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The map label for this gene is pgl [H]

Identifier: 126696169

GI number: 126696169

Start: 722920

End: 723657

Strand: Direct

Name: pgl [H]

Synonym: P9301_08311

Alternate gene names: 126696169

Gene position: 722920-723657 (Clockwise)

Preceding gene: 126696168

Following gene: 126696170

Centisome position: 44.03

GC content: 28.59

Gene sequence:

>738_bases
ATGGATGAAATGATTGAAAAGGTCAAAAATGGATACACCATAAATTTATACAAAGACAAATTAGAACTATCAACAGCTGT
TTTTAAGTTTATTGAAAGTCATATTATCCATACTTTAAAAAAGAAAGACAGGTTCAAATTTTGTGTAAGTGGAGGTTCAA
CTCCTAAATCTGTTTATAAGCTTTTATCAAAAAGTGATCTTAGATGGGATATGGTTGATGTCTTTTTAGGGGATGAAAGA
TGTGTTGATCCAAATTCAGAATTGAGTAACTCGTTAATGTTGAAGAATTCATTGTTAAAAAATTTTGGATCGAAAGCTTT
TTTTTATGAAATTTTCAATGATTTAAATGCTGATGATGAAGCTACAAAGAATCAATTTGTTTCTAAATTATTTGAAAAAT
GCGGATCAAACCCTCCAACTTTTGATTTAACATTATTAGGTCTCGGAGACGATGGTCATACAGCCTCACTATTTCCTTAT
CAAAAAAATAATAATGTAGATGATTTTGTTATTTTTAATGATGGTAAAGGTTTAAAAAGAATTTCACTAACTCCAAAGGT
TCTATCAGCCTCATCAAAGATTGTATTTTTAGTAAGTGGAGCTTCTAAAAGAATTGCTCTTGAGAGGTTATTAGATGAAA
AAGAGTCACCAGATAGAACACCATCAAAATTAATAAAATCTATTAATCAAATTTCAATATTTTGTGATCTGGAATCAGCA
AAAGAATTAGAAATTTAG

Upstream 100 bases:

>100_bases
GAACCAATAGACTTCCTCAGAATCTCGTTCAGGCAATGAGAGACTGTTTTGGCTCTCATACATATGAAAGAATTGATAAG
AAAGGTAGTTTTCATACTGA

Downstream 100 bases:

>100_bases
TTAAAGTCTAGTAATAATTAAAAATATTCAATGAGTAAGAAAAAATTTTTATTTCAGAAAAAAGAGTTCGATGGTTGGAA
AACATTAAATGATACTGTTA

Product: putative 6-phosphogluconolactonase (DevB, Pgl)

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MDEMIEKVKNGYTINLYKDKLELSTAVFKFIESHIIHTLKKKDRFKFCVSGGSTPKSVYKLLSKSDLRWDMVDVFLGDER
CVDPNSELSNSLMLKNSLLKNFGSKAFFYEIFNDLNADDEATKNQFVSKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPY
QKNNNVDDFVIFNDGKGLKRISLTPKVLSASSKIVFLVSGASKRIALERLLDEKESPDRTPSKLIKSINQISIFCDLESA
KELEI

Sequences:

>Translated_245_residues
MDEMIEKVKNGYTINLYKDKLELSTAVFKFIESHIIHTLKKKDRFKFCVSGGSTPKSVYKLLSKSDLRWDMVDVFLGDER
CVDPNSELSNSLMLKNSLLKNFGSKAFFYEIFNDLNADDEATKNQFVSKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPY
QKNNNVDDFVIFNDGKGLKRISLTPKVLSASSKIVFLVSGASKRIALERLLDEKESPDRTPSKLIKSINQISIFCDLESA
KELEI
>Mature_245_residues
MDEMIEKVKNGYTINLYKDKLELSTAVFKFIESHIIHTLKKKDRFKFCVSGGSTPKSVYKLLSKSDLRWDMVDVFLGDER
CVDPNSELSNSLMLKNSLLKNFGSKAFFYEIFNDLNADDEATKNQFVSKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPY
QKNNNVDDFVIFNDGKGLKRISLTPKVLSASSKIVFLVSGASKRIALERLLDEKESPDRTPSKLIKSINQISIFCDLESA
KELEI

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533058, Length=242, Percent_Identity=26.0330578512397, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533060, Length=242, Percent_Identity=26.0330578512397, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321957, Length=230, Percent_Identity=27.8260869565217, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319918, Length=209, Percent_Identity=30.1435406698565, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324362, Length=216, Percent_Identity=28.7037037037037, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321687, Length=219, Percent_Identity=30.5936073059361, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 27645; Mature: 27645

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEMIEKVKNGYTINLYKDKLELSTAVFKFIESHIIHTLKKKDRFKFCVSGGSTPKSVYK
CCHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
LLSKSDLRWDMVDVFLGDERCVDPNSELSNSLMLKNSLLKNFGSKAFFYEIFNDLNADDE
HHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCH
ATKNQFVSKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPYQKNNNVDDFVIFNDGKGLKR
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCCEE
ISLTPKVLSASSKIVFLVSGASKRIALERLLDEKESPDRTPSKLIKSINQISIFCDLESA
EECCHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEEECCCC
KELEI
CCCCC
>Mature Secondary Structure
MDEMIEKVKNGYTINLYKDKLELSTAVFKFIESHIIHTLKKKDRFKFCVSGGSTPKSVYK
CCHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
LLSKSDLRWDMVDVFLGDERCVDPNSELSNSLMLKNSLLKNFGSKAFFYEIFNDLNADDE
HHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCH
ATKNQFVSKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPYQKNNNVDDFVIFNDGKGLKR
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCCEE
ISLTPKVLSASSKIVFLVSGASKRIALERLLDEKESPDRTPSKLIKSINQISIFCDLESA
EECCHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEEECCCC
KELEI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]