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The map label for this gene is hisD [H]

Identifier: 146300626

GI number: 146300626

Start: 3413728

End: 3415011

Strand: Reverse

Name: hisD [H]

Synonym: Fjoh_2877

Alternate gene names: 146300626

Gene position: 3415011-3413728 (Counterclockwise)

Preceding gene: 146300627

Following gene: 146300625

Centisome position: 56.01

GC content: 36.6

Gene sequence:

>1284_bases
ATGAATAAAATAGACAATCCAAAACCAGATACTTGGTCTGAAATATTAAAAAGACCAACCCAGACAATAGACGATATTGA
AGTAACCGTAAAAGAAATCTTCAAAGAAATTCAAAAAAAGGGTGACGAAGCGGTAGCAAAATATACCTCAATTTTTGATG
GAATTGCTTTAGACAGCTACGAAGTTACAAAGGAAGAAATACAAGAAGCAATTGAAAAGATTCCCAATGATTTGAAAGAA
TCAATTCAATTGGCAAAAGACAATATTTATAAATTTCACAGCGCTCAAAAAACAAACAGGATTGACGTTGAAACTATCGA
AGGCGTAAACTGCTGGCAGGAAAAAAGACCAATTCAAAAAATTGGATTGTATATTCCGGGCGGTACAGCACCTTTATTTT
CAACAGTTTTGATGCTGGCAGTTCCAGCAGAGATTGCAGGATGTAAAGAAATAGTATTATGCTCGCCGCCAGATAAAAAA
GGAAAAATTAATCCGGCAATTTTATATGCTGCTAATTTATGCGGTGTAACTAAAATTATAAAAGCAGGCGGAATTCAGGC
AATTGCAGGGATGACCTTCGGTACACAATCTATTCCAAAAGTGTATAAAATTTTTGGACCTGGTAATCAGTTTGTAACCG
TTGCCAAACAATTAGCGACACAATTTGGAGTAGCAATTGATATGCCGGCCGGACCTTCAGAATTATTAATTGTAGCCGAT
GATACAGCAGTTCCGGCTTTTGTAGCTTCTGATTTGCTTTCTCAGGCAGAACACGGAACAGACAGTCAGGTAATTTTGGT
TTCGACTTCAAAAAAATTGATTGCCGAAGTAGAAAAAGAAGTTCAGTCACAGCTCGAAGTTCTTCCAAGAAAAGCTATTG
CAGAGAAAGCAATCGAAAATTCAAAACTAATTTATGTTGAAAATGATCAGAGAGCTTTAGATTTAATTAACGAATACGGT
CCGGAACACTTTATAATCTGCTCTCAATATGATGATTTTTACTGTAACGGAATTGTAAACGCGGGTTCTGTTTTTATTGG
AAATTATACGCCGGAAAGCGCCGGAGATTACGCTTCAGGTACCAATCATACTTTACCAACCAATGGTTACGCTAAGAATT
ACAGCGGTGTAAATCTGGATAGTTTTATGAAATCAATGACATTCCAGAAAATTTCTGAAAAAGGAATTCAAAACATCGGA
AAAGCAATCGAAACTATGGCTGAGGCCGAAGGGCTGCAAGCGCATAAAAATGCTGTGACGTTAAGATTAAAGAGTTTAGA
GTAA

Upstream 100 bases:

>100_bases
TTAAGCTTTAGGCTTTTGAAAAGTTTGCTCCTTAAGAAAAAAATAAACACAACGTTAATAAAGCCTAAAGCCCACAGCTT
AAAGCTTAAAGCTTAAGAAA

Downstream 100 bases:

>100_bases
AAGACAAAGGAAGAAGAAAGAAGCAAGAGTTAAGATTTTTTAAAGTCTTTCTTTTTAATTCTTGCTTCTTAAAAAATTAA
AGCAATGAATACGTTCGATA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNKIDNPKPDTWSEILKRPTQTIDDIEVTVKEIFKEIQKKGDEAVAKYTSIFDGIALDSYEVTKEEIQEAIEKIPNDLKE
SIQLAKDNIYKFHSAQKTNRIDVETIEGVNCWQEKRPIQKIGLYIPGGTAPLFSTVLMLAVPAEIAGCKEIVLCSPPDKK
GKINPAILYAANLCGVTKIIKAGGIQAIAGMTFGTQSIPKVYKIFGPGNQFVTVAKQLATQFGVAIDMPAGPSELLIVAD
DTAVPAFVASDLLSQAEHGTDSQVILVSTSKKLIAEVEKEVQSQLEVLPRKAIAEKAIENSKLIYVENDQRALDLINEYG
PEHFIICSQYDDFYCNGIVNAGSVFIGNYTPESAGDYASGTNHTLPTNGYAKNYSGVNLDSFMKSMTFQKISEKGIQNIG
KAIETMAEAEGLQAHKNAVTLRLKSLE

Sequences:

>Translated_427_residues
MNKIDNPKPDTWSEILKRPTQTIDDIEVTVKEIFKEIQKKGDEAVAKYTSIFDGIALDSYEVTKEEIQEAIEKIPNDLKE
SIQLAKDNIYKFHSAQKTNRIDVETIEGVNCWQEKRPIQKIGLYIPGGTAPLFSTVLMLAVPAEIAGCKEIVLCSPPDKK
GKINPAILYAANLCGVTKIIKAGGIQAIAGMTFGTQSIPKVYKIFGPGNQFVTVAKQLATQFGVAIDMPAGPSELLIVAD
DTAVPAFVASDLLSQAEHGTDSQVILVSTSKKLIAEVEKEVQSQLEVLPRKAIAEKAIENSKLIYVENDQRALDLINEYG
PEHFIICSQYDDFYCNGIVNAGSVFIGNYTPESAGDYASGTNHTLPTNGYAKNYSGVNLDSFMKSMTFQKISEKGIQNIG
KAIETMAEAEGLQAHKNAVTLRLKSLE
>Mature_427_residues
MNKIDNPKPDTWSEILKRPTQTIDDIEVTVKEIFKEIQKKGDEAVAKYTSIFDGIALDSYEVTKEEIQEAIEKIPNDLKE
SIQLAKDNIYKFHSAQKTNRIDVETIEGVNCWQEKRPIQKIGLYIPGGTAPLFSTVLMLAVPAEIAGCKEIVLCSPPDKK
GKINPAILYAANLCGVTKIIKAGGIQAIAGMTFGTQSIPKVYKIFGPGNQFVTVAKQLATQFGVAIDMPAGPSELLIVAD
DTAVPAFVASDLLSQAEHGTDSQVILVSTSKKLIAEVEKEVQSQLEVLPRKAIAEKAIENSKLIYVENDQRALDLINEYG
PEHFIICSQYDDFYCNGIVNAGSVFIGNYTPESAGDYASGTNHTLPTNGYAKNYSGVNLDSFMKSMTFQKISEKGIQNIG
KAIETMAEAEGLQAHKNAVTLRLKSLE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=417, Percent_Identity=51.0791366906475, Blast_Score=428, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319819, Length=418, Percent_Identity=49.7607655502392, Blast_Score=397, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46657; Mature: 46657

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIDNPKPDTWSEILKRPTQTIDDIEVTVKEIFKEIQKKGDEAVAKYTSIFDGIALDSY
CCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCH
EVTKEEIQEAIEKIPNDLKESIQLAKDNIYKFHSAQKTNRIDVETIEGVNCWQEKRPIQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHCCCHHH
IGLYIPGGTAPLFSTVLMLAVPAEIAGCKEIVLCSPPDKKGKINPAILYAANLCGVTKII
HCEECCCCCHHHHHHHHHHHHCHHHCCCCEEEEECCCCCCCCCCHHEEEHHHHHHHHHHH
KAGGIQAIAGMTFGTQSIPKVYKIFGPGNQFVTVAKQLATQFGVAIDMPAGPSELLIVAD
HHCCCCEECCCCCCCCCCCHHHEEECCCHHHHHHHHHHHHHHCCEEECCCCCCCEEEEEC
DTAVPAFVASDLLSQAEHGTDSQVILVSTSKKLIAEVEKEVQSQLEVLPRKAIAEKAIEN
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SKLIYVENDQRALDLINEYGPEHFIICSQYDDFYCNGIVNAGSVFIGNYTPESAGDYASG
CEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCHHCCCCCCCCEEECCCCCCCCCCCCCC
TNHTLPTNGYAKNYSGVNLDSFMKSMTFQKISEKGIQNIGKAIETMAEAEGLQAHKNAVT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCEEE
LRLKSLE
EEEECCC
>Mature Secondary Structure
MNKIDNPKPDTWSEILKRPTQTIDDIEVTVKEIFKEIQKKGDEAVAKYTSIFDGIALDSY
CCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCH
EVTKEEIQEAIEKIPNDLKESIQLAKDNIYKFHSAQKTNRIDVETIEGVNCWQEKRPIQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHCCCHHH
IGLYIPGGTAPLFSTVLMLAVPAEIAGCKEIVLCSPPDKKGKINPAILYAANLCGVTKII
HCEECCCCCHHHHHHHHHHHHCHHHCCCCEEEEECCCCCCCCCCHHEEEHHHHHHHHHHH
KAGGIQAIAGMTFGTQSIPKVYKIFGPGNQFVTVAKQLATQFGVAIDMPAGPSELLIVAD
HHCCCCEECCCCCCCCCCCHHHEEECCCHHHHHHHHHHHHHHCCEEECCCCCCCEEEEEC
DTAVPAFVASDLLSQAEHGTDSQVILVSTSKKLIAEVEKEVQSQLEVLPRKAIAEKAIEN
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SKLIYVENDQRALDLINEYGPEHFIICSQYDDFYCNGIVNAGSVFIGNYTPESAGDYASG
CEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCHHCCCCCCCCEEECCCCCCCCCCCCCC
TNHTLPTNGYAKNYSGVNLDSFMKSMTFQKISEKGIQNIGKAIETMAEAEGLQAHKNAVT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCEEE
LRLKSLE
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]