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The map label for this gene is phoA [H]

Identifier: 126453494

GI number: 126453494

Start: 369219

End: 370622

Strand: Direct

Name: phoA [H]

Synonym: BURPS1106A_0405

Alternate gene names: 126453494

Gene position: 369219-370622 (Clockwise)

Preceding gene: 126454088

Following gene: 126452050

Centisome position: 9.26

GC content: 68.66

Gene sequence:

>1404_bases
ATGTCGACTATCAAGCGCATCGCGGCGGCGGCGTTCGCCGCGGCGGCCCTCTCGGGCGGTTTCGGCCACGCGGCGCACGC
CGCGGGCCAGGCGAAGAACGTGATCTTCTTCCTCGGCGACGGGATGGGGCCGGCCACCGTGACGGCGAGCCGCCTCTACA
AGGTCGGCGAAGCCGGCCAACTGACGATGGAAAAGCTGCCGCGCACCGCGCGCATCAAGACCTTCTCGAACGACGCGCAG
ACGACGGACAGCGCACCGTCGATGGCCGCGTACATGACCGGCGTGAAGATGAACAACGAGGTGCTGTCGATGTCGCCGGA
CACGCGCGCGATCGCCCCCGGCAGCGATGCGAACGGCAACAAGACGGTGAACCGCTGCGGCGTGGGCAACGGCACGCCGG
CGACGACGCTGCTCGAGCTCGCGAAGGCGCGCGGCAAGGCGGTCGGCGCGATCACGACGACCGAGCTCACGCACGCGACG
CCCGCGGCGACTTACTCGCACATCTGCCATCGCGACGCGCAGTACGACATTGCCGCGCAGGCCGTGCCGGGCGGCGCGGG
CTACAACGCGGCGCTCGGCGACGGCGTCGACGTGCTGATGGGCGGCGGCCGCAATCACTGGACGCCGTACGATCCGCTCG
CCAACAGGCGCGGCCGCGCGGACGGGCGCAACCTGCTCGCCGAGCTGCAGGCGAAGGGCTACGCGGTGGTCGCGACGAAG
GATCAGCTCGCGCAGGCGGGCGCGGGCAAGCTGATCGGCCTTTTCAGCACGACGAGCCATCTCGAATACGAGCTCGACCG
CGTCGCGGGCAAGGGCGAGGGCGCGACGCAGCCGAGCCTCGCGGAGATGACCGCGAAGGCGATCGACGTGTTGCGGAAGA
ATCCGAACGGCTATTTCCTGATGGTCGAAGGCGGGCGCATCGACCACGCGCTGCACGGCACGAACGCGAAGCGCGCGCTC
GAAGACACGGTGGCGTTCGACGAGGCGATCCGCACCGCGCTCGCGAAGGTCGATCTATCGGATACGCTGATCGTCGTGAC
GGCCGATCACGATCACACGATGACGATCAACGGCTATTCGAAGCGCGGCAATCCGGTGCTCGACATCAGCCGCAACTATC
GCGACGGCCAGCCGAACAAGGACGCGGACGGCAACCCGTACACGACGCTCGTGTTCGGCAATGGCGCGAACCGGCCGAAC
GTGCGCGTGCCGGTGGATTCGTCGACGGCGACGAACGACGCGTATCTGCAGGAAGTCGGCGTGCGCATGGGCAGCGCGGG
TTCCGAGACGCATGGCGGCGGCGACGTGATGCTGTTCGCCGACGGCGCCGGCGCGAAGGCGTTCAAGGGCACGCTCGACA
ACACGAAGGTGTTCGGCCTCGTGAAGGCCGCGTTCGGGTTCTGA

Upstream 100 bases:

>100_bases
ACGGCTTTCACGGCGTGATCGAGAACAACAAGGTGTTCGAGCTCGTGCGCGGCGCGGCGCAGCTCTGAGCGCGGCTTGAC
GGGAAACAGGGGAATACAGG

Downstream 100 bases:

>100_bases
GCGCAATGGCTGCGATGCGAACGTTCGCGATGAAGCTCGATGCCGTGCGGCGCGCATGCGCGGCGCTCGGCGGCGCGGCC
GTGCTCGCCGCCGCGCCGGC

Product: alkaline phosphatase family protein

Products: NA

Alternate protein names: APase [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSTIKRIAAAAFAAAALSGGFGHAAHAAGQAKNVIFFLGDGMGPATVTASRLYKVGEAGQLTMEKLPRTARIKTFSNDAQ
TTDSAPSMAAYMTGVKMNNEVLSMSPDTRAIAPGSDANGNKTVNRCGVGNGTPATTLLELAKARGKAVGAITTTELTHAT
PAATYSHICHRDAQYDIAAQAVPGGAGYNAALGDGVDVLMGGGRNHWTPYDPLANRRGRADGRNLLAELQAKGYAVVATK
DQLAQAGAGKLIGLFSTTSHLEYELDRVAGKGEGATQPSLAEMTAKAIDVLRKNPNGYFLMVEGGRIDHALHGTNAKRAL
EDTVAFDEAIRTALAKVDLSDTLIVVTADHDHTMTINGYSKRGNPVLDISRNYRDGQPNKDADGNPYTTLVFGNGANRPN
VRVPVDSSTATNDAYLQEVGVRMGSAGSETHGGGDVMLFADGAGAKAFKGTLDNTKVFGLVKAAFGF

Sequences:

>Translated_467_residues
MSTIKRIAAAAFAAAALSGGFGHAAHAAGQAKNVIFFLGDGMGPATVTASRLYKVGEAGQLTMEKLPRTARIKTFSNDAQ
TTDSAPSMAAYMTGVKMNNEVLSMSPDTRAIAPGSDANGNKTVNRCGVGNGTPATTLLELAKARGKAVGAITTTELTHAT
PAATYSHICHRDAQYDIAAQAVPGGAGYNAALGDGVDVLMGGGRNHWTPYDPLANRRGRADGRNLLAELQAKGYAVVATK
DQLAQAGAGKLIGLFSTTSHLEYELDRVAGKGEGATQPSLAEMTAKAIDVLRKNPNGYFLMVEGGRIDHALHGTNAKRAL
EDTVAFDEAIRTALAKVDLSDTLIVVTADHDHTMTINGYSKRGNPVLDISRNYRDGQPNKDADGNPYTTLVFGNGANRPN
VRVPVDSSTATNDAYLQEVGVRMGSAGSETHGGGDVMLFADGAGAKAFKGTLDNTKVFGLVKAAFGF
>Mature_466_residues
STIKRIAAAAFAAAALSGGFGHAAHAAGQAKNVIFFLGDGMGPATVTASRLYKVGEAGQLTMEKLPRTARIKTFSNDAQT
TDSAPSMAAYMTGVKMNNEVLSMSPDTRAIAPGSDANGNKTVNRCGVGNGTPATTLLELAKARGKAVGAITTTELTHATP
AATYSHICHRDAQYDIAAQAVPGGAGYNAALGDGVDVLMGGGRNHWTPYDPLANRRGRADGRNLLAELQAKGYAVVATKD
QLAQAGAGKLIGLFSTTSHLEYELDRVAGKGEGATQPSLAEMTAKAIDVLRKNPNGYFLMVEGGRIDHALHGTNAKRALE
DTVAFDEAIRTALAKVDLSDTLIVVTADHDHTMTINGYSKRGNPVLDISRNYRDGQPNKDADGNPYTTLVFGNGANRPNV
RVPVDSSTATNDAYLQEVGVRMGSAGSETHGGGDVMLFADGAGAKAFKGTLDNTKVFGLVKAAFGF

Specific function: Unknown

COG id: COG1785

COG function: function code P; Alkaline phosphatase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alkaline phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI157266292, Length=455, Percent_Identity=35.8241758241758, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI116734717, Length=458, Percent_Identity=36.2445414847162, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI94721246, Length=455, Percent_Identity=35.3846153846154, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI157266296, Length=455, Percent_Identity=35.1648351648352, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI294660770, Length=453, Percent_Identity=35.5408388520971, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI294660772, Length=421, Percent_Identity=33.4916864608076, Blast_Score=190, Evalue=3e-48,
Organism=Escherichia coli, GI48994877, Length=474, Percent_Identity=29.535864978903, Blast_Score=131, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6320689, Length=349, Percent_Identity=32.378223495702, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21355151, Length=455, Percent_Identity=34.5054945054945, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI21358067, Length=470, Percent_Identity=35.531914893617, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI21355149, Length=466, Percent_Identity=34.3347639484979, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI85725200, Length=456, Percent_Identity=33.9912280701754, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI85815833, Length=456, Percent_Identity=33.9912280701754, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI21355981, Length=457, Percent_Identity=35.2297592997812, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI19921912, Length=472, Percent_Identity=34.5338983050847, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24585213, Length=462, Percent_Identity=33.1168831168831, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI18859923, Length=446, Percent_Identity=33.6322869955157, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651554, Length=474, Percent_Identity=33.1223628691983, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24657835, Length=470, Percent_Identity=33.8297872340426, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24657827, Length=479, Percent_Identity=33.4029227557411, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24657842, Length=471, Percent_Identity=32.484076433121, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24651556, Length=461, Percent_Identity=32.5379609544469, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR001952
- InterPro:   IPR018299
- InterPro:   IPR017850 [H]

Pfam domain/function: PF00245 Alk_phosphatase [H]

EC number: =3.1.3.1 [H]

Molecular weight: Translated: 48616; Mature: 48485

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIKRIAAAAFAAAALSGGFGHAAHAAGQAKNVIFFLGDGMGPATVTASRLYKVGEAGQ
CCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCC
LTMEKLPRTARIKTFSNDAQTTDSAPSMAAYMTGVKMNNEVLSMSPDTRAIAPGSDANGN
HHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHCCCEECCCEEEECCCCCEECCCCCCCCC
KTVNRCGVGNGTPATTLLELAKARGKAVGAITTTELTHATPAATYSHICHRDAQYDIAAQ
CCHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEE
AVPGGAGYNAALGDGVDVLMGGGRNHWTPYDPLANRRGRADGRNLLAELQAKGYAVVATK
ECCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCEEEEEEH
DQLAQAGAGKLIGLFSTTSHLEYELDRVAGKGEGATQPSLAEMTAKAIDVLRKNPNGYFL
HHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEE
MVEGGRIDHALHGTNAKRALEDTVAFDEAIRTALAKVDLSDTLIVVTADHDHTMTINGYS
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCC
KRGNPVLDISRNYRDGQPNKDADGNPYTTLVFGNGANRPNVRVPVDSSTATNDAYLQEVG
CCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHH
VRMGSAGSETHGGGDVMLFADGAGAKAFKGTLDNTKVFGLVKAAFGF
HHCCCCCCCCCCCCEEEEEECCCCCCHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
STIKRIAAAAFAAAALSGGFGHAAHAAGQAKNVIFFLGDGMGPATVTASRLYKVGEAGQ
CHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCC
LTMEKLPRTARIKTFSNDAQTTDSAPSMAAYMTGVKMNNEVLSMSPDTRAIAPGSDANGN
HHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHCCCEECCCEEEECCCCCEECCCCCCCCC
KTVNRCGVGNGTPATTLLELAKARGKAVGAITTTELTHATPAATYSHICHRDAQYDIAAQ
CCHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEE
AVPGGAGYNAALGDGVDVLMGGGRNHWTPYDPLANRRGRADGRNLLAELQAKGYAVVATK
ECCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCEEEEEEH
DQLAQAGAGKLIGLFSTTSHLEYELDRVAGKGEGATQPSLAEMTAKAIDVLRKNPNGYFL
HHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEE
MVEGGRIDHALHGTNAKRALEDTVAFDEAIRTALAKVDLSDTLIVVTADHDHTMTINGYS
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCC
KRGNPVLDISRNYRDGQPNKDADGNPYTTLVFGNGANRPNVRVPVDSSTATNDAYLQEVG
CCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHH
VRMGSAGSETHGGGDVMLFADGAGAKAFKGTLDNTKVFGLVKAAFGF
HHCCCCCCCCCCCCEEEEEECCCCCCHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2129542 [H]