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The map label for this gene is hisG [H]

Identifier: 146300627

GI number: 146300627

Start: 3415139

End: 3415996

Strand: Reverse

Name: hisG [H]

Synonym: Fjoh_2878

Alternate gene names: 146300627

Gene position: 3415996-3415139 (Counterclockwise)

Preceding gene: 146300628

Following gene: 146300626

Centisome position: 56.03

GC content: 33.68

Gene sequence:

>858_bases
ATGAGTACTTTAAAAATTGCAATTCAAAAATCAGGTCGTTTAAACGAAGACAGTATCCAAATCCTTAAAGACTGCGGTAT
TTCAATCAATAACGGAATCGACCAGTTAAAAGCCGAAGCTTCAAACTTTCCTCTTGAAGTTTTGTATTTAAGAAATTCAG
ATATTCCTCAGTATTTAATTGACGGTGTAGTAGATTTAGCCATTGTAGGCGACAATCTTTTAGTAGAAAAAGGAAAAAAC
ATCGAAGTTGTACAGCGATTGGGATTCTCAAAATGCAAAGTTTCTGTAGCAGTTCCTAAAACTTTTGATTACAAATCGAT
ACAGGATTTAGCAGGTCTTAGAATCGCAACTTCTTATCCAAATACCGTAAATGAATACTTTAATTCATTTGGTTTAAAGG
TTGATATTCACCAAATTTCAGGTTCAGTAGAAATTGCGCCAAATATAGGACTTGCAGATGCTATTGTAGATATTGTTTCA
AGTGGAAGCACCTTATTCAAAAACAATTTAAAAGAAGTTGAAGTTATCCTGAAAAGTGAAGCCGTTTTAGCTGTTTCGCC
AAAAGTTTCTCCAGAAATTCAAAAACACATTGATACCTTAAAATTCAGAATTCAGTCGGTTTTAAGAGCCAGAAATTCAA
AATACATTTTGATGAACGTTCCAAATGACAAAATTGATGCAGTTGGAAAAATCCTTCCGGTTTTAAGAAGTTTAACCGTT
CTGCCATTAGCAGAGGAAGGCTGGAGCAGTGTACACTCAGTAATTGATAAAGATACTTTTTGGGATGTAATCGATAAATT
AAAAGAAGTAGGAGCAGAAGGAATTTTAGTATGCCCAATTGAAAAAATGGTTCTTTAG

Upstream 100 bases:

>100_bases
TGTAAATCATCATATTTTAAAACCCGTTTGAGTACATCAAACGGGTTTTTTTATACCAATTCTTTGTACTCAAACTATTA
ATTAAACAACAACTAAAAAA

Downstream 100 bases:

>100_bases
GGCTTCGCCCGCTTTAGGCAGTAGGCTTTAAGCTTTAGGCTTTTGAAAAGTTTGCTCCTTAAGAAAAAAATAAACACAAC
GTTAATAAAGCCTAAAGCCC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSTLKIAIQKSGRLNEDSIQILKDCGISINNGIDQLKAEASNFPLEVLYLRNSDIPQYLIDGVVDLAIVGDNLLVEKGKN
IEVVQRLGFSKCKVSVAVPKTFDYKSIQDLAGLRIATSYPNTVNEYFNSFGLKVDIHQISGSVEIAPNIGLADAIVDIVS
SGSTLFKNNLKEVEVILKSEAVLAVSPKVSPEIQKHIDTLKFRIQSVLRARNSKYILMNVPNDKIDAVGKILPVLRSLTV
LPLAEEGWSSVHSVIDKDTFWDVIDKLKEVGAEGILVCPIEKMVL

Sequences:

>Translated_285_residues
MSTLKIAIQKSGRLNEDSIQILKDCGISINNGIDQLKAEASNFPLEVLYLRNSDIPQYLIDGVVDLAIVGDNLLVEKGKN
IEVVQRLGFSKCKVSVAVPKTFDYKSIQDLAGLRIATSYPNTVNEYFNSFGLKVDIHQISGSVEIAPNIGLADAIVDIVS
SGSTLFKNNLKEVEVILKSEAVLAVSPKVSPEIQKHIDTLKFRIQSVLRARNSKYILMNVPNDKIDAVGKILPVLRSLTV
LPLAEEGWSSVHSVIDKDTFWDVIDKLKEVGAEGILVCPIEKMVL
>Mature_284_residues
STLKIAIQKSGRLNEDSIQILKDCGISINNGIDQLKAEASNFPLEVLYLRNSDIPQYLIDGVVDLAIVGDNLLVEKGKNI
EVVQRLGFSKCKVSVAVPKTFDYKSIQDLAGLRIATSYPNTVNEYFNSFGLKVDIHQISGSVEIAPNIGLADAIVDIVSS
GSTLFKNNLKEVEVILKSEAVLAVSPKVSPEIQKHIDTLKFRIQSVLRARNSKYILMNVPNDKIDAVGKILPVLRSLTVL
PLAEEGWSSVHSVIDKDTFWDVIDKLKEVGAEGILVCPIEKMVL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=294, Percent_Identity=43.1972789115646, Blast_Score=232, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320896, Length=284, Percent_Identity=33.4507042253521, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 31299; Mature: 31168

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLKIAIQKSGRLNEDSIQILKDCGISINNGIDQLKAEASNFPLEVLYLRNSDIPQYLI
CCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHH
DGVVDLAIVGDNLLVEKGKNIEVVQRLGFSKCKVSVAVPKTFDYKSIQDLAGLRIATSYP
HHHHEEEEECCCEEEECCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCEEEECCCC
NTVNEYFNSFGLKVDIHQISGSVEIAPNIGLADAIVDIVSSGSTLFKNNLKEVEVILKSE
HHHHHHHHHCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCCHHHHCCHHHHHHHHHCC
AVLAVSPKVSPEIQKHIDTLKFRIQSVLRARNSKYILMNVPNDKIDAVGKILPVLRSLTV
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHC
LPLAEEGWSSVHSVIDKDTFWDVIDKLKEVGAEGILVCPIEKMVL
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCHHHHCC
>Mature Secondary Structure 
STLKIAIQKSGRLNEDSIQILKDCGISINNGIDQLKAEASNFPLEVLYLRNSDIPQYLI
CCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHH
DGVVDLAIVGDNLLVEKGKNIEVVQRLGFSKCKVSVAVPKTFDYKSIQDLAGLRIATSYP
HHHHEEEEECCCEEEECCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCEEEECCCC
NTVNEYFNSFGLKVDIHQISGSVEIAPNIGLADAIVDIVSSGSTLFKNNLKEVEVILKSE
HHHHHHHHHCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCCHHHHCCHHHHHHHHHCC
AVLAVSPKVSPEIQKHIDTLKFRIQSVLRARNSKYILMNVPNDKIDAVGKILPVLRSLTV
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHC
LPLAEEGWSSVHSVIDKDTFWDVIDKLKEVGAEGILVCPIEKMVL
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA