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The map label for this gene is acsA2 [H]

Identifier: 150398386

GI number: 150398386

Start: 3365302

End: 3367251

Strand: Reverse

Name: acsA2 [H]

Synonym: Smed_3194

Alternate gene names: 150398386

Gene position: 3367251-3365302 (Counterclockwise)

Preceding gene: 150398388

Following gene: 150398384

Centisome position: 89.04

GC content: 61.08

Gene sequence:

>1950_bases
ATGGACGTCAAGACCTACCCGGTCCTGGAAGCGGCCAAGAACCGTACGCTGCTCGACAATGAGACCTATCTGAAATGGTA
CCAGGAGAGCGTTGCCGATCCGGAGACGTTCTGGGGCGAGCATGGCAAGCGAATCGATTGGTTCGAGCCCTATACCAAGG
TCAAGAATACGACCTTCGAGGGCGATGTCTCGATCAAGTGGTTCGAAGACGGGCTGACTAACGTCTCCTACAACTGCATC
GATCGCCACCTGAAAGCGCATGGCGACAAGACGGCGATCATCTGGGAGGGAGACAATCCCTATCTCGACAAGAAGATCAC
TTATAATGAGCTCTACGACACGGTTTGCCGTCTTGCCAACGTCTTGAAAAAGCATGGCGTCAAGAAGGGCGACCGCGTTA
CAATATACATGCCGATGATCCCCGAAGCGGCCTATGCCATGCTTGCCTGCACCCGCATCGGCGCCGTCCATTCGGTCGTA
TTCGGCGGCTTTTCGCCTGAGGCCCTGGCGGGCCGGATCGTCGATTGCGAGTCGACCTTCGTGATCACCTGCGACGAGGG
CGTGCGTGGCGGCAAGCCCGTGGCGCTGAAGGAGAACACCGATACGGCCGTGGGGATCGCCGCCAAGCAGAATGTCACGG
TCGGCAAGGTTCTGGTCGTGCGCCGCACCGGCGGCAAGGTCGGATGGGCCCCGGAGCGCGATCTCTGGTACCACCAGGAG
ACTGCGGCAGTGGAGCCGCATTGCCCCCCGGAAAGGATGAATGCCGAGGACCCGCTCTTCATTCTCTATACCTCGGGATC
CACCGGAAAGCCGAAGGGCGTGCTGCATACGACCGGCGGCTATCTGGTCTATGCCTCGATGACGCATCAATACGTGTTCG
ACTACCAGGACGGCGACATCTACTGGTGCACGGCCGATGTCGGCTGGGTCACCGGCCACTCCTATATCGTCTATGGTCCG
CTCGCCAATGCGGCGACGACCCTGATGTTCGAGGGCGTGCCGAACTTTCCGGATGCGGGACGGTTCTGGGAAGTCGTGGA
CAAGCACAAGGTCAACATCTTCTATACCGCACCCACGGCAATCCGGTCGCTGATGGGCGCCGGCGACGATTTCGTCAAGC
GCTCCTCGCGCTCGTCGCTGCGCCTGCTCGGAACCGTCGGCGAGCCGATCAATCCGGAAGCCTGGGAATGGTACTATCAC
GTGGTCGGCGACGAGCGTTGTCCAGTCGTCGATACCTGGTGGCAGACGGAAACCGGCGGCATTCTGATCACGCCGCTGCC
CGGCGCTACGGACCTCAAACCGGGTTCCGCGACGCGGCCGTTCTTCGGAGTCCAGCCGCAGATCGTCGACGGCGAGGGCA
ATGTCGTCGAGGGTGCGGCCGACGGCAACCTTTGCATCATCGACAGCTGGCCCGGTCAGATGCGGACGGTCTATGGCGAT
CACGAACGCTTTATCCAGACGTATTTTTCTACCTACAAGGGCAAGTATTTCACCGGAGACGGCTGCCGCCGCGACGAGGA
TGGTTATTACTGGATCACCGGCCGCGTCGATGACGTGCTCAACGTCTCGGGACACCGGCTAGGGACGGCTGAGGTTGAAT
CGGCGCTGGTCTCGCACCAGCTCGTCTCCGAGGCCGCGGTCGTCGGCTATCCGCATTCGATCAAGGGTCAGGGCATCTAT
TGCTATGTCTCGCTGATGGCGGGCGAGGTCGGCAACGACGAACTGCGCCAGGCACTCGTCAAGCACGTACGCTCGGAAAT
CGGACCGATCGCGACACCGGACAAGATCCAGTTCGCGCCCGGCCTGCCCAAGACGCGTTCGGGCAAGATCATGCGCCGGA
TTCTTCGGAAGATCGCCGAGGACGATTTCGGTTCGCTTGGCGACACTTCGACGCTGGCCGATCCCTCGGTCGTCGATGAC
CTGATCGCCAATCGCCAGAACCGCGCCTGA

Upstream 100 bases:

>100_bases
AGGAACGGTGGGAGCCGGGCCGGAGCGGGACGAGGAAACTGCGCGCGGTTTCTGGTGCATTCCGCTCATGATCAGATCAG
AAATACGCAGGGAGGAAAAT

Downstream 100 bases:

>100_bases
CGTGAGTTGGGTACGGGCGCTCCGCTTCGTCCCTAACCCTAACCCTAACCCTCTCCTTCTCCCCGCATGCGGGGAGAAGG
TCGCGGCGCATTGAGGGGCT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase 2; Acyl-activating enzyme 2 [H]

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MDVKTYPVLEAAKNRTLLDNETYLKWYQESVADPETFWGEHGKRIDWFEPYTKVKNTTFEGDVSIKWFEDGLTNVSYNCI
DRHLKAHGDKTAIIWEGDNPYLDKKITYNELYDTVCRLANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACTRIGAVHSVV
FGGFSPEALAGRIVDCESTFVITCDEGVRGGKPVALKENTDTAVGIAAKQNVTVGKVLVVRRTGGKVGWAPERDLWYHQE
TAAVEPHCPPERMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYQDGDIYWCTADVGWVTGHSYIVYGP
LANAATTLMFEGVPNFPDAGRFWEVVDKHKVNIFYTAPTAIRSLMGAGDDFVKRSSRSSLRLLGTVGEPINPEAWEWYYH
VVGDERCPVVDTWWQTETGGILITPLPGATDLKPGSATRPFFGVQPQIVDGEGNVVEGAADGNLCIIDSWPGQMRTVYGD
HERFIQTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHQLVSEAAVVGYPHSIKGQGIY
CYVSLMAGEVGNDELRQALVKHVRSEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGSLGDTSTLADPSVVDD
LIANRQNRA

Sequences:

>Translated_649_residues
MDVKTYPVLEAAKNRTLLDNETYLKWYQESVADPETFWGEHGKRIDWFEPYTKVKNTTFEGDVSIKWFEDGLTNVSYNCI
DRHLKAHGDKTAIIWEGDNPYLDKKITYNELYDTVCRLANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACTRIGAVHSVV
FGGFSPEALAGRIVDCESTFVITCDEGVRGGKPVALKENTDTAVGIAAKQNVTVGKVLVVRRTGGKVGWAPERDLWYHQE
TAAVEPHCPPERMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYQDGDIYWCTADVGWVTGHSYIVYGP
LANAATTLMFEGVPNFPDAGRFWEVVDKHKVNIFYTAPTAIRSLMGAGDDFVKRSSRSSLRLLGTVGEPINPEAWEWYYH
VVGDERCPVVDTWWQTETGGILITPLPGATDLKPGSATRPFFGVQPQIVDGEGNVVEGAADGNLCIIDSWPGQMRTVYGD
HERFIQTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHQLVSEAAVVGYPHSIKGQGIY
CYVSLMAGEVGNDELRQALVKHVRSEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGSLGDTSTLADPSVVDD
LIANRQNRA
>Mature_649_residues
MDVKTYPVLEAAKNRTLLDNETYLKWYQESVADPETFWGEHGKRIDWFEPYTKVKNTTFEGDVSIKWFEDGLTNVSYNCI
DRHLKAHGDKTAIIWEGDNPYLDKKITYNELYDTVCRLANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACTRIGAVHSVV
FGGFSPEALAGRIVDCESTFVITCDEGVRGGKPVALKENTDTAVGIAAKQNVTVGKVLVVRRTGGKVGWAPERDLWYHQE
TAAVEPHCPPERMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYQDGDIYWCTADVGWVTGHSYIVYGP
LANAATTLMFEGVPNFPDAGRFWEVVDKHKVNIFYTAPTAIRSLMGAGDDFVKRSSRSSLRLLGTVGEPINPEAWEWYYH
VVGDERCPVVDTWWQTETGGILITPLPGATDLKPGSATRPFFGVQPQIVDGEGNVVEGAADGNLCIIDSWPGQMRTVYGD
HERFIQTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHQLVSEAAVVGYPHSIKGQGIY
CYVSLMAGEVGNDELRQALVKHVRSEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGSLGDTSTLADPSVVDD
LIANRQNRA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=667, Percent_Identity=53.3733133433283, Blast_Score=717, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=680, Percent_Identity=52.3529411764706, Blast_Score=712, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=630, Percent_Identity=52.2222222222222, Blast_Score=669, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=629, Percent_Identity=38.79173290938, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI38505220, Length=598, Percent_Identity=30.1003344481605, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI42544132, Length=518, Percent_Identity=29.3436293436293, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI122937307, Length=568, Percent_Identity=27.8169014084507, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI115511026, Length=522, Percent_Identity=28.3524904214559, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI31982927, Length=632, Percent_Identity=25, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=27.4853801169591, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI157311624, Length=515, Percent_Identity=26.9902912621359, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI157311622, Length=515, Percent_Identity=26.9902912621359, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI195947378, Length=440, Percent_Identity=25.9090909090909, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI187761345, Length=389, Percent_Identity=26.4781491002571, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI187761343, Length=389, Percent_Identity=26.4781491002571, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI42544134, Length=336, Percent_Identity=25.297619047619, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI156151445, Length=558, Percent_Identity=22.9390681003584, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790505, Length=635, Percent_Identity=66.7716535433071, Blast_Score=884, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=638, Percent_Identity=37.1473354231975, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1788107, Length=579, Percent_Identity=22.6252158894646, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI145693145, Length=548, Percent_Identity=21.8978102189781, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=657, Percent_Identity=49.923896499239, Blast_Score=647, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=657, Percent_Identity=49.923896499239, Blast_Score=647, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=670, Percent_Identity=20.8955223880597, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=516, Percent_Identity=24.4186046511628, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI32563687, Length=525, Percent_Identity=22.0952380952381, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=137, Percent_Identity=29.9270072992701, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323182, Length=651, Percent_Identity=49.0015360983103, Blast_Score=625, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6319264, Length=643, Percent_Identity=46.1897356143079, Blast_Score=568, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319699, Length=369, Percent_Identity=25.2032520325203, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24667955, Length=656, Percent_Identity=54.4207317073171, Blast_Score=718, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=566, Percent_Identity=57.5971731448763, Blast_Score=662, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=524, Percent_Identity=57.824427480916, Blast_Score=616, Evalue=1e-176,
Organism=Drosophila melanogaster, GI21355225, Length=632, Percent_Identity=37.0253164556962, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI21355181, Length=589, Percent_Identity=22.9202037351443, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI18859661, Length=550, Percent_Identity=23.4545454545455, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24656500, Length=550, Percent_Identity=22.9090909090909, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24581924, Length=359, Percent_Identity=23.1197771587744, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71982; Mature: 71982

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKTYPVLEAAKNRTLLDNETYLKWYQESVADPETFWGEHGKRIDWFEPYTKVKNTTFE
CCCCCCCHHHHHCCCEEECCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHCCCEEC
GDVSIKWFEDGLTNVSYNCIDRHLKAHGDKTAIIWEGDNPYLDKKITYNELYDTVCRLAN
CCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
VLKKHGVKKGDRVTIYMPMIPEAAYAMLACTRIGAVHSVVFGGFSPEALAGRIVDCESTF
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEECCCEE
VITCDEGVRGGKPVALKENTDTAVGIAAKQNVTVGKVLVVRRTGGKVGWAPERDLWYHQE
EEEECCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCEEECC
TAAVEPHCPPERMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYQDGDI
CCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEECEEEEEEECCCCE
YWCTADVGWVTGHSYIVYGPLANAATTLMFEGVPNFPDAGRFWEVVDKHKVNIFYTAPTA
EEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCEEEEEEECHHH
IRSLMGAGDDFVKRSSRSSLRLLGTVGEPINPEAWEWYYHVVGDERCPVVDTWWQTETGG
HHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEEECCCCCCCCC
ILITPLPGATDLKPGSATRPFFGVQPQIVDGEGNVVEGAADGNLCIIDSWPGQMRTVYGD
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCEEEEECCCCCEEEEECC
HERFIQTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHQ
HHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
LVSEAAVVGYPHSIKGQGIYCYVSLMAGEVGNDELRQALVKHVRSEIGPIATPDKIQFAP
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECC
GLPKTRSGKIMRRILRKIAEDDFGSLGDTSTLADPSVVDDLIANRQNRA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDVKTYPVLEAAKNRTLLDNETYLKWYQESVADPETFWGEHGKRIDWFEPYTKVKNTTFE
CCCCCCCHHHHHCCCEEECCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHCCCEEC
GDVSIKWFEDGLTNVSYNCIDRHLKAHGDKTAIIWEGDNPYLDKKITYNELYDTVCRLAN
CCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
VLKKHGVKKGDRVTIYMPMIPEAAYAMLACTRIGAVHSVVFGGFSPEALAGRIVDCESTF
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEECCCEE
VITCDEGVRGGKPVALKENTDTAVGIAAKQNVTVGKVLVVRRTGGKVGWAPERDLWYHQE
EEEECCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCEEECC
TAAVEPHCPPERMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYQDGDI
CCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEECEEEEEEECCCCE
YWCTADVGWVTGHSYIVYGPLANAATTLMFEGVPNFPDAGRFWEVVDKHKVNIFYTAPTA
EEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCEEEEEEECHHH
IRSLMGAGDDFVKRSSRSSLRLLGTVGEPINPEAWEWYYHVVGDERCPVVDTWWQTETGG
HHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEEECCCCCCCCC
ILITPLPGATDLKPGSATRPFFGVQPQIVDGEGNVVEGAADGNLCIIDSWPGQMRTVYGD
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCEEEEECCCCCEEEEECC
HERFIQTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHQ
HHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
LVSEAAVVGYPHSIKGQGIYCYVSLMAGEVGNDELRQALVKHVRSEIGPIATPDKIQFAP
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECC
GLPKTRSGKIMRRILRKIAEDDFGSLGDTSTLADPSVVDDLIANRQNRA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]