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The map label for this gene is trpE [H]

Identifier: 148643206

GI number: 148643206

Start: 1124386

End: 1125894

Strand: Reverse

Name: trpE [H]

Synonym: Msm_1146

Alternate gene names: 148643206

Gene position: 1125894-1124386 (Counterclockwise)

Preceding gene: 148643207

Following gene: 148643205

Centisome position: 60.76

GC content: 33.0

Gene sequence:

>1509_bases
ATGTTTTCCCCAAGTTTGGAAGAAGTAAAAGAAATTGCAAAAAATAAAGAATATAAAAGAATTCCAGTAGCTTATGAGTT
ATACTCAGATATGGCTACTCCAATAGAAGTATTAAGGATTTTAAAAGAAATCAGTAAACATTGTTATATGCTGGAAAGTG
TTGAAGATTCACAAAAATGGGGAAGATACACCTTTTTAGGATTTGATCCGCTTTTAGAGTTTACCTGTCAAAATGGATGT
GTTCAAATTAAGGGAGACAGCAAATTTGAAGACAGTTCCAAATTAACAGATGATGATAAGGTAATTATTGAAACAAACAA
TCCTGGTGAAGTTATTAAAGATTTGGTCAGACAAAACAAATCTCCAAAATTAACTAATTTGCCTCCATTTACTGGAGGAT
TTGTGGGATATTTTGCTTATGATTATATTAAATATGCAGAACCTTCCCTAAACCTCGATGCTGAAAATCAGGATCAATTT
AAAGACATTGATTTGATGTTGTTTGATAAGGTTGTTGCATTTGATAATTTCAGACAAAAAATTGTTTTGATTGCAAATAT
GAAAACAGACAATTTGGATGAAAACTATAAGAAAGCCTGTGATGATTTGGAAAAAATAGCCAGATTAATTAAAACAGGAA
AAAAAGCAAAAATAGAACCTCTGACATTAAAATCTGATTTCAAACCAGTATTTTCACGTGAAAAATATTGTCAAATGGTT
AATAAGGCTAAAGATTACATTAAAGAGGGGGATATTTTTCAGGTTGTACTGTCAAACAGGATTGAAGCAGATATTTCAGG
AAGCTTGTTTGATACATACAGGGTCTTGAGAACTACAAATCCTTCACCCTATATGTTTTATTTTTCAAGTAATGACATTG
AAATAGCCGGTGCTTCACCTGAAACCCTGGTTAAATTAAACAATAGAAAATTATACACTTTTCCACTAGCGGGAACAAGA
CCTAGAGGAAAAACGGAAAGTGAAGATTTGGCCCTTGAAAAAGAGCTTTTAAGTGATGAAAAAGAATTGGCTGAACATAA
TATGCTTGTAGACCTGGGACGTAATGATATTGGAAAAATATCTGAAATAGGATCTGTCAATGTTGATAAATACCTGTCAA
TTGAGAGGTTTTCTCATGTAATGCATATTGGTTCAACAGTAACTGGAACTTTAAGAAAAGATCTGGATTCACTTGCGGCT
ATTGATTCCATACTTCCTGCAGGAACACTGTCCGGAGCTCCAAAAATAAGAGCATGTGAAATTATTAATGAACTTGAAAA
TAATAAAAGAGGGATTTATGGTGGAGCTATTGGATATATTGATTTAAGTGGCAATGTAGACACCTGCATATCAATCAGGA
TTGCTTTTGCACGTAATAATAAAGTTTTCATAAGGTCAGGTGCAGGAATTGTAGCTGACAGTGTTCCGGATAATGAATTT
GACGAGTGTTTAAATAAAGCAGCAGCAGTTATTGATGCTTTAAAAATAGCTGACGGGGGAATTTTATGA

Upstream 100 bases:

>100_bases
AGGACAAATTATAATTTTTTTTCAAATATTTTAAAATGTACAAAAAAGTACAACAAGGATTTAAATAGTACATTATTCTA
ATTATATTATAGTGATTAAA

Downstream 100 bases:

>100_bases
TTTTATTAATAGATAACTATGATAGCTTTTCATATAATTTATATCAATTAATCGGACAGGTAAATAGGGATATTGAAGTT
TATAGAAATGATAAAATCAC

Product: anthranilate/para-aminobenzoate synthase component I, TrpE

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MFSPSLEEVKEIAKNKEYKRIPVAYELYSDMATPIEVLRILKEISKHCYMLESVEDSQKWGRYTFLGFDPLLEFTCQNGC
VQIKGDSKFEDSSKLTDDDKVIIETNNPGEVIKDLVRQNKSPKLTNLPPFTGGFVGYFAYDYIKYAEPSLNLDAENQDQF
KDIDLMLFDKVVAFDNFRQKIVLIANMKTDNLDENYKKACDDLEKIARLIKTGKKAKIEPLTLKSDFKPVFSREKYCQMV
NKAKDYIKEGDIFQVVLSNRIEADISGSLFDTYRVLRTTNPSPYMFYFSSNDIEIAGASPETLVKLNNRKLYTFPLAGTR
PRGKTESEDLALEKELLSDEKELAEHNMLVDLGRNDIGKISEIGSVNVDKYLSIERFSHVMHIGSTVTGTLRKDLDSLAA
IDSILPAGTLSGAPKIRACEIINELENNKRGIYGGAIGYIDLSGNVDTCISIRIAFARNNKVFIRSGAGIVADSVPDNEF
DECLNKAAAVIDALKIADGGIL

Sequences:

>Translated_502_residues
MFSPSLEEVKEIAKNKEYKRIPVAYELYSDMATPIEVLRILKEISKHCYMLESVEDSQKWGRYTFLGFDPLLEFTCQNGC
VQIKGDSKFEDSSKLTDDDKVIIETNNPGEVIKDLVRQNKSPKLTNLPPFTGGFVGYFAYDYIKYAEPSLNLDAENQDQF
KDIDLMLFDKVVAFDNFRQKIVLIANMKTDNLDENYKKACDDLEKIARLIKTGKKAKIEPLTLKSDFKPVFSREKYCQMV
NKAKDYIKEGDIFQVVLSNRIEADISGSLFDTYRVLRTTNPSPYMFYFSSNDIEIAGASPETLVKLNNRKLYTFPLAGTR
PRGKTESEDLALEKELLSDEKELAEHNMLVDLGRNDIGKISEIGSVNVDKYLSIERFSHVMHIGSTVTGTLRKDLDSLAA
IDSILPAGTLSGAPKIRACEIINELENNKRGIYGGAIGYIDLSGNVDTCISIRIAFARNNKVFIRSGAGIVADSVPDNEF
DECLNKAAAVIDALKIADGGIL
>Mature_502_residues
MFSPSLEEVKEIAKNKEYKRIPVAYELYSDMATPIEVLRILKEISKHCYMLESVEDSQKWGRYTFLGFDPLLEFTCQNGC
VQIKGDSKFEDSSKLTDDDKVIIETNNPGEVIKDLVRQNKSPKLTNLPPFTGGFVGYFAYDYIKYAEPSLNLDAENQDQF
KDIDLMLFDKVVAFDNFRQKIVLIANMKTDNLDENYKKACDDLEKIARLIKTGKKAKIEPLTLKSDFKPVFSREKYCQMV
NKAKDYIKEGDIFQVVLSNRIEADISGSLFDTYRVLRTTNPSPYMFYFSSNDIEIAGASPETLVKLNNRKLYTFPLAGTR
PRGKTESEDLALEKELLSDEKELAEHNMLVDLGRNDIGKISEIGSVNVDKYLSIERFSHVMHIGSTVTGTLRKDLDSLAA
IDSILPAGTLSGAPKIRACEIINELENNKRGIYGGAIGYIDLSGNVDTCISIRIAFARNNKVFIRSGAGIVADSVPDNEF
DECLNKAAAVIDALKIADGGIL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=373, Percent_Identity=38.0697050938338, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788114, Length=410, Percent_Identity=31.219512195122, Blast_Score=218, Evalue=9e-58,
Organism=Escherichia coli, GI1786809, Length=267, Percent_Identity=28.4644194756554, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082077, Length=297, Percent_Identity=25.9259259259259, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=454, Percent_Identity=37.2246696035242, Blast_Score=279, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6324361, Length=393, Percent_Identity=23.1552162849873, Blast_Score=107, Evalue=6e-24,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56298; Mature: 56298

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSPSLEEVKEIAKNKEYKRIPVAYELYSDMATPIEVLRILKEISKHCYMLESVEDSQKW
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHC
GRYTFLGFDPLLEFTCQNGCVQIKGDSKFEDSSKLTDDDKVIIETNNPGEVIKDLVRQNK
CCEEEEEHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCC
SPKLTNLPPFTGGFVGYFAYDYIKYAEPSLNLDAENQDQFKDIDLMLFDKVVAFDNFRQK
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCE
IVLIANMKTDNLDENYKKACDDLEKIARLIKTGKKAKIEPLTLKSDFKPVFSREKYCQMV
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHH
NKAKDYIKEGDIFQVVLSNRIEADISGSLFDTYRVLRTTNPSPYMFYFSSNDIEIAGASP
HHHHHHHHCCCEEEEEHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCC
ETLVKLNNRKLYTFPLAGTRPRGKTESEDLALEKELLSDEKELAEHNMLVDLGRNDIGKI
CCEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCEEEECCCCCCCHH
SEIGSVNVDKYLSIERFSHVMHIGSTVTGTLRKDLDSLAAIDSILPAGTLSGAPKIRACE
HHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
IINELENNKRGIYGGAIGYIDLSGNVDTCISIRIAFARNNKVFIRSGAGIVADSVPDNEF
HHHHHHCCCCCEECCEEEEEEECCCCCEEEEEEEEEEECCEEEEEECCCEEECCCCCHHH
DECLNKAAAVIDALKIADGGIL
HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSPSLEEVKEIAKNKEYKRIPVAYELYSDMATPIEVLRILKEISKHCYMLESVEDSQKW
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHC
GRYTFLGFDPLLEFTCQNGCVQIKGDSKFEDSSKLTDDDKVIIETNNPGEVIKDLVRQNK
CCEEEEEHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCC
SPKLTNLPPFTGGFVGYFAYDYIKYAEPSLNLDAENQDQFKDIDLMLFDKVVAFDNFRQK
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCE
IVLIANMKTDNLDENYKKACDDLEKIARLIKTGKKAKIEPLTLKSDFKPVFSREKYCQMV
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHH
NKAKDYIKEGDIFQVVLSNRIEADISGSLFDTYRVLRTTNPSPYMFYFSSNDIEIAGASP
HHHHHHHHCCCEEEEEHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCC
ETLVKLNNRKLYTFPLAGTRPRGKTESEDLALEKELLSDEKELAEHNMLVDLGRNDIGKI
CCEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCEEEECCCCCCCHH
SEIGSVNVDKYLSIERFSHVMHIGSTVTGTLRKDLDSLAAIDSILPAGTLSGAPKIRACE
HHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
IINELENNKRGIYGGAIGYIDLSGNVDTCISIRIAFARNNKVFIRSGAGIVADSVPDNEF
HHHHHHCCCCCEECCEEEEEEECCCCCEEEEEEEEEEECCEEEEEECCCEEECCCCCHHH
DECLNKAAAVIDALKIADGGIL
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]