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The map label for this gene is hisC

Identifier: 146300625

GI number: 146300625

Start: 3412594

End: 3413643

Strand: Reverse

Name: hisC

Synonym: Fjoh_2876

Alternate gene names: 146300625

Gene position: 3413643-3412594 (Counterclockwise)

Preceding gene: 146300626

Following gene: 146300624

Centisome position: 55.99

GC content: 32.19

Gene sequence:

>1050_bases
ATGAATACGTTCGATATAAATACAATAACAAGAGAAAACGTAAAATCTTTAAAACCATATTCTTCAGCAAGAGATGAATT
TGAAGATTTTGATACAGCCGAAATGATTTTTCTGGATGCTAATGAAAATCCGTTTCAAAATGGTGTAAACCGTTACCCGG
ATCCGCAGCAAAACTCAGTTAAAGCGATTTTGGCTAAAAACAATAATACAAAACAAAGTCAGATTTTATTAGGAAACGGA
AGCGATGAAGTTTTAGATTTACTTTTCAGAGCTTTTTGCGAACCAAATAAAGACAATATCATTTCATTGCCGCCAACTTA
CGGTATGTATGGTGTTTTAGCAAATATCAATGCGGTAGAAAACAGAGAAATTTTGCTGACAACTGATTTTCAGCCACAAG
TTGAAAAGATTTTAGAAGCAGTTGATGAAAATACCAAAATCATCTTTTTATGTTCGCCAAACAATCCAACAGGAAATTCA
TTTTCTGATGAAAGTGTGGTGAAACTGCTTCAAAACTTCAAAGGTCTAGTGGTTATTGACGAAGCGTATATTGACTTTTC
AGAAAAGGAAAGCTGGCTGACAGAAATCGATGAATATCCGAATTTAGTAATTACACAAACGCTTTCTAAGGCTTATGGTT
TAGCAGGAATTCGTTTAGGGATTTGTTATGCATCAGAGGCTGTAATCTCGGTTTTAAATAAAATCAAACCGCCTTATAAT
GTAAACGAATTAACGCAGCAAAGGGCGAAAGAGCGTTTAAAAGATTTAGATAAAATTAAGCAAGAAATAGCTTCAATTAT
TGAGCAAAGAGAAGAATTGCTTAAAGTTTTACTTGAAGTAAATTTTGTTGAAAAAGTATATCCAACAGAAGCTAATTTTA
TCTTAGCAAAAGTGGATGATGCTAATAAAAGATACAATCAATTAATCGAAAAAGGAATCGTTATTCGTAACAGAACAACA
CAGCCTTTATGTGAAAATTGTCTTCGTTTTACAATTGGAACAAAAGAAGAAAATGCGGTTGTAATTAAAGAATTAAAATT
ATTGAACTAA

Upstream 100 bases:

>100_bases
AAAGAGTTTAGAGTAAAAGACAAAGGAAGAAGAAAGAAGCAAGAGTTAAGATTTTTTAAAGTCTTTCTTTTTAATTCTTG
CTTCTTAAAAAATTAAAGCA

Downstream 100 bases:

>100_bases
AAATATTAGCCACAGATTATACAGATTAAAATGATTTCTTTCTGTGTATGATTTTTCGCCACGAATTGCACGAATTAGCA
CAAATTAAATTAGTGAAAAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MNTFDINTITRENVKSLKPYSSARDEFEDFDTAEMIFLDANENPFQNGVNRYPDPQQNSVKAILAKNNNTKQSQILLGNG
SDEVLDLLFRAFCEPNKDNIISLPPTYGMYGVLANINAVENREILLTTDFQPQVEKILEAVDENTKIIFLCSPNNPTGNS
FSDESVVKLLQNFKGLVVIDEAYIDFSEKESWLTEIDEYPNLVITQTLSKAYGLAGIRLGICYASEAVISVLNKIKPPYN
VNELTQQRAKERLKDLDKIKQEIASIIEQREELLKVLLEVNFVEKVYPTEANFILAKVDDANKRYNQLIEKGIVIRNRTT
QPLCENCLRFTIGTKEENAVVIKELKLLN

Sequences:

>Translated_349_residues
MNTFDINTITRENVKSLKPYSSARDEFEDFDTAEMIFLDANENPFQNGVNRYPDPQQNSVKAILAKNNNTKQSQILLGNG
SDEVLDLLFRAFCEPNKDNIISLPPTYGMYGVLANINAVENREILLTTDFQPQVEKILEAVDENTKIIFLCSPNNPTGNS
FSDESVVKLLQNFKGLVVIDEAYIDFSEKESWLTEIDEYPNLVITQTLSKAYGLAGIRLGICYASEAVISVLNKIKPPYN
VNELTQQRAKERLKDLDKIKQEIASIIEQREELLKVLLEVNFVEKVYPTEANFILAKVDDANKRYNQLIEKGIVIRNRTT
QPLCENCLRFTIGTKEENAVVIKELKLLN
>Mature_349_residues
MNTFDINTITRENVKSLKPYSSARDEFEDFDTAEMIFLDANENPFQNGVNRYPDPQQNSVKAILAKNNNTKQSQILLGNG
SDEVLDLLFRAFCEPNKDNIISLPPTYGMYGVLANINAVENREILLTTDFQPQVEKILEAVDENTKIIFLCSPNNPTGNS
FSDESVVKLLQNFKGLVVIDEAYIDFSEKESWLTEIDEYPNLVITQTLSKAYGLAGIRLGICYASEAVISVLNKIKPPYN
VNELTQQRAKERLKDLDKIKQEIASIIEQREELLKVLLEVNFVEKVYPTEANFILAKVDDANKRYNQLIEKGIVIRNRTT
QPLCENCLRFTIGTKEENAVVIKELKLLN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=357, Percent_Identity=38.655462184874, Blast_Score=249, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322075, Length=380, Percent_Identity=39.7368421052632, Blast_Score=242, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_FLAJ1 (A5FFY0)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001195216.1
- ProteinModelPortal:   A5FFY0
- SMR:   A5FFY0
- STRING:   A5FFY0
- GeneID:   5092696
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_2876
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   NLCLGVG
- ProtClustDB:   CLSK2784490
- BioCyc:   FJOH376686:FJOH_2876-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39654; Mature: 39654

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFDINTITRENVKSLKPYSSARDEFEDFDTAEMIFLDANENPFQNGVNRYPDPQQNSV
CCCEECCCCCHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCCCCCCCCCE
KAILAKNNNTKQSQILLGNGSDEVLDLLFRAFCEPNKDNIISLPPTYGMYGVLANINAVE
EEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHCCCCCC
NREILLTTDFQPQVEKILEAVDENTKIIFLCSPNNPTGNSFSDESVVKLLQNFKGLVVID
CCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEE
EAYIDFSEKESWLTEIDEYPNLVITQTLSKAYGLAGIRLGICYASEAVISVLNKIKPPYN
HHHCCCCHHHHHHHHHHHCCCEEEHHHHHHHHCCCHHHEEHHHHHHHHHHHHHHCCCCCC
VNELTQQRAKERLKDLDKIKQEIASIIEQREELLKVLLEVNFVEKVYPTEANFILAKVDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
ANKRYNQLIEKGIVIRNRTTQPLCENCLRFTIGTKEENAVVIKELKLLN
HHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHCC
>Mature Secondary Structure
MNTFDINTITRENVKSLKPYSSARDEFEDFDTAEMIFLDANENPFQNGVNRYPDPQQNSV
CCCEECCCCCHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCCCCCCCCCE
KAILAKNNNTKQSQILLGNGSDEVLDLLFRAFCEPNKDNIISLPPTYGMYGVLANINAVE
EEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHCCCCCC
NREILLTTDFQPQVEKILEAVDENTKIIFLCSPNNPTGNSFSDESVVKLLQNFKGLVVID
CCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEE
EAYIDFSEKESWLTEIDEYPNLVITQTLSKAYGLAGIRLGICYASEAVISVLNKIKPPYN
HHHCCCCHHHHHHHHHHHCCCEEEHHHHHHHHCCCHHHEEHHHHHHHHHHHHHHCCCCCC
VNELTQQRAKERLKDLDKIKQEIASIIEQREELLKVLLEVNFVEKVYPTEANFILAKVDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
ANKRYNQLIEKGIVIRNRTTQPLCENCLRFTIGTKEENAVVIKELKLLN
HHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA