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The map label for this gene is gnd [H]

Identifier: 126696168

GI number: 126696168

Start: 721514

End: 722932

Strand: Direct

Name: gnd [H]

Synonym: P9301_08301

Alternate gene names: 126696168

Gene position: 721514-722932 (Clockwise)

Preceding gene: 126696167

Following gene: 126696169

Centisome position: 43.94

GC content: 35.8

Gene sequence:

>1419_bases
ATGTCCAAGGCACATTTTGGTTTAATAGGTCTTGGTGTTATGGGCGAAAATTTAGTTCTTAACGCAGAGAGAAATGGATT
TTCTAGTGTAGTTTTTAATAGGACTTACTCCAAAACCGAGGAATTTTTACAAGGTCGTGGCCTTGGAAAGAATATTGAAG
GAGCTGAAACTCTTCAAGAATTTGTTAATAAGCTAGAGAGACCTAGAAGAATTCTAATGATGGTAAAAGCTGGGCCCGCA
ACAGATGCTGTCATTGATAATATTTCTGGATATCTCGAGGAAGGAGATTTATTAATAGATGGCGGCAACTCTCAATTTAA
AGATACAGAAAGAAGGGTGAATACTCTTGAAAGTAAAAGTTTTGGATACATTGGGATGGGAGTCTCTGGAGGTGCTAAAG
GAGCTCTAGAGGGCCCAAGCATGATGCCCGGTGGAACTAAGGCTTCATATGATGCAATAGAAAGCTTATTAACAAAAATG
GCTGCCAAAGTTGAAGACGGACCATGTGTCGCATATGTTGGACCAGGAGGCTCAGGTCATTTTGTAAAAACTGTTCATAA
CGGAATTGAATATGGAATTGAACAAATACTTGCAGAAGCTTATGACCTTATGAAGAGAGTCAAAGGTATGAATGGACAGC
AGATGTCAGAGGTATTTGGTATTTGGAATAATACTGATGAATTAGCTTCTTATCTTGTTGAGATAACAGAGATTTGTCTA
AATACAAAAGATGAGATAACTGGAGATGATGTCGTGGAAAAAATATTAGATAAAGCTGGCCAGAAAGGTACAGGGTTATG
GACTGTTGTAAGTGCTCTAGAACTGGGGGTATCAGTCCCAACTATTTATGCATCTTTAAATGCAAGAGTAATGAGTTCTT
TAAAAGAGCAACGTAGTGAGATTGAAAAAACTATTCCATCTAAAGAGATAGAAGATTTTGATTTAGGAAATATATCAGAT
GGAATGAAACCTTTATTTGATGCTGTAGTCCTTGCCACAATTGCTAGCTATGCCCAAGGTATGGATATTTTAAGAGAAGC
ATCTGCAGTATATAACTATGGTTTAAATATGCCGTCAATTGCTCAAATATGGAAAGGTGGTTGCATAATTAGATCAAAAT
TATTAAGTAAAATTCAAGATGCCTATAATAAAGACCCTAATCTAAAAAATTTAATTTTTGATGATTGGTTTAATAATGAA
ATTGCGACAAGATTAGATAACTTAGCTAAAGTAGTCTCTCTATCCACAAAGGCAGGTATACCAGTGCCATGTTTATCCAG
TACTTTAGATTATTTAAATAGTTATAGAACCAATAGACTTCCTCAGAATCTCGTTCAGGCAATGAGAGACTGTTTTGGCT
CTCATACATATGAAAGAATTGATAAGAAAGGTAGTTTTCATACTGAATGGATGAAATGA

Upstream 100 bases:

>100_bases
TTTAAATCTTTTCCATCATTTTTCGCTGACATAAGTATTTTTTTTGAGCAATTTTGTTGAGTTGCAGGCACACTATATTT
ATTGAGTTTTTTAATTTTTT

Downstream 100 bases:

>100_bases
TTGAAAAGGTCAAAAATGGATACACCATAAATTTATACAAAGACAAATTAGAACTATCAACAGCTGTTTTTAAGTTTATT
GAAAGTCATATTATCCATAC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQEFVNKLERPRRILMMVKAGPA
TDAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKM
AAKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
NTKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSEIEKTIPSKEIEDFDLGNISD
GMKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSIAQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNE
IATRLDNLAKVVSLSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKKGSFHTEWMK

Sequences:

>Translated_472_residues
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQEFVNKLERPRRILMMVKAGPA
TDAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKM
AAKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
NTKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSEIEKTIPSKEIEDFDLGNISD
GMKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSIAQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNE
IATRLDNLAKVVSLSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKKGSFHTEWMK
>Mature_471_residues
SKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQEFVNKLERPRRILMMVKAGPAT
DAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMA
AKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICLN
TKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSEIEKTIPSKEIEDFDLGNISDG
MKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSIAQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNEI
ATRLDNLAKVVSLSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKKGSFHTEWMK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=46.1864406779661, Blast_Score=414, Evalue=1e-115,
Organism=Escherichia coli, GI1788341, Length=472, Percent_Identity=47.6694915254237, Blast_Score=439, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=44.7033898305085, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321695, Length=474, Percent_Identity=44.0928270042194, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321977, Length=462, Percent_Identity=45.4545454545455, Blast_Score=416, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24639279, Length=471, Percent_Identity=43.9490445859873, Blast_Score=386, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51705; Mature: 51573

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQE
CCCCCCCEEEECCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHH
FVNKLERPRRILMMVKAGPATDAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKS
HHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMAAKVEDGPCVAYVGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NTKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSE
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEKTIPSKEIEDFDLGNISDGMKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNEIATRLDNLAKVVSLSTKAGI
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKKGSFHTEWMK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQE
CCCCCCEEEECCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHH
FVNKLERPRRILMMVKAGPATDAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKS
HHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMAAKVEDGPCVAYVGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NTKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSE
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEKTIPSKEIEDFDLGNISDGMKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNEIATRLDNLAKVVSLSTKAGI
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKKGSFHTEWMK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]