGGACGCCCACGGATCGGAACGACCCGC
AGCGGGGCATCTGGGGCGAC

Downstream 100 bases:

>100_bases
AGCGGCCAAAAGCATCGACGGCTCAAAAAGCTGGGGTGAGAAGCGTCGCTCCAGAGGAGCCGGTCCCGTTGAGCATGGTG
ACCGCCACGCCCCTCACCCC

Product: ComEC/Rec2-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 757; Mature: 756

Protein sequence:

>757_residues
MTQQDQRPARTSGRAAVLGGARTAARRAMPPGLARVLDALRARLAADLAAEAASGRLILWLPAAFTLGILIYFGAAQEPS
LAVAGVLLAALCGGAVLLRARPVAFGAMVALAAVTAGFTTASVRTALVAHEIATPGKGPVRLSGFVERVEHRPKGDRILL
RLDAGPVKGLDKVPRLVRLTLRKGWAPPVGTHVTQLAQLLPPLGPAMPGAHDFGRNPWFAGIGGVGYGLGRPKLAEPAEP
PLSVRLAMAVEAVRDSLSRRIRASLSGTPAEIAVALVAGDRSAIAPEVEESMRVSGLTHILSISGLHMALVAGTLFAFMR
GGLALVPALALGFPIKSLAAVAALTGSAAYLVLSGNDVPAQRSFVMTALVLSGVLVGRPALTLRTVGVAGVCVLAFTPEA
ALDPGTQMSFAATLALVAAYERLRPMRALPRPDGWVGQAAIWLAVLVGGTALTSLVAGLATAPYGIFHFQRVAPYGLLAN
LAAMPAVSFMVMPFGLLGVLLMPFGFDHLAWPVMGKGIEIMVAVSDAIAVLPGADGRVDPVGAPTLALFSLGLTALCLLR
GWLTAVAIVPFALALLMSGAPPRPDILIAPDAQTVAVRGPDGRLSVLGARSQRLVVEQWMTREGDMRKAGAEGLAALFTC
DPLGCTAPLPGGGTIAVSRRAESLEADCLESRIVVTRDVPPRRCPAQVVTPETLQRTGTLAYHFRKGMSSEGASGGDWQI
EPTRKPNVQRPWMPPLPPEPAPQRPATDDPEADAASE

Sequences:

>Translated_757_residues
MTQQDQRPARTSGRAAVLGGARTAARRAMPPGLARVLDALRARLAADLAAEAASGRLILWLPAAFTLGILIYFGAAQEPS
LAVAGVLLAALCGGAVLLRARPVAFGAMVALAAVTAGFTTASVRTALVAHEIATPGKGPVRLSGFVERVEHRPKGDRILL
RLDAGPVKGLDKVPRLVRLTLRKGWAPPVGTHVTQLAQLLPPLGPAMPGAHDFGRNPWFAGIGGVGYGLGRPKLAEPAEP
PLSVRLAMAVEAVRDSLSRRIRASLSGTPAEIAVALVAGDRSAIAPEVEESMRVSGLTHILSISGLHMALVAGTLFAFMR
GGLALVPALALGFPIKSLAAVAALTGSAAYLVLSGNDVPAQRSFVMTALVLSGVLVGRPALTLRTVGVAGVCVLAFTPEA
ALDPGTQMSFAATLALVAAYERLRPMRALPRPDGWVGQAAIWLAVLVGGTALTSLVAGLATAPYGIFHFQRVAPYGLLAN
LAAMPAVSFMVMPFGLLGVLLMPFGFDHLAWPVMGKGIEIMVAVSDAIAVLPGADGRVDPVGAPTLALFSLGLTALCLLR
GWLTAVAIVPFALALLMSGAPPRPDILIAPDAQTVAVRGPDGRLSVLGARSQRLVVEQWMTREGDMRKAGAEGLAALFTC
DPLGCTAPLPGGGTIAVSRRAESLEADCLESRIVVTRDVPPRRCPAQVVTPETLQRTGTLAYHFRKGMSSEGASGGDWQI
EPTRKPNVQRPWMPPLPPEPAPQRPATDDPEADAASE
>Mature_756_residues
TQQDQRPARTSGRAAVLGGARTAARRAMPPGLARVLDALRARLAADLAAEAASGRLILWLPAAFTLGILIYFGAAQEPSL
AVAGVLLAALCGGAVLLRARPVAFGAMVALAAVTAGFTTASVRTALVAHEIATPGKGPVRLSGFVERVEHRPKGDRILLR
LDAGPVKGLDKVPRLVRLTLRKGWAPPVGTHVTQLAQLLPPLGPAMPGAHDFGRNPWFAGIGGVGYGLGRPKLAEPAEPP
LSVRLAMAVEAVRDSLSRRIRASLSGTPAEIAVALVAGDRSAIAPEVEESMRVSGLTHILSISGLHMALVAGTLFAFMRG
GLALVPALALGFPIKSLAAVAALTGSAAYLVLSGNDVPAQRSFVMTALVLSGVLVGRPALTLRTVGVAGVCVLAFTPEAA
LDPGTQMSFAATLALVAAYERLRPMRALPRPDGWVGQAAIWLAVLVGGTALTSLVAGLATAPYGIFHFQRVAPYGLLANL
AAMPAVSFMVMPFGLLGVLLMPFGFDHLAWPVMGKGIEIMVAVSDAIAVLPGADGRVDPVGAPTLALFSLGLTALCLLRG
WLTAVAIVPFALALLMSGAPPRPDILIAPDAQTVAVRGPDGRLSVLGARSQRLVVEQWMTREGDMRKAGAEGLAALFTCD
PLGCTAPLPGGGTIAVSRRAESLEADCLESRIVVTRDVPPRRCPAQVVTPETLQRTGTLAYHFRKGMSSEGASGGDWQIE
PTRKPNVQRPWMPPLPPEPAPQRPATDDPEADAASE

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 78600; Mature: 78469

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQDQRPARTSGRAAVLGGARTAARRAMPPGLARVLDALRARLAADLAAEAASGRLILW
CCCCCCCCCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LPAAFTLGILIYFGAAQEPSLAVAGVLLAALCGGAVLLRARPVAFGAMVALAAVTAGFTT
EHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCHH
ASVRTALVAHEIATPGKGPVRLSGFVERVEHRPKGDRILLRLDAGPVKGLDKVPRLVRLT
HHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
LRKGWAPPVGTHVTQLAQLLPPLGPAMPGAHDFGRNPWFAGIGGVGYGLGRPKLAEPAEP
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCEECCCCCCCCCCCCCCCCCCCC
PLSVRLAMAVEAVRDSLSRRIRASLSGTPAEIAVALVAGDRSAIAPEVEESMRVSGLTHI
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCHHHHHHHHHHHHHH
LSISGLHMALVAGTLFAFMRGGLALVPALALGFPIKSLAAVAALTGSAAYLVLSGNDVPA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCC
QRSFVMTALVLSGVLVGRPALTLRTVGVAGVCVLAFTPEAALDPGTQMSFAATLALVAAY
HHHHHHHHHHHHHHHHCCCCCEEEECCHHEEEEEEECCHHHCCCCCCHHHHHHHHHHHHH
ERLRPMRALPRPDGWVGQAAIWLAVLVGGTALTSLVAGLATAPYGIFHFQRVAPYGLLAN
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LAAMPAVSFMVMPFGLLGVLLMPFGFDHLAWPVMGKGIEIMVAVSDAIAVLPGADGRVDP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCEEECCCCCCCCC
VGAPTLALFSLGLTALCLLRGWLTAVAIVPFALALLMSGAPPRPDILIAPDAQTVAVRGP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECC
DGRLSVLGARSQRLVVEQWMTREGDMRKAGAEGLAALFTCDPLGCTAPLPGGGTIAVSRR
CCCEEEECCCCHHHHHHHHHCCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEECC
AESLEADCLESRIVVTRDVPPRRCPAQVVTPETLQRTGTLAYHFRKGMSSEGASGGDWQI
HHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCEEE
EPTRKPNVQRPWMPPLPPEPAPQRPATDDPEADAASE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQQDQRPARTSGRAAVLGGARTAARRAMPPGLARVLDALRARLAADLAAEAASGRLILW
CCCCCCCCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LPAAFTLGILIYFGAAQEPSLAVAGVLLAALCGGAVLLRARPVAFGAMVALAAVTAGFTT
EHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCHH
ASVRTALVAHEIATPGKGPVRLSGFVERVEHRPKGDRILLRLDAGPVKGLDKVPRLVRLT
HHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
LRKGWAPPVGTHVTQLAQLLPPLGPAMPGAHDFGRNPWFAGIGGVGYGLGRPKLAEPAEP
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCEECCCCCCCCCCCCCCCCCCCC
PLSVRLAMAVEAVRDSLSRRIRASLSGTPAEIAVALVAGDRSAIAPEVEESMRVSGLTHI
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCHHHHHHHHHHHHHH
LSISGLHMALVAGTLFAFMRGGLALVPALALGFPIKSLAAVAALTGSAAYLVLSGNDVPA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCC
QRSFVMTALVLSGVLVGRPALTLRTVGVAGVCVLAFTPEAALDPGTQMSFAATLALVAAY
HHHHHHHHHHHHHHHHCCCCCEEEECCHHEEEEEEECCHHHCCCCCCHHHHHHHHHHHHH
ERLRPMRALPRPDGWVGQAAIWLAVLVGGTALTSLVAGLATAPYGIFHFQRVAPYGLLAN
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LAAMPAVSFMVMPFGLLGVLLMPFGFDHLAWPVMGKGIEIMVAVSDAIAVLPGADGRVDP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCEEECCCCCCCCC
VGAPTLALFSLGLTALCLLRGWLTAVAIVPFALALLMSGAPPRPDILIAPDAQTVAVRGP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECC
DGRLSVLGARSQRLVVEQWMTREGDMRKAGAEGLAALFTCDPLGCTAPLPGGGTIAVSRR
CCCEEEECCCCHHHHHHHHHCCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEECC
AESLEADCLESRIVVTRDVPPRRCPAQVVTPETLQRTGTLAYHFRKGMSSEGASGGDWQI
HHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCEEE
EPTRKPNVQRPWMPPLPPEPAPQRPATDDPEADAASE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]