Click here to switch to the map view.

The map label for this gene is mmuM [H]

Identifier: 119945820

GI number: 119945820

Start: 2637096

End: 2638028

Strand: Direct

Name: mmuM [H]

Synonym: Ping_2160

Alternate gene names: 119945820

Gene position: 2637096-2638028 (Clockwise)

Preceding gene: 119945819

Following gene: 119945838

Centisome position: 57.84

GC content: 44.48

Gene sequence:

>933_bases
ATGGATAACAGATTAAATATCACTATGAAAAGTCAGTTTAGATTACCGATAATTCTTGATGGCGGAATGGGCCGTGAGCT
TAAGCGCATTGGTGCTCCTTTTCAGCAGCCTGAATGGTCAGCTCAAGCGTTAATTGAATCCCCTCATTTTATCTCTGAAG
TACATAAAAGCTTTATAGAGGCAGGGGCTGAGGTTATTACCACTAATACCTACGCATTAGTACCCTTTCATATTGGTGAG
AAGCGTTTTAACGAACAAGGTGCTGACCTTATTAAGCTTGCCGCAAGATTAGCCCGCGAGTGCGTCAAGGAGAATTCAGC
TGTGTTGGTCGCTGGTTGTATTCCGCCAGTGTTAGGCTCTTACCGGCCAGATCTGTTTTCAGTGGAAAAAGCTAAGCCAG
TGCTTGAGCTATTGATAAAAAATCAGGAAGCTGATGTGGACATTTGGTTAGCCGAAACGATATCTTCTATCGCAGAAGCC
GCCATGATCAAGGCTCGTACTGTTGTCACCAATAAACCAACTTGGATTGCGTTTACCATTAAAGATGAAATAACTACCGA
GCCGGCCCTGCGTTCAGGAGAGTCAGTTTATGATGCGGTTAGCCAAATCGCAGGACAAAATGTTTCGGCGATCTTATTTA
ATTGCAGCGGTGTCGAAGTGATGGAGACAGCACTTATCACCGCAAAACAGGCGTTATTAGATAAAGAAATTGAAGACCAA
GTCCAGTTGGGCGTGTACGCGAATAATTTCCCTCCGATCGGTGAACTGCATCAGGCGAATCAGGATCATGGTGTCTCCGG
CATAAGAGATGATGTTCCCCCGGAAAAATACCATGAATTTGGATTATCTTGGATTAACGCTGGCGCCTCTATTATTGGTG
GATGTTGCGGGGTTTCACCGGCACATATCAAAAAATTAGCCGAGCTTAAATAG

Upstream 100 bases:

>100_bases
CTTTTCCATCCATTAGTTCTTACTGGTGCAAAAAAACCCAAGAAGTTCTAAGTGTCGTGCTTGCTTTACGCCAAGTGCAC
GGTTATTCTGCTCCTATTTT

Downstream 100 bases:

>100_bases
CCTTATAACCTTATTGCTTTCAAGCTTCGAGCCTTACTGCTTTACAGCCCTTATAGCTTGAATGTCAGTCCCTCCTGAGA
CATCATTCGCTTAATAGAGT

Product: homocysteine S-methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MDNRLNITMKSQFRLPIILDGGMGRELKRIGAPFQQPEWSAQALIESPHFISEVHKSFIEAGAEVITTNTYALVPFHIGE
KRFNEQGADLIKLAARLARECVKENSAVLVAGCIPPVLGSYRPDLFSVEKAKPVLELLIKNQEADVDIWLAETISSIAEA
AMIKARTVVTNKPTWIAFTIKDEITTEPALRSGESVYDAVSQIAGQNVSAILFNCSGVEVMETALITAKQALLDKEIEDQ
VQLGVYANNFPPIGELHQANQDHGVSGIRDDVPPEKYHEFGLSWINAGASIIGGCCGVSPAHIKKLAELK

Sequences:

>Translated_310_residues
MDNRLNITMKSQFRLPIILDGGMGRELKRIGAPFQQPEWSAQALIESPHFISEVHKSFIEAGAEVITTNTYALVPFHIGE
KRFNEQGADLIKLAARLARECVKENSAVLVAGCIPPVLGSYRPDLFSVEKAKPVLELLIKNQEADVDIWLAETISSIAEA
AMIKARTVVTNKPTWIAFTIKDEITTEPALRSGESVYDAVSQIAGQNVSAILFNCSGVEVMETALITAKQALLDKEIEDQ
VQLGVYANNFPPIGELHQANQDHGVSGIRDDVPPEKYHEFGLSWINAGASIIGGCCGVSPAHIKKLAELK
>Mature_310_residues
MDNRLNITMKSQFRLPIILDGGMGRELKRIGAPFQQPEWSAQALIESPHFISEVHKSFIEAGAEVITTNTYALVPFHIGE
KRFNEQGADLIKLAARLARECVKENSAVLVAGCIPPVLGSYRPDLFSVEKAKPVLELLIKNQEADVDIWLAETISSIAEA
AMIKARTVVTNKPTWIAFTIKDEITTEPALRSGESVYDAVSQIAGQNVSAILFNCSGVEVMETALITAKQALLDKEIEDQ
VQLGVYANNFPPIGELHQANQDHGVSGIRDDVPPEKYHEFGLSWINAGASIIGGCCGVSPAHIKKLAELK

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786456, Length=313, Percent_Identity=29.7124600638978, Blast_Score=96, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 33828; Mature: 33828

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRLNITMKSQFRLPIILDGGMGRELKRIGAPFQQPEWSAQALIESPHFISEVHKSFIE
CCCCEEEEEECCCCEEEEEECCCCHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
AGAEVITTNTYALVPFHIGEKRFNEQGADLIKLAARLARECVKENSAVLVAGCIPPVLGS
CCCCEEECCCEEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCC
YRPDLFSVEKAKPVLELLIKNQEADVDIWLAETISSIAEAAMIKARTVVTNKPTWIAFTI
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHEEEECCCCEEEEEE
KDEITTEPALRSGESVYDAVSQIAGQNVSAILFNCSGVEVMETALITAKQALLDKEIEDQ
CCCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
VQLGVYANNFPPIGELHQANQDHGVSGIRDDVPPEKYHEFGLSWINAGASIIGGCCGVSP
HEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCH
AHIKKLAELK
HHHHHHHHCC
>Mature Secondary Structure
MDNRLNITMKSQFRLPIILDGGMGRELKRIGAPFQQPEWSAQALIESPHFISEVHKSFIE
CCCCEEEEEECCCCEEEEEECCCCHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
AGAEVITTNTYALVPFHIGEKRFNEQGADLIKLAARLARECVKENSAVLVAGCIPPVLGS
CCCCEEECCCEEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCC
YRPDLFSVEKAKPVLELLIKNQEADVDIWLAETISSIAEAAMIKARTVVTNKPTWIAFTI
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHEEEECCCCEEEEEE
KDEITTEPALRSGESVYDAVSQIAGQNVSAILFNCSGVEVMETALITAKQALLDKEIEDQ
CCCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
VQLGVYANNFPPIGELHQANQDHGVSGIRDDVPPEKYHEFGLSWINAGASIIGGCCGVSP
HEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCH
AHIKKLAELK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]